Transforming growth factor-β and abdominal aortic aneurysms

Cardiovascular Pathology

Volumn 22, Issue 2, 2013, Pages 126-132

  Wang, Yutang ^a   Krishna, Smriti ^a   Walker, Philip J ^b   Norman, Paul ^c   Golledge, Jonathan ^a  

^a JAMES COOK UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Abdominal aortic aneurysm; Extracellular matrix; Matrix metalloproteinase; Transforming growth factor

Indexed keywords

COLLAGEN; CYCLOSPORIN A; ELASTIN; GELATINASE A; GELATINASE B; IMMUNOSUPPRESSIVE AGENT; MACROPHAGE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; SMAD UBIQUITINATION REGULATORY FACTOR 1; SMAD UBIQUITINATION REGULATORY FACTOR 2; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; AORTA ANEURYSM; AORTA RUPTURE; APOPTOSIS; COLLAGEN SYNTHESIS; DISEASE COURSE; DNA POLYMORPHISM; DOWN REGULATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY INFILTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION; THORACIC AORTA ANEURYSM; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTIC ANEURYSM, ABDOMINAL; AORTIC ANEURYSM, THORACIC; HEMODYNAMICS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; POLYMORPHISM, GENETIC; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84873413659     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2012.07.005     Document Type: Review

References (111)

1. KW Johnston, RB Rutherford, MD Tilson, DM Shah, L Hollier, and JC Stanley Suggested standards for reporting on arterial aneurysms. Subcommittee on Reporting Standards for Arterial Aneurysms, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery J Vasc Surg 13 1991 452 458
2. SN Hasham, DC Guo, and DM Milewicz Genetic basis of thoracic aortic aneurysms and dissections Curr Opin Cardiol 17 2002 677 683
3. J Golledge, J Muller, A Daugherty, and P Norman Abdominal aortic aneurysm: pathogenesis and implications for management Arterioscler Thromb Vasc Biol 26 2006 2605 2613
4. HA Ashton, MJ Buxton, NE Day, LG Kim, TM Marteau, and RA Scott The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial Lancet 360 2002 1531 1539
5. RA Scott, KA Vardulaki, NM Walker, NE Day, SW Duffy, and HA Ashton The long-term benefits of a single scan for abdominal aortic aneurysm (AAA) at age 65 Eur J Vasc Endovasc Surg 21 2001 535 540
6. HG Alcorn, SK Wolfson, K Sutton-Tyrrell, LH Kuller, and D O'Leary Risk factors for abdominal aortic aneurysms in older adults enrolled in The Cardiovascular Health Study Arterioscler Thromb Vasc Biol 16 1996 963 970
7. FA Lederle, GR Johnson, and SE Wilson Abdominal aortic aneurysm in women J Vasc Surg 34 2001 122 126
8. JB Semmens, PE Norman, MM Lawrence-Brown, and CD Holman Influence of gender on outcome from ruptured abdominal aortic aneurysm Br J Surg 87 2000 191 194
9. Long-term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms N Engl J Med 346 2002 1445 1452
10. A Hallin, D Bergqvist, and L Holmberg Literature review of surgical management of abdominal aortic aneurysm Eur J Vasc Endovasc Surg 22 2001 197 204
11. DC Brewster, JL Cronenwett, JW Hallett, KW Johnston, WC Krupski, and JS Matsumura Guidelines for the treatment of abdominal aortic aneurysms. Report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery J Vasc Surg 37 2003 1106 1117
12. AC Brox, KB Filion, X Zhang, L Pilote, D Obrand, and S Haider In-hospital cost of abdominal aortic aneurysm repair in Canada and the United States Arch Intern Med 163 2003 2500 2504
13. JA Jones, FG Spinale, and JS Ikonomidis Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis J Vasc Res 46 2009 119 137
14. R Lemaire, J Bayle, and R Lafyatis Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis Curr Opin Rheumatol 18 2006 582 587
15. MW Majesky Developmental basis of vascular smooth muscle diversity Arterioscler Thromb Vasc Biol 27 2007 1248 1258
16. P Wasteson, BR Johansson, T Jukkola, S Breuer, LM Akyurek, and J Partanen Developmental origin of smooth muscle cells in the descending aorta in mice Development 135 2008 1823 1832
17. S Topouzis, and MW Majesky Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta. Dev Biol 178 1996 430 445
18. AE Koch, GK Haines, RJ Rizzo, JA Radosevich, RM Pope, and PG Robinson Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response Am J Pathol 137 1990 1199 1213
19. ND Forester, SM Cruickshank, DJ Scott, and SR Carding Functional characterization of T cells in abdominal aortic aneurysms Immunology 115 2005 262 270
20. M Nataatmadja, J West, and M West Overexpression of transforming growth factor-beta is associated with increased hyaluronan content and impairment of repair in Marfan syndrome aortic aneurysm Circulation 114 2006 I371 I377
21. T Radonic, P de Witte, M Groenink, V de Waard, R Lutter, and M van Eijk Inflammation aggravates disease severity in Marfan syndrome patients PLoS One 7 2012 e32963
22. B Schmierer, and CS Hill TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility Nat Rev Mol Cell Biol 8 2007 970 982
23. WA Border, and NA Noble Transforming growth factor beta in tissue fibrosis N Engl J Med 331 1994 1286 1292
24. DA Cox Transforming growth factor-beta 3 Cell Biol Int 19 1995 357 371
25. JP Grande Role of transforming growth factor-beta in tissue injury and repair Proc Soc Exp Biol Med 214 1997 27 40
26. T Brand, and MD Schneider Transforming growth factor-beta signal transduction Circ Res 78 1996 173 179
27. C Hugo The thrombospondin 1-TGF-beta axis in fibrotic renal disease Nephrol Dial Transplant 18 2003 1241 1245
28. JS Munger, X Huang, H Kawakatsu, MJ Griffiths, SL Dalton, and J Wu The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis Cell 96 1999 319 328
29. JL Wrana, L Attisano, R Wieser, F Ventura, and J Massague Mechanism of activation of the TGF-beta receptor Nature 370 1994 341 347
30. F Lopez-Casillas, HM Payne, JL Andres, and J Massague Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites J Cell Biol 124 1994 557 568
31. R Derynck, and YE Zhang Smad-dependent and Smad-independent pathways in TGF-beta family signalling Nature 425 2003 577 584
32. S Cheifetz, H Hernandez, M Laiho, P ten Dijke, KK Iwata, and J Massague Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms J Biol Chem 265 1990 20533 20538
33. S Akool el, A Doller, A Babelova, W Tsalastra, K Moreth, and L Schaefer Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506 J Immunol 181 2008 2831 2845
34. S Itoh, F Itoh, MJ Goumans, and P Ten Dijke Signaling of transforming growth factor-beta family members through Smad proteins Eur J Biochem 267 2000 6954 6967
35. A Nakao, M Afrakhte, A Moren, T Nakayama, JL Christian, and R Heuchel Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling Nature 389 1997 631 635
36. J Massague How cells read TGF-beta signals Nat Rev Mol Cell Biol 1 2000 169 178
37. A Moustakas, S Souchelnytskyi, and CH Heldin Smad regulation in TGF-beta signal transduction J Cell Sci 114 2001 4359 4369
38. CH Heldin, K Miyazono, and P ten Dijke TGF-beta signalling from cell membrane to nucleus through SMAD proteins Nature 390 1997 465 471
39. Y Shi, and J Massague Mechanisms of TGF-beta signaling from cell membrane to the nucleus Cell 113 2003 685 700
40. K Arora, and R Warrior A new Smurf in the village Dev Cell 1 2001 441 442
41. K Yamaguchi, K Shirakabe, H Shibuya, K Irie, I Oishi, and N Ueno Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction Science 270 1995 2008 2011
42. MK Lee, C Pardoux, MC Hall, PS Lee, D Warburton, and J Qing TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA EMBO J 26 2007 3957 3967
43. AV Bakin, AK Tomlinson, NA Bhowmick, HL Moses, and CL Arteaga Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration J Biol Chem 275 2000 36803 36810
44. F Vinals, and J Pouyssegur Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling Mol Cell Biol 21 2001 7218 7230
45. M Dziembowska, M Danilkiewicz, A Wesolowska, A Zupanska, S Chouaib, and B Kaminska Cross-talk between Smad and p38 MAPK signalling in transforming growth factor beta signal transduction in human glioblastoma cells Biochem Biophys Res Commun 354 2007 1101 1106
46. M Pessah, J Marais, C Prunier, N Ferrand, F Lallemand, and A Mauviel c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity J Biol Chem 277 2002 29094 29100
47. M Kretzschmar, J Doody, and J Massague Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1 Nature 389 1997 618 622
48. N Kimura, R Matsuo, H Shibuya, K Nakashima, and T Taga BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 J Biol Chem 275 2000 17647 17652
49. A Mazars, F Lallemand, C Prunier, J Marais, N Ferrand, and M Pessah Evidence for a role of the JNK cascade in Smad7-mediated apoptosis J Biol Chem 276 2001 36797 36803
50. RW Thompson, PJ Geraghty, and JK Lee Abdominal aortic aneurysms: basic mechanisms and clinical implications Curr Probl Surg 39 2002 110 230
51. G Ailawadi, JL Eliason, and GR Upchurch Current concepts in the pathogenesis of abdominal aortic aneurysm J Vasc Surg 38 2003 584 588
52. FJ Miller, WJ Sharp, X Fang, LW Oberley, TD Oberley, and NL Weintraub Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling Arterioscler Thromb Vasc Biol 22 2002 560 565
53. EL Henderson, YJ Geng, GK Sukhova, AD Whittemore, J Knox, and P Libby Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms Circulation 99 1999 96 104
54. A Lopez-Candales, DR Holmes, S Liao, MJ Scott, SA Wickline, and RW Thompson Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms Am J Pathol 150 1997 993 1007
55. E Ocana, JC Bohorquez, J Perez-Requena, JA Brieva, and C Rodriguez Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms Atherosclerosis 170 2003 39 48
56. FE Parodi, D Mao, TL Ennis, MA Bartoli, and RW Thompson Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB J Vasc Surg 41 2005 479 489
57. JH Lindeman, TJ Rabelink, and JH van Bockel Immunosuppression and the abdominal aortic aneurysm: doctor jekyll or mister hyde? Circulation 124 2011 e463 e465
58. NP Kadoglou, and CD Liapis Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms Curr Med Res Opin 20 2004 419 432
59. DA Bigatel, JR Elmore, DJ Carey, G Cizmeci-Smith, DP Franklin, and JR Youkey The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms J Vasc Surg 29 1999 130 139
60. R Pyo, JK Lee, JM Shipley, JA Curci, D Mao, and SJ Ziporin Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms J Clin Invest 105 2000 1641 1649
61. E Allaire, B Muscatelli-Groux, AM Guinault, C Pages, A Goussard, and C Mandet Vascular smooth muscle cell endovascular therapy stabilizes already developed aneurysms in a model of aortic injury elicited by inflammation and proteolysis Ann Surg 239 2004 417 427
62. E Biros, PJ Walker, M Nataatmadja, M West, and J Golledge Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm Atherosclerosis 221 2012 383 386
63. AR Thompson, JA Cooper, GT Jones, F Drenos, FM van Bockxmeer, and E Biros Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm Atherosclerosis 209 2010 367 373
64. AF Baas, J Medic, R van 't Slot, CG de Kovel, A Zhernakova, and RH Geelkerken Association of the TGF-beta receptor genes with abdominal aortic aneurysm Eur J Hum Genet 18 2010 240 244
65. J Golledge, P Clancy, GT Jones, M Cooper, LJ Palmer, and AM van Rij Possible association between genetic polymorphisms in transforming growth factor beta receptors, serum transforming growth factor beta1 concentration and abdominal aortic aneurysm Br J Surg 96 2009 628 632
66. E Biros, PE Norman, GT Jones, AM van Rij, G Yu, and JV Moxon Meta-analysis of the association between single nucleotide polymorphisms in TGF-beta receptor genes and abdominal aortic aneurysm Atherosclerosis 219 2011 218 223
67. GG Vaday, H Schor, MA Rahat, N Lahat, and O Lider Transforming growth factor-beta suppresses tumor necrosis factor alpha-induced matrix metalloproteinase-9 expression in monocytes J Leukoc Biol 69 2001 613 621
68. L Lucarini, E Sticchi, F Sofi, G Pratesi, C Pratesi, and R Pulli ACE and TGFBR1 genes interact in influencing the susceptibility to abdominal aortic aneurysm Atherosclerosis 202 2009 205 210
69. JS Lindholt Activators of plasminogen and the progression of small abdominal aortic aneurysms Ann N Y Acad Sci 1085 2006 139 150
70. Y Wang, H Ait-Oufella, O Herbin, P Bonnin, B Ramkhelawon, and S Taleb TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice J Clin Invest 120 2010 422 432
71. JT Powell, and RM Greenhalgh Clinical practice. Small abdominal aortic aneurysms N Engl J Med 348 2003 1895 1901
72. S Michineau, J Dai, M Gervais, M Zidi, AW Clowes, and JP Becquemin Aortic length changes during abdominal aortic aneurysm formation, expansion and stabilisation in a rat model Eur J Vasc Endovasc Surg 40 2010 468 474
73. J Dai, F Losy, AM Guinault, C Pages, I Anegon, and P Desgranges Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy Circulation 112 2005 1008 1015
74. J Dai, S Michineau, G Franck, P Desgranges, JP Becquemin, and M Gervais Long term stabilization of expanding aortic aneurysms by a short course of cyclosporine A through transforming growth factor-beta induction PLoS One 6 2011 e28903
75. M Islam, JF Burke, TA McGowan, Y Zhu, SR Dunn, and P McCue Effect of anti-transforming growth factor-beta antibodies in cyclosporine-induced renal dysfunction Kidney Int 59 2001 498 506
76. A Rijbroek, FL Moll, HA von Dijk, R Meijer, and JW Jansen Inflammation of the abdominal aortic aneurysm wall Eur J Vasc Surg 8 1994 41 46
77. T Freestone, RJ Turner, A Coady, DJ Higman, RM Greenhalgh, and JT Powell Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm Arterioscler Thromb Vasc Biol 15 1995 1145 1151
78. VJ Halpern, GB Nackman, RH Gandhi, E Irizarry, JV Scholes, and WG Ramey The elastase infusion model of experimental aortic aneurysms: synchrony of induction of endogenous proteinases with matrix destruction and inflammatory cell response J Vasc Surg 20 1994 51 60
79. S Anidjar, PB Dobrin, M Eichorst, GP Graham, and G Chejfec Correlation of inflammatory infiltrate with the enlargement of experimental aortic aneurysms J Vasc Surg 16 1992 139 147
80. GM Longo, W Xiong, TC Greiner, Y Zhao, N Fiotti, and BT Baxter Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms J Clin Invest 110 2002 625 632
81. SD Shapiro, SK Endicott, MA Province, JA Pierce, and EJ Campbell Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon J Clin Invest 87 1991 1828 1834
82. EC Davis Stability of elastin in the developing mouse aorta: a quantitative radioautographic study Histochemistry 100 1993 17 26
83. RP Mecham, TJ Broekelmann, CJ Fliszar, SD Shapiro, HG Welgus, and RM Senior Elastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis J Biol Chem 272 1997 18071 18076
84. E Petersen, A Gineitis, F Wagberg, and KA Angquist Activity of matrix metalloproteinase-2 and -9 in abdominal aortic aneurysms. Relation to size and rupture Eur J Vasc Endovasc Surg 20 2000 457 461
85. CR Kothapalli, PM Taylor, RT Smolenski, MH Yacoub, and A Ramamurthi Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells Tissue Eng Part A 15 2009 501 511
86. CE Gacchina, P Deb, JL Barth, and A Ramamurthi Elastogenic inductability of smooth muscle cells from a rat model of late stage abdominal aortic aneurysms Tissue Eng Part A 17 2011 1699 1711
87. C Gacchina, T Brothers, and A Ramamurthi Evaluating smooth muscle cells from CaCl2-induced rat aortal expansions as a surrogate culture model for study of elastogenic induction of human aneurysmal cells Tissue Eng Part A 17 2011 1945 1958
88. AB Roberts, MB Sporn, RK Assoian, JM Smith, NS Roche, and LM Wakefield Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro Proc Natl Acad Sci USA 83 1986 4167 4171
89. EG Nabel, L Shum, VJ Pompili, ZY Yang, H San, and HB Shu Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia Proc Natl Acad Sci USA 90 1993 10759 10763
90. RW Thompson, DR Holmes, RA Mertens, S Liao, MD Botney, and RP Mecham Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages J Clin Invest 96 1995 318 326
91. F Zhang, G Banker, X Liu, PA Suwanabol, J Lengfeld, and D Yamanouchi The novel function of advanced glycation end products in regulation of MMP-9 production J Surg Res 171 2011 871 876
92. S Rydziel, S Varghese, and E Canalis Transforming growth factor beta1 inhibits collagenase 3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures J Cell Physiol 170 1997 145 152
93. F Losy, J Dai, C Pages, M Ginat, B Muscatelli-Groux, and AM Guinault Paracrine secretion of transforming growth factor-beta1 in aneurysm healing and stabilization with endovascular smooth muscle cell therapy J Vasc Surg 37 2003 1301 1309
94. K Hoshina, E Sho, M Sho, TK Nakahashi, and RL Dalman Wall shear stress and strain modulate experimental aneurysm cellularity J Vasc Surg 37 2003 1067 1074
95. TK Nakahashi, K Hoshina, PS Tsao, E Sho, M Sho, and JK Karwowski Flow loading induces macrophage antioxidative gene expression in experimental aneurysms Arterioscler Thromb Vasc Biol 22 2002 2017 2022
96. MM Dua, and RL Dalman Hemodynamic influences on abdominal aortic aneurysm disease: Application of biomechanics to aneurysm pathophysiology Vascul Pharmacol 53 2010 11 21
97. M Ohno, JP Cooke, VJ Dzau, and GH Gibbons Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade J Clin Invest 95 1995 1363 1369
98. H Ueba, M Kawakami, and T Yaginuma Shear stress as an inhibitor of vascular smooth muscle cell proliferation. Role of transforming growth factor-beta 1 and tissue-type plasminogen activator Arterioscler Thromb Vasc Biol 17 1997 1512 1516
99. RH Song, HK Kocharyan, JE Fortunato, S Glagov, and HS Bassiouny Increased flow and shear stress enhance in vivo transforming growth factor-beta1 after experimental arterial injury Arterioscler Thromb Vasc Biol 20 2000 923 930
100. J Ahamed, N Burg, K Yoshinaga, CA Janczak, DB Rifkin, and BS Coller In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1 Blood 112 2008 3650 3660
101. RD Shepherd, SM Kos, and KD Rinker Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells Am J Physiol Heart Circ Physiol 301 2011 H98 H107
102. A Cucina, AV Sterpetti, V Borrelli, S Pagliei, A Cavallaro, and LS D'Angelo Shear stress induces transforming growth factor-beta 1 release by arterial endothelial cells Surgery 123 1998 212 217
103. T Okamoto, S Takahashi, E Nakamura, K Nagaya, T Hayashi, and K Fujieda Transforming growth factor-beta1 induces matrix metalloproteinase-9 expression in human meningeal cells via ERK and Smad pathways Biochem Biophys Res Commun 383 2009 475 479
104. T Kobayashi, S Hattori, and H Shinkai Matrix metalloproteinases-2 and -9 are secreted from human fibroblasts Acta Derm Venereol 83 2003 105 107
105. T Salo, JG Lyons, F Rahemtulla, H Birkedal-Hansen, and H Larjava Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes J Biol Chem 266 1991 11436 11441
106. D Dang, Y Yang, X Li, A Atakilit, J Regezi, and D Eisele Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix Biochem Biophys Res Commun 316 2004 937 942
107. A Safina, E Vandette, and AV Bakin ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells Oncogene 26 2007 2407 2422
108. SN Sinpitaksakul, A Pimkhaokham, N Sanchavanakit, and P Pavasant TGF-beta1 induced MMP-9 expression in HNSCC cell lines via Smad/MLCK pathway Biochem Biophys Res Commun 371 2008 713 718
109. MW Majesky, V Lindner, DR Twardzik, SM Schwartz, and MA Reidy Production of transforming growth factor beta 1 during repair of arterial injury J Clin Invest 88 1991 904 910
110. C Li, and AI Gotlieb Transforming growth factor-beta regulates the growth of valve interstitial cells in vitro Am J Pathol 179 2011 1746 1755
111. S Xu, AC Liu, and AI Gotlieb Common pathogenic features of atherosclerosis and calcific aortic stenosis: role of transforming growth factor-beta Cardiovasc Pathol 19 2010 236 247