Evaluation of the general suitability of the rat for the micronucleus assay: The effect of cyclophosphamide in 14 strains

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 495, Issue 1-2, 2001, Pages 127-134

  Hamada, Shuichi ^a,b   Yamasaki, Ken Ichi ^b   Nakanishi, Satoshi ^b   Omori, Takashi ^c   Serikawa, Tadao ^b   Hayashi, Makoto ^c  

^a SSP CO LTD   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

CSGMT; Cyclophosphamide; Micronucleus assay; Rat; Strain differences

Indexed keywords

CYCLOPHOSPHAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BONE MARROW; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; EVALUATION; MALE; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; RAT; STRAIN DIFFERENCE;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, OUTBRED STRAINS; BONE MARROW CELLS; CYCLOPHOSPHAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; MICRONUCLEUS TESTS; MUTAGENS; RATS; RATS, INBRED STRAINS; RETICULOCYTES; SENSITIVITY AND SPECIFICITY; SPECIES SPECIFICITY;

EID: 0035934436     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00208-X     Document Type: Article

References (21)

1. Sex difference in the micronucleus test
2. Strain difference in the micronucleus test
3. Difference between intraperitoneal and oral gavage application in the micronucleus test: 3rd collaborative study by CSGMT/JEMS. MMS
4. Single versus multiple dosing in the micronucleus test: The summary of the fourth collaborative study by CSGMT/JEMS. MMS
5. Micronucleus test with mouse peripheral blood erythrocytes by acridine orange supravital staining: The summary report of the 5th collaborative study by CSGMT/JEMS. MMS
6. Protocol recommended by the CSGMT/JEMS. MMS for the short-term mouse peripheral blood micronucleus test
7. Effect of aging on spontaneous micronucleus frequencies in peripheral blood of several strains of mouse by the acridine orange supravital staining
8. Individual data in the results of 7th collaborative study organized by the CSGMT/JEMS. MMS
9. Lifetime micronucleus frequencies in MS/Ae mice treated with mitomycin C: A report of the 8th collaborative study organized by the CSGMT/JEMS. MMS
10. Effect of aging on mouse micronucleus test results: A report of the 8th collaborative study organized by the CSGMT/JEMS. MMS
11. The micronucleus assay using peripheral blood reticulocytes from mitomycin C- and cyclophosphamide-treated rats
12. Evaluation of the rat micronucleus test with bone marrow and peripheral blood: Summary of the 9th collaborative study by CSGMT/JEMS. MMS
13. The suitability of rat peripheral blood in subchronic studies for the micronucleus assay
14. Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th collaborative study by CSGMT/JEMS. MMS
15. Oxidative metabolism of cyclophosphamide: Identification of the hepatic monooxygenase catalysts of drug action
16. An application of acridine orange fluorescent staining to the micronucleus test
17. Tables for determining the statistical significance of mutation frequencies
18. Properties of sufficiency and statistical tests
19. The BN rat strain carries dominant hepatocarcinogen resistance loci
20. Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci
21. Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats