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Volumn 301, Issue 1, 2011, Pages

Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells

Author keywords

Mechanotransduction; Mitogen activated protein kinases; Plasminogen activator inhibitor 1; Platelet derived growth factor subunit b; Shear stress; Transforming growth interacting factor

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; GROWTH FACTOR; MESSENGER RNA; PROTEIN KINASE B; SERINE; SMAD2 PROTEIN; THREONINE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH INTERACTING FACTOR; UNCLASSIFIED DRUG;

EID: 79959902697     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00668.2010     Document Type: Article
Times cited : (20)

References (45)
  • 1
    • 23344448458 scopus 로고    scopus 로고
    • Differential global gene expression response patterns of human endothelium exposed to shear stress and intraluminal pressure
    • Andersson M, Karlsson L, Svensson PA, Ulfhammer E, Ekman M, Jernas M, Carlsson LMS, Jern S. Differential global gene expression response patterns of human endothelium exposed to shear stress and intraluminal pressure. J Vasc Res 42: 441-452, 2005.
    • (2005) J Vasc Res , vol.42 , pp. 441-452
    • Andersson, M.1    Karlsson, L.2    Svensson, P.A.3    Ulfhammer, E.4    Ekman, M.5    Jernas, M.6    Carlsson, L.M.S.7    Jern, S.8
  • 3
    • 0033605559 scopus 로고    scopus 로고
    • MEKK-1, a component of the stress (stress-activated protein kinase/ c-jun n-terminal kinase) pathway, can selectively activate smad2-mediated transcriptional activation in endothelial cells
    • Brown JD, DiChiara MR, Anderson KR, Gimbrone MA Jr, Topper JN. MEKK-1, a component of the stress (stress-activated protein kinase/ c-jun n-terminal kinase) pathway, can selectively activate smad2-mediated transcriptional activation in endothelial cells. J Biol Chem 274: 8797-8805, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 8797-8805
    • Brown, J.D.1    Dichiara, M.R.2    Anderson, K.R.3    Gimbrone Jr, M.A.4    Topper, J.N.5
  • 4
    • 34547118365 scopus 로고    scopus 로고
    • Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress
    • Chiu JJ, Chen LJ, Lee CI, Lee PL, Lee DY, Tsai MC, Lin CW, Usami S, Chien S. Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. Blood 110: 519-528, 2007.
    • (2007) Blood , vol.110 , pp. 519-528
    • Chiu, J.J.1    Chen, L.J.2    Lee, C.I.3    Lee, P.L.4    Lee, D.Y.5    Tsai, M.C.6    Lin, C.W.7    Usami, S.8    Chien, S.9
  • 7
    • 37349112714 scopus 로고    scopus 로고
    • Akt kinase targets association of CBP with smad3 to regulate TGF-beta induced expression of plasminogen activator inhibitior-1
    • Das F, Ghosh-Choudhury N, Venkatesan B, Li X, Mahimainathan L, Choudhury GG. Akt kinase targets association of CBP with smad3 to regulate TGF-beta induced expression of plasminogen activator inhibitior-1. J Cell Physiol 214: 513-527, 2008.
    • (2008) J Cell Physiol , vol.214 , pp. 513-527
    • Das, F.1    Ghosh-Choudhury, N.2    Venkatesan, B.3    Li, X.4    Mahimainathan, L.5    Choudhury, G.G.6
  • 9
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGFb-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGFb-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17: 3091-3100, 1998.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    ten Dijke, P.4    Huet, S.5    Gauthier, J.M.6
  • 10
    • 0032504745 scopus 로고    scopus 로고
    • Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: Involvement in suppression of apoptosis
    • Dimmeler S, Assmus B, Hermann C, Haendeler J, Zeiher AM. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ Res 83: 334-341, 1998.
    • (1998) Circ Res , vol.83 , pp. 334-341
    • Dimmeler, S.1    Assmus, B.2    Hermann, C.3    Haendeler, J.4    Zeiher, A.M.5
  • 11
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt dependent phosphorylation. Nature 399: 601-605, 1999.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 12
    • 0033601179 scopus 로고    scopus 로고
    • Interdependent smad and JNK signaling in transforming growth factor B-mediated transcription
    • Engel ME, McDonnell MA, Law BK, Moses HL. Interdependent smad and JNK signaling in transforming growth factor B-mediated transcription. J Biol Chem 274: 37413-37420, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 37413-37420
    • Engel, M.E.1    McDonnell, M.A.2    Law, B.K.3    Moses, H.L.4
  • 15
    • 0036829567 scopus 로고    scopus 로고
    • Modulation of smad2-mediated signaling by extracellular signal-regulated kinase
    • Funaba F, Zimmerman CM, Mathews LS. Modulation of smad2-mediated signaling by extracellular signal-regulated kinase. J Biol Chem 277: 41361-41368, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 41361-41368
    • Funaba, F.1    Zimmerman, C.M.2    Mathews, L.S.3
  • 16
    • 34547148984 scopus 로고    scopus 로고
    • Frequency-dependent response of the vascular endothelium to pulsatile shear stress
    • Himburg HA, Dowd SE, Friedman MH. Frequency-dependent response of the vascular endothelium to pulsatile shear stress. Am J Physiol Heart Circ Physiol 293: H645-H653, 2007.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Himburg, H.A.1    Dowd, S.E.2    Friedman, M.H.3
  • 17
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGF-B/smad signaling by oncogenic Ras
    • Kretzschmar M, Doody J, Timokhina I, Massague J. A mechanism of repression of TGF-B/smad signaling by oncogenic Ras. Genes Dev 13: 804-816, 1999.
    • (1999) Genes Dev , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massague, J.4
  • 18
    • 36049042911 scopus 로고    scopus 로고
    • Individual and combined effects of shear stress magnitude and spatial gradient on endothelial cell gene expression
    • LaMack JA, Friedman MH. Individual and combined effects of shear stress magnitude and spatial gradient on endothelial cell gene expression. Am J Physiol Heart Circ Physiol 293: H2853-H2859, 2007.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Lamack, J.A.1    Friedman, M.H.2
  • 19
    • 0034666302 scopus 로고    scopus 로고
    • Interaction and functional cooperation of NF-kB with smads: Transcriptional regulation of the junB promoter
    • Lopez-Rovira T, Chalaux E, Rosa JL, Bartrons R, Ventura F. Interaction and functional cooperation of NF-kB with smads: transcriptional regulation of the junB promoter. J Biol Chem 275: 28937-28946, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 28937-28946
    • Lopez-Rovira, T.1    Chalaux, E.2    Rosa, J.L.3    Bartrons, R.4    Ventura, F.5
  • 20
    • 0029587668 scopus 로고
    • Control of endothelial cell gene expression by flow
    • Malek AM, Izumo S. Control of endothelial cell gene expression by flow. J Biomech 28: 1515-1528, 1995.
    • (1995) J Biomech , vol.28 , pp. 1515-1528
    • Malek, A.M.1    Izumo, S.2
  • 21
    • 0027359453 scopus 로고
    • Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium
    • Malek AM, Gibbons GH, Dzau VJ, Izumo S. Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest 92: 2013-2021, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 2013-2021
    • Malek, A.M.1    Gibbons, G.H.2    Dzau, V.J.3    Izumo, S.4
  • 22
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-B/smad signaling system
    • Massague J, Wotton D. Transcriptional control by the TGF-B/smad signaling system. EMBO J 19: 1745-1754, 2004.
    • (2004) EMBO J , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 26
    • 0038801663 scopus 로고    scopus 로고
    • Functional cooperation between smad proteins and activator protein-1 regulates transforming growth factor-β-mediated induction of endothelin-1 expression
    • Rodriguez-Pascual F, Redondo-Horcajo M, Lamas S. Functional cooperation between smad proteins and activator protein-1 regulates transforming growth factor-β-mediated induction of endothelin-1 expression. Circ Res 92: 1288-1295, 2003.
    • (2003) Circ Res , vol.92 , pp. 1288-1295
    • Rodriguez-Pascual, F.1    Redondo-Horcajo, M.2    Lamas, S.3
  • 27
    • 39049121312 scopus 로고    scopus 로고
    • How the smads regulate transcription
    • Ross S, Hill CS. How the smads regulate transcription. Int J Biochem Cell Biol 40: 383-408, 2008.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 383-408
    • Ross, S.1    Hill, C.S.2
  • 28
    • 1642535424 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/Akt pathway enhances smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1
    • Runyan CE, Schnaper HW, Poncelet AC. The phosphatidylinositol 3-kinase/Akt pathway enhances smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1. J Biol Chem 279: 2632-2639, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 2632-2639
    • Runyan, C.E.1    Schnaper, H.W.2    Poncelet, A.C.3
  • 29
    • 36448936383 scopus 로고    scopus 로고
    • TGFβ-SMAD signal transduction: Molecular specificity and functional flexibility
    • Schmierer B, Hill CS. TGFβ-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 8: 970-982, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 30
    • 29244459866 scopus 로고    scopus 로고
    • Differing mechanisms of leukocyte recruitment and sensitivity to conditioning by shear stress for endothelial cells treated with tumour necrosis factor-βor interleukin-1β
    • Sheikh T, Rahman M, Gale Z, Luu NT, Stone PCW, Matharu NM, Rainger GEL, Nash GB. Differing mechanisms of leukocyte recruitment and sensitivity to conditioning by shear stress for endothelial cells treated with tumour necrosis factor-βor interleukin-1β. Br J Pharmacol 145: 1052-1061, 2005.
    • (2005) Br J Pharmacol , vol.145 , pp. 1052-1061
    • Sheikh, T.1    Rahman, M.2    Gale, Z.3    Luu, N.T.4    Stone, P.C.W.5    Matharu, N.M.6    Rainger, G.E.L.7    Nash, G.B.8
  • 31
    • 77249084624 scopus 로고    scopus 로고
    • Long term shear stress leads to increased phosphorylation of multiple MAPK species in cultured human aortic endothelial cells
    • Shepherd RD, Kos SM, Rinker KD. Long term shear stress leads to increased phosphorylation of multiple MAPK species in cultured human aortic endothelial cells. Biorheology 46: 529-538, 2009.
    • (2009) Biorheology , vol.46 , pp. 529-538
    • Shepherd, R.D.1    Kos, S.M.2    Rinker, K.D.3
  • 32
    • 33845970937 scopus 로고    scopus 로고
    • The DNA binding activities of Smad2 and Smad3 are regulated by coactivatormediated acetylation
    • Simonsson M, Kanduri M, Grönroos E, Heldin CH, Ericsson J. The DNA binding activities of Smad2 and Smad3 are regulated by coactivatormediated acetylation. J Biol Chem 281: 39870-39880, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 39870-39880
    • Simonsson, M.1    Kanduri, M.2    Grönroos, E.3    Heldin, C.H.4    Ericsson, J.5
  • 34
    • 0034595653 scopus 로고    scopus 로고
    • Induction of platelet-derived growth factor B-chain expression by transforming growth factor-_ involve transactivation by smads
    • Taylor LM, Khachigian LM. Induction of platelet-derived growth factor B-chain expression by transforming growth factor-_ involve transactivation by smads. J Biol Chem 275: 16709-16716, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 16709-16716
    • Taylor, L.M.1    Khachigian, L.M.2
  • 35
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-β-smad signaling
    • ten Dijke P, Hill CS. New insights into TGF-β-smad signaling. Trends Biochem Sci 29: 265-273, 2000.
    • (2000) Trends Biochem Sci , vol.29 , pp. 265-273
    • ten Dijke, P.1    Hill, C.S.2
  • 37
    • 0035179082 scopus 로고    scopus 로고
    • Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation
    • Urbich C, Mallat Z, Tedgui A, Clauss M, Zeiher AM, Dimmeler S. Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation. J Clin Invest 108: 1451-1458, 2001.
    • (2001) J Clin Invest , vol.108 , pp. 1451-1458
    • Urbich, C.1    Mallat, Z.2    Tedgui, A.3    Clauss, M.4    Zeiher, A.M.5    Dimmeler, S.6
  • 38
    • 79953120996 scopus 로고    scopus 로고
    • Methicillin resistant Staphylococcus aureus adhesion to human umbilical vein endothelial cells demonstrates wall shear stress dependent behavior
    • Viegas KD, Dol SS, Salek MM, Shepherd RD, Martinuzzi RM, Rinker KD. Methicillin resistant Staphylococcus aureus adhesion to human umbilical vein endothelial cells demonstrates wall shear stress dependent behavior. Biomed Eng Online 10: 20, 2011.
    • (2011) Biomed Eng Online , vol.10 , pp. 20
    • Viegas, K.D.1    Dol, S.S.2    Salek, M.M.3    Shepherd, R.D.4    Martinuzzi, R.M.5    Rinker, K.D.6
  • 39
    • 3042816833 scopus 로고    scopus 로고
    • Adaptation of the endothelium to fluid flow: In vitro analyses of gene expression and in vivo implications
    • Wasserman SM, Topper JN. Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications. Vasc Med 9: 35-45, 2004.
    • (2004) Vasc Med , vol.9 , pp. 35-45
    • Wasserman, S.M.1    Topper, J.N.2
  • 40
    • 0035933046 scopus 로고    scopus 로고
    • Temporal gradients in shear, but not spatial gradients, stimulate endothelial cell proliferation
    • White CR, Haidekker M, Bao X, Frangos JA. Temporal gradients in shear, but not spatial gradients, stimulate endothelial cell proliferation. Circulation 103: 2508-2513, 2001.
    • (2001) Circulation , vol.103 , pp. 2508-2513
    • White, C.R.1    Haidekker, M.2    Bao, X.3    Frangos, J.A.4
  • 41
    • 28144441355 scopus 로고    scopus 로고
    • Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells
    • White CR, Stevens HY, Haidekker M, Frangos JA. Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells. Am J Physiol Heart Circ Physiol 289: H2350-H2355, 2005.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • White, C.R.1    Stevens, H.Y.2    Haidekker, M.3    Frangos, J.A.4
  • 43
    • 0033515620 scopus 로고    scopus 로고
    • A smad transcriptional corepressor
    • Wotton D, Lo RS, Lee S, Massague J. A smad transcriptional corepressor. Cell 97: 29-39, 1999.
    • (1999) Cell , vol.97 , pp. 29-39
    • Wotton, D.1    Lo, R.S.2    Lee, S.3    Massague, J.4
  • 44
    • 33846011104 scopus 로고    scopus 로고
    • Regulation of smad activities
    • Xu L. Regulation of smad activities. Biochim Biophys Acta 1759: 503-513, 2006.
    • (2006) Biochim Biophys Acta , vol.1759 , pp. 503-513
    • Xu, L.1


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