Comparison of the peripheral blood micronucleus test using flow cytometry in rat and mouse exposed to aneugens after single-dose applications

Mutagenesis

Volumn 22, Issue 2, 2007, Pages 129-134

  Cammerer, Zoryana ^a   Elhajouji, Azeddine ^a   Kirsch Volders, Micheline ^b   Suter, Willi ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUGEN; COLCHICINE; VINBLASTINE; VINCRISTINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD; BONE MARROW; CELL SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ERYTHROCYTE; FLOW CYTOMETRY; GENOTOXICITY; INTERMETHOD COMPARISON; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOCYTE; SPLEEN; SPLENECTOMY; STATISTICAL SIGNIFICANCE; TARGET ORGAN;

ANEUGENS; ANIMALS; BLOOD CELLS; BONE MARROW CELLS; COLCHICINE; ERYTHROCYTES; FLOW CYTOMETRY; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; RATS; RATS, WISTAR; SPLENECTOMY; VINBLASTINE; VINCRISTINE;

MUS; RATTUS;

EID: 33847660479     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gel066     Document Type: Article

References (36)

1. Heddle, J. A. (1973) Rapid in-vivo test for chromosomal damage. Mutat. Res., 18, 187-190.
2. Schmid, W. (1975) Micronucleus test. Mutat. Res., 31, 9-15.
3. International Committee on Harmonisation (ICH) (1997) Harmonised Tripartite Guideline S2B. Genotoxicity: A Standard for Genotoxicity Testing of Pharmaceuticals. (Adopted by CPMP, September 1997, issued as CPMP/ICH/174/95).
4. Schalm, O. W. (1968) Veterinary Hematology. 2nd edn. Lea and Febiger, Philadelphia, PA, 417 p.
5. Von Ledebur, M. and Schmid, W. (1973) The micronucleus test, methodological aspects. Mutat. Res., 19, 109-117.
6. Schlegel, R. and MacGregor, J. T. (1984) The persistence of micronucleated erythrocytes in the peripheral-circulation of normal and splenectomized Fischer 344 rats - implications for cytogenetic screening. Mutat. Res., 127, 169-174.
7. Wintrobe, M. M. (1981) Clinical Hematology. 8th edn. Lea and Febiger, Philadelphia, PA, 262 p.
8. MacGregor, J. T., Wehr, C. M. and Gould, D. H. (1980) Clastogen-induced micronuclei in peripheral blood erythrocytes: the basis of an improved micronucleus test. Environ. Mutagen., 2, 509-514.
9. Schlegel, R. and MacGregor, J. T. (1982) The persistence of micronuclei in peripheral-blood erythrocytes - detection of chronic chromosome breakage in mice. Mutat. Res., 104, 367-369.
10. Hayashi, M., Kodama, Y., Awogi, T., Suzuki, T., Asita, A. O. and Sofuni, T. (1992) The micronucleus assay using peripheral-blood reticulocytes from mitomycin-C-treated and cyclophosphamide-treated rats. Mutat. Res., 278, 209-213.
11. Holden, H. E., Majeska, J. B. and Studwell, D. (1997) A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay. Mutat. Res., 391, 87-89.
12. Tometsko, A. M., Torous, D. K. and Dertinger, S. D. (1993) Analysis of micronucleated cells by flow-cytometry.1. Achieving high-resolution with a malaria model. Mutat. Res., 292, 129-135.
13. Dertinger, S. D., Torous, D. K., Hall, N. E., Tometsko, C. R. and Gasiewicz, T. A. (2000) Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry. Mutat. Res., 464, 195-200.
14. Romagna, F. (1988) Improved method of preparing bone marrow micronucleus slides: fractionation of a pure PE and NE population from rodent bone marrow. Mutat. Res., 206, 307-309.
15. Romagna, F. and Staniforth, C. D. (1989) The automated bone marrow micronucleus test. Mutat. Res., 213, 91-104.
16. Milliken, G. A. and Johnson, D. E. (1992) Analysis of Messy Data, Volume 1: Design of Experiments. Chapman & Hall, London, pp. 19-23.
17. Anderson, V. L. and McLean, R. A. (1974) Design of Experiments: A Realistic Aproach. Marcel Dekkar, New York, pp. 16-22.
18. Kempthorne, O. (1960) The Design and Analysis of Experiments. John Wiley, New York.
19. Dunnett, C. W. (1955) A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc., 50, 1096-1121.
20. Kruskal, W. H. and Wallis, W. A. (1952) Use of ranks in one-criterion analysis of variance. J. Am. Stat. Assoc., 47, 583-621.
21. Miller, R. G. (1966) Simultaneous Statistical Inference. McGraw Hill, New York.
22. Yamamoto, K. I. and Kikuchi, Y. (1980) A comparison of diameter of micronuclei induced by clastogens and by spindel poisons. Mutat. Res., 71, 127-131.
23. Högstedt, B. and Karlsson, A. (1985) The size of micronuclei in human lymphocytes varies according to inducing agent used. Mutat. Res., 156, 229-232.
24. Ferguson, L. R., Morcombe, P. and Triggs, C. N. (1993) The size of cytokinesis-blocked MN in human peripheral blood lymphocytes as a measure of aneuploidy induction by a set compounds in the EEC trial. Mutat. Res., 287, 101-112.
25. Wakata, A., Miyamae, Y., Sato, S., Suzuki, T., Morita, T., Asano, N., Awogi, T., Kondo, K. and Hayashi, M. (1998) Evaluation of the rat micronucleus test with bone marrow and peripheral blood: summary of the 9th collaborative study by CSGMT/JEMS Center Dot MMS. Environ. Mol. Mutagen., 32, 84-100.
26. Hynes, G. M., Torous, D. K., Tometsko, C. R., Burlinson, B. and Gatehouse, D. G. (2002) The single laser flow cytometric micronucleus test: a time course study using colchicine and urethane in rat and mouse peripheral blood and acetaldehyde in rat peripheral blood. Mutagenesis, 17, 15-23.
27. Asano, N., Morita, T. and Watanabe, Y. (1989) Micronucleus test with colchicine given by intraperitoneal injection and oral gavage. Mutat. Res., 223, 391-394.
28. Grawe, J., Nüsse, M. and Adler, I. (1997) Quantitative and qualitative studies of micronucleus induction in mouse erythrocytes using flow cytometry. I. Measurement of micronucleus induction in peripheral blood polychromatic erythrocytes by chemicals with known and suspected genotoxicity. Mutagenesis, 12, 1-8.
29. Ohuchida, A., Furukawa, A., Kondo, Y., Ono, T. and Nito, S. (1989) Micronucleus test with vincristine administered by intraperitoneal injection and oral gavage. Mutat. Res., 223, 395-398.
30. Maier, P. and Schmid, W. (1976) Ten model mutagens evaluated by the microunucleus test. Mutat. Res., 40, 325-338.
31. De Boeck, M., Van der Leede, B. J., Van Goethem,, F., De Smedt,, A., Steemans, M., Lampo, A. and Vanparys, P. (2005) Flow cytometric analysis of micronucleated reticulocytes: time- and dose-dependent response of known mutagens in mice, using multiple blood sampling. Environ. Mol. Mutagen., 46, 30-42.
32. Cammerer, Z., Elhajouji, A. and Suter, W. (2007) In vivo micronucleus test with flow cytometry after acute and chronic exposures of rats to chemicals. Mutat. Res., 626, 26-33.
33. Abramsson-Zetterberg, L., Grawe, J. and Zetterberg, G. (1999) The micronucleus test in rat erythrocytes from bone marrow, spleen and peripheral blood: the response to low doses of ionizing radiation, cyclophosphamide and vincristine determined by flow cytometry. Mutat. Res., 423, 113-124.
34. Torous, D. K., Hall, N. E., Murante, F. G., Gleason, S. E., Tometsko, C. R. and Dertinger, S. D. (2003) Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy. Toxicol. Sci., 74, 309-314.
35. MacGregor, J. T., Bishop, M. E., McNamee, J. P. et al. (2006) Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat. Toxicol. Sci., 94, 92-107.
36. Recio, L., Caspary, W., Torous, D., Livanos, E., Kissling, G. and Witt, K. (2006) Dose-response comparison of micronucleated reticulocyte frequencies in rodent peripheral blood with four genotoxic agents by flow cytometry and slide-based enumeration. The Toxicologist CD - An official Journal of the Society of Toxicology, 90.