Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor - A basally active GPCR

Cellular and Molecular Life Sciences

Volumn 65, Issue 22, 2008, Pages 3664-3676

  Kleinau, G ^a   Jaeschke, H ^b   Mueller, S ^b   Worth, C L ^a   Paschke, R ^b   Krause, G ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Activation mechanism; Endocrinology; FSHR; Glycoprotein hormone receptors; Inverse agonism; LHCGR; LHR; Signal transduction; TSHR

Indexed keywords

FOLLITROPIN RECEPTOR BINDING INHIBITOR; G PROTEIN COUPLED RECEPTOR; LUTEINIZING HORMONE RECEPTOR; OPSIN; PROTIRELIN RECEPTOR; RHODOPSIN; THYROTROPIN; THYROTROPIN RECEPTOR;

ARTICLE; BASAL METABOLIC RATE; CELL CULTURE; CELL SURFACE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; FLUORESCENCE ACTIVATED CELL SORTING; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PHENOTYPE; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURAL BIOINFORMATICS; WILD TYPE;

COMPUTATIONAL BIOLOGY; CYCLIC AMP; FLOW CYTOMETRY; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, THYROTROPIN; REGRESSION ANALYSIS; SIGNAL TRANSDUCTION;

EID: 56549103329     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-8450-2     Document Type: Article

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