Preparation and characterization of PLGA microspheres by the electrospraying method for delivering simvastatin for bone regeneration

International Journal of Pharmaceutics

Volumn 443, Issue 1-2, 2013, Pages 87-94

  Nath, Subrata Deb ^a   Son, Sora ^a   Sadiasa, Alexandar ^a   Min, Young Ki ^a   Lee, Byong Taek ^a  

^a Soonchunhyang University   (South Korea)

Author keywords

Drug delivery system; Electrospraying; Microspheres; PLGA; Simvastatin

Indexed keywords

DICHLOROMETHANE; MICROSPHERE; POLYGLACTIN; SIMVASTATIN;

ADHESION; ARTICLE; BIOCOMPATIBILITY; BONE REGENERATION; CELL ADHESION; CELL PROLIFERATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ANALYSIS; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; ELECTROSPRAY; ENCAPSULATION; IN VITRO STUDY; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

BONE REGENERATION; CALORIMETRY, DIFFERENTIAL SCANNING; CELL ADHESION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; OSTEOBLASTS; PARTICLE SIZE; POLYGLYCOLIC ACID; SIMVASTATIN; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES;

EID: 84873026507     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.12.037     Document Type: Article

References (56)

1. T.Q. Bao, N.T. Hiep, Y.H. Kim, H.M. Yang, and B.T. Lee Fabrication and characterization of porous poly (lactice-co-glycolic acid) (PLGA) microspheres for use as a drug delivery system J. Mater. Sci. 46 2011 2510 2517
2. R.D. Barber GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues Physiol. Genomics 21 2005 389 395
3. C. Berkland, C. Kim, and D.W. Pack Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions J. Controlled Release 73 2001 59 74
4. C. Berkland, M. King, A. Cox, K. Kim, and D.W. Pack Precise control of PLG microsphere size provides enhanced control of drug release rate J. Controlled Release 82 2002 137 147
5. A. Bohr, J. Kristensen, E. Stride, M. Dyas, and M. Edirisinghe Preparation of microspheres containing low solubility drug compound by electrohydrodynamic spraying Int. J. Pharm. 412 2011 59 67
6. A. Bohr, J. Kristensen, M. Dyas, M. Edirisinghe, and E. Stride Release profile and characteristics of electrosprayed particles for oral delivery of a practically insoluble drug J. R. Soc. Interface 75 2012 2437 2449
7. A. Bohr, M. Yang, S. Baldursdóttir, J. Kristensen, M. Dyas, E. Stride, and M. Edirisinghe Particle formation and characteristics of celecoxib-loaded poly(lactic-co-glycolic acid) microparticles prepared in different solvents using electrospraying Polymer 53 2012 3220 3229
8. M. Edirisinghe, and S. Jayasinghe Electrohydrodynamic atomization of a concentrated nano-suspension Int. J. Appl. Ceram. Technol. 1 2004 140 145
9. M. Enayati, M.W. Chang, F. Bragman, M. Edirisinghe, and E. Stride Electrohydrodynamic preparation of particles, capsules and bubbles for biomedical engineering applications Colloids Surf. A: Physicochem. Eng. Aspects 382 2011 154 164
10. T.M. Fahmy, P.M. Fong, A. Goyal, and W.M. Saltzman Targeted for drug delivery Mater. Today 8 2005 18 26
11. T.M. Fahmy, P.M. Fong, J. Park, T. Constable, and W.M. Saltzman Nanosystems for simultaneous imaging and drug delivery to T cells AAPS J. 9 2 2007 171 180
12. O.C. Farokhzad, J. Cheng, B.A. Teply, I. Sherifi, S. Jon, P.W. Kantoff, J.P. Richie, and R. Langer Nanotechnology in cancer treatment and detection PNAS 103 2006 6315 6320
13. S. Freiberg, and X.X. Zhu Polymer microspheres for controlled drug release Int. J. Pharm. 282 2004 1 18
14. R. Garrett, and G. Mundy The role of statins as potential targets for bone formation Arthritis Res. 4 2002 237 240
15. I. Hayati, A.I. Bailey, and T.F. Tadros Mechanism of stable jet formation in electrohydrodynamic atomization Nature 319 1986 41 43
16. D. Horter, and J.B. Dressman Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract Adv. Drug Delivery Rev. 46 2001 75 87
17. Y.Y. Huang, T.W. Chung, and T.W. Tzeng Drug release from PLA/PEG microparticulates Int. J. Pharm. 156 1997 9 15
18. S.B. Jadhav, and G.K. Jain Statins and osteoporosis: new role for old drugs J. Pharm. Pharmacol. 58 2006 3 18
19. A. Jaworek Micro- and nanoparticle production by electrospraying Powder Technol. 176 2007 18 35
20. S.W. Jun, M.S. Kim, J.S. Kim, H.J. Park, S. Lee, J.S. Woo, and S.J. Hwang Preparation and characterization of simvastatin/hydroxypropyl-β- cyclodextrin inclusion complex using supercritical antisolvent (SAS) process Eur. J. Pharm. Biopharm. 66 2007 413 421
21. H. Katou, A.J. Wandrey, and B. Gander Kinetics of solvent extraction/evaporation process for PLGA microparticle fabrication Int. J. Pharm. 364 2008 45 53
22. S.H. Kim, J.H. Jeong, K.W. Chun, and T.G. Park Target-specific cellular uptake of PLGA nanoparticles coated with poly(l-lysine)-poly(ethylene glycol), folate conjugate Langmuir 21 2005 8852 8857
23. I.W. Lenggoro, T. Hata, F. Iskandar, M.M. Lunden, and K. Okuyama An experimental and modeling investigation of particle production by spray pyrolysis using a laminar flow aerosol reactor J. Mater. Res. 15 2000 733 743
24. G. Ma, M. Nagai, and S. Omi Preparation of uniform poly(lacide) microspheres by employing the shirasu porous glass (SPG) emulsifying technique Colloids Surf. A: Physiochem. Eng. Aspects 153 1999 383 394
25. T. Meada, T. Kawane, and N. Horiuchi Statins augment vascular endothelial growth expression in osteoblastic cells via inhibition of protein prenylation Endocrinology 144 2 2003 681 692
26. T. Meada, A. Matunuma, I. kurahasi, T. Yanagawa, H. Yoshida, and N. Horiuchi Introduction of osteoblast differentiation indices by statins by MC3T3-E1 cells J. Cell. Biochem. 92 3 2004 458 471
27. S.M. Moghimi, A.C. Hunter, and J.C. Murray Long-circulating and target-specific nanoparticles: theory to practice Pharmacol. Rev. 53 2001 283 318
28. G. Mundy, R. Garrett, S. Harris, J. Chan, D. Chen, G. Rossini, B. Boyce, M. Zhao, and G. Gutierrez Stimulation of bone formation in vitro and in rodents by statins Science 286 1999 1946 1949
29. ®) J. Controlled Release 80 2002 129 144
30. M. Murillo, C. Gamazo, M.M. Goni, J.M. Irache, and M.J. Blanco-Prieto Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis Int. J. Pharm. 242 2002 341 344
31. A.A. Noyes, and W.R. Whitney The rate of solution of solid substances in their own solutions J. Am. Chem. Soc. 19 1897 930 934
32. K. Okuyama, and I.W. Lenggoro Preparation of nanoparticles via spray route Chem. Eng. Sci. 58 2003 537 547
33. R. Pareta, and M.J. Edirisinghe A novel method for the preparation of biodegradable microspheres for protein drug delivery J. R. Soc. Interface 3 2006 573 582
34. P. Patil, V. Patil, and A. Paradkar Formulation of a self-emulsifying system for oral delivery of simvastatin: in vitro and in vivo evaluation Acta Pharm. 57 2007 111 122
35. C.H. Park, and J. Lee Electrosprayed polymer particles: effect of the solvent properties J. Appl. Polym. Sci. 114 2009 430 437
36. B. Phillips, N. Belmonte, C. Vernochet, G. Ailhaud, and C. Dani Compactin enhances osteogenesis in murine embryonic stem cells Biochem. Biophys. Res. Commun. 284 2001 478 484
37. S.E. Pinon, Q.A. Ganem, P.V. Alonso, and G.D. Quintanar Preparation and characterization of triclosan nanoparticles for periodontal treatment Int. J. Pharm. 294 2005 217 232
38. L. Reyderman, and S. Stavchansky Electrostatic spraying and its use in drug delivery-cholesterol microspheres Int. J. Pharm. 124 1995 75 85
39. A.L. Rubio, and J.M. Lagaron Whey protein capsules obtained through electrospraying for the encapsulation of bioactives Innovative Food Sci. Emerg. Technol. 13 2012 200 206
40. S. Ruiz-Gaspa, X. Nogues, A. Enjuances, J.C. Monllau, J. Blanch, and R. Carreras Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures J. Cell. Biochem. 101 6 2007 1430 1438
41. P. Sansdrap, and A.J. Moes Influence of manufacturing parameters on the size characteristics and the release profiles of nifedipine from poly(D,L-lactide-co-glycolide) microspheres Int. J. Pharm. 124 1993 75 85
42. S.L. Shenoy, W.D. Bates, H.L. Frisch, and G.E. Wnek Role of chain entanglements on fiber formation during electrospinning of polymer solutions: good solvent, non-specific polymer-polymer interaction limit 46 2005 3372 3384
43. V.R. Sinha, K. Bansal, R. Kaushik, R. Kumria, and A. Trehan Poly-ε-caprolactone microspheres and nanospheres: an overview Int. J. Pharm. 278 2004 1 23
44. J.S. Sun The influence on gene-expression profiling of osteoblasts behavior following treatment with the ionic products of sintered β-dicalcium pyrophosphate dissolution Biomaterials 25 4 2004 607 616
45. H. Takeuchi, H. Yamamoto, and Y. Kawashima Mucoadhesive nanoparticulate systems for peptide drug delivery Adv. Drug. Deliv. Rev. 47 2001 39 54
46. T. Tanigo, R. Takaoka, and Y. Tabata Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration J. Controlled Release 143 2010 201 206
47. O.A. Trentz Osteoblasts response to allogenic and xenogenic solvent dehydrated cancellous bone in vitro Biomaterials 24 20 2003 3417 3426
48. C. Washington Drug release from microdisperse systems: a critical review Int. J. Pharm. 58 1990 1 12
49. R.W. Wong, and A.B. Rabie Statin collagen grafts used to repair defects in the parietal bone of rabbits Br. J. Oral Maxillofac. Surg. 41 2003 244 248
50. R.W. Wong, and A.B. Rabie Histologic and ultrastructural study on statin graft in rabbit skulls J. Oral Maxillofac. Surg. 63 2005 1515 1521
51. R.W. Wong, and A.B. Rabie Early healing pattern of statin-induced osteogenesis Br. J. Oral Maxillofac. Surg. 43 2005 46 50
52. J. Xie, J.C.M. Marijnissen, and H. Wang Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro Biomaterials 27 2006 3321 3332
53. Y. Xu, and M.A. Hanna Electrospray encapsulation of water-soluble protein with polylactide: effects of formulations on encapsulation efficiency and release Int. J. Pharm. 320 2006 30 36
54. J. Yao, L.K. Lim, J. Xie, J. Hua, and C.H. Wang Characterization of electrospraying process for polymeric particle fabrication J. Aerosol Sci. 39 2008 987 1002
55. J.W. Yoo, N. Doshi, and S. Mitragotri Adaptive micro and nanoparticles: temporal control over carrier properties to facilitate drug delivery Adv. Drug Delivery Rev. 63 2011 1247 1256
56. Z. Zhang, and S.S. Feng Self assembled nanoparticles of poly(lactic)-vitamin E TGPS copolymers for oral chemotherapy Int. J. Pharm. 324 2006 191 198