The automated micronucleus assay for early assessment of genotoxicity in drug discovery

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 751, Issue 1, 2013, Pages 1-11

  Tilmant, K ^a,b   Gerets, H H J ^a   De Ron, P ^a   Cossu Leguille, C ^b   Vasseur, P ^b   Dhalluin, S ^a   Atienzar, F A ^a  

^a UCB PHARMA   (Belgium)

^b UNIVERSITÉ DE LORRAINE   (France)

Author keywords

MN frequency; CBPI; Cellular imaging; CHO; Flow cytometry; HepaRG; HepG2; LOAEL; Micronucleus; MN RET; RCC; S9

Indexed keywords

ANIMAL CELL; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINESIS; CYTOTOXICITY; DRUG EXPOSURE; FLOW CYTOMETRY; GENOTOXICITY; IMAGING SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LABORATORY AUTOMATION; MICRONUCLEUS; MICRONUCLEUS TEST; MOLECULAR IMAGING; MOUSE; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ANEUGENS; ANIMALS; BIOTRANSFORMATION; CELL COUNT; CHO CELLS; CRICETINAE; CRICETULUS; CYTOKINESIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FLOW CYTOMETRY; IMAGE PROCESSING, COMPUTER-ASSISTED; MICRONUCLEUS TESTS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84873460406     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.10.011     Document Type: Article

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