Inflammatory mechanisms of neurodegeneration in toxin-based models of Parkinson's disease

Parkinson's Disease

Volumn , Issue , 2011, Pages

  Litteljohn, Darcy ^a   Mangano, Emily ^a   Clarke, Melanie ^a   Bobyn, Jessica ^a   Moloney, Kerry ^a   Hayley, Shawn ^a  

^a CARLETON UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DOPAMINE TRANSPORTER; GAMMA INTERFERON; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE; LEUCINE RICH REPEAT KINASE 2; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PARAQUAT; PESTICIDE; QUINONE DERIVATIVE; RANTES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RNA; ROTENONE; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BLOOD BRAIN BARRIER; CELL LOSS; CENTRAL NERVOUS SYSTEM FUNCTION; GENE MUTATION; HUMAN; MICROGLIA; NERVE DEGENERATION; NONHUMAN; PARAQUAT POISONING; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 79952172294     PISSN: None     EISSN: 20420080     Source Type: Journal    
DOI: 10.4061/2011/713517     Document Type: Review

References (211)

1. Klockgether T., Parkinson's disease: clinical aspects C (Pubitemid 39362632)
2. Menza M., Dobkin R. D., Marin H., Treatment of depression in parkinson's disease Current Psychiatry Reports 2006 8 3 234 240
3. Mari R. M., Barr L., Dupuy B., Viader F., Defer G., Baron J. C., Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease Neuroscience Letters 1999 260 2 77 80 (Pubitemid 29066869)
4. Wolters E. C., Braak H., Parkinson's disease: premotor clinico-pathological correlations Journal of Neural Transmission, Supplement 2006 70 309 319 (Pubitemid 44622216)
5. Kosti V. S., Agosta F., Petrovi I., Galantucci S., pica V., Jemenica-Lukic M., Filippi M., Regional patterns of brain tissue loss associated with depression in Parkinson disease Neurology 2010 75 10 857 863
6. Dick F. D., de Palma G., Ahmadi A., Scott N. W., Prescott G. J., Bennett J., Semple S., Dick S., Counsell C., Mozzoni P., Haites N., Bezzina Wettinger S., Mutti A., Otelea M., Seaton A., Sderkvist P., Felice A., Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study Occupational and Environmental Medicine 2007 64 10 666 672 (Pubitemid 47488093)
7. Weisskopf M. G., Weuve J., Nie H., Saint-Hilaire M.-H., Sudarsky L., Simon D. K., Hersh B., Schwartz J., Wright R. O., Hu H., Association of cumulative lead exposure with Parkinson's disease Environmental Health Perspectives 2010 118 11 1609 1613
8. McCormack A. L., Thiruchelvam M., Manning-Bog A. B., Thiffault C., Langston J. W., Cory-Slechta D. A., Di Monte D. A., Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat Neurobiology of Disease 2002 10 2 119 127 (Pubitemid 34775465)
9. Cannon J. R., Tapias V., Na H. M., Honick A. S., Drolet R. E., Greenamyre J. T., A highly reproducible rotenone model of Parkinson's disease Neurobiology of Disease 2009 34 2 279 290
10. Bolin L. M., Strycharska-Orczyk I., Murray R., Langston J. W., Di Monte D., Increased vulnerability of dopaminergic neurons in MPTP-lesioned interleukin-6 deficient mice Journal of Neurochemistry 2002 83 1 167 175
11. Sriram K., Matheson J. M., Benkovic S. A., Miller D. B., Luster M. I., O'Callaghan J. P., Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF- FASEB Journal 2006 20 6 670 682 (Pubitemid 44933311)
12. Purisai M. G., McCormack A. L., Cumine S., Li J., Isla M. Z., Di Monte D. A., Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration Neurobiology of Disease 2007 25 2 392 400 (Pubitemid 46124019)
13. Sanchez-Guajardo V., Febbraro F., Kirik D., Romero-Ramos M., Microglia acquire distinct activation profiles depending on the degree of -synuclein neuropathology in a rAAV based model of Parkinson's disease PLoS ONE 2010 5 1, article e8784
14. McGeer P. L., Itagaki S., Boyes B. E., McGeer E. G., Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains Neurology 1988 38 8 1285 1291
15. Nagatsu T., Mogi M., Ichinose H., Togari A., Changes in cytokines and neurotrophins in Parkinson's disease Journal of Neural Transmission, Supplement 2000 60 277 290 (Pubitemid 32037200)
16. Hunot S., Boissire F., Faucheux B., Brugg B., Mouatt-Prigent A., Agid Y., Hirsch E. C., Nitric oxide synthase and neuronal vulnerability in Parkinson's disease Neuroscience 1996 72 2 355 363 (Pubitemid 26111202)
17. Hirsch E. C., Hunot S., Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurology 2009 8 4 382 397
18. Davalos D., Grutzendler J., Yang G., Kim J. V., Zuo YI., Jung S., Littman D. R., Dustin M. L., Gan W. B., ATP mediates rapid microglial response to local brain injury in vivo Nature Neuroscience 2005 8 6 752 758 (Pubitemid 43085841)
19. Nimmerjahn A., Kirchhoff F., Helmchen F., Neuroscience: resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 2005 308 5726 1314 1318 (Pubitemid 40746128)
20. Cotrina M. L., Lin J. H. C., Lpez-Garca J. C., Naus C. C. G., Nedergaard M., ATP-mediated glia signaling Journal of Neuroscience 2000 20 8 2835 2844 (Pubitemid 30220308)
21. Popovich P. G., Longbrake E. E., Can the immune system be harnessed to repair the CNS? Nature Reviews Neuroscience 2008 9 6 481 493 (Pubitemid 351704948)
22. Michelucci A., Heurtaux T., Grandbarbe L., Morga E., Heuschling P., Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid- Journal of Neuroimmunology 2009 210 1-2 3 12
23. Baquet Z. C., Bickford P. C., Jones K. R., Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta Journal of Neuroscience 2005 25 26 6251 6259 (Pubitemid 40923492)
24. Peterson A. L., Nutt J. G., Treatment of Parkinson's disease with trophic factors Neurotherapeutics 2008 5 2 270 280 (Pubitemid 351454059)
25. Gao H. M., Hong J. S., Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression Trends in Immunology 2008 29 8 357 365
26. Anrather J., Racchumi G., Iadecola C., NF- B regulates phagocytic NADPH oxidase by inducing the expression of gp91phox Journal of Biological Chemistry 2006 281 9 5657 5667 (Pubitemid 43847663)
27. Gao H. M., Liu B., Zhang W., Hong J. S., Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease FASEB Journal 2003 17 13 1954 1956
28. Wu D. C., Teismann P., Tieu K., Vila M., Jackson-Lewis V., Ischiropoulos H., Przedborski S., NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 2003 100 10 6145 6150 (Pubitemid 36576945)
29. Vilar R., Coelho H., Rodrigues E., Gama M. J., Rivera I., Taioli E., Lechner M. C., Association of A313 G polymorphism (GSTP1B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease European Journal of Neurology 2007 14 2 156 161 (Pubitemid 46148302)
30. Singh M., Khan A. J., Shah P. P., Shukla R., Khanna V. K., Parmar D., Polymorphism in environment responsive genes and association with Parkinson disease Molecular and Cellular Biochemistry 2008 312 1-2 131 138
31. Hancock D. B., Martin E. R., Mayhew G. M., Stajich J. M., Jewett R., Stacy M. A., Scott B. L., Vance J. M., Scott W. K., Pesticide exposure and risk of Parkinson's disease: a family-based case-control study BMC Neurology 2008 8, article 6
32. Bonifati V., LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)linking familial and sporadic Parkinson's disease Neurochemical Research 2007 32 10 1700 1708 (Pubitemid 47428849)
33. Firestone J. A., Smith-Weller T., Franklin G., Swanson P., Longstreth W. T. Jr., Checkoway H., Pesticides and risk of Parkinson disease: a population-based case-control study Archives of Neurology 2005 62 1 91 95 (Pubitemid 40105040)
34. Costello S., Cockburn M., Bronstein J., Zhang X., Ritz B., Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California American Journal of Epidemiology 2009 169 8 919 926
35. Baldi I., Cantagrel A., Lebailly P., Tison F., Dubroca B., Chrysostome V., Dartigues J. F., Brochard P., Association between Parkinson's disease and exposure to pesticides in southwestern France Neuroepidemiology 2003 22 5 305 310 (Pubitemid 36993912)
36. Dhillon A. S., Tarbutton G. L., Levin J. L., Plotkin G. M., Lowry L. K., Nalbone J. T., Shepherd S., Pesticide/environmental exposures and Parkinson's disease in East Texas Journal of Agromedicine 2008 13 1 37 48
37. Liou H. H., Tsai M. C., Chen C. J., Jeng J. S., Chang Y. C., Chen S. Y., Chen R. C., Environmental risk factors and Parkinson's disease: a case-control study in Taiwan Neurology 1997 48 6 1583 1588
38. Li X., Yin J., Cheng C. M., Sun J. L., Li Z., Wu Y. L., Paraquat induces selective dopaminergic nigrostriatal degeneration in aging C57BL/6 mice Chinese Medical Journal 2005 118 16 1357 1361 (Pubitemid 41223172)
39. Brooks A. I., Chadwick C. A., Gelbard H. A., Cory-Slechta D. A., Federoff H. J., Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss Brain Research 1999 823 1-2 1 10 (Pubitemid 29225488)
40. Chanyachukul T., Yoovathaworn K., Thongsaard W., Chongthammakun S., Navasumrit P., Satayavivad J., Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo Toxicology Letters 2004 150 3 259 269 (Pubitemid 38510577)
41. Chen P., Chen Z., Li A., Lou X. C., Wu X. K., Zhao C. J., Wang S. L., Liang L. P., Catalytic metalloporphyrin protects against paraquat neurotoxicity in vivo Biomedical and Environmental Sciences 2008 21 3 233 238
42. Litteljohn D., Mangano E., Shukla N., Hayley S., Interferon- deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat Neuroscience 2009 164 4 1894 1906
43. Chen Q., Niu Y., Zhang R., Guo H., Gao Y., Li Y., Liu R., The toxic influence of paraquat on hippocampus of mice: involvement of oxidative stress NeuroToxicology 2010 31 3 310 316
44. Mangano E. N., Litteljohn D., So R., Interferon-gamma plays a crucial role in paraquat-induced neurodegeneration involving oxidative and pro-inflammatory pathways. Neurobiology of Aging. In press
45. Thiruchelvam M., McCormack A., Richfield E. K., Baggs R. B., Tank A. W., Di Monte D. A., Cory-Slechta D. A., Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype European Journal of Neuroscience 2003 18 3 589 600 (Pubitemid 37045378)
46. Rojo A. I., Cavada C., de Sagarra M. R., Cuadrado A., Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats Experimental Neurology 2007 208 1 120 126 (Pubitemid 47600154)
47. Prasad K., Tarasewicz E., Mathew J., Strickland P. A. O., Buckley B., Richardson J. R., Richfield E. K., Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain Experimental Neurology 2009 215 2 358 367
48. Kang M. J., Gil S. J., Lee J. E., Koh H. C., Selective vulnerability of the striatal subregions of C57BL/6 mice to paraquat Toxicology Letters 2010 195 2-3 127 134
49. Meredith G. E., Sonsalla P. K., Chesselet M. F., Animal models of Parkinson's disease progression Acta Neuropathologica 2008 115 4 385 398
50. Cicchetti F., Drouin-Ouellet J., Gross R. E., Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? Trends in Pharmacological Sciences 2009 30 9 475 483
51. Greenamyre J. T., Cannon J. R., Drolet R., Mastroberardino P. G., Lessons from the rotenone model of Parkinson's disease Trends in Pharmacological Sciences 2010 31 4 141 142
52. Uversky V. N., Li J., Fink A. L., Pesticides directly accelerate the rate of -synuclein fibril formation: a possible factor in Parkinson's disease FEBS Letters 2001 500 3 105 108 (Pubitemid 32607541)
53. Manning-Bog A. B., McCormack A. L., Li J., Uversky V. N., Fink A. L., Di Monte D. A., The herbicide paraquat causes up-regulation and aggregation of -synuclein in mice: paraquat and -synuclein Journal of Biological Chemistry 2002 277 3 1641 1644 (Pubitemid 34968732)
54. Drolet R. E., Cannon J. R., Montero L., Greenamyre J. T., Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology Neurobiology of Disease 2009 36 1 96 102
55. Uversky V. N., Li J., Bower K., Fink A. L., Synergistic effects of pesticides and metals on the fibrillation of -synuclein: implications for Parkinson's disease NeuroToxicology 2002 23 4-5 527 536 (Pubitemid 36527673)
56. Peng J., Peng L., Stevenson F. F., Doctrow S. R., Andersen J. K., Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration Journal of Neuroscience 2007 27 26 6914 6922 (Pubitemid 47015904)
57. Peng J., Stevenson F. F., Oo M. L., Andersen J. K., Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation Free Radical Biology and Medicine 2009 46 2 312 320
58. Thiruchelvam M., Richfield E. K., Baggs R. B., Tank A. W., Cory-Slechta D. A., The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: Implications for Parkinson's disease Journal of Neuroscience 2000 20 24 9207 9214 (Pubitemid 32042923)
59. Wu X. F., Block M. L., Zhang W., Qin L., Wilson B., Zhang W. Q., Veronesi B., Hong J. S., The role of microglia in paraquat-induced dopaminergic neurotoxicity Antioxidants and Redox Signaling 2005 7 5-6 654 661 (Pubitemid 40563204)
60. Klintworth H., Garden G., Xia Z., Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release Neuroscience Letters 2009 462 1 1 5
61. Wilson E. H., Weninger W., Hunter C. A., Trafficking of immune cells in the central nervous system Journal of Clinical Investigation 2010 120 5 1368 1379
62. Glass C. K., Saijo K., Winner B., Marchetto M. C., Gage F. H., Mechanisms underlying inflammation in neurodegeneration Cell 2010 140 6 918 934
63. Wyss-Coray T., Mucke L., Inflammation in neurodegenerative diseasea double-edged sword Neuron 2002 35 3 419 432 (Pubitemid 34879943)
64. Tansey M. G., McCoy M. K., Frank-Cannon T. C., Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention Experimental Neurology 2007 208 1 1 25 (Pubitemid 47603240)
65. Goehler L. E., Erisir A., Gaykema R. P. A., Neural-immune interface in the rat area postrema Neuroscience 2006 140 4 1415 1434 (Pubitemid 43928278)
66. Suzumura A., Sawada M., Takayanagi T., Production of interleukin-12 and expression of its receptors by murine microglia Brain Research 1998 787 1 139 142 (Pubitemid 28279810)
67. Benveniste E. N., Cytokine actions in the central nervous system Cytokine and Growth Factor Reviews 1998 9 3-4 259 275 (Pubitemid 29019710)
68. Banks W. A., Ortiz L., Plotkin S. R., Kastin A. J., Human interleukin (IL) 1, murine IL-1 and murine IL-1 are transported from blood to brain in the mouse by a shared saturable mechanism Journal of Pharmacology and Experimental Therapeutics 1991 259 3 988 996
69. Gutierrez E. G., Banks W. A., Kastin A. J., Murine tumor necrosis factor alpha is transported from blood to brain in the mouse Journal of Neuroimmunology 1993 47 2 169 176 (Pubitemid 23284281)
70. Rivest S., How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis Psychoneuroendocrinology 2001 26 8 761 788 (Pubitemid 32918282)
71. Schobitz B., Reul J. M. H. M., Holsboer F., The role of the hypothalamic-pituitary-adrenocortical system during inflammatory conditions Critical Reviews in Neurobiology 1994 8 4 263 291 (Pubitemid 24349710)
72. Nadeau S., Rivest S., Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier Neuroscience 1999 93 4 1449 1464 (Pubitemid 29397574)
73. Tancredi V., D'Arcangelo G., Grassi F., Tarroni P., Palmieri G., Santoni A., Eusebi F., Tumor necrosis factor alters synaptic transmission in rat hippocampal slices Neuroscience Letters 1992 146 2 176 178
74. Wuchert F., Ott D., Rafalzik S., Roth J., Gerstberger R., Tumor necrosis factor-, interleukin-1 and nitric oxide induce calcium transients in distinct populations of cells cultured from the rat area postrema Journal of Neuroimmunology 2009 206 1-2 44 51
75. Kamm K., Vanderkolk W., Lawrence C., Jonker M., Davis A. T., The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat Journal of Trauma 2006 60 1 152 157
76. Banks W. A., Ader R., Felten D. L., Cohen N., Cytokines, CVSs, and the blood-brain-barrier Psychoneuroimmunology 2001 New York, NY, USA Academic Press 483 498
77. Clausen F., Hnell A., Bjrk M., Hillered L., Mir A. K., Gram H., Marklund N., Neutralization of interleukin-1 modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice European Journal of Neuroscience 2009 30 3 385 396
78. Clausen B. H., Lambertsen K. L., Babcock A. A., Holm T. H., Dagnaes-Hansen F., Finsen B., Interleukin-1 beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice Journal of Neuroinflammation 2008 5, article 46
79. Shen Y.-Q., Hebert G., Lin L.-Y., Luo Y.-L., Moze E., Li K.-S., Neveu P. J., Interleukine-1 and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization Journal of Neuroimmunology 2005 158 1-2 14 25 (Pubitemid 39626066)
80. Perry V. H., Cunningham C., Holmes C., Systemic infections and inflammation affect chronic neurodegeneration Nature Reviews Immunology 2007 7 2 161 167 (Pubitemid 46174862)
81. Gao H. M., Hong J. S., Zhang W., Liu B., Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease Journal of Neuroscience 2003 23 4 1228 1236 (Pubitemid 36258901)
82. Mangano E. N., Hayley S., Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: neuroimmune sensitization of neurodegeneration Neurobiology of Aging 2009 30 9 1361 1378
83. Kim W. G., Mohney R. P., Wilson B., Jeohn G. H., Liu B., Hong J. S., Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia Journal of Neuroscience 2000 20 16 6309 6316 (Pubitemid 30658427)
84. Castao A., Herrera A. J., Cano J., Machado A., The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF- IL-1 IFN- Journal of Neurochemistry 2002 81 1 150 157 (Pubitemid 34808862)
85. Ling Z., Zhu Y., Tong C. W., Snyder J. A., Lipton J. W., Carvey P. M., Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally Experimental Neurology 2006 199 2 499 512 (Pubitemid 43928976)
86. Barlow B. K., Cory-Slechta D. A., Richfield E. K., Thiruchelvam M., The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder Reproductive Toxicology 2007 23 3 457 470 (Pubitemid 46628874)
87. Carvey P. M., Chang Q., Lipton J. W., Ling Z., Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: a potential, new model of Parkinson's disease Frontiers in Bioscience 2003 8 s826 s837
88. Ling Z., Chang Q. A., Tong C. W., Leurgans S. E., Lipton J. W., Carvey P. M., Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally Experimental Neurology 2004 190 2 373 383 (Pubitemid 39504993)
89. Hagberg H., Mallard C., Jacobsson B., Role of cytokines in preterm labour and brain injury British Journal of Obstetrics and Gynaecology 2005 112 supplement 1 16 18 (Pubitemid 40313975)
90. Ribiani E., Rosati A., Romanelli M., Cruciani L., Incalza F., Di Renzo G. C., Perinatal infections and cerebral palsy Minerva Ginecologica 2007 59 2 151 157 (Pubitemid 47066374)
91. Anisman H., Merali Z., Hayley S., Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders Progress in Neurobiology 2008 85 1 1 74
92. Hayley S., Mangano E., Strickland M., Anisman H., Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: divergent actions in cyclooxygenase-2 deficient mice and wild type controls Journal of Neuroimmunology 2008 197 1 29 36
93. Basic Kes V., Simundic A. M., Nikolac N., Topic E., Demarin V., Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome Clinical Biochemistry 2008 41 16-17 1330 1334
94. Brodacki B., Staszewski J., Toczyowska B., Kozowska E., Drela N., Chalimoniuk M., Stepien A., Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNF, and INF concentrations are elevated in patients with atypical and idiopathic parkinsonism Neuroscience Letters 2008 441 2 158 162
95. Goodman J. C., Van M., Gopinath S. P., Robertson C. S., Pro-inflammatory and pro-apoptotic elements of the neuroinflammatory response are activated in traumatic brain injury Acta neurochirurgica. Supplement 2008 102 437 439
96. Reale M., Iarlori C., Thomas A., Gambi D., Perfetti B., Di Nicola M., Onofrj M., Peripheral cytokines profile in Parkinson's disease Brain, Behavior, and Immunity 2009 23 1 55 63
97. Bruce A. J., Boling W., Kindy M. S., Peschon J., Kraemer P. J., Carpenter M. K., Holtsberg F. W., Mattson M. P., Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors Nature Medicine 1996 2 7 788 794 (Pubitemid 26225095)
98. Rogers R. J., Monnier J. M., Nick H. S., Tumor necrosis factor- selectively induces MnSOD expression via mitochondria-to-nucleus signaling, whereas interleukin-1 utilizes an alternative pathway Journal of Biological Chemistry 2001 276 23 20419 20427
99. von Boyen G. B. T., Steinkamp M., Geerling I., Reinshagen M., Schfer K. H., Adler G., Kirsch J., Proinflammatory cytokines induce neurotrophic factor expression in enteric glia: a key to the regulation of epithelial apoptosis in Crohn's disease Inflammatory Bowel Diseases 2006 12 5 346 354
100. Barone F. C., Arvin B., White R. F., Miller A., Webb C. L., Willette R. N., Lysko P. G., Feuerstein G. Z., Tumor necrosis factor- : a mediator of focal ischemic brain injury Stroke 1997 28 6 1233 1244 (Pubitemid 27248902)
101. Barone F. C., White R. F., Spera P. A., Ellison J., Currie R. W., Wang X., Feuerstein G. Z., Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression Stroke 1998 29 9 1937 1950 (Pubitemid 28399995)
102. Kawanokuchi J., Mizuno T., Takeuchi H., Kato H., Wang J., Mitsuma N., Suzumura A., Production of interferon- by microglia Multiple Sclerosis 2006 12 5 558 564
103. Schroder K., Hertzog P. J., Ravasi T., Hume D. A., Interferon- : an overview of signals, mechanisms and functions Journal of Leukocyte Biology 2004 75 2 163 189 (Pubitemid 38174573)
104. Decker T., Mller M., Stockinger S., The Yin and Yang of type I interferon activity in bacterial infection Nature Reviews Immunology 2005 5 9 675 687 (Pubitemid 43086170)
105. Rayamajhi M., Humann J., Penheiter K., Andreasen K., Lenz L. L., Induction of IFN- enables Listeria monocytogenes to suppress macrophage activation by IFN- Journal of Experimental Medicine 2010 207 2 327 337
106. Sarasombath P., Sumida K., Kaku D. A., Parkinsonism associated with interferon alpha therapy for chronic myelogenous leukemia Hawaii Medical Journal 2002 61 3 48 57
107. Kajihara M., Montagnese S., Khanna P., Amodio P., Schapira A. H. V., Dusheiko G. M., Morgan M. Y., Parkinsonism in patients with chronic hepatitis C treated with interferon- 2b: a report of two cases European Journal of Gastroenterology and Hepatology 2010 22 5 628 631
108. Yamada T., Horisberger M. A., Kawaguchi N., Moroo I., Toyoda T., Immunohistochemistry using antibodies to -interferon and its induced protein, MxA, in Alzheimer's and Parkinson's disease brain tissues Neuroscience Letters 1994 181 1-2 61 64
109. Yamada T., Further observations on MxA-positive Lewy bodies in Parkinson's disease brain tissues Neuroscience Letters 1995 195 1 41 44
110. Mount M. P., Lira A., Grimes D., Smith P. D., Faucher S., Slack R., Anisman H., Hayley S., Park D. S., Involvement of interferon- in microglial-mediated loss of dopaminergic neurons Journal of Neuroscience 2007 27 12 3328 3337 (Pubitemid 46474138)
111. Gribova I. E., Gnedenko B. B., Poleshchuk V. V., Morozov S. G., Content of interferon-gamma, alpha tumor necrosis factor and autoantibodies to them in blood serum during Parkinson's disease Biomeditsinskaya Khimiya 2003 49 2 208 212 (Pubitemid 38019519)
112. Hunot S., Dugas N., Faucheux B., Hartmann A., Tardieu M., Debr P., Agid Y., Dugas B., Hirsch E. C., Fc RII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor- in glial cells Journal of Neuroscience 1999 19 9 3440 3447 (Pubitemid 29203124)
113. Mogi M., Kondo T., Mizuno Y., Nagatsu T., p53 protein, interferon-, and NF- B levels are elevated in the parkinsonian brain Neuroscience Letters 2007 414 1 94 97 (Pubitemid 46241643)
114. Mizuta I., Nishimura M., Mizuta E., Yamasaki S., Ohta M., Kuno S., Nishimura M., Ohta M., Relation between the high production related allele of the interferon- (IFN- ) gene and age at onset of idiopathic Parkinson's disease in Japan Journal of Neurology Neurosurgery and Psychiatry 2001 71 6 818 819 (Pubitemid 33121933)
115. Widner B., Leblhuber F., Fuchs D., Increased neopterin production and tryptophan degradation in advanced Parkinson's disease Journal of Neural Transmission, Supplement 2002 109 2 181 189 (Pubitemid 34185664)
116. Kawaguchi N., Yamada T., Takahashi M., Hattori T., Expression of MxA mRNA in peripheral blood mononuclear cells in Parkinson's disease Parkinsonism and Related Disorders 1999 5 1-2 43 47 (Pubitemid 29256366)
117. D'Amelio M., Ragonese P., Morgante L., Epifanio A., Callari G., Salemi G., Savettiere G., Tumor diagnosis preceding Parkinson's disease: a case-control study Movement Disorders 2004 19 7 807 811 (Pubitemid 39139592)
118. Mizuno T., Zhang G., Takeuchi H., Kawanokuchi J., Wang J., Sonobe Y., Jin S., Takada N., Komatsu Y., Suzumura A., Interferon- directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN- receptor and AMPA GluR1 receptor FASEB Journal 2008 22 6 1797 1806 (Pubitemid 351811457)
119. Moran L. B., Duke D. C., Tarkheimer F. E., Banati R. B., Graeber M. B., Towards a transcriptome definition of microglial cells Neurogenetics 2004 5 2 95 108 (Pubitemid 38828669)
120. Rock R. B., Hu S., Deshpande A., Munir S., May B. J., Baker C. A., Peterson P. K., Kapur V., Transcriptional response of human microglial cells to interferon- Genes and Immunity 2005 6 8 712 719 (Pubitemid 41741717)
121. Kurkowska-Jastrzebska I., Wroska A., Kohutnicka M., Czonkowski A., Czonkowska A., MHC class II positive microglia and lymphocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson's disease Acta Neurobiologiae Experimentalis 1999 59 1 1 8 (Pubitemid 29100019)
122. Imamura K., Hishikawa N., Sawada M., Nagatsu T., Yoshida M., Hashizume Y., Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains Acta Neuropathologica 2003 106 6 518 526 (Pubitemid 37441607)
123. Loeffler D. A., Camp D. M., Conant S. B., Complement activation in the Parkinson's disease substantia nigra: an immunocytochemical study Journal of Neuroinflammation 2006 3, article 29
124. Brochard V., Combadire B., Prigent A., Laouar Y., Perrin A., Beray-Berthat V., Bonduelle O., Alvarez-Fischer D., Callebert J., Launay J. M., Duyckaerts C., Flavell R. A., Hirsch E. C., Hunot S., Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease Journal of Clinical Investigation 2009 119 1 182 192
125. Ju K. R., Kim H. S., Kim J. H., Lee N. Y., Park C. K., Retinal glial cell responses and Fas/FasL activation in rats with chronic ocular hypertension Brain Research 2006 1122 1 209 221 (Pubitemid 44708124)
126. Mir M., Asensio V. J., Tolosa L., Gou-Fabregas M., Soler R. M., Llad J., Olmos G., Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants Neuroscience 2009 162 4 959 971
127. Jana M., Liu X., Koka S., Ghosh S., Petro T. M., Pahan K., Ligation of CD40 stimulates the induction of nitric-oxide synthase in microglial cells Journal of Biological Chemistry 2001 276 48 44527 44533
128. Zamanian-Daryoush M., Mogensen T. H., DiDonato J. A., Williams B. R. G., NF- B activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF- B-inducing kinase and I B kinase Molecular and Cellular Biology 2000 20 4 1278 1290 (Pubitemid 30069249)
129. Esposito E., Iacono A., Mui C., Crisafulli C., Mattace Raso G., Bramanti P., Meli R., Cuzzocrea S., Signal transduction pathways involved in protective effects of melatonin in C6 glioma cells Journal of Pineal Research 2008 44 1 78 87 (Pubitemid 350231099)
130. Moran L. B., Duke D. C., Graeber M. B., The microglial gene regulatory network activated by interferon-gamma Journal of Neuroimmunology 2007 183 1-2 1 6 (Pubitemid 46210097)
131. Baba Y., Kuroiwa A., Uitti R. J., Wszolek Z. K., Yamada T., Alterations of T-lymphocyte populations in Parkinson disease Parkinsonism and Related Disorders 2005 11 8 493 498 (Pubitemid 41627840)
132. Durbin J., Doughty L., Nguyen K., Caligiuri M., van Deusen J., Biron C., The role of STAT1 in viral sensitization to LPS Journal of Endotoxin Research 2003 9 5 313 316 (Pubitemid 37193039)
133. Qian L., Block M. L., Wei S. J., Lin C. F., Reece J., Pang H., Wilson B., Hong J. S., Flood P. M., Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase Journal of Pharmacology and Experimental Therapeutics 2006 319 1 44 52 (Pubitemid 44455109)
134. Johnston L. C., Su X., Maguire-Zeiss K., Horovitz K., Ankoudinova I., Guschin D., Hadaczek P., Federoff H. J., Bankiewicz K., Forsayeth J. R., Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease Molecular Therapy 2008 16 8 1392 1399
135. Quesada A., Lee B. Y., Micevych P. E., PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease Developmental Neurobiology 2008 68 5 632 644 (Pubitemid 351466293)
136. Meller R., Stevens S. L., Minami M., Cameron J. A., King S., Rosenzweig H., Doyle K., Lessov N. S., Simon R. P., Stenzel-Poore M. P., Neuroprotection by osteopontin in stroke Journal of Cerebral Blood Flow and Metabolism 2005 25 2 217 225 (Pubitemid 40171203)
137. Iczkiewicz J., Jackson M. J., Smith L. A., Rose S., Jenner P., Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson's disease Brain Research 2006 1118 1 239 250 (Pubitemid 44740248)
138. Maetzler W., Berg D., Schalamberidze N., Melms A., Schott K., Mueller J. C., Liaw L., Gasser T., Nitsch C., Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model Neurobiology of Disease 2007 25 3 473 482
139. Hashioka S., Klegeris A., Schwab C., McGeer P. L., Interferon- -dependent cytotoxic activation of human astrocytes and astrocytoma cells Neurobiology of Aging 2009 30 12 1924 1935
140. Hashioka S., Klegeris A., Qing H., McGeer P. L., STAT3 inhibitors
141. Ryu H. J., Kim J.-E., Kim M.-J., Kwon H.-J., Suh S. W., Song H.-K., Kang T.-C., The protective effects of interleukin-18 and interferon- on neuronal damages in the rat hippocampus following status epilepticus Neuroscience 2010 170 3 711 721
142. Ramrez G., Toro R., Dbeli H., von Bernhardi R., Protection of rat primary hippocampal cultures from A cytotoxicity by pro-inflammatory molecules is mediated by astrocytes Neurobiology of Disease 2005 19 1-2 243 254 (Pubitemid 40544742)
143. Thornberry N. A., Bull H. G., Calaycay J. R., Chapman K. T., Howard A. D., Kostura M. J., Miller D. K., Molineaux S. M., Weidner J. R., Aunins J., Elliston K. O., Ayala J. M., Casano F. J., Chin J., Ding G. J. F., Egger L. A., Gaffney E. P., Limjuco G., Palyha O. C., A novel heterodimeric cysteine protease is required for interleukin-1 processing in monocytes Nature 1992 356 6372 768 774
144. Dinarello C. A., Biology of interleukin 1 FASEB Journal 1988 2 2 108 115
145. Rothwell N. J., Hopkins S. J., Cytokines and the nervous system II: actions and mechanisms of action Trends in Neurosciences 1995 18 3 130 136
146. Eigler A., Sinha B., Hartmann G., Endres S., Taming TNF: strategies to restrain this proinflammatory cytokine Immunology Today 1997 18 10 487 492 (Pubitemid 27441592)
147. Mandel S., Grnblatt E., Youdim M. B. H., cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson's disease Journal of Neural Transmission, Supplement 2000 60 117 124 (Pubitemid 32037188)
148. Bian M. J., Li L. M., Yu M., Fei J., Huang F., Elevated interleukin-1 induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice Brain Research 2009 1302 256 264
149. Jin F., Wu Q., Lu Y. F., Gong Q. H., Shi J. S., Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats European Journal of Pharmacology 2008 600 13 78 82
150. Koprich J. B., Reske-Nielsen C., Mithal P., Isacson O., Neuroinflammation mediated by IL-1 increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease Journal of Neuroinflammation 2008 5, article 8
151. Pott Godoy M. C., Tarelli R., Ferrari C. C., Sarchi M. I., Pitossi F. J., Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease Brain 2008 131 7 1880 1894 (Pubitemid 351957456)
152. Pott Godoy M. C., Ferrari C. C., Pitossi F. J., Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression Journal of Neuroimmunology 2010 222 1-2 29 39
153. Wang J., Bankiewicz K. S., Plunkett R. J., Oldfield E. H., Intrastriatal implantation of interleukin-1. Reduction of parkinsonism in rats by enhancing neuronal sprouting from residual dopaminergic neurons in the ventral tegmental area of the midbrain Journal of Neurosurgery 1994 80 3 484 490 (Pubitemid 24073010)
154. Saura J., Pars M., Bov J., Pezzi S., Alberch J., Marin C., Tolosa E., Mart M. J., Intranigral infusion of interleukin-1 activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity Journal of Neurochemistry 2003 85 3 651 661 (Pubitemid 36531928)
155. Sriram K., Matheson J. M., Benkovic S. A., Miller D. B., Luster M. I., O'Callaghan J. P., Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease FASEB Journal 2002 16 11 1474 1476
156. Ferger B., Leng A., Mura A., Hengerer B., Feldon J., Genetic ablation of tumor necrosis factor-alpha (TNF- ) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum Journal of Neurochemistry 2004 89 4 822 833 (Pubitemid 38684730)
157. Rousselet E., Callebert J., Parain K., Joubert C., Hunot S., Hartmann A., Jacque C., Perez-Diaz F., Cohen-Salmon C., Launay J. M., Hirsch E. C., Role of TNF- receptors in mice intoxicated with the parkinsonian toxin MPTP Experimental Neurology 2002 177 1 183 192 (Pubitemid 35356832)
158. de Lella Ezcurra A. L., Chertoff M., Ferrari C., Graciarena M., Pitossi F., Chronic expression of low levels of tumor necrosis factor- in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation Neurobiology of Disease 2010 37 3 630 640
159. McCoy M. K., Ruhn K. A., Martinez T. N., McAlpine F. E., Blesch A., Tansey M. G., Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats Molecular Therapy 2008 16 9 1572 1579
160. Lucas P. C., McAllister-Lucas L. M., Nunez G., NF- B in signaling in lymphocytes: a new cast of characters Journal of Cell Science 2004 117 1 31 39 (Pubitemid 38072118)
161. Poynter M. E., Cloots R., van Woerkom T., Butnor K. J., Vacek P., Taatjes D. J., Irvin C. G., Janssen-Heininger Y. M. W., NF- B activation in airways modulates allergic inflammation but not hyperresponsiveness Journal of Immunology 2004 173 11 7003 7009 (Pubitemid 39541089)
162. Konsman J. P., Tridon V., Dantzer R., Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS Neuroscience 2000 101 4 957 967
163. Mattson M. P., NF- B in the survival and plasticity of neurons Neurochemical Research 2005 30 6-7 883 893
164. Hartlage-Rbsamen M., Lemke R., Schliebs R., Interleukin-1, inducible nitric oxide synthase, and nuclear factor- B are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon- injection Journal of Neuroscience Research 1999 57 3 388 398 (Pubitemid 29339795)
165. Pahan K., Sheikh F. G., Liu X., Hilger S., McKinney M., Petro T. M., Induction of nitric-oxide synthase and activation of NF- B by interleukin-12 p40 in microglial cells Journal of Biological Chemistry 2001 276 11 7899 7905
166. Madrigal J. L. M., Garca-Bueno B., Caso J. R., Prez-Nievas B. G., Leza J. C., Stress-induced oxidative changes in brain CNS and Neurological DisordersDrug Targets 2006 5 5 561 568 (Pubitemid 44523873)
167. Minghetti L., Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases Journal of Neuropathology and Experimental Neurology 2004 63 9 901 910 (Pubitemid 39202493)
168. Brock T. G., McNish R. W., Peters-Golden M., Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E Journal of Biological Chemistry 1999 274 17 11660 11666
169. Chandrasekharan N. V., Dai H., Roos K. L.T., Evanson N. K., Tomsik J., Elton T. S., Simmons D. L., COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression Proceedings of the National Academy of Sciences of the United States of America 2002 99 21 13926 13931 (Pubitemid 35215482)
170. Davies N. M., Good R. L., Roupe K. A., Yez J. A., Cyclooxygenase-3: axiom, dogma, anomaly, enigma or splice error?Not as easy as 1, 2, 3 Journal of Pharmacy and Pharmaceutical Sciences 2004 7 2 217 226
171. Phillis J. W., Horrocks L. A., Farooqui A. A., Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders Brain Research Reviews 2006 52 2 201 243 (Pubitemid 44291802)
172. Appleby S. B., Ristimaki A., Neilson K., Narko K., Hla T., Structure of the human cyclo-oxygenase-2 gene Biochemical Journal 1994 302 3 723 727 (Pubitemid 24289307)
173. Elmquist J. K., Breder C. D., Sherin J. E., Scammell T. E., Hickey W. F., Dewitt D., Saper C. B., Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages Journal of Comparative Neurology 1997 381 2 119 128 (Pubitemid 27423781)
174. Vijitruth R., Liu M., Choi D. Y., Nguyen X. V., Hunter R. L., Bing G., Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease Journal of Neuroinflammation 2006 3, article 6
175. Knott C., Stern G., Wilkin G. P., Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2 Molecular and Cellular Neuroscience 2000 16 6 724 739 (Pubitemid 32062060)
176. Teismann P., Tieu K., Choi D. K., Wu D. C., Naini A., Hunot S., Vila M., Jackson-Lewis V., Przedborski S., Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration Proceedings of the National Academy of Sciences of the United States of America 2003 100 9 5473 5478 (Pubitemid 36542729)
177. Feng Z. H., Wang T. G., Li D. D., Fung P., Wilson B. C., Liu B., Ali S. F., Langenbach R., Hong J. S., Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra Neuroscience Letters 2002 329 3 354 358 (Pubitemid 35245358)
178. Snchez-Pernaute R., Ferree A., Cooper O., Yu M., Brownell A. L., Isacson O., Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease Journal of Neuroinflammation 2004 1 1, article 6
179. Yang W., Tiffany-Castiglioni E., Lee M.-Y., Son I.-H., Paraquat induces cyclooxygenase-2 (COX-2) implicated toxicity in human neuroblastoma SH-SY5Y cells Toxicology Letters 2010 199 3 239 246
180. Litteljohn D., Mangano E. N., Hayley S., Cyclooxygenase-2 deficiency modifies the neurochemical effects, motor impairment and co-morbid anxiety provoked by paraquat administration in mice European Journal of Neuroscience 2008 28 4 707 716
181. Asanuma M., Nishibayashi-Asanuma S., Miyazaki I., Kohno M., Ogawa N., Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals Journal of Neurochemistry 2001 76 6 1895 1904 (Pubitemid 32221130)
182. Costa D., Moutinho L., Lima J. L. F. C., Fernandes E., Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs Biological and Pharmaceutical Bulletin 2006 29 8 1659 1670 (Pubitemid 44166370)
183. Chen H., Jacobs E., Schwarzschild M. A., McCullough M. L., Calle E. E., Thun M. J., Ascherio A., Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease Annals of Neurology 2005 58 6 963 967 (Pubitemid 41746889)
184. Hernn M. A., Logroscino G., Rodrguez L. A. G., Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease Neurology 2006 66 7 1097 1099 (Pubitemid 44044799)
185. Wahner A. D., Bronstein J. M., Bordelon Y. M., Ritz B., Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease Neurology 2007 69 19 1836 1842 (Pubitemid 350071144)
186. Ton T. G., Heckbert S. R., Longstreth W. T. Jr., Rossing M. A., Kukull W. A., Franklin G. M., Swanson P. D., Smith-Weller T., Checkoway H., Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease Movement Disorders 2006 21 7 964 969 (Pubitemid 44184597)
187. Bornebroek M., de Lau L. M. L., Haag M. D. M., Koudstaal P. J., Hofman A., Stricker B. H. C., Breteler M. M. B., Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease Neuroepidemiology 2007 28 4 193 196 (Pubitemid 47573713)
188. Etminan M., Carleton B. C., Samii A., Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study Journal of Clinical Neuroscience 2008 15 5 576 577
189. Gagne J. J., Power M. C., Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis Neurology 2010 74 12 995 1002
190. Kawano T., Anrather J., Zhou P., Park L., Wang G., Frys K. A., Kunz A., Cho S., Orio M., Iadecola C., Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity Nature Medicine 2006 12 2 225 229 (Pubitemid 43214750)
191. Carrasco E., Casper D., Werner P., PGE2 receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE2 neurotoxicity Journal of Neuroscience Research 2007 85 14 3109 3117 (Pubitemid 350057366)
192. Shie F. S., Montine K. S., Breyer R. M., Montine T. J., Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity GLIA 2005 52 1 70 77 (Pubitemid 41532139)
193. Vichai V., Suyarnsesthakorn C., Pittayakhajonwut D., Sriklung K., Kirtikara K., Positive feedback regulation of COX-2 expression by prostaglandin metabolites Inflammation Research 2005 54 4 163 172 (Pubitemid 41175267)
194. Poligone B., Baldwin A. S., Positive and negative regulation of NF- B by COX-2. Roles of different prostaglandins Journal of Biological Chemistry 2001 276 42 38658 38664
195. Nadjar A., Tridon V., May M. J., Ghosh S., Dantzer R., Amde T., Parnet P., NF B activates in vivo the synthesis of inducible Cox-2 in the brain Journal of Cerebral Blood Flow and Metabolism 2005 25 8 1047 1059 (Pubitemid 41061720)
196. Wang T., Pei Z., Zhang W., Liu B., Langenbach R., Lee C., Wilson B., Reece J. M., Miller D. S., Hong J. S., MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration FASEB Journal 2005 19 9 1134 1136 (Pubitemid 40946442)
197. Hunot S., Vila M., Teismann P., Davis R. J., Hirsch E. C., Przedborski S., Rakic P., Flavell R. A., JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 2004 101 2 665 670 (Pubitemid 38084694)
198. Wang Y., Zhang Y., Wei Z., Li H., Zhou H., Zhang Z., Zhang Z., JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease Journal of the Neurological Sciences 2009 285 1-2 172 177
199. Peng J., Mao X. O., Stevenson F. F., Hsu M., Andersen J. K., The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway Journal of Biological Chemistry 2004 279 31 32626 32632 (Pubitemid 39014720)
200. Choi W.-S., Abel G., Klintworth H., Flavell R. A., Xia Z., JNK3 mediates paraquat-and rotenone-induced dopaminergic neuron death Journal of Neuropathology and Experimental Neurology 2010 69 5 511 520
201. Vzquez-Claverie M., Garrido-Gil P., San Sebastin W., Belzunegui S., Izal-Azcrate A., Lpez B., Marcilla I., Luquin M. R., 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) does not elicit long-lasting increases in cyclooxygenase-2 expression in dopaminergic neurons of monkeys Journal of Neuropathology and Experimental Neurology 2009 68 1 26 36
202. Boyd J. D., Jang H., Shepherd K. R., Faherty C., Slack S., Jiao Y., Smeyne R. J., Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta Brain Research 2007 1175 1 107 116 (Pubitemid 47513006)
203. McCullough L., Wu L., Haughey N., Liang X., Hand T., Wang Q., Breyer R. M., Andreasson K., Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia Journal of Neuroscience 2004 24 1 257 268 (Pubitemid 38181690)
204. Ahmad A. S., Zhuang H., Echeverria V., Dor S., Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity Journal of Neurotrauma 2006 23 12 1895 1903 (Pubitemid 46034458)
205. Echeverria V., Clerman A., Dor S., Stimulation of PGE2 receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following -amyloid exposure European Journal of Neuroscience 2005 22 9 2199 2206 (Pubitemid 41653533)
206. Carrasco E., Werner P., Casper D., Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress Neuroscience Letters 2008 441 1 44 49
207. Shi J., Johansson J., Woodling N. S., Wang Q., Montine T. J., Andreasson K., The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity Journal of Immunology 2010 184 12 7207 7218
208. Tzeng S. F., Hsiao H. Y., Mak O. T., Prostaglandins and cyclooxygenases in glial cells during brain inflammation Current Drug Targets: Inflammation and Allergy 2005 4 3 335 340
209. Hutchinson A. J., Chou C. L., Israel D. D., Xu W., Regan J. W., Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF Neurochemistry International 2009 54 7 439 446
210. Bazan N. G., Marcheselli V. L., Cole-Edwards K., Brain response to injury and neurodegeneration: endogenous neuroprotective signaling Annals of the New York Academy of Sciences 2005 1053 137 147 (Pubitemid 43031090)
211. Farooqui A. A., Horrocks L. A., Farooqui T., Modulation of inflammation in brain: a matter of fat Journal of Neurochemistry 2007 101 3 577 599 (Pubitemid 46633316)