Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists

Biochemical Society Transactions

Volumn 41, Issue 1, 2013, Pages 213-217

  Hoyer, Inna ^a   Haas, Ann Karin ^a   Kreuchwig, Annika ^a   Schülein, Ralf ^a   Krause, Gerd ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

Compound 52; Constitutively activating mutation; G coupled protein receptor; Small molecular ligands; Thyrotropin receptor

Indexed keywords

ASPARTIC ACID; CAM Y667A; GLUTAMIC ACID; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; ISOLEUCINE; LEUCINE; METHIONINE; ORG 41841; PHENYLALANINE; PROLINE; THYROTROPIN RECEPTOR; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE;

BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; CONFERENCE PAPER; HYDROGEN BOND; MUTAGENESIS; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; BINDING SITES; MODELS, MOLECULAR; RECEPTORS, THYROTROPIN;

EID: 84873109084     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120319     Document Type: Conference Paper

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