Selective proteolysis of human type 2 deiodinase: A novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation

Molecular Endocrinology

Volumn 14, Issue 11, 2000, Pages 1697-1708

  Gereben, B ^a   Goncalves, C ^a   Harney, J W ^a   Larsen, P R ^a   Bianco, A C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; EPITOPE; IODIDE PEROXIDASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HORMONAL REGULATION; HUMAN; HUMAN CELL; HYPOPHYSIS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TEMPERATURE;

EID: 0033650596     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.14.11.0558     Document Type: Article

References (26)

1. Degradation of ornithine decarboxylase by the 26S proteasome
2. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis
3. Catabolite inactivation of fructose-1,6-bisphosphatase of Saccharomyces cerevisiae. Degradation occurs via the ubiquitin pathway
4. Proteins of newly isolated mutants and the amino-terminal proline are essential for ubiquitin-proteasome-catalyzed catabolite degradation of fructose-1,6-bisphosphatase of Saccharomyces cerevisiae
5. Relationships between circulating and intracellular thyroid hormones: Physiological and clinical implications
6. The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II iodothyronine 5'-deiodinase
7. Cerebral cortex responds rapidly to thyroid hormones
8. Regulation of rat cerebrocortical and adenohypophyseal type II 5'-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine
9. Hormonal control of a low Km (type II) iodothyronine 5'-deiodinase in cultured NB41A3 mouse neuroblastoma cells
10. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes
11. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation, requires interaction with the enzyme's active center
12. Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation
13. Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway
14. Comparison of kidney and brown adipose tissue iodothyronine 5'-deiodinases
15. The ubiquitin system
16. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
17. Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein
18. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
19. Selenocysteine and the structure, function, and regulation of iodothyronine deiodination: Update 1994
20. Dual mechanisms of regulation of type I iodothyronine 5'-deiodinase in the rat kidney, liver, and thyroid gland. Implications for the treatment of hyperthyroidism with radiographic contrast agents
21. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
22. Ligand-induced inactivation of type I iodothyronine 5'-deiodinase: Protection by propylthiouracil in vivo and reversibility in vitro
23. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
24. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase
25. Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation Without affecting its biochemical properties
26. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding