Electrospray encapsulation of water-soluble protein with polylactide. Effects of formulations on morphology, encapsulation efficiency and release profile of particles

International Journal of Pharmaceutics

Volumn 320, Issue 1-2, 2006, Pages 30-36

  Xu, Yixiang ^a   Hanna, Milford A ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Bovine serum albumin; Electrospray; Encapsulation; Encapsulation efficiency; Poly(lactide); Release rate

Indexed keywords

NANOPARTICLE; POLYLACTIDE; PROTEIN; SERUM ALBUMIN; WATER;

AQUEOUS SOLUTION; ARTICLE; CONDUCTANCE; DRUG FORMULATION; DRUG RELEASE; ELECTRIC FIELD; ELECTROSPRAY; EMULSION; ENCAPSULATION; ORGANIC CHEMISTRY; PARTICLE SIZE; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; SURFACE PROPERTY; SURFACE TENSION; TECHNIQUE; VISCOSITY;

CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; ELECTRIC CONDUCTIVITY; EMULSIONS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYESTERS; POROSITY; PROTEINS; SERUM ALBUMIN, BOVINE; SOLUBILITY; SURFACE PROPERTIES; TIME FACTORS; VISCOSITY; WATER;

EID: 33746404654     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.03.046     Document Type: Article

References (22)

1. Alex R., and Bodmeier R. Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variable on drug entrapment. J. Microencapsul. 7 (1989) 347-355
2. Amsden B.G., and Goosen M.F.A. An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics. J. Control. Release 43 (1997) 183-196
3. Benoit M.A., Baras B., and Gillard J. Preparation and characterization of protein-loaded poly(ε-caprolactone) microparticles for oral vaccine delivery. Int. J. Pharm. 184 (1999) 73-84
4. Carrasquillo K.G., Stanley A.M., Aponte-Carro J.C., Jesus P.D., Costntito H.R., Bosques C.J., and Griebenow K. Non-aqueous encapsulation of excipient-stabilized spray-freeze dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein. J. Control. Release 76 (2001) 199-208
5. Felder C.H.B., Blanco-Prieto M.J., Heizmann J., Merkle H.P., and Gander B. Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters. J. Microencapsul. 20 (2003) 553-567
6. Freitas S., Merkle H.P., and Gander B. Ultrasonic atomization into reduced pressure atmosphere-envisaging aseptic spray-drying for microencapsulation. J. Control. Release 95 (2004) 185-195
7. Ijseaert J.C., Geerse K.B., Marijnissen J.M., Lammers J.W.J., and Zanen P. Electro-hydrodynamic atomization of drug solutions for inhalation purpose. J. Appl. Physiol. 91 (2001) 2735-2741
8. Kuo S.M., Niu G., Chang S.J., Kuo C.H., and Bair M.S. A one-step method for fabricating chitosan microspheres. J. Appl. Polym. Sci. 94 (2004) 2150-2157
9. Lamprecht A., Ubrich N., Hombreiro Perez M., Lehr C.M., Hoffman M., and Maincent P. Biodegradable monodispersed nanoparticles prepared by pressure homogenization-emulsification. Int. J. Pharm. 184 (1999) 97-105
10. Lamprecht A., Ubrich N., Hombreiro Perez M., Lehr C.M., Hoffman M., and Maincent P. Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int. J. Pharm. 196 (2000) 177-182
11. Langer R. Drug delivery and targeting. Nature 392 (1998) 5-10
12. Loscertales I.G., Barrero A., Guerrero I., Cortijo R., Marques M., and Ganan-Ca;vo A.M. Micro/nano encapsulation via electrified coaxial liquid jets. Science 295 (2002) 1695-1698
13. Ogawa Y., Yamamoto M., Okada H., Yashiki T., and Shimamoto T.A. New technique to efficiently entrap leuprolide acetate in microcapsules of copoly(lactic/glycolic acid). Chem. Pharm. Bull. 36 (1988) 1095-1103
14. Sanders E.H., Kloefkorn R., Bowlin G.L., Simpson D.G., and Wnek G.E. Two-phase electrospinning from a single electrified jet: microencapsulation of aqueous reservoirs in poly(ethylene-co-vinyl acetate) fibers. Macromolecules 36 (2003) 3803-3805
15. Tang K., and Gomez A. Generation by electrospray of monodisperse water droplets for targeted drug delivery by inhalation. J. Aerosol Sci. 25 (1994) 1237-1249
16. Weidenauer U., Bodmer D., and Kissel T. Microencapsulation of hydrophilic drug substance using biodegradable polyesters. Part I. Evaluation of different techniques for the encapsulation of pamidronate di-sodium salt. J. Microencapsul. 20 (2003) 509-524
17. Xu Y.M., and Du Y.M. Effect of the molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int. J. Pharm. 250 (2003) 215-226
18. Xu, Y.X., Skotak, M., Hanna, M.A. Electrospray encapsulation of water-soluble protein with polylactide. I. Effects of formulations and process on morphology and particle size, J. Microencapsul., in press.
19. Yang Y.Y., Chung T.S., Bai X.L., and Chan W.K. Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method. Chem. Eng. Sci. 55 (2000) 2223-2236
20. Yang Y.Y., Chung T.S., and Ng N.P. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation methods. Biomaterials 22 (2001) 231-241
21. Yang Y.Y., Wan J.P., Chung T.S., Pallathadka P.K., Ng S., and Heller J. POE-PEG-POE triblock copolymeric microspheres containing protein. I. Preparation and characterization. J. Control. Release 75 (2001) 115-128
22. Yeo L.Y., Lastochkin D.L., Wang S.C., and Chang H.C. A new ac electrospray mechanism by Maxwell-Wagner polarization and capillary resonance. Phys. Rev. Lett. 92 (2004) 133902 (4)