Release profile and characteristics of electrosprayed particles for oral delivery of a practically insoluble drug

Journal of the Royal Society Interface

Volumn 9, Issue 75, 2012, Pages 2437-2449

  Bohr, Adam ^a,b   Kristensen, Jakob ^b   Dyas, Mark ^b   Edirisinghe, Mohan ^a   Stride, Eleanor ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LifeCycle Pharma   (Denmark)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Celecoxib; Controlled release; Electrospraying; Low solubility; Microspheres; Porosity

Indexed keywords

BIOCHEMISTRY; CHEMICAL PROPERTIES; DISSOLUTION; MICROSPHERES; POROSITY; X RAY POWDER DIFFRACTION;

CELECOXIB; CONTROLLED RELEASE; DISSOLUTION CHAMBERS; DRUG LOADING; ELECTROSPRAYING; INNER STRUCTURE; INSOLUBLE DRUG; INTERNAL POROSITY; ORAL DELIVERY; PARTICLE CHARACTERISTICS; PARTICLE FORMATIONS; PHYSICOCHEMICAL PROPERTY; POLY(LACTIC-CO-GLYCOLIC ACID); PROCESSING PARAMETERS; RELEASE PROFILES; RELEASE RATE; SOLUTE CONCENTRATIONS; SOLVENT CONCENTRATION; SPRAY DRYING PROCESS; UNITED STATES PHARMACOPEIAS;

AGGLOMERATION;

CELECOXIB; MICROSPHERE; POLYGLACTIN; SOLVENT;

ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; ELECTROSPRAY; FLOW RATE; PARTICLE SIZE; POROSITY; SPRAY DRYING; X RAY POWDER DIFFRACTION;

EID: 84866253566     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2012.0166     Document Type: Article

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