Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 3560-3570

  Hong, Suntaek ^a   Kim, Hye Youn ^a   Kim, Jooyoung ^a   Ha, Huyen Trang ^a   Kim, Young Mi ^a   Bae, Eunjin ^b   Kim, Tae Hyung ^c   Lee, Kang Choon ^c   Kim, Seong Jin ^b  

^a Gachon University College of Medicine   (South Korea)

^b CHA University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS PATHWAYS; BINDING ACTIVITIES; BIOLOGICAL SIGNIFICANCE; BREAST CANCER CELLS; CASPASES; CELL-DEATH PATHWAYS; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEEDBACK REGULATION; GENE TRANSCRIPTIONS; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTORS; INTERFERON-STIMULATED RESPONSE ELEMENTS; MCF-7 CELLS; NEGATIVE REGULATORS; REGULATED GENES; SIGNALING PATHWAYS; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL CO-ACTIVATORS; TRANSFORMING GROWTH FACTORS; TUMOR GROWTH; TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGANDS; TUMOR NECROSIS FACTORS; UP-REGULATION;

ANTIBIOTICS; DIAGNOSIS; ELECTROPHORETIC MOBILITY; ENZYME INHIBITION; GENES; GLYCOPROTEINS; LIGANDS; MACROPHAGES; RESTORATION; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CELL DEATH;

CASPASE 8; INTERFERON REGULATORY FACTOR 1; SMAD7 PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASE 8; CELL SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON-GAMMA; MCF-7 CELLS; MICE; MICE, INBRED BALB C; PROMOTER REGIONS, GENETIC; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873281929     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.400408     Document Type: Article

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