Analysis of a long-range interaction between conserved domains of human telomerase RNA

RNA

Volumn 10, Issue 1, 2004, Pages 139-147

  Ueda, Christine T ^a   Roberts, Richard W ^a  

^a California Institute of Technology   (United States)

Author keywords

Mobility shift assay; RNA structure; RNA RNA interaction; Telomerase RNA; UV cross linking

Indexed keywords

4 THIOURACIL; MAGNESIUM ION; RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE RNA; UNCLASSIFIED DRUG;

ARTICLE; CROSS LINKING; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA BINDING; RNA RNA INTERACTION; RNA SEQUENCE; RNA STRUCTURE; TELOMERE; ULTRAVIOLET RADIATION;

BASE PAIRING; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CROSS-LINKING REAGENTS; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; RNA; TELOMERASE; TEMPLATES, GENETIC; ULTRAVIOLET RAYS;

EUKARYOTA; MAMMALIA;

EID: 0346362327     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1261/rna.5118104     Document Type: Article

References (39)

1. Antal, M., Boros, E., Solymosy, F., and Kiss, T. 2002. Analysis of the structure of human telomerase RNA in vivo. Nucleic Acids Res. 30: 912-920.
2. Autexier, C. and Greider, C.W. 1994. Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes & Dev. 8: 563-575.
3. Bachand, F. and Autexier, C. 2001. Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol. Cell Biol. 21: 1888-1897.
4. Beattie, T.L., Zhou, W., Robinson, M.O., and Harrington, L. 2000. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell 11: 3329-3340.
5. Bhattacharyya, A. and Blackburn, E.H. 1994. Architecture of telomerase RNA. EMBO J. 13: 5721-5731.
6. Blackburn, E.H. 1991. Structure and function of telomeres. Nature 350: 569-573.
7. -. 2000. The end of the (DNA) line. Nat. Struct. Biol. 7: 847-850.
8. Cech, T.R. 2000. Life at the end of chromosomes: Telomeres and telomerase. Angew. Chem. Int. Ed. 39: 34-43.
9. Chen, J.L. and Greider, C.W. 2003. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 22: 304-314.
10. Chen, J.L., Blasco, M.A., and Greider, C.W. 2000. Secondary structure of vertebrate telomerase RNA. Cell 100: 503-514.
11. Chen, J.L., Opperman, K.K., and Greider, C.W. 2002. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res. 30: 592-597.
12. Comolli, L.R., Smirnov, I., Xu, L., Blackburn, E.H., and James, T.L. 2002. A molecular switch underlies a human telomerase disease. Proc. Natl. Acad. Sci. 99: 16998-17003.
13. Corey, D.R. 2002. Telomerase inhibition, oligonucleotides, and clinical trials. Oncogene 21: 631-637.
14. Dubreuil, Y.L., Expert-Benzancon, A., and Favre, A. 1991. Conformation and structural fluctuations of a 218 nucleotides long rRNA fragment: 4-thiouridine as an intrinsic photolabeling probe. Nucleic Acids Res. 19: 3653-3660.
15. Feng, J., Funk, W.D., Wang, S., Weinrich, S.L., Avilion, A.A., Chiu, C., Adams, R.R., Chang, E., Allsopp, R.C., Yu, J., et al. 1995. The RNA component of human telomerase. Science 269: 1236-1241.
16. Ferrandon, D., Koch, I., Westhof, E., and Nüsslein-Volhard, C. 1997. RNA-RNA interaction is required for the formation of specific bicoid mRNA 3′ UTR-STAUFEN ribonucleoprotein particles. EMBO J. 16: 1751-1758.
17. Gavory, G., Farrow, M., and Balasubramanian, S. 2002. Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vivo. Nucleic Acids Res. 30: 4470-4480.
18. Greider, C.W. and Blackburn, E.H. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405-413.
19. -. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomerase repeat synthesis. Nature 337: 331-337.
20. Hahn, W.C., Counter, C.M., Lundberg, A.S., Beijersbergen, R.L., Brooks, M.W., and Weinberg, R.A. 1999. Creation of human tumour cells with defined genetic elements. Nature 400: 464-468.
21. Kim, N. W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
22. Lai, C.K., Miller, M.C., and Collins, K. 2003. Roles for RNA in telomerase nucleotide and repeat addition processivity. Mol. Cell 11: 1673-1683.
23. Leeper, T., Leulliot, N., and Varani, G. 2003. The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Res. 31: 2614-2621.
24. Lingner, J., Hughes, T.R., Shevchenko, A., Mann, M., Lundblad, V., and Cech, T.R. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276: 561-567.
25. Lowe, T.M. and Eddy, S.R. 1999. A computational screen for methylation guide snoRNAs in yeast. Science 283: 1168-1171.
26. Lukowiak, A.A., Narayanan, A., Li, Z., Terns, R.M., and Terns, M.P. 2001. The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus. RNA 7: 1833-1844.
27. Martín-Rivera, L. and Blasco, M. 2001. Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system. J. Biol. Chem. 276: 5856-5865.
28. Miller, M.C. and Collins, K. 2002. Telomerase recognizes its template by using an adjacent RNA motif. Proc. Natl. Acad. Sci. 99: 6585-6590.
29. Mitchell, J.R. and Collins, K. 2000. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell 6: 361-371.
30. Mitchell, J.R., Cheng, J., and Collins, K. 1999. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end. Mol. Cell Biol. 19: 567-576.
31. Morin, G.B. 1989. The human telomerase terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521-529.
32. Nakamura, T.M., Morin, G.B., Chapman, K.B., Weinrich, S.L., Andrews, W.H., Lingner, C.B., Harley, C.B., and Cech, T.R. 1997. Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959.
33. Palmer, C.R. 1998. Biopolymer Calculator. http://paris.chem.yale.edu/ extinct.html.
34. Prowse, K.R., Avilion, A.A., and Greider, C.W. 1993. Identification of a nonprocessive telomerase activity from mouse cells. Proc. Natl. Acad. Sci. 90: 1493-1497.
35. Rezler, E.M., Bearss, D.J., and Hurley, L.H. 2002. Telomeres and telomerase as drug targets. Curr. Opin. Pharm. 2: 415-423.
36. Romero, D.P. and Blackburn, E.H. 1991. A conserved secondary structure for telomerase RNA. Cell 67: 343-353.
37. Shippen-Lentz, D. and Blackburn, E.H. 1990. Functional evidence for an RNA template in telomerase. Science 247: 546-552.
38. Tesmer, V.M., Ford, L.P., Holt, S.E., Frank, B.C., Yi, X., Aisner, D.L., Ouellete, M., Shay, J.W., and Wright, W.E. 1999. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell Biol. 19: 6207-6216.
39. Theimer, C.A., Finger, L.D., Trantirek, L., and Feigon, J. 2003. Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc. Natl. Acad. Sci. 100: 449-454.