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Volumn 17, Issue 4, 2012, Pages 598-615

The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells

Author keywords

Dyskerin; Holoenzyme; hTERT; Marek's disease virus; Telomerase; vTR

Indexed keywords

TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; VIRUS RNA;

EID: 84873272782     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-012-0031-6     Document Type: Article
Times cited : (4)

References (62)
  • 1
    • 46249125488 scopus 로고    scopus 로고
    • How shelterin protects mammalian telomeres
    • Palm, W. and de Lange, T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42 (2008) 301-334.
    • (2008) Annu. Rev. Genet. , vol.42 , pp. 301-334
    • Palm, W.1    de Lange, T.2
  • 2
    • 33746211311 scopus 로고    scopus 로고
    • Telomere length homeostasis
    • Hug, N. and Lingner, J. Telomere length homeostasis. Chromosoma115 (2006) 413-425.
    • (2006) Chromosoma , vol.115 , pp. 413-425
    • Hug, N.1    Lingner, J.2
  • 4
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J. W. and Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer33 (1997) 787-791.
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 5
    • 33745849998 scopus 로고    scopus 로고
    • The Structure and Function of Telomerase Reverse Transcriptase
    • Autexier, C. and Lue, N. F. The Structure and Function of Telomerase Reverse Transcriptase. Annu. Rev. Biochem. 75 (2006) 493-517.
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 493-517
    • Autexier, C.1    Lue, N.F.2
  • 6
    • 33745862398 scopus 로고    scopus 로고
    • The biogenesis and regulation of telomerase holoenzymes
    • Collins, K. The biogenesis and regulation of telomerase holoenzymes. Nat. Rev. Mol. Cell. Biol. 7 (2006) 484-494.
    • (2006) Nat. Rev. Mol. Cell. Biol. , vol.7 , pp. 484-494
    • Collins, K.1
  • 7
  • 9
    • 4644354584 scopus 로고    scopus 로고
    • Adding to the ends: what makes telomerase processive and how important is it?
    • Lue, N. F. Adding to the ends: what makes telomerase processive and how important is it? Bioessays26 (2004) 955-962.
    • (2004) Bioessays , vol.26 , pp. 955-962
    • Lue, N.F.1
  • 10
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin, G. B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell59 (1989) 521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 11
    • 0027467847 scopus 로고
    • Identification of a nonprocessive telomerase activity from mouse cells
    • Prowse, K. R., Avilion, A. A. and Greider, C. W. Identification of a nonprocessive telomerase activity from mouse cells. Proc. Natl. Acad. Sci. USA90 (1993) 1493-1497.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1493-1497
    • Prowse, K.R.1    Avilion, A.A.2    Greider, C.W.3
  • 12
    • 0141557781 scopus 로고    scopus 로고
    • Comprehensive structurefunction analysis of the core domain of human telomerase RNA
    • Ly, H., Blackburn, E. H. and Parslow, T. G. Comprehensive structurefunction analysis of the core domain of human telomerase RNA. Mol. Cell. Biol. 23 (2003) 6849-6856.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6849-6856
    • Ly, H.1    Blackburn, E.H.2    Parslow, T.G.3
  • 13
    • 0037439107 scopus 로고    scopus 로고
    • Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
    • Chen, J. L. and Greider, C. W. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 22 (2003) 304-314.
    • (2003) EMBO J. , vol.22 , pp. 304-314
    • Chen, J.L.1    Greider, C.W.2
  • 14
    • 1942453903 scopus 로고    scopus 로고
    • Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer
    • Moriarty, T. J., Marie-Egyptienne, D. T. and Autexier, C. Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer. Mol. Cell. Biol. 24 (2004) 3720-3733.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3720-3733
    • Moriarty, T.J.1    Marie-Egyptienne, D.T.2    Autexier, C.3
  • 15
    • 21844457135 scopus 로고    scopus 로고
    • An anchor sitetype defect in human telomerase that disrupts telomere length maintenance and cellular immortalization
    • Moriarty, T. J., Ward, R. J., Taboski, M. A. and Autexier, C. An anchor sitetype defect in human telomerase that disrupts telomere length maintenance and cellular immortalization. Mol. Biol. Cell. 16 (2005) 3152-3161.
    • (2005) Mol. Biol. Cell. , vol.16 , pp. 3152-3161
    • Moriarty, T.J.1    Ward, R.J.2    Taboski, M.A.3    Autexier, C.4
  • 16
    • 11144235139 scopus 로고    scopus 로고
    • Processive utilization of the human telomerase template: lack of a requirement for template switching
    • Rivera, M. A. and Blackburn, E. H. Processive utilization of the human telomerase template: lack of a requirement for template switching. J. Biol. Chem. 279 (2004) 53770-53781.
    • (2004) J. Biol. Chem. , vol.279 , pp. 53770-53781
    • Rivera, M.A.1    Blackburn, E.H.2
  • 17
    • 0242286004 scopus 로고    scopus 로고
    • The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity
    • Huard, S., Moriarty, T. J. and Autexier, C. The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity. Nucleic Acids Res. 31 (2003) 4059-4070.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 4059-4070
    • Huard, S.1    Moriarty, T.J.2    Autexier, C.3
  • 18
    • 82455216720 scopus 로고    scopus 로고
    • Immortalization of human and rhesus macaque primary antigen-specific T cells by retrovirally transduced telomerase reverse transcriptase
    • Unit7 21B
    • Barsov, E. V. Immortalization of human and rhesus macaque primary antigen-specific T cells by retrovirally transduced telomerase reverse transcriptase. Curr. Protoc. Immunol. Chapter 7 (2011) Unit7 21B.
    • (2011) Curr. Protoc. Immunol. Chapter , vol.7
    • Barsov, E.V.1
  • 20
    • 84855241882 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase-immortalized porcine monomyeloid cell lines for the production of porcine reproductive and respiratory syndrome virus
    • Sagong, M., Park, C. K., Kim, S. H., Lee, K. K., Lee, O. S., Lee, D. S., Cha, S. Y. and Lee, C. Human telomerase reverse transcriptase-immortalized porcine monomyeloid cell lines for the production of porcine reproductive and respiratory syndrome virus. J. Virol. Methods179 (2011) 26-32.
    • (2011) J. Virol. Methods , vol.179 , pp. 26-32
    • Sagong, M.1    Park, C.K.2    Kim, S.H.3    Lee, K.K.4    Lee, O.S.5    Lee, D.S.6    Cha, S.Y.7    Lee, C.8
  • 21
    • 0037387730 scopus 로고    scopus 로고
    • Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb
    • Veitonmäki, N., Fuxe, J., Hultdin, M., Roos, G., Pettersson, R. F. and Cao, Y. Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb. FASEB J. 17 (2003) 764-766.
    • (2003) FASEB J. , vol.17 , pp. 764-766
    • Veitonmäki, N.1    Fuxe, J.2    Hultdin, M.3    Roos, G.4    Pettersson, R.F.5    Cao, Y.6
  • 22
    • 0034736044 scopus 로고    scopus 로고
    • hTERT can function with rabbit telomerase RNA: regulation of gene expression and attenuation of apoptosis
    • Xiang, H., Wang, J., Mao, Y. W. and Li, D. W. hTERT can function with rabbit telomerase RNA: regulation of gene expression and attenuation of apoptosis. Biochem. Biophys. Res. Commun. 278 (2000) 503-510.
    • (2000) Biochem. Biophys. Res. Commun. , vol.278 , pp. 503-510
    • Xiang, H.1    Wang, J.2    Mao, Y.W.3    Li, D.W.4
  • 23
    • 0036438794 scopus 로고    scopus 로고
    • Human telomerase can immortalize Indian muntjac cells
    • Zou, Y., Yi, X., Wright, W. E. and Shay, J. W. Human telomerase can immortalize Indian muntjac cells. Exp. Cell. Res. 281 (2002) 63-76.
    • (2002) Exp. Cell. Res. , vol.281 , pp. 63-76
    • Zou, Y.1    Yi, X.2    Wright, W.E.3    Shay, J.W.4
  • 26
    • 33644774920 scopus 로고    scopus 로고
    • Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
    • Middleman, E. J., Choi, J., Venteicher, A. S., Cheung, P. and Artandi, S. E. Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain. Mol. Cell. Biol. 26 (2006) 2146-2159.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 2146-2159
    • Middleman, E.J.1    Choi, J.2    Venteicher, A.S.3    Cheung, P.4    Artandi, S.E.5
  • 27
    • 0141783638 scopus 로고    scopus 로고
    • Cloning of rat telomerase catalytic subunit functional domains, reconstitution of telomerase activity and enzymatic profile of pig and chicken tissues
    • Wong, S. C., Ong, L. L., Er, C. P., Gao, S., Yu, H. and So, J. B. Cloning of rat telomerase catalytic subunit functional domains, reconstitution of telomerase activity and enzymatic profile of pig and chicken tissues. Life Sci. 73 (2003) 2749-2760.
    • (2003) Life Sci. , vol.73 , pp. 2749-2760
    • Wong, S.C.1    Ong, L.L.2    Er, C.P.3    Gao, S.4    Yu, H.5    So, J.B.6
  • 28
    • 0038032881 scopus 로고    scopus 로고
    • The RNA subunit of telomerase is encoded by Marek's disease virus
    • Fragnet, L., Blasco, M. A., Klapper, W. and Rasschaert, D. The RNA subunit of telomerase is encoded by Marek's disease virus. J. Virol. 77 (2003) 5985-5996.
    • (2003) J. Virol. , vol.77 , pp. 5985-5996
    • Fragnet, L.1    Blasco, M.A.2    Klapper, W.3    Rasschaert, D.4
  • 31
    • 80055086269 scopus 로고    scopus 로고
    • Herpesvirus Telomerase RNA (vTR) with a Mutated Template Sequence Abrogates Herpesvirus-Induced Lymphomagenesis
    • Kaufer, B. B., Arndt, S., Trapp, S., Osterrieder, N. and Jarosinski, K. W. Herpesvirus Telomerase RNA (vTR) with a Mutated Template Sequence Abrogates Herpesvirus-Induced Lymphomagenesis. PLoS Pathog. 7 (2011) e1002333.
    • (2011) PLoS Pathog. , vol.7
    • Kaufer, B.B.1    Arndt, S.2    Trapp, S.3    Osterrieder, N.4    Jarosinski, K.W.5
  • 32
    • 34247639366 scopus 로고    scopus 로고
    • Involvement of the Oncoprotein c-Myc in Viral Telomerase RNA Gene Regulation during Marek's Disease Virus-Induced Lymphomagenesis
    • Shkreli, M., Dambrine, G., Soubieux, D., Kut, E. and Rasschaert, D. Involvement of the Oncoprotein c-Myc in Viral Telomerase RNA Gene Regulation during Marek's Disease Virus-Induced Lymphomagenesis. J. Virol. 81 (2007) 4848-4857.
    • (2007) J. Virol. , vol.81 , pp. 4848-4857
    • Shkreli, M.1    Dambrine, G.2    Soubieux, D.3    Kut, E.4    Rasschaert, D.5
  • 33
    • 21244461242 scopus 로고    scopus 로고
    • Comparative functional study of the viral telomerase RNA based on natural mutations
    • Fragnet, L., Kut, E. and Rasschaert, D. Comparative functional study of the viral telomerase RNA based on natural mutations. J. Biol. Chem. 280 (2005) 23502-23515.
    • (2005) J. Biol. Chem. , vol.280 , pp. 23502-23515
    • Fragnet, L.1    Kut, E.2    Rasschaert, D.3
  • 34
    • 0037079673 scopus 로고    scopus 로고
    • A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
    • Chen, J. L., Opperman, K. K. and Greider, C. W. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res. 30 (2002) 592-597.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 592-597
    • Chen, J.L.1    Opperman, K.K.2    Greider, C.W.3
  • 35
    • 0034598919 scopus 로고    scopus 로고
    • Secondary structure of vertebrate telomerase RNA
    • Chen, J. L., Blasco, M. A. and Greider, C. W. Secondary structure of vertebrate telomerase RNA. Cell100 (2000) 503-514.
    • (2000) Cell , vol.100 , pp. 503-514
    • Chen, J.L.1    Blasco, M.A.2    Greider, C.W.3
  • 36
    • 0029958047 scopus 로고    scopus 로고
    • Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA
    • Autexier, C., Pruzan, R., Funk, W. D. and Greider, C. W. Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J. 15 (1996) 5928-5935.
    • (1996) EMBO J. , vol.15 , pp. 5928-5935
    • Autexier, C.1    Pruzan, R.2    Funk, W.D.3    Greider, C.W.4
  • 37
    • 0033790120 scopus 로고    scopus 로고
    • Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    • Beattie, T. L., Zhou, W., Robinson, M. O. and Harrington, L. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell. 11 (2000) 3329-3340.
    • (2000) Mol. Biol. Cell. , vol.11 , pp. 3329-3340
    • Beattie, T.L.1    Zhou, W.2    Robinson, M.O.3    Harrington, L.4
  • 38
    • 0035825601 scopus 로고    scopus 로고
    • Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
    • Guiducci, C., Cerone, M. A. and Bacchetti, S. Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene20 (2001) 714-725.
    • (2001) Oncogene , vol.20 , pp. 714-725
    • Guiducci, C.1    Cerone, M.A.2    Bacchetti, S.3
  • 40
    • 27244458940 scopus 로고    scopus 로고
    • A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation
    • Marie-Egyptienne, D. T., Cerone, M. A., Londono-Vallejo, J. A. and Autexier, C. A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation. Nucleic Acids Res. 33 (2005) 5446-5457.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 5446-5457
    • Marie-Egyptienne, D.T.1    Cerone, M.A.2    Londono-Vallejo, J.A.3    Autexier, C.4
  • 41
    • 0033636897 scopus 로고    scopus 로고
    • Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
    • Mitchell, J. R. and Collins, K. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell. 6 (2000) 361-371.
    • (2000) Mol. Cell. , vol.6 , pp. 361-371
    • Mitchell, J.R.1    Collins, K.2
  • 42
    • 0035137710 scopus 로고    scopus 로고
    • Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions
    • Bachand, F. and Autexier, C. Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol. Cell. Biol. 21 (2001) 1888-1897.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1888-1897
    • Bachand, F.1    Autexier, C.2
  • 43
    • 0035144580 scopus 로고    scopus 로고
    • RNA binding domain of telomerase reverse transcriptase
    • Lai, C. K., Mitchell, J. R. and Collins, K. RNA binding domain of telomerase reverse transcriptase. Mol. Cell. Biol. 21 (2001) 990-1000.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 990-1000
    • Lai, C.K.1    Mitchell, J.R.2    Collins, K.3
  • 44
    • 0038381556 scopus 로고    scopus 로고
    • The solution structure of an essential stem-loop of human telomerase RNA
    • Leeper, T., Leulliot, N. and Varani, G. The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Res. 31 (2003) 2614-2621.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2614-2621
    • Leeper, T.1    Leulliot, N.2    Varani, G.3
  • 45
    • 0346362327 scopus 로고    scopus 로고
    • Analysis of a long-range interaction between conserved domains of human telomerase RNA
    • Ueda, C. T. and Roberts, R. W. Analysis of a long-range interaction between conserved domains of human telomerase RNA. RNA10 (2004) 139-147.
    • (2004) Rna , vol.10 , pp. 139-147
    • Ueda, C.T.1    Roberts, R.W.2
  • 46
    • 0035444984 scopus 로고    scopus 로고
    • Telomere maintenance by telomerase and by recombination can coexist in human cells
    • Cerone, M. A., Londono-Vallejo, J. A. and Bacchetti, S. Telomere maintenance by telomerase and by recombination can coexist in human cells. Hum. Mol. Genet. 10 (2001) 1945-1952.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1945-1952
    • Cerone, M.A.1    Londono-Vallejo, J.A.2    Bacchetti, S.3
  • 47
    • 25444519237 scopus 로고    scopus 로고
    • Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation
    • Cerone, M. A., Ward, R. J., Londono-Vallejo, J. A. and Autexier, C. Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation. Cell Cycle4 (2005) 585-589.
    • (2005) Cell Cycle , vol.4 , pp. 585-589
    • Cerone, M.A.1    Ward, R.J.2    Londono-Vallejo, J.A.3    Autexier, C.4
  • 48
    • 0038392866 scopus 로고    scopus 로고
    • Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs
    • Fu, D. and Collins, K. Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol. Cell. 11 (2003) 1361-1372.
    • (2003) Mol. Cell. , vol.11 , pp. 1361-1372
    • Fu, D.1    Collins, K.2
  • 49
    • 0032803237 scopus 로고    scopus 로고
    • Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro
    • Tesmer, V. M., Ford, L. P., Holt, S. E., Frank, B. C., Yi, X., Aisner, D. L., Ouellette, M., Shay, J. W. and Wright, W. E. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell. Biol. 19 (1999) 6207-6216.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6207-6216
    • Tesmer, V.M.1    Ford, L.P.2    Holt, S.E.3    Frank, B.C.4    Yi, X.5    Aisner, D.L.6    Ouellette, M.7    Shay, J.W.8    Wright, W.E.9
  • 50
    • 0031801205 scopus 로고    scopus 로고
    • Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells
    • Wen, J., Cong, Y. S. and Bacchetti, S. Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells. Hum. Mol. Genet. 7 (1998) 1137-1141.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1137-1141
    • Wen, J.1    Cong, Y.S.2    Bacchetti, S.3
  • 52
    • 0038701907 scopus 로고    scopus 로고
    • Biochemical aspects of telomerase function
    • Harrington, L. Biochemical aspects of telomerase function. Cancer Lett. 194 (2003) 139-154.
    • (2003) Cancer Lett. , vol.194 , pp. 139-154
    • Harrington, L.1
  • 53
    • 0035253526 scopus 로고    scopus 로고
    • Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p
    • Dez, C., Henras, A., Faucon, B., Lafontaine, D., Caizergues-Ferrer, M. and Henry, Y. Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p. Nucleic Acids Res. 29 (2001) 598-603.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 598-603
    • Dez, C.1    Henras, A.2    Faucon, B.3    Lafontaine, D.4    Caizergues-Ferrer, M.5    Henry, Y.6
  • 54
    • 0343183144 scopus 로고    scopus 로고
    • In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs
    • Dragon, F., Pogacic, V. and Filipowicz, W. In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell. Biol. 20 (2000) 3037-3048.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3037-3048
    • Dragon, F.1    Pogacic, V.2    Filipowicz, W.3
  • 55
    • 0034459569 scopus 로고    scopus 로고
    • Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10
    • Pogacic, V., Dragon, F. and Filipowicz, W. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Mol. Cell. Biol. 20 (2000) 9028-9040.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9028-9040
    • Pogacic, V.1    Dragon, F.2    Filipowicz, W.3
  • 56
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • Mitchell, J. R., Wood, E. and Collins, K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature402 (1999) 551-555.
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1    Wood, E.2    Collins, K.3
  • 58
    • 34147095342 scopus 로고    scopus 로고
    • Protein composition of catalytically active human telomerase from immortal cells
    • Cohen, S. B., Graham, M. E., Lovrecz, G. O., Bache, N., Robinson, P. J. and Reddel, R. R. Protein composition of catalytically active human telomerase from immortal cells. Science315 (2007) 1850-1853.
    • (2007) Science , vol.315 , pp. 1850-1853
    • Cohen, S.B.1    Graham, M.E.2    Lovrecz, G.O.3    Bache, N.4    Robinson, P.J.5    Reddel, R.R.6
  • 60
    • 0032961170 scopus 로고    scopus 로고
    • A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end
    • Mitchell, J. R., Cheng, J. and Collins, K. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell. Biol. 19 (1999) 567-576.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 567-576
    • Mitchell, J.R.1    Cheng, J.2    Collins, K.3
  • 61
    • 33751072682 scopus 로고    scopus 로고
    • Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita
    • Wong, J. M. and Collins, K. Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. Genes Dev. 20 (2006) 2848-2858.
    • (2006) Genes Dev. , vol.20 , pp. 2848-2858
    • Wong, J.M.1    Collins, K.2
  • 62
    • 25144455033 scopus 로고    scopus 로고
    • Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts
    • Michailidis, G., Saretzki, G. and Hall, J. Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts. Biochem. Biophys. Res. Commun. 335 (2005) 240-246.
    • (2005) Biochem. Biophys. Res. Commun. , vol.335 , pp. 240-246
    • Michailidis, G.1    Saretzki, G.2    Hall, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.