Retina and omega-3

Journal of Nutrition and Metabolism

Volumn 2011, Issue , 2011, Pages

  Querques, Giuseppe ^a   Forte, Raimondo ^a   Souied, Eric H ^a  

^a Creteil University Eye Clinic   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873128354     PISSN: 20900724     EISSN: 20900732     Source Type: Journal    
DOI: 10.1155/2011/748361     Document Type: Review

References (109)

1. Simopoulos A. P., Leaf A., Salem N. J., Conference report: workshop on the essentiality of an recommended dietary intakes for Omega-6 and Omega-3 fatty acids. Journal of the American College of Nutrition 1999 18 5 487 489 2-s2.0-0032881440 (Pubitemid 29455723)
2. Parkinson A. J., Cruz A. L., Heyward W. L., Bulkow L. R., Hall D., Barstaed L., Connor W. E., Elevated concentrations of plasma ω -3 polyunsaturated fatty acids among Alaskan Eskimos. American Journal of Clinical Nutrition 1994 59 2 384 388 2-s2.0-0028055157 (Pubitemid 24055905)
3. Davidson M., Bulkow L. R., Gellin B. G., Cardiac mortality in Alaska's indigenous and non-native residents. International Journal of Epidemiology 1993 22 1 62 71 2-s2.0-0027341042
4. Middaugh J. P., Cardiovascular deaths among Alaskan Natives, 1980-1986. American Journal of Public Health 1990 80 3 282 285 2-s2.0-0025069996 (Pubitemid 20080909)
5. Kris-Etherton P. M., Taylor D. S., Yu-Poth S., Huth P., Moriarty K., Fishell V., Hargrove R. L., Zhao G., Etherton T. D., Polyunsaturated fatty acids in the food chain in the United States. American Journal of Clinical Nutrition 2000 71 1 179S 188S 2-s2.0-0033954765 (Pubitemid 30046114)
6. Medline Plus, Omega-3 fatty acids, fish oil, alpha-linolenic acid. 2011, http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-fishoil.html#grade
7. http://archive.issfal.org/index.php/home-mainmenu-1
8. Scott B. C., Aruoma O. I., Evansi P. J., O'Neill C., Van Der Vliet A., Cross C. E., Tritschler H. A., Halliwell B., Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation. Free Radical Research 1994 20 2 119 133 2-s2.0-0028345285 (Pubitemid 24103740)
9. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Scientific Opinion on the substantiation of health claims related to EPA, DHA, DPA and maintenance of normal blood pressure (ID 502), maintenance of normal HDL-choles-terol concentrations (ID 515), maintenance of normal (fasting) blood concentrations of triglycerides (ID 517), maintenance of normal LDL-cholesterol concentrations (ID 528, 698) and maintenance of joints (ID 503, 505, 507, 511, 518, 524, 526, 535, 537) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 on request from the European Commission. European Food Safety Authority Journal 2009 7 9, article 1263 26
10. Kris-Etherton P. M., Harris W. S., Appel L. J., Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002 106 21 2747 2757 2-s2.0-0037137299 10.1161/01.CIR.0000038493.65177.94 (Pubitemid 35364932)
11. Roche H. M., Unsaturated fatty acids. Proceedings of the Nutrition Society 1999 58 2 397 401 2-s2.0-0032792739 (Pubitemid 29398125)
12. http://www.omega-3.ch/DACH-WerteTabellei.htm
13. Burns C. P., Halabi S., Clamon G. H., Hars V., Wagner B. A., Hohl R. J., Lester E., Kirshner J. J., Vinciguerra V., Paskett E., Phase I clinical study of fish oil fatty acid capsules for patients with cancer cachexia: cancer and leukemia group B study 9473. Clinical Cancer Research 1999 5 12 3942 3947 2-s2.0-18544391450 (Pubitemid 30013768)
14. Bush R. A., Malnoe A., Reme C. E., Williams T. P., Dietary deficiency of N-3 fatty acids alters rhodopsin content and function in the rat retina. Investigative Ophthalmology and Visual Science 1994 35 1 91 100 2-s2.0-0028125865 (Pubitemid 24046831)
15. Stillwell W., Wassall S. R., Docosahexaenoic acid: membrane properties of a unique fatty acid. Chemistry and Physics of Lipids 2003 126 1 1 27 2-s2.0-0142059080 10.1016/S0009-3084(03)00101-4 (Pubitemid 37297962)
16. Stinson A. M., Wiegand R. D., Anderson R. E., Recycling of docosahexaenoic acid in rat retinas during n-3 fatty acid deficiency. Journal of Lipid Research 1991 32 12 2009 2017 2-s2.0-0026316984
17. Acar N., Bonhomme B., Joffre C., Bron A. M., Creuzot-Garcher C., Bretillon L., Doly M., Chardigny J. M., The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid. Reproduction Nutrition Development 2006 46 5 515 525 2-s2.0-33750060730 10.1051/rnd:2006033 (Pubitemid 44578056)
18. Huang M. C., Brenna J. T., Chao A. C., Tschanz C., Diersen-Schade D. A., Hung H. C., Differential tissue dose responses of (n-3) and (n-6) PUFA in neonatal piglets fed docosahexaenoate and arachidonoate. Journal of Nutrition 2007 137 9 2049 2055 2-s2.0-34548446048 (Pubitemid 47367264)
19. Grierson I., Hiscott P., Hogg P., Robey H., Mazure A., Larkin G., Development, repair and regeneration of the retinal pigment epithelium. Eye 1994 8 2 255 262 2-s2.0-0028286255 (Pubitemid 24189835)
20. Huber T., Rajamoorthi K., Kurze V. F., Beyer K., Brown M. F., Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by 2H NMR and molecular dynamics simulations. Journal of the American Chemical Society 2002 124 2 298 309 2-s2.0-0037116523 10.1021/ja011383j (Pubitemid 34062760)
21. Bok D., Young R. W., The renewal of diffusely distributed protein in the outer segments of rods and cones. Vision Research 1972 12 2 161 168 2-s2.0-0015290639
22. Young R. W., The renewal of photoreceptor cell outer segments. Journal of Cell Biology 1967 33 1 61 72 2-s2.0-0014077497
23. Garelli A., Rotstein N. P., Politi L. E., Docosahexaenoic acid promotes photoreceptor differentiation without altering Crx expression. Investigative Ophthalmology and Visual Science 2006 47 7 3017 3027 2-s2.0-33746764582 10.1167/iovs.05-1659 (Pubitemid 351639781)
24. Brown M. F., Modulation of rhodopsin function by properties of the membrane bilayer. Chemistry and Physics of Lipids 1994 73 1-2 159 180 2-s2.0-0028124422 10.1016/0009-3084(94)90180-5 (Pubitemid 24299194)
25. De Rodriguez Turco E. B., Deretic D., Bazan N. G., Papermaster D. S., Post-Golgi vesicles cotransport docosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. Journal of Biological Chemistry 1997 272 16 10491 10497 2-s2.0-0030978492 10.1074/jbc.272.16.10491 (Pubitemid 27181053)
26. Niu S. L., Mitchell D. C., Litman B. J., Optimization of receptor-G protein coupling by Bilayer lipid composition II: formation of metarhodopsin II-transducin complex. Journal of Biological Chemistry 2001 276 46 42807 42811 2-s2.0-0035900757 10.1074/jbc.M105778200
27. Mitchell D. C., Niu S. L., Litman B. J., Optimization of receptor-G protein coupling by Bilayer lipid composition I: kinetics of rhodopsin-transducin binding. Journal of Biological Chemistry 2001 276 46 42801 42806 2-s2.0-0035900770
28. Litman B. J., Mitchell D. C., A role for phospholipid polyunsaturation in modulating membrane protein function. Lipids 1996 31 3 S193 S197 2-s2.0-0029976262
29. Litman B. J., Niu S. L., Polozova A., Mitchell D. C., The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways: visual transduction. Journal of Molecular Neuroscience 2001 16 2-3 237 242 2-s2.0-0034913794 10.1385/JMN:16:2-3:237 (Pubitemid 32664785)
30. Turner D., Zlotkin S. H., Shah P. S., Griffiths A. M., Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease. Cochrane Database of Systematic Reviews 2007 2 2-s2.0-36749052045 10.1002/14651858. CD006320.pub2 CD006320 (Pubitemid 351805846)
31. Chen Y., Saari J. C., Noy N., Interactions of all-trans-retinol and long-chain fatty acids with interphotoreceptor retinoid-binding protein. Biochemistry 1993 32 42 11311 11318 2-s2.0-0027371156 10.1021/bi00093a007 (Pubitemid 23332042)
32. Chen Y., Houghton L. A., Brenna J. T., Noy N., Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal. Journal of Biological Chemistry 1996 271 34 20507 20515 2-s2.0-0029840350 10.1074/jbc.271.34.20507 (Pubitemid 26281824)
33. Bourre J. M., Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. Journal of Nutrition, Health and Aging 2004 8 3 163 174 2-s2.0-2542424033 (Pubitemid 38678591)
34. Pawlosky R. J., Denkins Y., Ward G., Salem N., Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: the effects of corn oil-based maternal diets. American Journal of Clinical Nutrition 1997 65 2 465 472 2-s2.0-0030895127 (Pubitemid 27130755)
35. Wang J. Y., Saito M., Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats. Free Radical Research 2003 37 4 419 424 2-s2.0-0037399841 10.1080/1071576031000070084 (Pubitemid 36240406)
36. Weisinger H. S., Vingrys A. J., Sinclair A. J., The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. Lipids 1996 31 1 65 70 2-s2.0-0030041215 (Pubitemid 26023679)
37. Weisinger H. S., Vingrys A. J., Sinclair A. J., Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig. Annals of Nutrition and Metabolism 1996 40 2 91 98 2-s2.0-0029923631 (Pubitemid 26152180)
38. Wheaton D. H., Hoffman D. R., Locke K. G., Watkins R. B., Birch D. G., Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. Archives of Ophthalmology 2003 121 9 1269 1278 2-s2.0-0141499056 10.1001/archopht.121.9.1269 (Pubitemid 37128404)
39. Benolken R. M., Anderson R. E., Wheeler T. G., Membrane fatty acids associated with the electrical response in visual excitation. Science 1973 182 4118 1253 1254 2-s2.0-0015765657
40. Weisinger H. S., Vingrys A. J., Bui B. V., Sinclair A. J., Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. Investigative Ophthalmology and Visual Science 1999 40 2 327 338 2-s2.0-0032894860 (Pubitemid 29063828)
41. Carrié I., Smirnova M., Clément M., De Javel D., Francès H., Bourre J. M., Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice. Nutritional Neuroscience 2002 5 1 43 52 10.1080/10284150290007074 (Pubitemid 34228993)
42. Neuringer M., Connor W. E., Van Petten C., Barstad L., Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. Journal of Clinical Investigation 1984 73 1 272 276 2-s2.0-0021350358 (Pubitemid 14222673)
43. Neuringer M., Connor W. E., Lin D. S., Biochemical and functional effects of prenatal and postnatal ω 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proceedings of the National Academy of Sciences of the United States of America 1986 83 11 4021 4025 2-s2.0-0022445141 (Pubitemid 16062414)
44. Jeffrey B. G., Weisinger H. S., Neuringer M., Mitchell D. C., The role of docosahexaenoic acid in retinal function. Lipids 2001 36 9 859 871 2-s2.0-0035160492 (Pubitemid 33065187)
45. Jeffrey B. G., Mitchell D. C., Gibson R. A., Neuringer M., n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. Investigative Ophthalmology and Visual Science 2002 43 8 2806 2814 2-s2.0-0036326098 (Pubitemid 34809476)
46. Innis S. M., Akrabawi S. S., Diersen-Schade D. A., Dobson M. V., Guy D. G., Visual acuity and blood lipids in term infants fed human milk or formulae. Lipids 1997 32 1 63 72 2-s2.0-0031037233 10.1007/s11745-997-0010-7 (Pubitemid 27057302)
47. Salem N. Jr., Loewke J., Catalan J. N., Majchrzak S., Moriguchi T., Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet. Experimental Eye Research 2005 81 6 655 663 2-s2.0-29044450118 10.1016/j.exer.2005.04.003 (Pubitemid 41790413)
48. Seddon J. M., Rosner B., Sperduto R. D., Yannuzzi L., Haller J. A., Blair N. P., Willett W., Dietary fat and risk for advanced age-related macular degeneration. Archives of Ophthalmology 2001 119 8 1191 1199 2-s2.0-0034899733 (Pubitemid 32730008)
49. Seddon J. M., Cote J., Rosner B., Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake. Archives of Ophthalmology 2003 121 12 1728 1737 2-s2.0-0344305692 10.1001/archopht.121.12.1728 (Pubitemid 37517440)
50. Seddon J. M., George S., Rosner B., Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US twin study of age-related macular degeneration. Archives of Ophthalmology 2006 124 7 995 1001 2-s2.0-33745839872 10.1001/archopht.124.7.995 (Pubitemid 44036322)
51. Reme C. E., Malnoe A., Jung H. H., Wei Q., Munz K., Effect of dietary fish oil on acute light-induced photoreceptor damage in the rat retina. Investigative Ophthalmology and Visual Science 1994 35 1 78 90 2-s2.0-0027982897 (Pubitemid 24046830)
52. Calder P. C., N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 2003 38 4 343 352 2-s2.0-0037971463 10.1007/s11745-003-1068-y (Pubitemid 36724290)
53. Smith W., Mitchell P., Wang J. J., Gender, oestrogen, hormone replacement and age-related macular degeneration: results from the blue mountains eye study. Australian and New Zealand Journal of Ophthalmology 1997 25 1 S13 S15 2-s2.0-0030876029 (Pubitemid 27337271)
54. Sperduto R. D., Hiller R., Systemic hypertension and age-related maculopathy in the Framingham study. Archives of Ophthalmology 1986 104 2 216 219 2-s2.0-0022588647 (Pubitemid 16119617)
55. Chen W., Esselman W. J., Jump D. B., Busik J. V., Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. Investigative Ophthalmology and Visual Science 2005 46 11 4342 4347 2-s2.0-33644691914 10.1167/iovs.05-0601 (Pubitemid 44264641)
56. Connor K. M., Sangiovanni J. P., Lofqvist C., Aderman C. M., Chen J., Higuchi A., Hong S., Pravda E. A., Majchrzak S., Carper D., Hellstrom A., Kang J. X., Chew E. Y., Salem N., Serhan C. N., Smith L. E. H., Increased dietary intake of ω -3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nature Medicine 2007 13 7 868 873 2-s2.0-34447119437 10.1038/nm1591 (Pubitemid 47038185)
57. Rotstein N. P., Politi L. E., German O. L., Girotti R., Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. Investigative Ophthalmology and Visual Science 2003 44 5 2252 2259 2-s2.0-0037407743 10.1167/iovs.02-0901 (Pubitemid 36520324)
58. Politi L., Rotstein N., Carri N., Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. Lipids 2001 36 9 927 935 2-s2.0-0035165071 (Pubitemid 33065194)
59. Chucair A. J., Rotstein N. P., SanGiovanni J. P., During A., Chew E. Y., Politi L. E., Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid. Investigative Ophthalmology and Visual Science 2007 48 11 5168 5177 2-s2.0-38449115096 10.1167/iovs.07-0037 (Pubitemid 351260928)
60. Moriguchi K., Yuri T., Yoshizawa K., Kiuchi K., Takada H., Inoue Y., Hada T., Matsumura M., Tsubura A., Dietary docosahexaenoic acid protects against N-methyl-N-nitrosourea-induced retinal degeneration in rats. Experimental Eye Research 2003 77 2 167 173 2-s2.0-0038504766 10.1016/S0014-4835(03)00114-3 (Pubitemid 36842808)
61. Murayama K., Yoneya S., Miyauchi O., Adachi-Usami E., Nishikawa M., Fish oil (polyunsaturated fatty acid) prevents ischemic-induced injury in the mammalian retina. Experimental Eye Research 2002 74 6 671 676 2-s2.0-0036349786 10.1006/exer.2002.1151 (Pubitemid 34948368)
62. Bazan N. G., Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Current Opinion in Clinical Nutrition and Metabolic Care 2007 10 2 136 141 2-s2.0-33846857139 10.1097/MCO.0b013e32802b7030 (Pubitemid 46220304)
63. German O. L., Insua M. F., Gentili C., Rotstein N. P., Politi L. E., Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. Journal of Neurochemistry 2006 98 5 1507 1520 2-s2.0-33746875974 10.1111/j.1471-4159.2006.04061.x (Pubitemid 44200442)
64. German O. L., Miranda G. E., Abrahan C. E., Rotstein N. P., Ceramide is a mediator of apoptosis in retina photoreceptors. Investigative Ophthalmology and Visual Science 2006 47 4 1658 1668 2-s2.0-33646004329 10.1167/iovs.05-1310 (Pubitemid 46780780)
65. Miyauchi O., Mizota A., Adachi-Usami E., Nishikawa M., Protective effect of docosahexaenoic acid against retinal ischemic injury: an electroretinographic study. Ophthalmic Research 2001 33 4 191 195 2-s2.0-0034921588 10.1159/000055669 (Pubitemid 32678985)
66. Yee P., Weymouth A. E., Fletcher E. L., Vingrys A. J., A role for omega-3 polyunsaturated fatty acid supplements in diabetic neuropathy. Investigative Ophthalmology & Visual Science 2010 51 3 1755 1764 2-s2.0-77949884326
67. Elner V. M., Retinal pigment epithelial acid lipase activity and lipoprotein receptors: effects of dietary omega-3 fatty acids. Transactions of the American Ophthalmological Society 2002 100 301 338 2-s2.0-0036981659 (Pubitemid 37039377)
68. Souied E., Le Tien V., Coscas G., Soubrane G., Toward prevention of age-related macular degeneration. Journal Francais d'Ophtalmologie 2007 30 5 449 455 2-s2.0-34250659273 10.1016/S0181-5512(07)89624-0
69. Wang J. Y., Saito M., Dietary supplementation of n-3 fatty acids and hydroperoxide levels in rat retinas. Free Radical Research 2001 35 4 367 375 2-s2.0-0034834078 (Pubitemid 32894355)
70. Mittag T., Role of oxygen radicals in ocular inflammation and cellular damage. Experimental Eye Research 1984 39 6 759 769 2-s2.0-0021711363 (Pubitemid 15199833)
71. Bush R. A., Reme C. E., Malnoe A., Light damage in the rat retina: the effect of dietary deprivation of n-3 fatty acids on acute structural alterations. Experimental Eye Research 1991 53 6 741 752 2-s2.0-0026343836 10.1016/0014-4835(91)90109-R
72. Organisciak D. T., Darrow R. M., Jiang Y. L., Blanks J. C., Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. Investigative Ophthalmology and Visual Science 1996 37 11 2243 2257 2-s2.0-0029816791 (Pubitemid 26338773)
73. Reinboth J. J., Clausen M., Remé C. E., Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro. Experimental Eye Research 1996 63 3 277 284 2-s2.0-0030248430 10.1006/exer.1996.0116 (Pubitemid 26325117)
74. Sunada S., Kiyose C., Kubo K., Takebayashi J., Sanada H., Saito M., Effect of docosahexaenoic acid intake on lipid peroxidation in diabetic rat retina under oxidative stress. Free Radical Research 2006 40 8 837 846 2-s2.0-33749245159 10.1080/10715760600719557 (Pubitemid 44480494)
75. Cosgrove J. P., Church D. F., Pryor W. A., The kinetics of the autoxidation of polyunsaturated fatty acids. Lipids 1987 22 5 299 304 2-s2.0-0023340011 10.1007/BF02533996
76. Birkle D. L., Bazan N. G., Lipoxygenase- and cyclooxygenase-reaction products and incorporation into glycerolipids of radiolabeled arachidonic acid in the bovine retina. Prostaglandins 1984 27 2 203 216 2-s2.0-0021250943 10.1016/0090-6980(84)90074-1 (Pubitemid 14129943)
77. Morrow J. D., Hill K. E., Burk R. F., Nammour T. M., Badr K. F., Roberts L. J., A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proceedings of the National Academy of Sciences of the United States of America 1990 87 23 9383 9387 2-s2.0-0025572704 10.1073/pnas.87.23.9383 (Pubitemid 120030630)
78. Nourooz-Zadeh J., Pereira P., F2 isoprostanes, potential specific markers of oxidative damage in human retina. Ophthalmic Research 2000 32 4 133 137 2-s2.0-0034025592 (Pubitemid 30303699)
79. Rokach J., Khanapure S. P., Hwang S. W., Adiyaman M., Lawson J. A., Fitzgerald G. A., Nomenclature of isoprostanes: a proposal. Prostaglandins 1997 54 6 853 873 2-s2.0-0031418335 10.1016/S0090-6980(97)00184-6 (Pubitemid 28124312)
80. Gopaul N. K., Anggård E. E., Measurement of 8-epi-PGF2alpha as a marker of lipid peroxidation in vivo by immunoaffinity extraction and gas chromatography-mass spectrometry. Methods in Molecular Biology 2003 225 329 342 2-s2.0-0041766144
81. Guymer R. H., Chong E. W. T., Modifiable risk factors for age-related macular degeneration. Medical Journal of Australia 2006 184 9 455 458 2-s2.0-33646403704 (Pubitemid 43676304)
82. Acar N., Chardigny J. M., Bonhomme B., Almanza S., Doly M., Sébédio J. L., Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. Journal of Nutrition 2002 132 10 3151 3154 2-s2.0-0036792213
83. Maruo T., Ikebukuro N., Kawanabe K., Kubota N., Changes in causes of visual handicaps in Tokyo. Japanese Journal of Ophthalmology 1991 35 3 268 272 2-s2.0-0026043607
84. Lands W. E. M., Hamazaki T., Yamazaki K., Okuyama H., Sakai K., Goto Y., Hubbard V. S., Changing dietary patterns. American Journal of Clinical Nutrition 1990 51 6 991 993 2-s2.0-0025346632
85. Jonasson F., Arnarsson A., Sasaki H., Peto T., Sasaki K., Bird A. C., The prevalence of age-related maculopathy in Iceland: reykjavik eye study. Archives of Ophthalmology 2003 121 3 379 385 2-s2.0-0037335023 (Pubitemid 36298121)
86. Sperling R. I., Robin J. L., Kylander K. A., Lee T. H., Lewis R. A., Austen K. F., The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. Journal of Immunology 1987 139 12 4186 4191 2-s2.0-0023604847 (Pubitemid 18013717)
87. Mares-Perlman J. A., Brady W. E., Klein R., VandenLangenberg G. M., Klein B. E. K., Palta M., Dietary fat and age-related maculopathy. Archives of Ophthalmology 1995 113 6 743 748 2-s2.0-0028997677
88. Seddon J. M., Ajani U. A., Mitchell B. D., Familial aggregation of age-related maculopathy. American Journal of Ophthalmology 1997 123 2 199 206 2-s2.0-0031022320 (Pubitemid 27066775)
89. Sanders T. A. B., Haines A. P., Wormald R., Wright L. A., Obeid O., Essential fatty acids, plasma cholesterol, and fat-soluble vitamins in subjects with age-related maculopathy and matched control subjects. American Journal of Clinical Nutrition 1993 57 3 428 433 2-s2.0-0027536053 (Pubitemid 23083656)
90. Seddon J. M., Dietary fat intake and age-related macular degeneration. Investigative Ophthalmology and Visual Science 1994 35 2003
91. Smith W., Mitchell P., Family history and age-related maculopathy. The Blue Mountains Eye Study. Australian and New Zealand Journal of Ophthalmology 1998 26 3 203 206 2-s2.0-0031857680 (Pubitemid 28372494)
92. Milton R. C., rmilton@emmes.com Clemons T. E., aredspub@emmes.com Klien R., aredspub@emmes.com Seddon J. M., aredspub@emmes.com Ferris III F. L., aredspub@emmes.com Risk factors for the incidence of advanced age-related macular degeneration in the Age-Related Eye Disease Study (AREDS): AREDS report no. 19. Ophthalmology 2005 112 4 533 539 10.1016/j.ophtha.2004.10.047
93. Chua B., Flood V., Rochtchina E., Wang J. J., Smith W., Mitchell P., Dietary fatty acids and the 5-year incidence of age-related maculopathy. Archives of Ophthalmology 2006 124 7 981 986 2-s2.0-33646432867 10.1001/archopht.124.7.981 (Pubitemid 44043098)
94. Heuberger R. A., Mares-Perlman J. A., Klein R., Klein B. E. K., Millen A. E., Palta M., Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey. Archives of Ophthalmology 2001 119 12 1833 1838 2-s2.0-0035208901 (Pubitemid 33139616)
95. Cho E., Hung S., Willett W. C., Spiegelman D., Rimm E. B., Seddon J. M., Colditz G. A., Hankinson S. E., Prospective study of dietary fat and the risk of age-related macular degeneration. American Journal of Clinical Nutrition 2001 73 2 209 218 2-s2.0-0035145758 (Pubitemid 32109848)
96. Augood C., Fletcher A., Bentham G., Chakravarthy U., De Jong P. T. V. M., Rahu M., Seland J., Soubrane G., Tomazzoli L., Topouzis F., Vioque J., Young I., Methods for a population-based study of the prevalence of and risk factors for age-related maculopathy and macular degeneration in elderly European populations. The EUREYE study. Ophthalmic Epidemiology 2004 11 2 117 129 2-s2.0-11144357411 10.1076/opep.11.2.117.28160 (Pubitemid 38530466)
97. Delcourt C., Cristol J. P., Tessier F., Léger C. L., Descomps B., Papoz L., Age-related macular degeneration and antioxidant status in the POLA study. Archives of Ophthalmology 1999 117 10 1384 1390 2-s2.0-0033391704 (Pubitemid 30029350)
98. Hodge W. G., Schachter H. M., Barnes D., Pan Y., Lowcock E. C., Zhang L., Sampson M., Morrison A., Tran K., Miguelez M., Lewin G., Efficacy of ω -3 fatty acids in preventing age-related macular degeneration. A systematic review. Ophthalmology 2006 113 7 1165 1173 2-s2.0-33745358664 10.1016/j.ophtha.2006.02.043 (Pubitemid 43947239)
99. Chong E. W.-T., e.chong2@pgrad.unimelb.edu.au Sinclair A. J., Guymer R. H., Facts on fats. Clinical and Experimental Ophthalmology 2006 34 5 464 471 10.1111/j.1442-9071.2006.01250.x (Pubitemid 44027236)
100. SanGiovanni J. P., Chew E. Y., Clemons T. E., Davis M. D., Ferris III F. L., Gensler G. R., Kurinij N., Lindblad A. S., Milton R. C., Seddon J. M., Sperduto Md R. D., The relationship of dietary lipid intake and age-related macular degeneration in a case-control study. AREDS report no. 20. Archives of Ophthalmology 2007 125 5 671 679 10.1001/archopht.125.5.671 (Pubitemid 46762729)
101. Robman L., Vu H., Hodge A., Tikellis G., Dimitrov P., McCarty C., Guymer R., Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. Canadian Journal of Ophthalmology 2007 42 5 720 726 2-s2.0-36348929276 10.3129/I07-116 (Pubitemid 350157561)
102. Querques G., Benlian P., Chanu B., Portal C., Coscas G., Soubrane G., Souied E. H., Nutritional AMD treatment phase I (NAT-1): feasibility of oral DHA supplementation in age-related macular degeneration. European Journal of Ophthalmology 2009 19 1 100 106 2-s2.0-69249105050
103. Feher J., Papale A., Mannino G., Gualdi L., Balacco Gabrieli C., Mitotropic compounds for the treatment of age-related macular degeneration: the metabolic approach and a pilot study. Ophthalmologica 2003 217 5 351 357 2-s2.0-0043163463 10.1159/000071351 (Pubitemid 36993958)
104. Feher J., Mitotrop compounds for the treatment of early age-related macular degeneration: the metabolic approach and a clinical trial. Investigative Ophthalmology and Visual Science 2003 44. ARVO E-Abstract 5031
105. Cangemi F. E., TOZAL study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD. BMC Ophthalmology 2007 7, article 3 2-s2.0-33947521044 10.1186/1471-2415-7-3 (Pubitemid 46474677)
106. Alan D. D., Clemens F., Elbourne D., Fasey N., Fletcher A. E., Hardy P., Holder G. E., Huppert F. A., Knight R., Letley L., Richards M., Truesdale A., Vickers M., Uauy R., A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People and n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. Nutrition Journal 2006 5, article 20 2-s2.0-33748694685 10.1186/1475-2891-5-20 (Pubitemid 44395207)
107. Souied E. H., NAT-2 Report #1: high HDL and low PUFAs levels in exudative AMD patients. Investigative Ophthalmology and Visual Science 2006 47. ARVO E-Abstract 2181
108. Coleman H., Chew E., Nutritional supplementation in age-related macular degeneration. Current Opinion in Ophthalmology 2007 18 3 220 223 2-s2.0-34247220303 10.1097/ICU.0b013e32814a586b (Pubitemid 46624920)
109. Hennekens C. H., Buring J. E., Manson J. E., Stampfer M., Rosner B., Cook N. R., Belanger C., Lamotte F., Gaziano J. M., Ridker P. M., Willett W., Peto R., Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New England Journal of Medicine 1996 334 18 1145 1149 2-s2.0-0345157579 10.1056/NEJM199605023341801 (Pubitemid 26137972)