Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 16, 2010, Pages 7604-7609

  Bassett, J H Duncan ^a   Boyde, Alan ^b   Howell, Peter G T ^b,c   Bassett, Richard H ^d   Galliford, Thomas M ^a   Archanco, Marta ^a   Evans, Holly ^e   Lawson, Michelle A ^e   Croucher, Peter ^e   St Germain, Donald L ^f   Galton, Valerie Anne ^f   Williams, Graham R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Bone formation; Fracture; Hypothyroidism; Skeleton; Thyroid hormone metabolism

Indexed keywords

LIOTHYRONINE; THYROXINE; THYROXINE DEIODINASE;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; BONE STRENGTH; CONTROLLED STUDY; FRACTURE; HYPOTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PHENOTYPE; PRIORITY JOURNAL; TARGET CELL; THYROTOXICOSIS;

ANIMALS; BONE AND BONES; BONE DENSITY; BONE RESORPTION; HYPOTHYROIDISM; IODIDE PEROXIDASE; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; OSTEOBLASTS; PHENOTYPE; STRESS, MECHANICAL; X-RAY MICROTOMOGRAPHY;

MUS;

EID: 77952140653     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911346107     Document Type: Article

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