메뉴 건너뛰기




Volumn 217, Issue 5, 2003, Pages 351-357

Mitotropic compounds for the treatment of age-related macular degeneration: The metabolic approach and a pilot study

Author keywords

Acetyl L carnitine; Age related macular degeneration; Coenzyme Q 10; Mitochondria; Photoreceptor; Polyunsaturated fatty acids; Retina; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEVACECARNINE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL; UBIDECARENONE;

EID: 0043163463     PISSN: 00303755     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071351     Document Type: Article
Times cited : (39)

References (59)
  • 1
    • 0031695623 scopus 로고    scopus 로고
    • Age-specific prevalence and causes of blindness and visual impairment in an older population: The Rotterdam study
    • Klaver ED, Wolfs RC, Vingerling JR, Hoffman A, de Jong PT: Age-specific prevalence and causes of blindness and visual impairment in an older population: The Rotterdam Study. Arch Ophthalmol 1998;116:653-658.
    • (1998) Arch Ophthalmol , vol.116 , pp. 653-658
    • Klaver, E.D.1    Wolfs, R.C.2    Vingerling, J.R.3    Hoffman, A.4    De Jong, P.T.5
  • 3
    • 0033795036 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of age-related macular degeneration
    • Beatty S, Koh H, Phil M, Henson D, Boulton M: The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000;45:115-134.
    • (2000) Surv Ophthalmol , vol.45 , pp. 115-134
    • Beatty, S.1    Koh, H.2    Phil, M.3    Henson, D.4    Boulton, M.5
  • 5
    • 0020525981 scopus 로고
    • Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina
    • Wiegand RD, Giusto NM, Rapp LM, Anderson RE: Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Invest Ophthalmol Vis Sci 1983;24:1433-1435.
    • (1983) Invest Ophthalmol Vis Sci , vol.24 , pp. 1433-1435
    • Wiegand, R.D.1    Giusto, N.M.2    Rapp, L.M.3    Anderson, R.E.4
  • 6
    • 0032808546 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid biosynthesis: A microsomal-peroxisomal process
    • Sprecher H, Chen Q: Polyunsaturated fatty acid biosynthesis: A microsomal-peroxisomal process. Prostaglandins Leukot Essent Fatty Acids 1999;60:317-321.
    • (1999) Prostaglandins Leukot Essent Fatty Acids , vol.60 , pp. 317-321
    • Sprecher, H.1    Chen, Q.2
  • 7
  • 8
    • 4243753812 scopus 로고    scopus 로고
    • Mitochondrial damage and protection in retinal dystrophies
    • (abstract 2637). ARVO Abstracts
    • Feher J, Papale A, Tomei M, Balacco Gabrieli C: Mitochondrial damage and protection in retinal dystrophies (abstract 2637). ARVO Abstracts. Invest Ophthalmol Vis Sci 1998;39:S570.
    • (1998) Invest Ophthalmol Vis Sci , vol.39
    • Feher, J.1    Papale, A.2    Tomei, M.3    Balacco Gabrieli, C.4
  • 9
    • 26744445918 scopus 로고    scopus 로고
    • Peroxisomal contribution to the basement membrane thickening in age-related macular degeneration
    • (abstract 1194). ARVO Abstracts
    • Feher J, Papale A, Balacco Gabrieli C: Peroxisomal contribution to the basement membrane thickening in age-related macular degeneration (abstract 1194). ARVO Abstracts. Invest Ophthalmol Vis Sci 2001;42:S222.
    • (2001) Invest Ophthalmol Vis Sci , vol.42
    • Feher, J.1    Papale, A.2    Balacco Gabrieli, C.3
  • 10
    • 0029562829 scopus 로고
    • Lipofuscin of the retinal pigment epithelium: A review
    • Kennedy CJ, Rakoczy PE, Constable IJ: Lipofuscin of the retinal pigment epithelium: A review. Eye 1995;9:262-274.
    • (1995) Eye , vol.9 , pp. 262-274
    • Kennedy, C.J.1    Rakoczy, P.E.2    Constable, I.J.3
  • 12
    • 0035018921 scopus 로고    scopus 로고
    • The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing light microscopy
    • Haimovici R, Gantz DL, Rumelt S, Freddo TF, Small DM: The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing light microscopy. Invest Ophthalmol Vis Sci 2001;42:1592-1599.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1592-1599
    • Haimovici, R.1    Gantz, D.L.2    Rumelt, S.3    Freddo, T.F.4    Small, D.M.5
  • 13
    • 0033499606 scopus 로고    scopus 로고
    • Characterization of peroxidized lipids in Bruch's membrane
    • Spaide RF, Ho-Spaide WC, Browne RW, Armstrong D: Characterization of peroxidized lipids in Bruch's membrane. Retina 1999;19:141-147.
    • (1999) Retina , vol.19 , pp. 141-147
    • Spaide, R.F.1    Ho-Spaide, W.C.2    Browne, R.W.3    Armstrong, D.4
  • 14
    • 0034717940 scopus 로고    scopus 로고
    • Fatty acid import into mitochondria
    • Kerner J, Hoppel C: Fatty acid import into mitochondria. Biochim Biophys Acta 2000;1486:1-17.
    • (2000) Biochim Biophys Acta , vol.1486 , pp. 1-17
    • Kerner, J.1    Hoppel, C.2
  • 16
    • 0034033501 scopus 로고    scopus 로고
    • Essential fatty acids in early life: Structural and functional role
    • Uauy R, Mena P, Rojas C: Essential fatty acids in early life: Structural and functional role. Proc Nutr Soc 2000;59:3-15.
    • (2000) Proc Nutr Soc , vol.59 , pp. 3-15
    • Uauy, R.1    Mena, P.2    Rojas, C.3
  • 18
    • 0029928093 scopus 로고    scopus 로고
    • + channels by directly binding to the channel proteins
    • + channels by directly binding to the channel proteins. Proc Natl Acad Sci USA 1996;93:3542-3546.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3542-3546
    • Kang, J.X.1    Leaf, A.2
  • 19
    • 0033799483 scopus 로고    scopus 로고
    • Dietary 20:4n-6 and 22:6n-3 modulates the profile of long- and very-long-chain fatty acids, rhodopsin content, and kinetics in developing photoreceptor cells
    • Suh M, Wierzbicki AA, Lien EL, Clandinin MT: Dietary 20:4n-6 and 22:6n-3 modulates the profile of long- and very-long-chain fatty acids, rhodopsin content, and kinetics in developing photoreceptor cells. Pediatr Res 2000;48:524-530.
    • (2000) Pediatr Res , vol.48 , pp. 524-530
    • Suh, M.1    Wierzbicki, A.A.2    Lien, E.L.3    Clandinin, M.T.4
  • 20
    • 0034237584 scopus 로고    scopus 로고
    • Essential fatty acids and the brain: Possible health implications
    • Youdim KA, Martin A, Joseph JA: Essential fatty acids and the brain: Possible health implications. Int J Dev Neurosci 2000;18:383-399.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 383-399
    • Youdim, K.A.1    Martin, A.2    Joseph, J.A.3
  • 21
    • 0028080342 scopus 로고
    • Determination of tocopherols and tocopherolquinonone in human red blood cells and platelet samples
    • Vatassery GT: Determination of tocopherols and tocopherolquinonone in human red blood cells and platelet samples. Methods Enzymol 1994;234:327-331.
    • (1994) Methods Enzymol , vol.234 , pp. 327-331
    • Vatassery, G.T.1
  • 22
    • 0003452898 scopus 로고
    • Roma, Casa Editrice Scientifica Internazionale
    • 10 in Biology and Medicine. Roma, Casa Editrice Scientifica Internazionale, 1994, pp 1-91.
    • (1994) 10 in Biology and Medicine , pp. 1-91
    • Littarru, G.P.1
  • 23
    • 0033864129 scopus 로고    scopus 로고
    • 10 and vitamin E alter the status of these compounds in rat tissues and mitochondria
    • 10 and vitamin E alter the status of these compounds in rat tissues and mitochondria. J Nutr 2000;130:2343-2348.
    • (2000) J Nutr , vol.130 , pp. 2343-2348
    • Ibrahim, W.H.1    Bhagavan, H.N.2    Chopra, R.K.3    Chow, C.K.4
  • 24
    • 0030739681 scopus 로고    scopus 로고
    • The reduction of alpha-tocopherolquinone by human NAD(P)H:quinone oxidoreductase: The role of alpha-tocopherolhydroquinone as a cellular antioxidant
    • Siegel D, Bolton EM, Burr JA, Liebler DC, Ross D: The reduction of alpha-tocopherolquinone by human NAD(P)H:quinone oxidoreductase: The role of alpha-tocopherolhydroquinone as a cellular antioxidant. Mol Pharmacol 1997;52:300-305.
    • (1997) Mol Pharmacol , vol.52 , pp. 300-305
    • Siegel, D.1    Bolton, E.M.2    Burr, J.A.3    Liebler, D.C.4    Ross, D.5
  • 26
    • 0030812111 scopus 로고    scopus 로고
    • Alpha-tocopherylhydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low-density lipoprotein lipids
    • Neuzil J, Witting PX, Stocker R: Alpha-tocopherylhydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low-density lipoprotein lipids. Proc Natl Acad Sci USA 1997;94:7885-7890.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7885-7890
    • Neuzil, J.1    Witting, P.X.2    Stocker, R.3
  • 27
  • 30
    • 0025184297 scopus 로고
    • The macular photostress test in diabetic retinopathy and age-related macular degeneration
    • Wu G, Weiter M, Santos S, Ginsburg L, Villalobos R: The macular photostress test in diabetic retinopathy and age-related macular degeneration. Arch Ophthalmol 1990;108:1556-1558.
    • (1990) Arch Ophthalmol , vol.108 , pp. 1556-1558
    • Wu, G.1    Weiter, M.2    Santos, S.3    Ginsburg, L.4    Villalobos, R.5
  • 31
    • 0028881870 scopus 로고
    • Slow photostress recovery and disease severity in age-related macular degeneration
    • Sandberg MA, Gaudio AR: Slow photostress recovery and disease severity in age-related macular degeneration. Retina 1995;15:407-412.
    • (1995) Retina , vol.15 , pp. 407-412
    • Sandberg, M.A.1    Gaudio, A.R.2
  • 32
    • 0025736176 scopus 로고
    • Spatial-frequency-dependent changes in the human pattern electroretinogram after acute acetyl-L-carnitine administration
    • Falsini B, Porciatti V, Bolzani R, Marchionni A: Spatial-frequency-dependent changes in the human pattern electroretinogram after acute acetyl-L-carnitine administration. Graefes Arch Clin Exp Ophthalmol 1991;229:262-266.
    • (1991) Graefes Arch Clin Exp Ophthalmol , vol.229 , pp. 262-266
    • Falsini, B.1    Porciatti, V.2    Bolzani, R.3    Marchionni, A.4
  • 33
    • 0027203693 scopus 로고
    • Acetyl-L-carnitine corrects electroretinographic deficits in experimental diabetes
    • Lowitt S, Malone M, Salem A, Kozak WM, Orfalian Z: Acetyl-L-carnitine corrects electroretinographic deficits in experimental diabetes. Diabetes 1993;42:1115-1118.
    • (1993) Diabetes , vol.42 , pp. 1115-1118
    • Lowitt, S.1    Malone, M.2    Salem, A.3    Kozak, W.M.4    Orfalian, Z.5
  • 34
    • 0031215875 scopus 로고    scopus 로고
    • Effect of acute acetyl-L-carnitine treatment on daytime melatonin synthesis in the rat
    • Olatunji-Bello II, Reiter RJ: Effect of acute acetyl-L-carnitine treatment on daytime melatonin synthesis in the rat. Afr J Med Med Sci 1997;26:175-177.
    • (1997) Afr J Med Med Sci , vol.26 , pp. 175-177
    • Olatunji-Bello, I.I.1    Reiter, R.J.2
  • 36
    • 0025648163 scopus 로고
    • Preferential uptake and metabolism of decosahexaenoic acid in membrane phospholipids from rod and cone photoreceptor cells of human and monkey retinas
    • Rodriguez de Turco EB, Gordon WC, Peyman GA, Bazan NG: Preferential uptake and metabolism of decosahexaenoic acid in membrane phospholipids from rod and cone photoreceptor cells of human and monkey retinas. J Neurosci Res 1990;17:522-532.
    • (1990) J Neurosci Res , vol.17 , pp. 522-532
    • Rodriguez De Turco, E.B.1    Gordon, W.C.2    Peyman, G.A.3    Bazan, N.G.4
  • 37
    • 0030978492 scopus 로고    scopus 로고
    • Post-Golgi vesicles cotransport decosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis
    • Rodriguez de Turco EB, Deretic D, Bazan NG, Papermaster DS: Post-Golgi vesicles cotransport decosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. J Biol Chem 1997;272:10491-10497.
    • (1997) J Biol Chem , vol.272 , pp. 10491-10497
    • Rodriguez De Turco, E.B.1    Deretic, D.2    Bazan, N.G.3    Papermaster, D.S.4
  • 39
    • 0036326098 scopus 로고    scopus 로고
    • n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys
    • Jeffrey BG, Mitchell DC, Gibson RA, Neuringen M: n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. Invest Ophthalmol Vis Sci 2002;43:2806-2814.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2806-2814
    • Jeffrey, B.G.1    Mitchell, D.C.2    Gibson, R.A.3    Neuringen, M.4
  • 40
    • 0027982897 scopus 로고
    • Effect of dietary fish oil on acute light-induced photoreceptor damage in the rat retina
    • Reme CE, Malnoe A, Jung HH, Wei Q, Munz K: Effect of dietary fish oil on acute light-induced photoreceptor damage in the rat retina. Invest Ophthalmol Vis Sci 1994;35:78-90.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 78-90
    • Reme, C.E.1    Malnoe, A.2    Jung, H.H.3    Wei, Q.4    Munz, K.5
  • 41
    • 0033972081 scopus 로고    scopus 로고
    • Essential fat requirements of preterm infants
    • Uauy R, Hoffman DR: Essential fat requirements of preterm infants. Am J Clin Nutr 2000;71:245S-250S.
    • (2000) Am J Clin Nutr , vol.71
    • Uauy, R.1    Hoffman, D.R.2
  • 42
    • 0034098652 scopus 로고    scopus 로고
    • A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants
    • Birch EE, Garfield S, Hoffman DR, Uauy R, Birch DG: A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol 2000;42:174-181.
    • (2000) Dev Med Child Neurol , vol.42 , pp. 174-181
    • Birch, E.E.1    Garfield, S.2    Hoffman, D.R.3    Uauy, R.4    Birch, D.G.5
  • 47
    • 0035208901 scopus 로고    scopus 로고
    • Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey
    • Heuberger RA, Mares-Perlman JA, Klein R, Klein BE, Millen AE, Palta M: Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey. Arch Ophthalmol 2001;119:1833-1838.
    • (2001) Arch Ophthalmol , vol.119 , pp. 1833-1838
    • Heuberger, R.A.1    Mares-Perlman, J.A.2    Klein, R.3    Klein, B.E.4    Millen, A.E.5    Palta, M.6
  • 48
    • 0027536053 scopus 로고
    • Essential fatty acids, plasma cholesterol, and fat-soluble vitamins in subjects with age-related maculopathy and matched control subjects
    • Sanders TA, Haines AP, Wormald R, Wright LA, Obeid O: Essential fatty acids, plasma cholesterol, and fat-soluble vitamins in subjects with age-related maculopathy and matched control subjects. Am J Clin Nutr 1993;57:428-433.
    • (1993) Am J Clin Nutr , vol.57 , pp. 428-433
    • Sanders, T.A.1    Haines, A.P.2    Wormald, R.3    Wright, L.A.4    Obeid, O.5
  • 50
    • 0033499069 scopus 로고    scopus 로고
    • Dietary antioxidants and age-related maculopathy: The Blue Mountains Eye study
    • Smith W, Mitchell P, Webb K, Leeder SR: Dietary antioxidants and age-related maculopathy: The Blue Mountains Eye Study. Ophthalmology 1999;106:761-767.
    • (1999) Ophthalmology , vol.106 , pp. 761-767
    • Smith, W.1    Mitchell, P.2    Webb, K.3    Leeder, S.R.4
  • 51
    • 0034896106 scopus 로고    scopus 로고
    • Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration
    • Ikeda T, Obayashi H, Hasegawa G, Nakamura N, Yoshikawa T, Imamura Y, Koizumi K, Kinoshita S: Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration. Am J Ophthalmol 2001;132:191-195.
    • (2001) Am J Ophthalmol , vol.132 , pp. 191-195
    • Ikeda, T.1    Obayashi, H.2    Hasegawa, G.3    Nakamura, N.4    Yoshikawa, T.5    Imamura, Y.6    Koizumi, K.7    Kinoshita, S.8
  • 54
    • 0030723366 scopus 로고    scopus 로고
    • The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans
    • Nelson GJ, Schmidt PC, Bartolini GL, Kelley DS, Kyle D: The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids 1997;32:1137-1146.
    • (1997) Lipids , vol.32 , pp. 1137-1146
    • Nelson, G.J.1    Schmidt, P.C.2    Bartolini, G.L.3    Kelley, D.S.4    Kyle, D.5
  • 55
    • 0032527738 scopus 로고    scopus 로고
    • Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye study
    • Van den Langenberg GM, Mares-Perlman JA, Klein R, Klein BE, Brady WE, Palta M: Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am J Epidemiol 1998;148:204-214.
    • (1998) Am J Epidemiol , vol.148 , pp. 204-214
    • Van Den Langenberg, G.M.1    Mares-Perlman, J.A.2    Klein, R.3    Klein, B.E.4    Brady, W.E.5    Palta, M.6
  • 56
    • 0030831131 scopus 로고    scopus 로고
    • Serum beta carotene, alpha tocopherol, and age-related maculopathy: The Blue Mountains Eye study
    • Smith W, Mitchell P, Rochester C: Serum beta carotene, alpha tocopherol, and age-related maculopathy: The Blue Mountains Eye Study. Am J Ophthalmol 1997;124:838-840.
    • (1997) Am J Ophthalmol , vol.124 , pp. 838-840
    • Smith, W.1    Mitchell, P.2    Rochester, C.3
  • 57
    • 0034800655 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No 8
    • Age-Related Eye Disease Study Research Group: A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No 8. Arch Ophthalmol 2001;119:1417-1436.
    • (2001) Arch Ophthalmol , vol.119 , pp. 1417-1436


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.