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Volumn 36, Issue 3, 2008, Pages 334-339

Role of NF-κB in β-cell death

Author keywords

cell; Apoptosis; Cytokine; Islet graft rejection; Nuclear factor B (NF B); Type 1 diabetes

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOTRANSFERASE; CYTOKINE;

EID: 45249090859     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360334     Document Type: Conference Paper
Times cited : (91)

References (59)
  • 1
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death: The signal-transduction of immune-mediated β-cell apoptosis
    • Eizirik, D.L. and Mandrup-Poulsen, T. (2001) A choice of death: the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44, 2115-2133
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 2
    • 0035856952 scopus 로고    scopus 로고
    • β-Cell death during progression to diabetes
    • Mathis, D., Vence, L. and Benoist, C. (2001) β-Cell death during progression to diabetes. Nature 414, 792-798
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 3
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes: A matter of β-cell life and death?
    • Rhodes, C.J. (2005) Type 2 diabetes: a matter of β-cell life and death? Science 307, 380-384
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 4
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • Cnop, M., Welsh, N., Jonas, J.C., Jorns, A., Lenzen, S. and Eizirik, D.L. (2005) Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 (Suppl. 2), S97-S107
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 5
    • 0027078251 scopus 로고
    • Pancreatic β-cells in insulin-dependent diabetes
    • Pipeleers, D. and Ling, Z. (1992) Pancreatic β-cells in insulin-dependent diabetes. Diabetes Metab. Rev. 8, 209-227
    • (1992) Diabetes Metab. Rev , vol.8 , pp. 209-227
    • Pipeleers, D.1    Ling, Z.2
  • 6
    • 0034084572 scopus 로고    scopus 로고
    • The β-cell in autoimmune diabetes: Many mechanisms and pathways of loss
    • Kay, T.W., Thomas, H.E., Harrison, L.C. and Allison, J. (2000) The β-cell in autoimmune diabetes: many mechanisms and pathways of loss. Trends Endocrinol. Metab. 11, 11-15
    • (2000) Trends Endocrinol. Metab , vol.11 , pp. 11-15
    • Kay, T.W.1    Thomas, H.E.2    Harrison, L.C.3    Allison, J.4
  • 8
    • 0031667779 scopus 로고    scopus 로고
    • Apoptosis and the pathogenesis of IDDM: A guestion of life and death
    • Mauricio, D. and Mandrup-Poulsen, T. (1998) Apoptosis and the pathogenesis of IDDM: a guestion of life and death. Diabetes 47, 1537-1543
    • (1998) Diabetes , vol.47 , pp. 1537-1543
    • Mauricio, D.1    Mandrup-Poulsen, T.2
  • 9
    • 0030937468 scopus 로고    scopus 로고
    • Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
    • O'Brien, B.A., Harmon, B.V., Cameron, D.P. and Allan, D.J. (1997) Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46, 750-757
    • (1997) Diabetes , vol.46 , pp. 750-757
    • O'Brien, B.A.1    Harmon, B.V.2    Cameron, D.P.3    Allan, D.J.4
  • 10
    • 33744900639 scopus 로고    scopus 로고
    • Lessons on autoimmune diabetes from animal models
    • Yang, Y. and Santamaria, P. (2006) Lessons on autoimmune diabetes from animal models. Clin. Sci. 110, 627-639
    • (2006) Clin. Sci , vol.110 , pp. 627-639
    • Yang, Y.1    Santamaria, P.2
  • 11
    • 3042731121 scopus 로고    scopus 로고
    • The pathogenesis of diabetes in the NOD mouse
    • Solomon, M. and Sarvetnick, N. (2004) The pathogenesis of diabetes in the NOD mouse. Adv. Immunol. 84, 239-264
    • (2004) Adv. Immunol , vol.84 , pp. 239-264
    • Solomon, M.1    Sarvetnick, N.2
  • 13
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • Anderson, M.S. and Bluestone, J.A. (2005) The NOD mouse: a model of immune dysregulation. Annu. Rev. Immunol. 23, 447-485
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 15
    • 0035128723 scopus 로고    scopus 로고
    • β-Cell apoptosis: Stimuli and signaling
    • Mandrup-Poulsen, T. (2001) β-Cell apoptosis: stimuli and signaling. Diabetes 50 (Suppl. 1), S58-S63
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Mandrup-Poulsen, T.1
  • 16
    • 0442305381 scopus 로고    scopus 로고
    • Apoptotic signal transduction pathways in diabetes
    • Mandrup-Poulsen, T. (2003) Apoptotic signal transduction pathways in diabetes. Biochem. Pharmacol. 66, 1433-1440
    • (2003) Biochem. Pharmacol , vol.66 , pp. 1433-1440
    • Mandrup-Poulsen, T.1
  • 17
    • 0022491931 scopus 로고
    • Mechanisms of pancreatic islet cell destruction: Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans
    • Mandrup-Poulsen, T., Bendtzen, K., Nerup, J., Egeberg, J. and Nielsen, J.H. (1986) Mechanisms of pancreatic islet cell destruction: dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans. Allergy 41, 250-259
    • (1986) Allergy , vol.41 , pp. 250-259
    • Mandrup-Poulsen, T.1    Bendtzen, K.2    Nerup, J.3    Egeberg, J.4    Nielsen, J.H.5
  • 18
    • 0037203550 scopus 로고    scopus 로고
    • Cytokine synergism in apoptosis: Its role in diabetes and cancer
    • Lee, M.S. (2002) Cytokine synergism in apoptosis: its role in diabetes and cancer. J. Biochem. Mol. Biol. 35, 54-60
    • (2002) J. Biochem. Mol. Biol , vol.35 , pp. 54-60
    • Lee, M.S.1
  • 19
    • 0030923812 scopus 로고    scopus 로고
    • Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
    • Delaney, C.A., Pavlovic, D., Hoorens, A., Pipeleers, D.G. and Eizirik, D.L. (1997) Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138, 2610-2614
    • (1997) Endocrinology , vol.138 , pp. 2610-2614
    • Delaney, C.A.1    Pavlovic, D.2    Hoorens, A.3    Pipeleers, D.G.4    Eizirik, D.L.5
  • 21
    • 33746594835 scopus 로고    scopus 로고
    • Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-κB activation
    • Ortis, F., Cardozo, A.K., Crispim, D., Storling, J., Mandrup-Poulsen, T. and Eizirik, D.L. (2006) Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-κB activation. Mol. Endocrinol. 20, 1867-1879
    • (2006) Mol. Endocrinol , vol.20 , pp. 1867-1879
    • Ortis, F.1    Cardozo, A.K.2    Crispim, D.3    Storling, J.4    Mandrup-Poulsen, T.5    Eizirik, D.L.6
  • 22
    • 33747038451 scopus 로고    scopus 로고
    • Interventional strategies to prevent β-cell apoptosis in islet transplantation
    • Emamaullee, J.A. and Shapiro, A.M. (2006) Interventional strategies to prevent β-cell apoptosis in islet transplantation. Diabetes 55, 1907-1914
    • (2006) Diabetes , vol.55 , pp. 1907-1914
    • Emamaullee, J.A.1    Shapiro, A.M.2
  • 23
    • 0024405152 scopus 로고
    • Differential sensitivity to β-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1β
    • Eizirik, D.L., Sandler, S., Hallberg, A., Bendtzen, K., Sener, A. and Malaisse, W.J. (1989) Differential sensitivity to β-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1β. Endocrinology 125, 752-759
    • (1989) Endocrinology , vol.125 , pp. 752-759
    • Eizirik, D.L.1    Sandler, S.2    Hallberg, A.3    Bendtzen, K.4    Sener, A.5    Malaisse, W.J.6
  • 25
    • 0033778471 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic β-cells
    • Pavlovic, D., Andersen, N.A., Mandrup-Poulsen, T. and Eizirik, D.L. (2000) Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic β-cells. Eur. Cytokine Network 11, 267-274
    • (2000) Eur. Cytokine Network , vol.11 , pp. 267-274
    • Pavlovic, D.1    Andersen, N.A.2    Mandrup-Poulsen, T.3    Eizirik, D.L.4
  • 26
    • 0033850451 scopus 로고    scopus 로고
    • The c-jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic β-cells
    • Annmendrup, A., Maillard, A., Nielsen, K., Aabenhus Andersen, N., Serup, P., Dragsbaek Madsen, O., Mandrup-Poulsen, T. and Bonny, C. (2000) The c-jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic β-cells. Diabetes 49, 1468-1476
    • (2000) Diabetes , vol.49 , pp. 1468-1476
    • Annmendrup, A.1    Maillard, A.2    Nielsen, K.3    Aabenhus Andersen, N.4    Serup, P.5    Dragsbaek Madsen, O.6    Mandrup-Poulsen, T.7    Bonny, C.8
  • 27
    • 0035152487 scopus 로고    scopus 로고
    • Cell-permeable peptide inhibitors of JNK: Novel blockers of β-cell death
    • Bonny, C., Oberson, A., Negri, S., Sauser, C. and Schorderet, D.F. (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of β-cell death. Diabetes 50, 77-82
    • (2001) Diabetes , vol.50 , pp. 77-82
    • Bonny, C.1    Oberson, A.2    Negri, S.3    Sauser, C.4    Schorderet, D.F.5
  • 28
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiguitination: The control of NF-κB activity
    • Karin, M. and Ben-Neriah, Y. (2000) Phosphorylation meets ubiguitination: the control of NF-κB activity. Annu. Rev. Immunol. 18, 621-663
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 29
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin, M. and Lin, A. (2002) NF-κB at the crossroads of life and death. Nat. Immunol. 3, 221-227.
    • (2002) Nat. Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 30
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionary conserved mediators of immune responses
    • Ghosh, S., May, M.J. and Kopp, E.B. (1998) NF-κB and Rel proteins: evolutionary conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260
    • (1998) Annu. Rev. Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 31
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hacker, H. and Karin, M. (2006) Regulation and function of IKK and IKK-related kinases. Science STKE 2006, re13
    • (2006) Science STKE , vol.2006
    • Hacker, H.1    Karin, M.2
  • 32
    • 0031827241 scopus 로고    scopus 로고
    • Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells
    • Darville, M.I. and Eizirik, D.L. (1998) Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41, 1101-1108
    • (1998) Diabetologia , vol.41 , pp. 1101-1108
    • Darville, M.I.1    Eizirik, D.L.2
  • 33
    • 0035124875 scopus 로고    scopus 로고
    • Molecular regulation of Fas expression in β-cells
    • Darville, M.I., Liu, D., Chen, M.C. and Eizirik, D.L. (2001) Molecular regulation of Fas expression in β-cells. Diabetes 50 (Suppl. 1), S83
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Darville, M.I.1    Liu, D.2    Chen, M.C.3    Eizirik, D.L.4
  • 34
    • 14544285567 scopus 로고    scopus 로고
    • New approaches for in silico identification of cytokine-modified β-cell gene networks
    • Kutlu, B., Naamane, N., Berthou, L. and Eizirik, D.L. (2004) New approaches for in silico identification of cytokine-modified β-cell gene networks. Ann. N.Y. Acad. Sci. 1037, 41-58
    • (2004) Ann. N.Y. Acad. Sci , vol.1037 , pp. 41-58
    • Kutlu, B.1    Naamane, N.2    Berthou, L.3    Eizirik, D.L.4
  • 35
    • 85047685938 scopus 로고    scopus 로고
    • NF-κB is reguired for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells
    • Darville, M.I., Ho, Y.S. and Eizirik, D.L. (2000) NF-κB is reguired for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells. Endocrinology 141, 153-162
    • (2000) Endocrinology , vol.141 , pp. 153-162
    • Darville, M.I.1    Ho, Y.S.2    Eizirik, D.L.3
  • 36
    • 0031036369 scopus 로고    scopus 로고
    • Endothelial cells as cytotoxic effector cells: Cytokine-activated rat islet endothelial cells lyse syngeneic islet cells via nitric oxide
    • Steiner, L., Kroncke, K., Fehsel, K. and Kolb-Bachofen, V. (1997) Endothelial cells as cytotoxic effector cells: cytokine-activated rat islet endothelial cells lyse syngeneic islet cells via nitric oxide. Diabetologia 40, 150-155
    • (1997) Diabetologia , vol.40 , pp. 150-155
    • Steiner, L.1    Kroncke, K.2    Fehsel, K.3    Kolb-Bachofen, V.4
  • 37
    • 0032929766 scopus 로고    scopus 로고
    • Contribution of ductal cells to cytokine responses by human pancreatic islets
    • Pavlovic, D., Chen, M.C., Bouwens, L., Eizirik, D.I. and Pipeleers, D. (1999) Contribution of ductal cells to cytokine responses by human pancreatic islets. Diabetes 48, 29-33
    • (1999) Diabetes , vol.48 , pp. 29-33
    • Pavlovic, D.1    Chen, M.C.2    Bouwens, L.3    Eizirik, D.I.4    Pipeleers, D.5
  • 39
    • 26244436171 scopus 로고    scopus 로고
    • Storling, J., Binzer, J., Andersson, A.K., Zullig, R.A., Tonnesen, M., Lehmann, R., Spinas, G.A., Sandler, S., Billestrup, N. and Mandrup-Poulsen, T. (2005) Nitric oxide contributes to cytokine-induced apoptosis in pancreatic β-cells via potentiation of JNK activity and inhibition of Akt. Diabetologia 48, 2039-2050
    • Storling, J., Binzer, J., Andersson, A.K., Zullig, R.A., Tonnesen, M., Lehmann, R., Spinas, G.A., Sandler, S., Billestrup, N. and Mandrup-Poulsen, T. (2005) Nitric oxide contributes to cytokine-induced apoptosis in pancreatic β-cells via potentiation of JNK activity and inhibition of Akt. Diabetologia 48, 2039-2050
  • 40
    • 0029989197 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identification of iNOS-expressing cells and relationships to cytokines expressed in the islets
    • Rabinovitch, A., Suarez-Pinzon, W.L., Sorensen, O. and Bleackley, R.C. (1996) Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS-expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137, 2093-2099
    • (1996) Endocrinology , vol.137 , pp. 2093-2099
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3    Bleackley, R.C.4
  • 41
    • 0034949349 scopus 로고    scopus 로고
    • An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitnte prevents diabetes development in NOD mice
    • Suarez-Pinzon, W.L., Mabley, J.G., Strynadka, K., Power, R.F., Szabo, C. and Rabinovitch, A. (2001) An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitnte prevents diabetes development in NOD mice. J. Autoimmun. 16, 449-455
    • (2001) J. Autoimmun , vol.16 , pp. 449-455
    • Suarez-Pinzon, W.L.1    Mabley, J.G.2    Strynadka, K.3    Power, R.F.4    Szabo, C.5    Rabinovitch, A.6
  • 42
    • 0035488777 scopus 로고    scopus 로고
    • Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis
    • Heimberg, H., Heremans, Y., Jobin, C., Leemans, R., Cardozo, A.K., Darville, M. and Eizirik, D.L. (2001) Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis. Diabetes 50, 2219-2224
    • (2001) Diabetes , vol.50 , pp. 2219-2224
    • Heimberg, H.1    Heremans, Y.2    Jobin, C.3    Leemans, R.4    Cardozo, A.K.5    Darville, M.6    Eizirik, D.L.7
  • 43
    • 0034711250 scopus 로고    scopus 로고
    • Protection of human islets from the effects of interleukin-10 by adenoviral gene transfer of an IκB repressor
    • Giannoukakis, N., Rudert, W.A., Trucco, M. and Robbins, P.D. (2000) Protection of human islets from the effects of interleukin-10 by adenoviral gene transfer of an IκB repressor. J. Biol. Chem. 275, 36509-36513
    • (2000) J. Biol. Chem , vol.275 , pp. 36509-36513
    • Giannoukakis, N.1    Rudert, W.A.2    Trucco, M.3    Robbins, P.D.4
  • 44
    • 0035746917 scopus 로고    scopus 로고
    • Expression of a dominant negative inhibitor of NF-κB protects MIN6 β-cells from cytokine-induced apoptosis
    • Baker, M.S., Chen, X., Cao, X.C. and Kaufman, D.B. (2001) Expression of a dominant negative inhibitor of NF-κB protects MIN6 β-cells from cytokine-induced apoptosis. J. Surg. Res. 97, 117-122
    • (2001) J. Surg. Res , vol.97 , pp. 117-122
    • Baker, M.S.1    Chen, X.2    Cao, X.C.3    Kaufman, D.B.4
  • 45
    • 0037219109 scopus 로고    scopus 로고
    • Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells
    • Azevedo-Martins, A.K., Lortz, S., Lenzen, S., Curi, R., Eizirik, D.L. and Tiedge, M. (2003) Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells. Diabetes 52, 93-101
    • (2003) Diabetes , vol.52 , pp. 93-101
    • Azevedo-Martins, A.K.1    Lortz, S.2    Lenzen, S.3    Curi, R.4    Eizirik, D.L.5    Tiedge, M.6
  • 47
    • 0345196532 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of the anti-apoptotic protein A20 in rodent islets inhibits IL-1 β-induced NO release
    • Grey, S.T., Arvelo, M.B., Hasenkamp, W.M., Bach, F.H. and Ferren, C. (1999) Adenovirus-mediated gene transfer of the anti-apoptotic protein A20 in rodent islets inhibits IL-1 β-induced NO release. Transplant Proc. 31, 789
    • (1999) Transplant Proc , vol.31 , pp. 789
    • Grey, S.T.1    Arvelo, M.B.2    Hasenkamp, W.M.3    Bach, F.H.4    Ferren, C.5
  • 48
    • 4544228457 scopus 로고    scopus 로고
    • Functions of NF-κB1 and NF-κB2 in immune cell biology
    • Beinke, S. and Ley, S.C. (2004) Functions of NF-κB1 and NF-κB2 in immune cell biology. Biochem. J. 382, 393-409
    • (2004) Biochem. J , vol.382 , pp. 393-409
    • Beinke, S.1    Ley, S.C.2
  • 49
    • 0033532386 scopus 로고    scopus 로고
    • The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
    • Li, Z.W., Chu, W., Hu, Y., Delhase, M., Deerinck, T., Ellisman, M., Johnson, R. and Karin, M. (1999) The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis. J. Exp. Med. 189, 1839-1845
    • (1999) J. Exp. Med , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3    Delhase, M.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 50
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
    • Beg, A.A., Sha, W.C., Branson, R.T., Ghosh, S. and Baltimore, D. (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376, 167-170
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Branson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 53
    • 0038142707 scopus 로고    scopus 로고
    • Nuclear factor κB protects pancreatic β-cells from tumor necrosis factor-α-mediated apoptosis
    • Chang, I., Kim, S., Kim, J.Y., Cho, N., Kim, Y.H., Kim, H.S., Lee, M.K., Kim, K.W. and Lee, M.S. (2003) Nuclear factor κB protects pancreatic β-cells from tumor necrosis factor-α-mediated apoptosis. Diabetes 52, 1169-1175
    • (2003) Diabetes , vol.52 , pp. 1169-1175
    • Chang, I.1    Kim, S.2    Kim, J.Y.3    Cho, N.4    Kim, Y.H.5    Kim, H.S.6    Lee, M.K.7    Kim, K.W.8    Lee, M.S.9
  • 54
    • 0035983492 scopus 로고    scopus 로고
    • NFκB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes
    • Mabley, J.G., Hasko, G., Liaudet, L., Soriano, F., Southan, G.J., Salzman, A.L. and Szabo, C. (2002) NFκB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes. J. Endocrinol. 173, 457-464
    • (2002) J. Endocrinol , vol.173 , pp. 457-464
    • Mabley, J.G.1    Hasko, G.2    Liaudet, L.3    Soriano, F.4    Southan, G.J.5    Salzman, A.L.6    Szabo, C.7
  • 57
    • 12144279068 scopus 로고    scopus 로고
    • Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion
    • Norlin, S., Ahlgren, U. and Edlund, H. (2005) Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion. Diabetes 54, 125-132
    • (2005) Diabetes , vol.54 , pp. 125-132
    • Norlin, S.1    Ahlgren, U.2    Edlund, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.