The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid

Reproduction Nutrition Development

Volumn 46, Issue 5, 2006, Pages 515-525

  Acar, Niyazi ^a   Bonhomme, Brigitte ^b   Joffre, Corinne ^a   Bron, Alain M ^a,c   Creuzot Garcher, Catherine ^a,c   Bretillon, Lionel ^a   Doly, Michel ^b   Chardigny, Jean Michel ^a,d  

^a CEMAGREF   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c DIJON UNIVERSITY HOSPITAL   (France)

^d INRA and University of Auvergne   (France)

Author keywords

Cerebral cortex; Dietary trans polyunsaturated fatty acids; Electroretinography; Rat; Retina

Indexed keywords

DOCOSAHEXAENOIC ACID; LINOLENIC ACID; LIPID; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIETARY INTAKE; ELECTRORETINOGRAPHY; NERVOUS TISSUE; NONHUMAN; RETINA; TISSUE CULTURE; TRANS ISOMER;

ALPHA-LINOLENIC ACID; ANIMALS; BRAIN; ELECTRORETINOGRAPHY; ISOMERISM; LIVER; LONGITUDINAL STUDIES; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; RETINA;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33750060730     PISSN: 09265287     EISSN: 12979708     Source Type: Journal    
DOI: 10.1051/rnd:2006033     Document Type: Article

References (46)

1. Connor WE, Neuringer M, Reisbick S. Essential fatty acids: the importance of n-3 fatty acids in the retina and brain. Nutr Rev 1992, 50: 21-29.
2. Fliesler SJ, Anderson RE. Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipid Res 1983, 22: 79-131.
3. Crawford MA, Sinclair AJ. Nutritional influences in the evolution of the mammalian brain. In: CIBA Foundation Symposium on Lipids, malnutrition and the developing brain (Ed), Amsterdam, 1972, p 267-287.
4. Sinclair AJ. Long chain polyunsaturated fatty acids in mammalian brain. Proc Nutr Soc 1975, 34: 287-291.
5. Aid S, Vancassel S, Poumes-Ballihaut C, Chalon S, Guesnet P, Lavialle M. Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus. J Lipid Res 2003, 44: 1545-1551.
6. Kodas E, Galineau L, Bodard S, Vancassel S, Guilloteau D, Besnard JC, Chalon S. Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat. J Neurochem 2004, 89: 695-702.
7. Zimmer L, Vancassel S, Cantagrel S, Breton P, Delamanche S, Guilloteau D, Durand G, Chalon S. The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids. Am J Clin Nutr 2002, 75: 662-667.
8. Bourre JM, Francois M, Youyou A, Dumont O, Piciotti M, Pascal G, Durand G. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. J Nutr 1989, 119: 1880-1892.
9. Watanabe I, Kato M, Aonuma H, Hashimoto A, Naito Y, Moriuchi A, Okuyama H. Effect of dietary alpha-linolenate/linoleate balance on the lipid composition and electroretinographic responses in rats. Adv Biosci 1987, 62: 563-570.
10. Weisinger HS, Vingrys AJ, Sinclair AJ. Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig. Ann Nutr Metab 1996, 40: 91-98.
11. Weisinger HS, Vingrys AJ, Sinclair AJ. The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. Lipids 1996, 31: 65-70.
12. Neuringer M, Connor WE, Lin DS, Barstad L, Luck S. Biochemical and functional effects of prenatal and postnatal omega-3 fatty acid deficiency on retina and brain in rhesus monkey. Proc Natl Acad Sci USA 1986, 83: 4021-4025.
13. Uauy R, Hoffman DR. Essential fatty acid requirements for normal eye and brain development. Semin Perinatal 1991, 15: 449-455.
14. Litman BJ, Niu SL, Polozova A, Mitchell DC. The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways: visual transduction. J Mol Neurosci 2001, 16: 237-242.
15. Niu SL, Mitchell DC, Lim SY, Wen ZM, Kim HY, Salem N Jr, Litman BJ. Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. J Biol Chem 2004, 279: 31098-31104.
16. Ackman RG, Hooper SN. Linoleic acid artefacts from deodorization of oils. J Am Oil Chem Soc 1974, 51: 42-49.
17. Grandgirard A, Sebedio JL, Fleury J. Geometrical isomerization of linoleic acid during heat treatment of vegetable oils. J Am Oil Chem Soc 1984, 61: 1563-1568.
18. Sebedio JL, Grandgirard A, Prevost J. Linoleic acid isomers in heat-treated sunflower oils. J Am Oil Chem Soc 1988, 61: 362-366.
19. O'Keefe SF, Wiley V, Gaskins S. Geometrical isomers of essential fatty acids in liquid infant formulas. Food Res Intern 1994, 27: 7-13.
20. Sebedio JL, Grandgirard A, Septier C, Prevost J. État d'altération de quelques huiles de friture prélevées en restauration. Rev Fr Corps Gras 1987, 34: 15-18.
21. Wolff RL. Trans-polyunsaturated fatty acids in French edible rapeseed and soybean oil. J Am Oil Chem Soc 1992, 69: 106-110.
22. Chardigny JM, Wolff RL, Mager E, Bayard CC, Sebedio JL, Martine L, Ratnayake WMN. Fatty acid composition of French infant formulas with emphasis on the content and detailed profile of trans fatty acids. J Am Oil Chem Soc 1996, 73: 1595-1601.
23. Ratnayake WMN, Hollywood R, O'Grady E. Fatty acids in Canadian margarines. Can Inst Sci Technol 1991, 24: 81-86.
24. Chardigny JM, Sebedio JL, Grandgirard A, Martine L, Berdeaux O, Vatele JM. Identification of novel trans isomers of 20:5n-3 in liver lipids of rats fed a heated oil. Lipids 1996, 31: 165-168.
25. Grandgirard A, Piconneaux A, Sebedio JL, O'Keefe SF, Semon E, Le Quere JL. Occurrence of geometrical isomers of eicosapentaenoic and docosahexaenoic acids in liver lipids of rats fed heated linseed oil. Lipids 1989, 24: 799-804.
26. Chardigny JM, Bonhomme B, Sebedio JL, Juaneda P, Vatele JM, Doly M, Grandgirard A. Effects of dietary trans polyunsaturated fatty acids on the rat electroretinogram. Nutr Res 1998, 18: 1711-1721.
27. Chardigny JM, Bron A, Sebedio JL, Juaneda P, Grandgirard A. Kinetics of incorporation of n-3 trans fatty acids in the retina. Nutr Res 1994, 14: 909-917.
28. Henon G, Kemeny Z, Recseg K, Zwobada F, Kovari K. Deodorization of vegetable oils. Part 1: Modelling the geometrical isomerization of polyunsaturated fatty acids. J Am Oil Chem Soc 1999, 76: 73-81.
29. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957, 226: 497-509.
30. Juaneda P, Rocquelin G. Rapid and convenient separation of phospholipids and non phosphorus lipids from rat heart using silica cartridges. Lipids 1985, 20: 40-41.
31. Christie WW, Sebedio JL, Juaneda P. A practical guide to the analysis of conjugated linoleic acid. Inform 2001, 12: 147-152.
32. Doly M, Droy-Lefaix MT, Braquet P. Retinal electrophysiology and retinotoxicity. In: Droy-Le Faix MT, Ferradini C, Christen Y (Eds), Advances in Ginkgo biloba Extract Research: Ginkgo biloba Extract (EGb 761) as a Free-Radical Scavenger, Paris, 1993, p 61-71.
33. Grandgirard A, Bourre JM, Julliard F, Homayoun P, Dumont O, Piciotti M, Sebedio JL. Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. Lipids 1994, 29: 251-258.
34. Moore SA, Yoder E, Murphy S, Dutton GR, Spector AA. Astrocytes, not neurons, produce docosahexaenoic acid (22:6 omega-3) and arachidonic acid (20:4 omega-6). J Neurochem 1991, 56: 518-524.
35. Wang N, Anderson RE. Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. Biochemistry 1993, 32: 13703-13709.
36. Pawlosky RJ, Ward G, Salem N Jr. Essential fatty acid uptake and metabolism in the developing rodent brain. Lipids. 1996, 31: S103-S107.
37. Scott BL, Bazan NG. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc Natl Acad Sci USA 1989, 86: 2903-2907.
38. Benistant C, Dehouck MP, Fruchart JC, Cecchelli R, Lagarde M. Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes. J Lipid Res 1995, 36: 2311-2319.
39. Lecomte M, Paget C, Ruggiero D, Wiernsperger N, Lagarde M. Docosahexaenoic acid is a major n-3 polyunsaturated fatty acid in bovine retinal microvessels. J Neurochem 1996, 66: 2160-2167.
40. Kern TS, Engerman RL. Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia. Arch Ophthalmol 1996, 114: 306-310.
41. Rajah TT, Olson AL, Grammas P. Differential glucose uptake in retina- and brain-derived endothelial cells. Microvasc Res 2001, 62: 236-242.
42. Tang J, Zhu XW, Lust WD, Kern TS. Retina accumulates more glucose than does the embryologically similar cerebral cortex in diabetic rats. Diabetologia 2000, 43: 1417-1423.
43. Grammas P, Riden M. Retinal endothelial cells are more susceptible to oxidative stress and increased permeability than brain-derived endothelial cells. Microvasc Res 2003, 65: 18-23.
44. Acar N, Chardigny JM, Bonhomme B, Almanza S, Doly M, Sebedio JL. Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. J Nutr 2002, 132: 3151-3154.
45. Niu SL, Mitchell DC, Litman BJ. Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. Biochemistry. 2005, 44: 4458-4465.
46. Wolff RL. Ubiquité et caractéristiques des isomères trans de l'acide linolénique. OCL 1995, 2: 391-400.