Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation

Free Radical Biology and Medicine

Volumn 25, Issue 9, 1998, Pages 1075-1082

  Virág, László ^a   Marmer, Daniel J ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Caspase; Free radical; Inflammation Apoptosis; Nitric oxide; Peroxynitrite; Poly(ADP ribose) synthetase; Shock

Indexed keywords

3 AMINOBENZAMIDE; CASPASE; CASPASE 3; DNA FRAGMENT; INTERLEUKIN 1BETA CONVERTING ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PEROXYNITRITE; PHOSPHATIDYLSERINE; PYRONE DERIVATIVE; SUPEROXIDE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

APOPTOSIS; CASPASE 3; CASPASES; CELL SURVIVAL; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; NITRATES; PEPTIDES; PHOSPHATIDYLSERINES; POLY(ADP-RIBOSE) POLYMERASES;

EID: 0032403857     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00139-7     Document Type: Article

References (52)

1. Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite the good, the bad and the ugly . Am. J. Physiol. 271:1996;1424-1437.
2. Szabó C. The role of peroxynitrite in the pathophysiology of shock, inflammation and ischemia-reperfusion injury. Shock. 6:1996;79-88.
3. Szabó C., Saunders C., O'Connor M., Salzman A.L. Peroxynitrite causes energy depletion and increases permeability via activation of poly-ADP ribosyl synthetase in pulmonary epithelial cells. Am. J. Mol. Cell. Respir. Biol. 16:1997;105-109.
4. Szabó C., Cuzzocrea S., Zingarelli B., O'Connor M., Salzman A.L. Endothelial dysfunction in endotoxic shock importance of the activation of poly (ADP ribose) synthetase (PARS) by peroxynitrite . J. Clin. Invest. 100:1997;723-735.
5. Szabó C., Zingarelli B., O'Connor M., Salzman A.L. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA. 93:1996;1753-1758.
6. Eliasson M.J.L., Sampei K., Mandir A.S., Hurn P.D., Traystman R.J., Bao J., Pieper A., Wang Z-Q, Dawson T.M., Snyder S.H., Dawson V.L. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischaemia. Nature Med. 3:1997;1089-1095.
7. Szabó C. DNA strand breakage and activation of poly-ADP ribosyltransferase a cytotoxic pathway triggered by peroxynitrite . Free Radic. Biol. Med. 21:1996;855-869.
8. Szabó C., Zingarelli B., Salzman A.L. Role of poly-ADP ribosyltransferase activation in the nitric oxide- and peroxynitrite-induced vascular failure. Circ. Res. 78:1996;1051-1063.
9. Szabó C., Wong H.R., Bauer P.I., Kirsten E., O'Connor M., Zingarelli B., Mendeleyev J., Hasko G., Vizi S.E., Salzman A.L., Kun E. Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, and inhibitor of poly (ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways. Int. J. Oncol. 10:1997;1093-1101.
10. Cuzzocrea S., Zingarelli B., Costantino G., Szabó A., Salzman A.L., Caputi A.P., Szabó C. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br. J. Pharmacol. 121:1997;1065-1074.
11. Szabó C., Lim L.H.K., Cuzzocrea S., Getting S.J., Zingarelli B., Flower R.J., Salzman A.L., Perretti M. Inhibition of poly (ADP-ribose) Synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. J. Exp. Med. 186:1997;1041-1049.
12. Lin K-T, Xue J-Y, Nomen M., Spur B., Wong P. Y-K. Peroxynitrite-induced apoptosis in HL-60 cells. J. Biol. Chem. 270:1995;16487-16490.
13. Salgo M.G., Squadrito G.L., Pryor W.A. Peroxynitrite causes apoptosis in rat thymocytes. Biochem. Biophys. Res. Commun. 215:1995;1111-1118.
14. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S.A. Apoptosis and necrosis two distinct event induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures . Proc. Natl. Acad. Sci. 92:1995;7162-7166.
15. Sandoval M., Zhang X.J., Liu X., Mannick E.E., Clark D.A., Miller M.J. Peroxynitrite-induced apoptosis in T84 and RAW 264.7 cells attenuation by L-ascorbic acid . Free Radic. Biol. Med. 22:1997;489-495.
16. Lin K.T., Xue J.Y., Sun F.F., Wong P.Y. Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells. Biochem. Biophys. Res. Commun. 230:1997;115-119.
17. Lin K.T., Xue J.Y., Wong P.Y.K. BCL-2 blocks peroxynitrite-induced apoptosis in HL-60 cells, an association with reactive oxygen species. Inflamm. Res. 46S:1997;157-158.
18. Nicholson D.W., Ali A., Thornberry N.A., Vaillantcourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A., Munday N.A., Raju S.M., Samuelson M.E., Yamin T-T, Yu V.L., Miller D.K. Identification and inhibition of the ICE/CED-3 protease necessery for mammalian apoptosis. Nature. 376:1995;37-43.
19. Tewari M., Quan L.T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D.R., Poirier G.G., Salvesen G.S., Dixit V.M. Yama/CPP32β, a mammalian homolog of CED-3, is a crmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81:1995;801-809.
20. Nicholson D.W., Thornberry N.A. Caspases killer proteases . TIBS. 22:1997;299-306.
21. Kumar S. The apoptotic cysteine protease CPP32. Int. J. Biochem. Cell Biol. 29:1997;393-396.
22. Dixit V.M. The role of ICE-proteases in apoptosis. Adv. Exp. Med. Biol. 406:1996;113-117.
23. Kaufmann S.H., Desnoyers S., Ottaviano Y., Davidson N.E., Poirier G.G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase an early marker of chemotherapy-induced apoptosis . Cancer Res. 53:1993;3976-3985.
24. Takahashi A., Earnshaw W.C. ICE-related proteases in apoptosis. Curr. Opin. Gen. Dev. 6:1996;50-55.
25. Polverino A.J., Patterson S.D. Selective activation of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. J. Biol. Chem. 272:1997;7013-7021.
26. Hampton M.B., Orrenius S. Dual regulation of caspase activity by hydrogen peroxide implications for apoptosis . FEBS Lett. 414:1997;552-556.
27. Kaushal G.P., Ueda N., Shah S.V. Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A. Kidney Int. 52:1997;438-445.
28. Vanags D.M., Pörn-Ares M., Coppola S., Burgess D.H., Orenius S. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J. Biol. Chem. 271:1997;31075-31085.
29. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods. 184:1995;39-51.
30. Martin S.J., Reutelingsperger C.P.M., McGahon A.J., Rader J.A., van Schie R.C.A.A., LaFace D.M., Green D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus Inhibition by overexpression of Bcl-2 and Abl . J. Exp. Med. 182:1995;1545-1556.
31. 2+ associated with apoptosis. Methods Cell Biol. 46:1995;41-55.
32. Virag L., Scott G., Marmer D., Salzman A.L., Szabo C. Peroxynitrite-induced thymocyte apoptosis the role of caspases and poly(ADP-ribose) synthetase activation . Immunology. 94:1998;345-355.
33. Lizasoain I., Moro M.A., Knowles R.G., Darley-Usmar V., Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differetially blocked by glutathion or glucose. Biochem. J. 314:1996;877-880.
34. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones D.P., Wang X. Prevention of apoptosis by Bcl-2 release of cytochrome c from mitochondria blocked . Science. 275:1997;1129-1132.
35. Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D. The release of cytochrome c from mitochondria a primary site for Bcl-2 regulation of apoptosis . Science. 275:1997;1132-1136.
36. Mohr S., Zech B., Lapetina E.G., Brune B. Inhibition of caspase-3 by nitrosation and oxidation caused by nitric oxide. Biochem. Biophys. Res. Commun. 238:1997;387-391.
37. Kidd V.J. Proteolytic activities that mediate apoptosis. Annu. Rev. Physiol. 60:1998;533-573.
38. Armstrong R.C., Aja T., Xiang J., Gaur S., Krebs J.F. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J. Biol. Chem. 271:1996;16850-16855.
39. Los M., Van De Craen M., Penning L.C., Schenk H., Westendrop M. Requirement of an ICE/-CED-3 protease for Fas/Apo-1-mediated apoptosis. Nature. 375:1995;81-83.
40. Shiokawa D., Maruta H., Tanuma S. Inhibitors of poly(ADP-ribose) polimerase suppress nuclear fragmentation and apoptotic body formation during apoptosis in HL-60 cells. FEBS Lett. 413:1997;99-103.
41. Watson A.J., Askew J.N., Benson R.S. Poly(adenosine diphosphate ribose) polymerase inhibition prevents necrosis induced by H2O2 but not apoptosis. Gastroenterology. 109:1995;472-484.
42. Kuo M.L., Chau Y.P., Wang J.H., Shiah S.G. Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells. Biochem. Biophys. Res. Commun. 219:1996;502-508.
43. Tanaka Y., Yoshihara K., Tohno Y., Kojima K., Kameoka M., Kamiya T. Inhibition and down-regulation of poly(ADP-ribose) polymerase results in marked resistance of HL-60 cells to various apoptosis-inducers. Cell. Mol. Biol. 41:1995;771-781.
44. Malorni W., Rivabene R., Straface E., Rainaldi G., Monti D., Salvioli S., Cossariza A., Francesci C. 3-aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion. Biochem. Biophys. Res. Commun. 207:1995;715-724.
45. Leist M., Single B., Künstle G., Volbracht C., Hentze H., Nicotera P. Apoptosis in the absence of poly-(ADP-ribose) polymerase. Biochem. Biophys. Res. Commun. 233:1997;518-522.
46. Wang Z-Q, Stingl L., Morrison C., Jantsch M., Los M., Schulze-Osthof K., Wagner E.F. PARP is important for genomic stability but dispensible in apoptosis. Genes Develop. 11:1997;2347-2358.
47. De Murcia J.M., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M., Oliver F.J., Masson M., Dierich A., Lemeur M., Walztinger C., Chambon P., De Murcia G. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. USA. 94:1997;7303-7307.
48. 6-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide. Mol. Pharmacol. 52:1997;249-258.
49. 2+-dependent/poly(ADP-ribose)-sensitive endonuclease. J. Biol. Chem. 258:1983;9184-9191.
50. Coppola S., Nosseri C., Maresca V., Ghibelli L. Different basal NAD levels determine opposite effects of poly(ADP-ribosyl) polymerase inhibitors on H2O2-induced apoptosis. Exp. Cell. Res. 221:1995;462-469.
51. Weltin D., Marchal J., Dufour P., Potworowski E., Oth D., Bischoff P. Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. Oncol. Res. 6:1994;399-403.
52. Bauer P.I., Kirsten E., Young L.J.T., Varadi G., Csonka E., Buki K.G., Mikala G., Hu R., Comstock J.A., Mendeleyev J., Hakam A., Kun E. Modification of growth related enzymatic pathways and apparent loss of tumorigenicity of a ras-transformed bovine endothelial cell lineby treatment with 5-iodo-6-amino-1,2-benzopyrone. Int. J. Oncol. 8:1995;239-252.