Analysis of phospholipids in infant formulas using high performance liquid chromatography-tandem mass spectrometry

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 4, 2013, Pages 858-865

  Fong, Bertram ^a   Ma, Lin ^a   Norris, Carmen ^a  

^a FONTERRA RESEARCH CENTRE   (New Zealand)

Author keywords

HPLC MS MS; infant formulas; phospholipids

Indexed keywords

COEFFICIENT OF VARIATION; FATTY ACID PROFILES; FOOD INDUSTRIES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HPLC-MS/MS; INFANT DEVELOPMENT; INFANT FORMULA; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MOLECULAR SPECIES; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; SPHINGOMYELIN;

CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

PHOSPHOLIPIDS;

FATTY ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; SPHINGOMYELIN;

ARTICLE; ARTIFICIAL MILK; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; METHODOLOGY; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY ACIDS; HUMANS; INFANT; INFANT FORMULA; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLINOSITOLS; PHOSPHATIDYLSERINES; PHOSPHOLIPIDS; REPRODUCIBILITY OF RESULTS; SPHINGOMYELINS; TANDEM MASS SPECTROMETRY;

EID: 84873191052     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf304877k     Document Type: Article

References (62)

1. Jumpsen, J.; Clandinin, M. T. Brain Development: Relationship to Dietary Lipid and Lipid Metabolism; AOCS Press: Champaign, IL, 1995.
2. Hirabayashi, Y.; Furuya, S. Roles of L-serine and sphingolipid synthesis in brain development and neuronal survival Prog. Lipid Res. 2008, 47, 188-203
3. Oshida, K.; Shimizu, T.; Takase, M.; Tamura, Y.; Shimizu, T.; Yamashiro, Y. Effects of dietary sphingomyelin on central nervous system myelination in developing rats Pediatr. Res. 2003, 53, 589-593
4. Tanaka, K.; Hosozawa, M.; Kudo, N.; Yoshikawa, N.; Hisata, K.; Shoji, H.; Shinohara, K.; Shimizu, T. The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial Brain. Dev. 2013, 35, 45-52
5. Gurnida, D. A.; Rowan, A. M.; Idjradinata, P.; Muchtadi, D.; Sekarwana, N. Association of complex lipids containing gangliosides with cognitive development of 6-month-old infants Early Hum. Dev. 2012, 88, 595-601
6. Rueda, R.; Gil, A. Role of gangliosides in infant nutrition. In Lipids in Infant Nutrition; Huang, Y. S.; Sinclair, A. J., Eds.; AOCS Press: Champaign, IL, 1998; pp 213-234.
7. Küllenberg, D.; Taylor, L. A.; Schneider, M.; Massing, U. Health effects of dietary phospholipids Lipids Health Dis. 2012, 11
8. German, J. B. Dietary lipids from an evolutionary perspective: sources, structures and functions Matern. Child Nutr. 2011, 7, 2-16
9. Berger, A.; Fleith, M.; Crozier, G. Nutritional implications of replacing bovine milk fat with vegetable oil in infant formulas J. Pediatr. Gastroenterol. Nutr. 2000, 30, 115-130
10. Bitman, J.; Wood, D. L.; Mehta, N. R.; Hamosh, P.; Hamosh, M. Comparison of the phospholipid composition of breast milk from mothers of term and preterm infants during lactation Am. J. Clin. Nutr. 1984, 40, 1103-19
11. Bitman, J.; Wood, D. L. Changes in milk-fat phospholipids during lactation J. Dairy Sci. 1990, 73, 1208-1216
12. Zeisel, S. H.; Char, D.; Sheard, N. F. Choline, phosphatidylcholine and sphingomyelin in human and bovine-milk and infant formulas J. Nutr. 1986, 116, 50-58
13. Graves, E. L. F.; Beaulieu, A. D.; Drackley, J. K. Factors affecting the concentration of sphingomyelin in bovine milk J. Dairy Sci. 2007, 90, 706-715
14. Sommer, U.; Herscovitz, H.; Welty, F. K.; Costello, C. E. LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures J. Lipid Res. 2006, 47, 804-814
15. Gallier, S.; Gragson, D.; Cabral, C.; Jimenez-Flores, R.; Everett, D. W. Composition and fatty acid distribution of bovine milk phospholipids from processed milk products J. Agric. Food Chem. 2010, 58, 10503-10511
16. Fuchs, B.; Schiller, J.; Suess, R.; Schuerenberg, M.; Suckau, D. A direct and simple method of coupling matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) to thin-layer chromatography (TLC) for the analysis of phospholipids from egg yolk Anal. Bioanal. Chem. 2007, 389, 827-834
17. Vyssotski, M.; MacKenzie, A.; Scott, D. TLC and P-31-NMR analysis of low polarity phospholipids Lipids 2009, 44, 381-389
18. Sotirhos, N.; Herslof, B.; Kenne, L. Quantitative-analysis of phospholipids by p-31 NMR J. Lipid Res. 1986, 27, 386-392
19. 31P-NMR in phospholipid analysis Lipid Technol. 2002, 14, 62-65
20. MacKenzie, A.; Vyssotski, M.; Nekrasov, E. Quantitative analysis of dairy phospholipids by (31)P NMR J. Am. Oil Chem. Soc. 2009, 86, 757-763
21. Kynast, G.; Schmitz, C. Determination of the phospholipid content of human-milk, cows milk and various infant formulas Z. Ernaehrungswiss. 1988, 27, 252-265
22. Christie, W. W. Chromatographic analysis of phospholipids Z. Lebensm. Unters. Forsch. 1985, 181, 171-182
23. Rombaut, R.; Camp, J. V.; Dewettinck, K. Analysis of phospho- and sphingolipids in dairy products by a new HPLC method J. Dairy Sci. 2005, 88, 482-488
24. Rodriguez-Alcala, L. M.; Fontecha, J. Major lipid classes separation of buttermilk, and cows, goats and ewes milk by high performance liquid chromatography with an evaporative light scattering detector focused on the phospholipid fraction J. Chromatogr., A 2010, 1217, 3063-3066
25. Rombaut, R.; Dewettinck, K.; Van Camp, J. Phospho- and sphingolipid content of selected dairy products as determined by HPLC coupled to an evaporative light scattering detector (HPLC-ELSD) J. Food Comp. Anal. 2007, 20, 308-312
26. Vila, A. S.; Castellote-Bargallo, A. I.; Rodriguez-Palmero-Seuma, M.; Lopez-Sabater, M. C. High-performance liquid chromatography with evaporative light-scattering detection for the determination of phospholipid classes in human milk, infant formulas and phospholipid sources of long-chain polyunsaturated fatty acids J. Chromatogr., A 2003, 1008, 73-80
27. Braun, M.; Fluck, B.; Cotting, C.; Monard, F.; Giuffrida, F. Quantification of phospholipids in infant formula and growing up milk by high-performance liquid chromatography with evaporative light scattering detector J. Assoc. Off. Anal. Chem. Int. 2010, 93, 948-955
28. Fagan, P.; Wijesundera, C. Liquid chromatographic analysis of milk phospholipids with on-line pre-concentration J. Chromatogr., A 2004, 1054, 241-249
29. Zhou, L.; Le Grandois, J.; Marchioni, E.; Zhao, M. J.; Ennahar, S.; Bindler, F. Improvement of total lipid and glycerophospholipid recoveries from various food matrices using pressurized liquid extraction J. Agric. Food Chem. 2010, 58, 9912-9917
30. Donato, P.; Cacciola, F.; Cichello, F.; Russo, M.; Dugo, P.; Mondello, L. Determination of phospholipids in milk samples by means of hydrophilic interaction liquid chromatography coupled to evaporative light scattering and mass spectrometry detection J. Chromatogr., A 2011, 1218, 6476-6482
31. Christie, W. W.; Noble, R. C.; Davies, G. Phospholipids in milk and dairy-products J. Soc. Dairy Technol. 1987, 40, 10-12
32. Morin, P.; Jimenez-Flores, R.; Pouliot, Y. Effect of temperature and pore size on the fractionation of fresh and reconstituted buttermilk by microfiltration J. Dairy Sci. 2004, 87, 267-273
33. Olsson, P.; Holmback, J.; Herslof, B. Separation of lipid classes by HPLC on a cyanopropyl column Lipids 2012, 47, 93-9
34. Boyd, L. C.; Drye, N. C.; Hansen, A. P. Isolation and characterization of whey phospholipids J. Dairy Sci. 1999, 82, 2550-2557
35. Avalli, A.; Contarini, G. Determination of phospholipids in dairy products by SPE/HPLU/ELSD J. Chromatogr., A 2005, 1071, 185-190
36. Bunger, H.; Pison, U. Quantitative-analysis of pulmonary surfactant phospholipids by high-performance liquid-chromatography and light-scattering detection J. Chromatogr., Biomed. Appl. 1995, 672, 25-31
37. Homan, R.; Anderson, M. K. Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection J. Chromatogr., Biomed. Sci. Appl. 1998, 708, 21-26
38. Seppanen-Laakso, T.; Laakso, I.; Vanhanen, H.; Kiviranta, K.; Lehtimaki, T.; Hiltunen, R. Major human plasma lipid classes determined by quantitative high-performance liquid chromatography, their variation and associations with phospholipid fatty acids J. Chromatogr., B 2001, 754, 437-445
39. Christie, W. W., Detectors for high-performance liquid chromatography of lipids with special reference to evaporative light-scattering detection. In Advances in Lipid Methodology; Christie, W. W., Ed.; Oily Press: Ayr, Scotland, 1992; Vol. 1, pp 239-271.
40. Ramos, R. G.; Libong, D.; Rakotomanga, M.; Gaudin, K.; Loiseau, P. M.; Chaminade, P. Comparison between charged aerosol detection and light scattering detection for the analysis of Leishmania membrane phospholipids J. Chromatogr., A 2008, 1209, 88-94
41. Rabagny, Y.; Herrmann, W.; Geisel, J.; Kirsch, S. H.; Obeid, R. Quantification of plasma phospholipids by ultra performance liquid chromatography tandem mass spectrometry Anal. Bioanal. Chem. 2011, 401, 891-899
42. Bang, D. Y.; Lim, S.; Moon, M. H. Effect of ionization modifiers on the simultaneous analysis of all classes of phospholipids by nanoflow liquid chromatography/tandem mass spectrometry in negative ion mode J. Chromatogr., A 2012, 1240, 69-76
43. Min, H. K.; Kong, G.; Moon, M. H. Quantitative analysis of urinary phospholipids found in patients with breast cancer by nanoflow liquid chromatography-tandem mass spectrometry: II. Negative ion mode analysis of four phospholipid classes Anal. Bioanal. Chem. 2010, 396, 1273-1280
44. Peterson, B. L.; Cummings, B. S. A review of chromatographic methods for the assessment of phospholipids in biological samples Biomed. Chromatogr. 2006, 20, 227-243
45. Fong, B. Y.; Norris, C. S.; MacGibbon, A. K. H. Protein and lipid composition of bovine milk-fat-globule membrane Int. Dairy J. 2007, 17, 275-288
46. Buyukpamukcu, E.; Hau, J.; Fay, L. B.; Dionisi, F. Analysis of phospholipids using electrospray ionisation tandem mass spectrometry Lipid Technol. 2007, 19 (6) 136-138
47. Calvano, C. D.; Jensen, O. N.; Zambonin, C. G. Selective extraction of phospholipids from dairy products by micro-solid phase extraction based on titanium dioxide microcolumns followed by MALDI-TOF-MS analysis Anal. Bioanal. Chem. 2009, 394, 1453-1461
48. Byrdwell, W. C.; Perry, R. H. Liquid chromatography with dual parallel mass spectrometry and P-31 nuclear magnetic resonance spectroscopy for analysis of sphingomyelin and dihydrosphingomyelin-II. Bovine milk sphingolipids J. Chromatogr., A 2007, 1146, 164-185
49. Zhou, L.; Zhao, M.; Ennahar, S.; Bindler, F.; Marchioni, E. Determination of phosphatidylethanolamine molecular species in various food matrices by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS2) Anal. Bioanal. Chem. 2012, 403, 291-300
50. Montealegre, C.; Verardo, V.; Maria Gomez-Caravaca, A.; Garcia-Ruiz, C.; Luisa Marina, M.; Fiorenza Caboni, M. Molecular characterization of phospholipids by high-performance liquid chromatography combined with an evaporative light scattering detector, high-performance liquid chromatography combined with mass spectrometry, and gas chromatography combined with a flame ionization detector in different oat varieties J. Agric. Food Chem. 2012, 60, 10963-10969
51. Shen, Q.; Wang, Y.; Gong, L.; Guo, R.; Dong, W.; Cheung, H.-Y. Shotgun lipidomics strategy for fast analysis of phospholipids in fisheries waste and its potential in species differentiation J. Agric. Food Chem. 2012, 60, 9384-9393
52. Youyi, W.; Hong, Z. Tracking phospholipid profiling of muscle from Ctennopharyngodon idellus during storage by shotgun lipidomics J. Agric. Food Chem. 2011, 59, 11635-11642
53. Norris, C.; Fong, B.; MacGibbon, A.; McJarrow, P. Analysis of phospholipids in rat brain using liquid chromatography-mass spectrometry Lipids 2009, 44, 1047-1054
54. Svennerholm, L.; Fredman, P. A procedure for the quantitative isolation of brain gangliosides Biochim. Biophys. Acta 1980, 617, 97-109
55. Brugger, B.; Erben, G.; Sandhoff, R.; Wieland, F. T.; Lehmann, W. D. Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 2339-2344
56. Berry, K. A. Z.; Murphy, R. C. Electrospray ionization tandem mass spectrometry of glycerophosphoethanolamine plasmalogen phospholipids J. Am. Soc. Mass Spectrom. 2004, 15, 1499-1508
57. Christie, W. W.; Xianlin, H. Quantification of lipid molecular species by electrospray ionization mass spectrometry. In Lipid Analysis, 4 th ed.; Oily Press: Ayr, Scotland, 2010; pp 365-415.
58. Koivusalo, M.; Haimi, P.; Heikinheimo, L.; Kostiainen, R.; Somerharju, P. Quantitative determination of phospholipid compositions by ESI-MS: effects of acyl chain length, unsaturation, and lipid concentration on instrument response J. Lipid Res. 2001, 42, 663-672
59. Kim, H. Y.; Wang, T. C. L.; Ma, Y. C. Liquid-chromatography mass-spectrometry of phospholipids using electrospray-ionization Anal. Chem. 1994, 66, 3977-3982
60. DeLong, C. J.; Baker, P. R. S.; Samuel, M.; Cui, Z.; Thomas, M. J. Molecular species composition of rat liver phospholipids by ESI-MS/MS: the effect of chromatography J. Lipid Res. 2001, 42, 1959-1968
61. Folch, J.; Lees, M.; Stanley, G. H. S. A simple method for the isolation and purification of total lipids from animal tissues J. Biol. Chem. 1957, 226, 497-509
62. Le Grandois, J.; Marchioni, E.; Zhao, M.; Giuffrida, F.; Ennahar, S.; Bindler, F. Investigation of natural phosphatidylcholine sources: separation and identification by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS(2)) of molecular species J. Agric. Food Chem. 2009, 57, 6014-6020