Long term stabilization of expanding aortic aneurysms by a short course of cyclosporine a through transforming growth factor-beta induction

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Dai, Jianping ^a   Michineau, Stéphanie ^a   Franck, Grégory ^a   Desgranges, Pascal ^b   Becquemin, Jean Pierre ^b   Gervais, Marianne ^a   Allaire, Eric ^a,b  

^a FACULTÉ DE MÉDECINE   (France)

^b HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCIUM CHLORIDE; CYCLOSPORIN A; ELASTASE; GELATINASE B; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; CYCLOSPORIN; ELASTIN; PANCREATIC ELASTASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA;

ABDOMINAL AORTA ANEURYSM; ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ELASTIC FIBER; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MALE; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENZYMOLOGY; INFLAMMATION; METABOLISM; PATHOLOGY; SECRETION; SMOOTH MUSCLE FIBER; WISTAR RAT;

ANIMALS; AORTIC ANEURYSM, ABDOMINAL; CALCIUM CHLORIDE; CYCLOSPORINE; DISEASE MODELS, ANIMAL; ELASTIN; HUMANS; INFLAMMATION; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PANCREATIC ELASTASE; RATS; RATS, WISTAR; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA;

EID: 83355170626     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028903     Document Type: Article

References (37)

1. Baxter BT, Terrin MC, Dalman RL, (2008) Medical management of small abdominal aortic aneurysms. Circulation 117: 1883-1889.
2. EVAR trial 1 (2005) Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet 365: 2179-2186.
3. Jones A, Deb R, Torsney E, Howe F, Dunkley M, et al. (2009) Rosiglitazone reduces the development and rupture of experimental aortic aneurysms. Circulation 119: 3125-3132.
4. Walton LJ, Franklin IJ, Bayston T, Brown LC, Greenhalgh RM, et al. (1999) Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms. Circulation 100: 48-54.
5. Yoshimura K, Aoki H, Ikeda Y, Fujii K, Akiyama N, et al. (2005) Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med 11: 1330-1338.
6. Dai J, Losy F, Guinault AM, Pages C, Anegon I, et al. (2005) Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy. Circulation 112: 1008-1015.
7. Lopez-Candales A, Holmes DR, Liao S, Scott MJ, Wickline SA, et al. (1997) Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am J Pathol 150: 993-1007.
8. Losy F, Dai J, Pages C, Ginat M, Muscatelli-Groux B, et al. (2003) Paracrine secretion of transforming growth factor-beta1 in aneurysm healing and stabilization with endovascular smooth muscle cell therapy. J Vasc Surg 37: 1301-1309.
9. Akool el S, Doller A, Babelova A, Tsalastra W, Moreth K, et al. (2008) Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J Immunol 181: 2831-2845.
10. Islam M, Burke JF Jr, McGowan TA, Zhu Y, Dunn SR, et al. (2001) Effect of anti-transforming growth factor-beta antibodies in cyclosporine-induced renal dysfunction. Kidney Int 59: 498-506.
11. Chae HJ, Ha MS, Yun DH, Pae HO, Chung HT, et al. (2006) Mechanism of cyclosporine-induced overgrowth in gingiva. J Dent Res 85: 515-519.
12. Allaire E, Schneider F, Saucy F, Dai J, Cochennec F, et al. (2009) New insight in aetiopathogenesis of aortic diseases. Eur J Vasc Endovasc Surg 37: 531-537.
13. Allaire E, Forough R, Clowes M, Starcher B, Clowes AW, (1998) Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. J Clin Invest 102: 1413-1420.
14. Allaire E, Hasenstab D, Kenagy RD, Starcher B, Clowes MM, et al. (1998) Prevention of aneurysm development and rupture by local overexpression of plasminogen activator inhibitor-1. Circulation 98: 249-255.
15. Gao R, Lu Y, Xin YP, Zhang XH, Wang J, et al. (2006) The effects of different immunosuppressants on chronic allograft nephropathy by affecting the transforming growth factor-beta and Smads signal pathways. Transplant Proc 38: 2154-2157.
16. Cotrim P, de Andrade CR, Martelli-Junior H, Graner E, Sauk JJ, et al. (2002) Expression of matrix metalloproteinases in cyclosporin-treated gingival fibroblasts is regulated by transforming growth factor (TGF)-beta1 autocrine stimulation. J Periodontol 73: 1313-1322.
17. Ozdemir BH, Ozdemir FN, Demirhan B, Haberal M, (2005) TGF-beta1 expression in renal allograft rejection and cyclosporine A toxicity. Transplantation 80: 1681-1685.
18. Vieira JM Jr, Noronha IL, Malheiros DM, Burdmann EA, (1999) Cyclosporine-induced interstitial fibrosis and arteriolar TGF-beta expression with preserved renal blood flow. Transplantation 68: 1746-1753.
19. Yamaguchi T, Yokokawa M, Suzuki M, Higashide S, Katoh Y, et al. (2000) The effect of immunosuppression on aortic dilatation in a rat aneurysm model. Surg Today 30: 1093-1099.
20. Norman PE, Powell JT, (2010) Site specificity of aneurysmal disease. Circulation 121: 560-568.
21. Wang Y, Ait-Oufella H, Herbin O, Bonnin P, Ramkhelawon B, et al. (2010) TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest 120: 422-432.
22. Curci JA, Thompson RW, (2004) Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context? J Clin Invest 114: 168-171.
23. Sheu JJ, Chua S, Sun CK, Chang LT, Yen CH, et al. (2011) Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction. Int J Cardiol 147: 79-87.
24. Doller A, Akool el S, Muller R, Gutwein P, Kurowski C, et al. (2007) Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells. J Am Soc Nephrol 18: 581-592.
25. Satoh K, Nigro P, Matoba T, O'Dell MR, Cui Z, et al. (2009) Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med 15: 649-656.
26. Rizas KD, Ippagunta N, Tilson MD 3rd, (2009) Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm. Cardiol Rev 17: 201-210.
27. Satonaka H, Suzuki E, Nishimatsu H, Oba S, Takeda R, et al. (2004) Calcineurin promotes the expression of monocyte chemoattractant protein-1 in vascular myocytes and mediates vascular inflammation. Circ Res 94: 693-700.
28. Allaire E, Muscatelli-Groux B, Guinault AM, Pages C, Goussard A, et al. (2004) Vascular smooth muscle cell endovascular therapy stabilizes already developed aneurysms in a model of aortic injury elicited by inflammation and proteolysis. Ann Surg 239: 417-427.
29. Plissonnier D, Amichot G, Lecagneux J, Duriez M, Gentric D, et al. (1993) Additive and synergistic effects of a low-molecular-weight, heparin-like molecule and low doses of cyclosporin in preventing arterial graft rejection in rats. Arterioscler Thromb 13: 112-119.
30. Mallat Z, Gojova A, Marchiol-Fournigault C, Esposito B, Kamate C, et al. (2001) Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 89: 930-934.
31. Nabel EG, Shum L, Pompili VJ, Yang ZY, San H, et al. (1993) Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci U S A 90: 10759-10763.
32. Deux JF, Dai J, Riviere C, Gazeau F, Meric P, et al. (2008) Aortic aneurysms in a rat model: in vivo MR imaging of endovascular cell therapy. Radiology 246: 185-192.
33. Kajimoto M, Shimono T, Hirano K, Miyake Y, Sawada Y, et al. (2006) Development of a new method for endovascular aortic repair: combination therapy of cell transplantation and stent grafts with a drug delivery system. Circulation 114: I378-383.
34. Chiou AC, Chiu B, Pearce WH, (2001) Murine aortic aneurysm produced by periarterial application of calcium chloride. J Surg Res 99: 371-376.
35. Anidjar S, Salzmann JL, Gentric D, Lagneau P, Camilleri JP, et al. (1990) Elastase-induced experimental aneurysms in rats. Circulation 82: 973-981.
36. Allaire E, Bruneval P, Mandet C, Becquemin JP, Michel JB, (1997) The immunogenicity of the extracellular matrix in arterial xenografts. Surgery 122: 73-81.
37. Yu L, Border WA, Anderson I, McCourt M, Huang Y, et al. (2004) Combining TGF-beta inhibition and angiotensin II blockade results in enhanced antifibrotic effect. Kidney Int 66: 1774-1784.