An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G2/M-phase arrest in mammary adenocarcinoma TA3

Toxicology and Applied Pharmacology

Volumn 267, Issue 3, 2013, Pages 218-227

  Urra, Félix A ^a   Martínez Cifuentes, Maximiliano ^a   Pavani, Mario ^b   Lapier, Michel ^b   Jaña Prado, Fabián ^b   Parra, Eduardo ^c   Maya, Juan Diego ^b   Pessoa Mahana, Hernán ^a   Ferreira, Jorge ^b   Araya Maturana, Ramiro ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSIDAD DE TARAPACÁ   (Chile)

Author keywords

Anticancer agents; Cancer; Cell cycle arrest; Hydroquinone; Mitochondria; Mitochondrial bioenergetics; Oxidative phosphorylation

Indexed keywords

9,10 DIHYDROXY 4,4 DIMETHYL 5,8 DIHYDROANTHRACEN 1 (4H)ONE; ANTINEOPLASTIC AGENT; DUROQUINOL; HYDROQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOENERGY; BREAST ADENOCARCINOMA; BREAST EPITHELIUM; CELL VIABILITY; CONTROLLED STUDY; G2 PHASE CELL CYCLE CHECKPOINT; M PHASE CELL CYCLE CHECKPOINT; MALE; MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; ENERGY METABOLISM; G2 PHASE CELL CYCLE CHECKPOINTS; HYDROQUINONES; MALE; MAMMARY NEOPLASMS, ANIMAL; MICE; MITOCHONDRIA;

EID: 84873445182     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.12.023     Document Type: Article

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