Understanding the metabolic basis of drug resistance: Therapeutic induction of the Warburg effect kills cancer cells

Cell Cycle

Volumn 10, Issue 15, 2011, Pages 2521-2528

  Martinez Outschoorn, Ubaldo E ^a,b   Lin, Zhao ^a   Ko, Ying Hui ^a   Goldberg, Allison F ^b   Flomenberg, Neal ^a,b   Wang, Chenguang ^a   Pavlides, Stephanos ^a   Pestell, Richard G ^a   Howell, Anthony ^c   Sotgia, Federica ^a,c   Lisanti, Michael P ^a,b,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Aerobic glycolysis; Cancer associated fibroblasts; Dasatinib; Drug resistance; Glucose uptake; Microenvironment; Mitochondrial oxidative phosphorylation; Oxidative stress; Reactive oxygen species (ROD); Tamoxifen; Tumor stroma; Warburg effect

Indexed keywords

DASATINIB; ESTROGEN RECEPTOR; TAMOXIFEN; TELOMERASE REVERSE TRANSCRIPTASE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER RESISTANCE; CELL STRAIN MCF 7; COCULTURE; CONTROLLED STUDY; DRUG MECHANISM; FIBROBLAST CULTURE; GLYCOLYSIS; HUMAN; HUMAN CELL; NEOPLASM;

EID: 79961118758     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.15.16584     Document Type: Article

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