Targeted disruption of the type 2 selenodeiodinase gene (Dio2) results in a phenotype of pituitary resistance to T4

Molecular Endocrinology

Volumn 15, Issue 12, 2001, Pages 2137-2148

  Schneider, Mark J ^a   Fiering, Steven N ^a   Pallud, Sophie E ^a   Parlow, Albert F ^b   St Germain, Donald L ^a   Galton, Valerie Anne ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORSKOLIN; SELENOAMINO ACID; SELENODEIODINASE; THYROTROPIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CODON; CONTROLLED STUDY; DEIODINATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENE DISRUPTION; GENE EXPRESSION; GENE INACTIVATION; GENETIC RECOMBINATION; GROWTH RETARDATION; HYPOTHYROIDISM; KNOCKOUT GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE;

ANIMALIA;

EID: 0035211984     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.15.12.0740     Document Type: Article

References (49)

1. Biochemistry of deiodination
2. Regulatory influences on iodothyronine deiodination in animal tissues
3. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
4. A thyroid hormone regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase
5. Cloning of a cDNA for the type II iodothyronine deiodinase
6. The deiodinase family of selenoproteins
7. Role of sulfation in thyroid hormone metabolism
8. Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat
9. Local activation and inactivation of the thyroid hormones: The deiodinase family
10. Nature, sources, and relative biologic significance of circulating thyroid hormones
11. The thyroid gland is a major source of circulating T3 in the rat
12. Relationships between circulating and intracellular thyroid hormones: Physiological and clinical applications
13. An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum
14. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue
15. Direct measurement of the contributions of type I and type II 5′-deiodinases to whole body steady state 3,5,3′-triiodothyronine production from thyroxine in the rat
16. Adrenergic activation of triiodothyronine production in brown adipose tissue
17. Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase
18. Dibutyryl c-AMP induction of type II 5′deiodinase activity in rat brain astrocytes in culture
19. Expression of the type II iodothyronine deiodinase in cultured rat astrocytes is selenium-dependent
20. Regulation of type 3 iodothyronine deiodinase expression in cultured rat astrocytes: Role of the Erk cascade
21. Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase
22. The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat
23. Cloning, expression and functional characterization of the substrate binding subunit of rat type II iodothyronine 5′-deiodinase
24. Cloning of the mammalian type II iodothyronine deiodinase: A selenoprotein differentially expressed and regulated in the human brain and other tissues
25. The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3′-triiodothyronine in pituitary, liver and kidney of euthyroid rats
26. Evidence for two pathways of iodothyronine 5′-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism
27. Effect of perinatal hypothyroidism on the developmental regulation of rat pituitary growth hormone and thyrotropin genes
28. Rapid stimulation of type I 5′deiodinase in rat pituitaries by 3.3′,5′-triiodo-L-thyronine
29. Expression profiles of the three iodothyronine deiodinases, D1, D2 and D3, in the developing rat
30. Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats
31. Sources and quantities of 3,5,3′-triiodothyronine in several tissue of the rat
32. 4) with the biological effects of thyroid hormone replacement in propylthiouracil-treated rats
33. Comparison of the biological effects of thyroxine and triiodothyronine in the rat
34. Thyroid hormone metabolism and the source of plasma triiodothyronine in 2-week-old rats: Effects of thyroid status
35. The type III 5-deiodinase in Rana catesbeiana tadpoles is encoded by a thyroid hormone-responsive gene
36. Characteristics of iodothyronine tyrosyl ring deiodination by rat cerebral cortical microsomes
37. Maturational patterns of iodothyronine phenolic and tyrosyl ring deiodinase activities in rat cerebrum, cerebellum, and hypothalamus
38. Brown adipose tissue and cold-acclimation
39. Role of thyroid hormone in metabolic responses to a cold environment
40. Central role of brown adipose tissue thyroxine 5′-deiodinase on thyroid hormone-dependent thermogenic response to cold
41. Gene targeting in embryonic stem cells
42. The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles
43. Regulation of c-erbAα mRNA species in tadpole erythrocytes by thyroid hormone
44. Induction of type III-deiodinase activity in astroglial cells by retinoids
45. m activity
46. Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase
47. Similarities in the cytoplasmic proteins of different organs and species examined by SDS gel electrophoresis
48. Depletion of L-3,5,3′-triiodothyronine and L-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone
49. Expression of the mutant thyroid hormone receptor PV in the pituitary of transgenic mice leads to weight reduction