Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats

Osteoarthritis and Cartilage

Volumn 21, Issue 3, 2013, Pages 514-523

  Nagase, H ^a   Nagasawa, Y ^a   Tachida, Y ^a   Sakakibara, S ^a   Okutsu, J ^a   Suematsu, N ^b   Arita, S ^b   Shimada, K ^a  

^a DAIICHI SANKYO CO   (Japan)

^b Gunma Pref Cardiovascular Center   (Japan)

Author keywords

Cartilage specific transgenic rats; Chondrocyte hypertrophy; Gene expression; Iodothyronine deiodinase 2; Osteoarthritis; Thyroid hormone production

Indexed keywords

DEIODINASE 2; IODIDE PEROXIDASE; LIOTHYRONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION PROFILING; HUMAN; MICROARRAY ANALYSIS; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CASE-CONTROL STUDIES; CHONDROCYTES; GENE EXPRESSION PROFILING; HUMANS; INTERLEUKIN-1ALPHA; IODIDE PEROXIDASE; OSTEOARTHRITIS, KNEE; RATS; RATS, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRIIODOTHYRONINE;

EID: 84873164102     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.12.013     Document Type: Article

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