Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm

Atherosclerosis

Volumn 209, Issue 2, 2010, Pages 367-373

  Thompson, Andrew R ^a,b   Cooper, Jackie A ^a   Jones, Gregory T ^c   Drenos, Fotios ^a   van Bockxmeer, Frank M ^d   Biros, Erik ^e   Walker, Philip J ^f   van Rij, Andre M ^c   Golledge, Jonathan ^e   Norman, Paul E ^d   Hafez, Hany ^b   Humphries, Stephen E ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ST RICHARD S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e JAMES COOK UNIVERSITY   (Australia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Abdominal Aortic Aneurysm; Aneurysm expansion; binding protein; Latent transforming growth factor beta; Single nucleotide polymorphism; Transforming growth factor beta

Indexed keywords

BINDING PROTEIN; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 1; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 3; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 4; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; AGED; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

AGED; AORTIC ANEURYSM, ABDOMINAL; CASE-CONTROL STUDIES; FEMALE; HUMANS; LATENT TGF-BETA BINDING PROTEINS; MALE; POLYMORPHISM, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 77950020291     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.09.073     Document Type: Article

References (30)

1. Sandford R.M., Bown M.J., London N.J., Sayers R.D. The genetic basis of abdominal aortic aneurysms: a review. Eur J Vasc Endovasc Surg 2007, 33:381-390.
2. Habashi J.P., Judge D.P., Holm T.M., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006, 312:117-121.
3. Loeys B.L., Schwarze U., Holm T., et al. Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 2006, 355:788-798.
4. Fukui D., Miyagawa S., Soeda J., Tanaka K., Urayama H., Kawasaki S. Overexpression of transforming growth factor beta1 in smooth muscle cells of human abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2003, 25:540-545.
5. Dai J., Losy F., Guinault A.M., et al. Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy. Circulation 2005, 112:1008-1015.
6. Golledge, J, Clancy, P, Jones, GT, et al. Assessment of the association between genetic 17 polymorphisms in transforming growth factor beta receptors, serum transforming growth 18 factor beta1 concentration and abdominal aortic aneurysm. Br J Surg. doi:19 10.1002/bjs.6633. 2009. Published online in Wiley InterScience.
7. Lucarini L., Sticchi E., Sofi F., et al. ACE and TGFBR1 genes interact in influencing the susceptibility to abdominal aortic aneurysm. Atherosclerosis 2009, 202:205-210.
8. Qian R.Q., Glanville R.W. Alignment of fibrillin molecules in elastic microfibrils is defined by transglutaminase-derived cross-links. Biochemistry 1997, 36:15841-15847.
9. Hafez H., Druce P.S., Ashton H.A. Abdominal aortic aneurysm development in men following a " normal" aortic ultrasound scan. Eur J Vasc Endovasc Surg 2008, 36:553-558.
10. Miller G.J., Bauer K.A., Barzegar S., et al. The effects of quality and timing of venepuncture on markers of blood coagulation in healthy middle-aged men. Thromb Haemost 1995, 73:82-86.
11. Rossaak J.I., Hill T.M., Jones G.T., Phillips L.V., Harris E.L., van Rij A.M. Familial abdominal aortic aneurysms in the Otago region of New Zealand. Cardiovasc Surg 2001, 9:241-248.
12. Norman P.E., Jamrozik K., Lawrence-Brown M.M., et al. Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysm. BMJ 2004, 329:1259.
13. Golledge J., Jayalath R., Oliver L., Parr A., Schurgers L., Clancy P. Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification. Atherosclerosis 2008, 197:428-434.
14. Golledge J., Karan M., Moran C.S., et al. Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions. Eur Heart J 2008, 29:665-672.
15. Norman P., Spencer C.A., Lawrence-Brown M.M., Jamrozik K. C-reactive protein levels and the expansion of screen-detected abdominal aortic aneurysms in men. Circulation 2004, 110:862-866.
16. de Bakker P.I., Burtt N.P., Graham R.R., et al. Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet 2006, 38:1298-1303.
17. Higashi T., Kyo S., Inoue M., Tanii H., Saijoh K. Novel functional single nucleotide polymorphisms in the latent transforming growth factor-beta binding protein-1L promoter: effect on latent transforming growth factor-beta binding protein-1L expression level and possible prognostic significance in ovarian cancer. J Mol Diagn 2006, 8:342-350.
18. Stephens M., Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet 2005, 76:449-462.
19. Brady A.R., Thompson S.G., Fowkes F.G., Greenhalgh R.M., Powell J.T. Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance. Circulation 2004, 110:16-21.
20. Browne W.J. MCMC estimation in MLwiN, v2.10 2009, Centre for Multilevel Modelling, University of Bristol.
21. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B (Methodological) 1995, 57(1):289-300.
22. Koli K., Saharinen J., Karkkainen M., Keski-Oja J. Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition. J Cell Sci 2001, 114:2869-2878.
23. Perneger T.V. What's wrong with Bonferroni adjustments. BMJ 1998, 316:1236-1238.
24. Rothman K.J. No adjustments are needed for multiple comparisons. Epidemiology 1990, 1:43-46.
25. Liu J.P., Liu N.S., Yuan H.Y., Guo Q., Lu H., Li Y.Y. Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells. Mol Cell Biochem 2006, 292:189-195.
26. Saharinen J., Taipale J., Keski-Oja J. Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J 1996, 15:245-253.
27. Chen Y., Ali T., Todorovic V., O'leary J.M., Kristina D.A., Rifkin D.B. Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. J Mol Biol 2005, 345:175-186.
28. Mangasser-Stephan K., Gartung C., Lahme B., Gressner A.M. Expression of isoforms and splice variants of the latent transforming growth factor beta binding protein (LTBP) in cultured human liver myofibroblasts. Liver 2001, 21:105-113.
29. Thompson A.R., Drenos F., Hafez H., Humphries S.E. Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis. Eur J Vasc Endovasc Surg 2007.
30. Bachman K.E., Park B.H. Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter. Curr Opin Oncol 2005, 17:49-54.