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Volumn 289, Issue 1, 2010, Pages 119-126

Halofuginone enhances the radiation sensitivity of human tumor cell lines

Author keywords

Fibrosis; Halofuginone; Radiation sensitizer; TGF beta

Indexed keywords

HALOFUGINONE; RADIOSENSITIZING AGENT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 75949096432     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.08.009     Document Type: Article
Times cited : (20)

References (35)
  • 1
    • 0025342073 scopus 로고
    • Transforming growth factor-beta 1 expression in irradiated liver
    • Anscher M.S., Crocker I.R., and Jirtle R.L. Transforming growth factor-beta 1 expression in irradiated liver. Radiat. Res. 122 (1990) 77-85
    • (1990) Radiat. Res. , vol.122 , pp. 77-85
    • Anscher, M.S.1    Crocker, I.R.2    Jirtle, R.L.3
  • 2
    • 0028923805 scopus 로고
    • Short communication: normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGF beta
    • Anscher M.S., Kong F.M., Murase T., and Jirtle R.L. Short communication: normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGF beta. Br. J. Radiol. 68 (1995) 331-333
    • (1995) Br. J. Radiol. , vol.68 , pp. 331-333
    • Anscher, M.S.1    Kong, F.M.2    Murase, T.3    Jirtle, R.L.4
  • 5
    • 1542316342 scopus 로고    scopus 로고
    • Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-beta) receptor mediated by adenoviral vector
    • Nishioka A., Ogawa Y., Mima T., Jin Y.J., Sonobe H., Kariya S., Kubota K., Yoshida S., and Ueno H. Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-beta) receptor mediated by adenoviral vector. Int. J. Radiat. Oncol. Biol. Phys. 58 (2004) 1235-1241
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.58 , pp. 1235-1241
    • Nishioka, A.1    Ogawa, Y.2    Mima, T.3    Jin, Y.J.4    Sonobe, H.5    Kariya, S.6    Kubota, K.7    Yoshida, S.8    Ueno, H.9
  • 7
    • 33646919832 scopus 로고    scopus 로고
    • Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation
    • Anscher M.S., Thrasher B., Rabbani Z., Teicher B., and Vujaskovic Z. Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. Int. J. Radiat. Oncol. Biol. Phys. 65 (2006) 876-881
    • (2006) Int. J. Radiat. Oncol. Biol. Phys. , vol.65 , pp. 876-881
    • Anscher, M.S.1    Thrasher, B.2    Rabbani, Z.3    Teicher, B.4    Vujaskovic, Z.5
  • 9
    • 0028196623 scopus 로고
    • In vitro studes of paclitaxel (Taxol®) as a radiation sensitizer in human tumor cells
    • Liebmann J.E., Cook J.A., Fisher J., Teague D., and Mitchell J.B. In vitro studes of paclitaxel (Taxol®) as a radiation sensitizer in human tumor cells. J. Natl. Cancer Inst. 86 (1994) 441-446
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 441-446
    • Liebmann, J.E.1    Cook, J.A.2    Fisher, J.3    Teague, D.4    Mitchell, J.B.5
  • 10
    • 0030793369 scopus 로고    scopus 로고
    • Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells
    • Chang J., Park K., Bang Y.J., Kim W.S., Kim D., and Kim S.J. Expression of transforming growth factor beta type II receptor reduces tumorigenicity in human gastric cancer cells. Cancer Res. 57 (1997) 2856-2859
    • (1997) Cancer Res. , vol.57 , pp. 2856-2859
    • Chang, J.1    Park, K.2    Bang, Y.J.3    Kim, W.S.4    Kim, D.5    Kim, S.J.6
  • 11
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull T.T., Rogakou E.P., Yamazaki V., Kirchgessner C.U., Gellert M., and Bonner W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10 (2000) 886-895
    • (2000) Curr. Biol. , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 12
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav M., De Haro L.P., and Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18 (2008) 134-147
    • (2008) Cell Res. , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 13
    • 0038740579 scopus 로고    scopus 로고
    • The mammalian XRCC genes: their roles in DNA repair and genetic stability
    • Thacker J., and Zdzienicka M.Z. The mammalian XRCC genes: their roles in DNA repair and genetic stability. DNA Repair (Amst.) 2 (2003) 655-672
    • (2003) DNA Repair (Amst.) , vol.2 , pp. 655-672
    • Thacker, J.1    Zdzienicka, M.Z.2
  • 14
    • 29244448296 scopus 로고    scopus 로고
    • Radiation combined with EGFR signal inhibitors: head and neck cancer focus
    • Harari P.M., and Huang S. Radiation combined with EGFR signal inhibitors: head and neck cancer focus. Semin. Radiat. Oncol. 16 (2006) 38-44
    • (2006) Semin. Radiat. Oncol. , vol.16 , pp. 38-44
    • Harari, P.M.1    Huang, S.2
  • 15
    • 29244492286 scopus 로고    scopus 로고
    • Radiation and new molecular agents, part II: targeting HDAC, HSP90, IGF-1R, PI3K, and Ras
    • Chinnaiyan P., Allen G.W., and Harari P.M. Radiation and new molecular agents, part II: targeting HDAC, HSP90, IGF-1R, PI3K, and Ras. Semin. Radiat. Oncol. 16 (2006) 59-64
    • (2006) Semin. Radiat. Oncol. , vol.16 , pp. 59-64
    • Chinnaiyan, P.1    Allen, G.W.2    Harari, P.M.3
  • 16
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 134 (2008) 215-230
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 18
  • 19
    • 0032054482 scopus 로고    scopus 로고
    • Halofuginone: a novel antifibrotic therapy
    • Pines M., and Nagler A. Halofuginone: a novel antifibrotic therapy. Gen. Pharmacol. 30 (1998) 445-450
    • (1998) Gen. Pharmacol. , vol.30 , pp. 445-450
    • Pines, M.1    Nagler, A.2
  • 20
    • 0033205228 scopus 로고    scopus 로고
    • Inhibition of neovascularization and tumor growth, and facilitation of wound repair, by halofuginone, an inhibitor of collagen type I synthesis
    • Abramovitch R., Dafni H., Neeman M., Nagler A., and Pines M. Inhibition of neovascularization and tumor growth, and facilitation of wound repair, by halofuginone, an inhibitor of collagen type I synthesis. Neoplasia 1 (1999) 321-329
    • (1999) Neoplasia , vol.1 , pp. 321-329
    • Abramovitch, R.1    Dafni, H.2    Neeman, M.3    Nagler, A.4    Pines, M.5
  • 23
    • 6944224022 scopus 로고    scopus 로고
    • Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model - an MRI study
    • Abramovitch R., Itzik A., Harel H., Nagler A., Vlodavsky I., and Siegal T. Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model - an MRI study. Neoplasia 6 (2004) 480-489
    • (2004) Neoplasia , vol.6 , pp. 480-489
    • Abramovitch, R.1    Itzik, A.2    Harel, H.3    Nagler, A.4    Vlodavsky, I.5    Siegal, T.6
  • 24
    • 38849209865 scopus 로고    scopus 로고
    • Targeting TGFβ signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer: effect of halofuginone
    • Pines M. Targeting TGFβ signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer: effect of halofuginone. Expert Opin. Drug Discov. 3 (2008) 11-20
    • (2008) Expert Opin. Drug Discov. , vol.3 , pp. 11-20
    • Pines, M.1
  • 25
    • 0036121027 scopus 로고    scopus 로고
    • Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts
    • McGaha T.L., Phelps R.G., Spiera H., and Bona C. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J. Invest. Dermatol. 118 (2002) 461-470
    • (2002) J. Invest. Dermatol. , vol.118 , pp. 461-470
    • McGaha, T.L.1    Phelps, R.G.2    Spiera, H.3    Bona, C.4
  • 26
    • 0036205654 scopus 로고    scopus 로고
    • Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7
    • Chen R., Huang C., Morinelli T.A., Trojanowska M., and Paul R.V. Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7. J. Am. Soc. Nephrol. 13 (2002) 887-893
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 887-893
    • Chen, R.1    Huang, C.2    Morinelli, T.A.3    Trojanowska, M.4    Paul, R.V.5
  • 27
    • 0038274163 scopus 로고    scopus 로고
    • Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads
    • Cordenonsi M., Dupont S., Maretto S., Insinga A., Imbriano C., and Piccolo S. Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell 113 (2003) 301-314
    • (2003) Cell , vol.113 , pp. 301-314
    • Cordenonsi, M.1    Dupont, S.2    Maretto, S.3    Insinga, A.4    Imbriano, C.5    Piccolo, S.6
  • 28
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward I.M., and Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276 (2001) 47759-47762
    • (2001) J. Biol. Chem. , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 29
    • 34248184571 scopus 로고    scopus 로고
    • H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation
    • Ewald B., Sampath D., and Plunkett W. H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation. Mol. Cancer Ther. 6 (2007) 1239-1248
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1239-1248
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 31
    • 33745607326 scopus 로고    scopus 로고
    • H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks
    • Marti T.M., Hefner E., Feeney L., Natale V., and Cleaver J.E. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc. Natl. Acad. Sci. USA 103 (2006) 9891-9896
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9891-9896
    • Marti, T.M.1    Hefner, E.2    Feeney, L.3    Natale, V.4    Cleaver, J.E.5
  • 32
    • 33646414772 scopus 로고    scopus 로고
    • Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition
    • Taras D., Blanc J.F., Rullier A., Dugot-Senant N., Laurendeau I., Bieche I., Pines M., and Rosenbaum J. Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. Neoplasia 8 (2006) 312-318
    • (2006) Neoplasia , vol.8 , pp. 312-318
    • Taras, D.1    Blanc, J.F.2    Rullier, A.3    Dugot-Senant, N.4    Laurendeau, I.5    Bieche, I.6    Pines, M.7    Rosenbaum, J.8
  • 35
    • 33845303212 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress
    • Kirshner J., Jobling M.F., Pajares M.J., Ravani S.A., Glick A.B., Lavin M.J., Koslov S., Shiloh Y., and Barcellos-Hoff M.H. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res. 66 (2006) 10861-10869
    • (2006) Cancer Res. , vol.66 , pp. 10861-10869
    • Kirshner, J.1    Jobling, M.F.2    Pajares, M.J.3    Ravani, S.A.4    Glick, A.B.5    Lavin, M.J.6    Koslov, S.7    Shiloh, Y.8    Barcellos-Hoff, M.H.9


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