Poly-ε-caprolactone microspheres and nanospheres: An overview

International Journal of Pharmaceutics

Volumn 278, Issue 1, 2004, Pages 1-23

  Sinha, V R ^a   Bansal, K ^a   Kaushik, R ^a   Kumria, R ^a   Trehan, A ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Implant; Microsphere; Poly caprolactone

Indexed keywords

ANTIBIOTIC AGENT; ANTIGEN; ANTIHYPERTENSIVE AGENT; BOVINE SERUM ALBUMIN; CELLABURATE; CHLORPROMAZINE; CISPLATIN; COLCHICINE; COPOLYMER; CYCLOSPORIN; DICHLOROMETHANE; DODECYL SULFATE SODIUM; FLUOROURACIL; GENTAMICIN; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; KETOPROFEN; MICROSPHERE; MURAMYL DIPEPTIDE; NANOPARTICLE; NERVE GROWTH FACTOR; PADGEM PROTEIN; POLOXAMER; POLY(METHYL METHACRYLATE); POLYCAPROLACTONE; POLYCARBONATE; POLYGLYCOLIDE; POLYLACTIDE; PROPRANOLOL DERIVATIVE; RIBOZYME; STEROID; UNINDEXED DRUG; CAPROLACTONE; HEXANOIC ACID DERIVATIVE; LACTONE;

ANALYTIC METHOD; ARTHRITIS; BIOCOMPATIBILITY; BIODEGRADATION; BLOOD VESSEL INJURY; BRAIN INJURY; CONTROLLED DRUG RELEASE; DIALYSIS; DISPERSION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; EMULSION; ENCAPSULATION; GLASS TRANSITION TEMPERATURE; HUMAN; IMPLANT; NONHUMAN; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY; SPRAY DRYING; ANIMAL; CHEMISTRY; METHODOLOGY; NANOTECHNOLOGY;

ANIMALS; DRUG DELIVERY SYSTEMS; HEXANOIC ACIDS; HUMANS; LACTONES; MICROSPHERES; NANOTECHNOLOGY;

EID: 2442716075     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.01.044     Document Type: Review

References (108)

1. Aberturas M.R., Molpeceres J., Guzman M., Garcia F. Development of a new cyclosporine formulation based on poly (caprolactone) microspheres. J. Microenacpsul. 19:2002;61-72
2. Alonso M.J., Garcia M.L., Epsina M., Valls O., Egea M.A. Aclofenac-loaded poly-ε-caprolactone nanocapsules. Effects of coadjuvants on morphological properties and drug entrapment. Bollettino Cheimico Farmaceutico. 139:2000;114-119
3. Atkins T.W. Fabrication of microspheres using blends of poly(ethylene adipate) and poly(ethylene adipate)/poly (hydroxybutyrate-hydroxyvalerate) with poly (caprolactone): incorporation and release of bovine serum albumin. J. Biomater. Sci., Polym. Ed. 8:1997;833-845
4. Badri V.N., Thomas P.A., Pandit J.K., Kulkarni M.G., Mashelkar R.A. Preparation of non porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique. J. Control. Rel. 58:1999;9-20
5. Barbato F., Rotonda M.I.L., Maglio G., Palumbo R., Quaglia F. Biodegradable microspheres of novel segmented poly (ether-ester-amide)s based on poly(ε-caprolactone) for the delivery of bioactive compounds. Biomaterials. 22:2001;1371-1378
6. Benoit M.A., Baras B., Gillbard J. Preparation and characterization of protein-loaded poly(ε-caprolactone) microparticles for oral vaccine delivery. Int. J. Pharm. 184:1999;73-84
7. Birrenbach G., Speiser P.P. Polymer micelles and their use as adjutants in immunology. J. Pharm. Sci. 65:1976;1763-1766
8. Bleich J., Muller B.W., Wabmus W. Aerosol solvent extraction system a new microparticle production technique. Int. J. Pharm. 97:1993;111-117
9. Bodmeier R., Chen H. Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoporofen. J. Control. Rel. 7:1989;69-78
10. Bodmeier R., Hui W., David J.D., Simon M., Keith P.J. Polymeric microspheres prepared by spraying into compressed carbon dioxide. Pharm. Res. 12:1995;1211-1217
11. Buntner B., Nowak M., Bero M., Dobrzynski P., Kasperczyk J. Controlled release of 17β-estradiol from D, L-lactide/ε-caprolactone copolymers. J. Bioact. Compat. Polym. 11:1996;110-116
12. Buntner B., Nowak M., Kasperczyk U.J., Ryba M., Grieb P., Walski M., Dobrzynski P., Bero M. The application of microspheres from the copolymers of lactide and caprolactone to the controlled release of steroids. J. Control Rel. 56:1998;159-167
13. Calvo P., Alonso M.J., Vila-Jato J.L., Robinson J.R. Improved ocular bioavailability of Indomethacin by novel ocular drug carriers. J. Pharm. Pharmacol. 48:1996a;1147-1152
14. Calvo P., Vila-Jato J.L., Alonso M.J. Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules and nanoemulsions, as ocular drug carriers. J. Pharm. Sci. 85:1996b;530-536
15. Calvo P., Sanchez A., Martinez J., Lopez M.I., Calonge M., Pastor J.C., Alonso M.J. Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A. Pharm. Res. 13:1996c;1423
16. Calvo P., Vila-Jato J.L., Alonso M.J. Effect of lysozyme on the stability of polyester nanocapsules and nanoparticles: stabilization approaches. Biomaterials. 18:1997;1305-1310
17. Cao X., Shoichet M.S. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous disorders. Biomaterials. 20:1999;329-339
18. Cauchetier E., Deniau M., Fessi H., Astier A., Paul M. Atovaquone-loaded nanocapsules: influence of the nature of the polymer on their in vitro characteristics. Int. J. Pharm. 250:2003;273-281
19. Cha Y., Pitt C.G. A one week subdermal delivery system for L-methadone based on biodegradable microcapsules. J. Control. Rel. 7:1988;69-78
20. Chandy T., Wilson R.F., Rao Gundu H.R., Das G. Changes in cisplatin delivery due to surface-coated poly (lactic acid)-poly(epsilon-caprolactone) microspheres. J. Biomater. Appl. 16:2002;275-291
21. Chang R.K., Price J.C., Whitworth C.W. Dissolution characteristics of poly (ε-carolactone)-polylactide microspheres of chlorpromazine. Drug Dev. Ind. Pharm. 12:1986;2355-2380
22. Chang R.K., Price J.C., Whitworth C.W. Control of drug release rate by use of mixtures of poly (ε-caprolactone) and cellulose acetate butyrate polymers. Drug Dev. Ind. Pharm. 13:1987a;1119-1135
23. Chang R.K., Price J.C., Whitworth C.W. Enhancement of dissolution rate by incorporation into a water insoluble polymer, poly (ε-caprolactone). Drug Dev. Ind. Pharm. 13:1987b;249-256
24. Chawla J.S., Amiji M.M. Biodegradable poly(epsilon-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen. Int. J. Pharm. 249:2002;127-138
25. Chen D., Chen H., Bei J., Wang S. Morphology and biodegradation of microspheres of polyester-polyether block copolymer based on polycaprolactone/polylactide/poly(ethylene oxide). Polym. Int. 49:2000;269-276
26. Couvreur, P., Roland, M., Speiser, P., 1982. Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them. U.S. Patent 4,329,332.
27. Das G.S., Rao G.H., Wilson R.F., Chandy T. Colchicine encapsulation within poly (ethylene glycol)-coated poly (lactic acid)/poly (epsilon-caprolactone) microspheres-controlled release studies. Drug. Deliv.7:2000;129-138
28. de Chasteigner S., Cave G., Fessi H., Devissaguet J.P., Puisieux F. Freeze drying of itraconazole loaded nanosphere suspensions: feasibility study. Drug Dev. Res. 38:1996;116-124
29. Dickerson J.B., Blackwell J.E., Ou J.J., Patil V.R.S., Goetz D.J. Limited adhesion of biodegradable microspheres to E- and P-selectin under flow. Biotehnol. Bioeng. 73:2001;500-509
30. Donnelly E.F., Jonston D.S., Peffer D.C., Dunn D.J. Ionic and zwiterionic polymerization of n-alkyl 2-cyanoacrylates. Polym. Lett. Ed. 15:1977;399
31. Dordunoo S.K., Jackson J.K., Arsenault L.A., Oktaba A.M., Hunter W.L., Burt H.M. Taxol encapsulation in poly (epsilon-caprolactone) microspheres. Cancer Chemother. Pharmacol. 36:1995;279-282
32. Dubernet C., Benoit J.P., Couarraze G., Duchene D. Microencapsulation of nitrofurantoin in poly (ε-caprolactone): tabletting and in vitro release studies. Int. J. Pharm. 35:1987;145-156
33. Ekholm M., Hietanen J., Lindqvist C., Rautavuori J., Santavirta S., Suuronen R. Histological study of tissue reaction to ε-caprolactone-lactide copolymer in paste form. Biomaterials. 20:1999;1257-1262
34. Espuelas M.S., Legrand P., Iranche J.M., Gamazo C., Orecchioni A.M., Devissaguet J.P., Ygartua P. Poly(ε-caprolactone) nanospheres as an alternative way to reduce amphotericin B toxicity. Int. J. Pharm. 158:1997;19-27
35. Espuelas M.S., Legrand P., Cheron M., Barrat G., Puisieux F., Renedo M.J., Devissaguet J.P., Iranche J.M. Interaction of Amphotericin B with polymeric colloids: 2. Effect of Poloxamer on the adsorption of amphotericin B onto poly(ε-caprolactone) nanospheres. Colloids Surf., B: Biointerf. 11:1998;203-212
36. Espuelas M.S., Legrand P., Loiseau P.M., Bories C., Barratt G., Irache J.M. In vitro antileishmanial activity of amphotericin B loaded in poly(epsilon-caprolactone) nanospheres. J. Drug Target. 10:2002;593-599
37. Ferranti Y., Maochais H., Chabenat C., Orecchioni A.M., Lafont O. Primidone-loaded poly (ε-caprolactone) nanocapsules: incorporation efficiency and in vitro release profile. Int. J. Pharm. 193:1999;107-111
38. Fessi H., Puisieux F., Devissaguet J.Ph., Ammoury N., Benita S. Nanocapsule formation by interfacial polymer disposition following solvent displacement. Int. J. Pharm. 55:1989;R1-R4
39. Gadzinowski M., Slomkowski S., Elaissari A., Pichot C. Phase transfer and characterization of poly (ε-caprolactone) and poly(L-lactide) microspheres. J. Biomater. Sci., Polym. Ed. 11:2000;459-480
40. Gamisans F., Lacoulonche F., Chauvet A., Espina M., Garcia M.L., Egea M.A. Flurbiprofen loaded nanospheres: analysis of the matrix structure by thermal methods. Int. J. Pharm. 179:1999;37-48
41. Gamisans F., Egea M.A., Garcia M.L. Flurbiprofen loaded poly-ε-caprolactone nanospheres: an in vitro release study performed under several conditions. J. Control. Rel. 64:2000;315-319
42. Ghaderi R., Artursson P., Carlfors J. Preparation of biodegradable microparticles using solution-enhanced dispersion by supercritical fluids (SEDS). Pharm. Res. 16:1999;676-681
43. Gibaud S., Bonneville A., Astier A. Preparation of 3, 4-diaminopyridine microparticles by solvent-evaporation methods. Int. J. Pharm. 242:2002;197-201
44. Giunchedi P., Conti B., Maggi L., Conte U. Cellulose acetate butyrate and polycaprolactone for ketoproton spray-dried microsphere preparation. J. Microencapsul. 11:1994;381-393
45. Gref R., Minamitake Y., Peracchia M.T., Trubetskoy V., Torchilin V., Langer R. Biodegradable long-circulating polymeric nanospheres. Science. 263:1994;1600-1603
46. Gref R., Luck M., Quellec P., Marchand M., Dellacherie E., Harnisch S., Blunk T., Muller R.H. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf. Biointerf. 18:2000;301-313
47. Guerra G.D., Tricoli M., Maltinti S. Release of 5- FU by biodegradable poly-(ester-ether-ester)s. Part 1. release by fused thin sheets. J. Mater. Sci: Mater. Med. 12:2001;313-317
48. Guterres S.S., Muller C.R., Michalowski C.B., Pohlmann A.R., Dalla Costa T. Gastrointestinal tolerance following oral administration of spray dried diclofenac loaded nanocapsules and nanospheres. S.T.P. Pharm. Sci. 11:2001;229-233
49. Guzman M., Molpeceres J., Aberturas M.R., Rodriguez M. Formation and characterization of cyclosporin loaded nanoparticles. J. Pharm. Sci. 82:1993;498-502
50. Guzman M., Molpeceres J., Garcia F., Aberturas M.R. Preparation, characterization and in vitro drug release of poly-epsilon-caprolactone and hydroxypropyl methylcellulose phthalate ketoprofen loaded microspheres. J. Microencapsul. 13:1996;25-39
51. Guzman M., Aberturas M.R., Rodriguez-Puyol M., Molpeceres J. Effect of nanoparticles on digitoxin uptake and pharmacologic activity in rat glomerular mesangial cell cultures. Drug Deliv. 7:2000;215-222
52. Huatan H., Collett J.H., Attwood D. The microencapsulation of protein using a novel ternary blend based on poly (ε-caprolactone). J. Microencapsul. 12:1995;557-565
53. Iooss P., Le Ray A.M., Grimandi G., Daculsi G., Merle C. A new injectable bone substitute combining poly(epsilon-caprolactone) microparticles with biphasic calcium phosphate granules. Biomaterials. 22:2001;2785-2794
54. Jackson J.K., Springate C.M.K., Hunter W.L., Burt H.M. Neutrophil activation by plasma opsonization polymeric microspheres: inhibitory effect of pluronic. Biomaterials. 21:2000;1483-1491
55. Jackson J.K., Liang L.S., Hunter W.L., Reynolds M., Sandberg J.A., Springate C., Burt H.M. The encapsulation of ribozymes in biodegradable polymeric matrices. Int. J. Pharm. 243:2002;43-55
56. Jameela S.R., Suma N., Misra A., Raghuvanshi R., Ganga S., Jayakrishnan A. Poly (ε-Caprolactone) microspheres as a vaccine carrier. Curr. Sci. 70:1996;669-671
57. Jameela S.R., Suma N., Jayakrishana A. Protein release from poly (epsilon-caprolactone) microspheres prepared by melt encapsulation and solvent evaporation techniques: a comparative study. J. Biomater. Sci Polym. 8:1997;457-466
58. Jiao Y.Y., Ubrich N., Hoffart V., Marchand-Arvier M., Vigneron C., Hoffman M., Maincent P. Preparation and characterization of heparin-loaded polymeric microparticles. Drug Dev. Ind. Pharm. 28:2002;1033-1041
59. Kim S.Y., Ha J.C., Lee Y.M. Poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide)/poly (ε-caprolactone) amphiphillic block copolymeric nanospheres, thermo responsive drug release behaviors. J. Control. Rel. 65:2000;345-348
60. Kim S.Y., Lee Y.M. Taxol-loaded block copolymer nanospheres composed of methoxy poly(ethylene glycol) and poly (epsilon-caprolactone) as novel anticancer drug carriers. Biomaterials. 22:2001;1697-1704
61. Kim S.Y., Lee Y.M., Shin H.J., Kang J.S. Indomethacin-loaded methoxypoly (ethylene glycol)/ poly(ε-caprolactone) diblock copolymer nanospheres: pharmacokinetic characterstics of indimethacin in normal Sprague Dawley rats. Biomaterials. 22:2001;2049-2056
62. Koleske, J.V., 1978. Blends containing poly(ε-caprolactone) and related polymers. In: Paul, D.R., Newman, S. (Eds.), Polymer Blends, vol. 2. Academic Press, New York, pp. 369-389.
63. Kreuter J. Nanoparticle-based drug delivery systems. J. Control. Rel. 16:1991;169-178
64. Lacoulonche F., Gamisans F., Chauvet A., Garcia M.L., Epsina M., Egea M.A. Stability and in vitro drug release of Flurbiprofen loaded poly (ε-caprolactone) nanospheres. Drug Dev. Ind. Pharm. 25:1999;983-993
65. Lamprecht A., Ubrich N., Hombreiro Perez M., Lehr C., Hoffman M., Maincent P. Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int. J. Pharm. 196:2000;177-182
66. Leroueil-Le Verger M., Fluckiger L., Kim Y.I., Hoffman M., Maincent P. Preparation and characterization of nanoparticles containing an antihypertensive agent. Eur. J. Pharm. Biopharm. 46:1998;137-143
67. Le Roy Boehm A.L., Zerrouk R., Fessi H. Poly epsilon-caprolactone nanoparticles containing a poorly soluble pesticide: formulation and stability study. J. Microencapsul. 17:2000;195-205
68. Limin M., Yuzhin Z.Q.L., Zhongwel G. Study on preparation and pharmacodynamics of insulin-loaded polyester microparticles. Yaoxue Xuebao. 35:2000;850-853
69. Lin W.J., Flanagan D.R., Linchardt R.J. A novel fabrication of poly (ε-caprolactone) microspheres from blends of poly (ε-caprolactone) and poly(ethylene glycol). Polymer. 40:1998;1731-1735
70. Lin W.J., Huang L.I., Chang R.R. Characterization of protein-loaded poly(epsilon-caprolactone) microparticles based on a factorial design. J. Microencapsul. 18:2001;183-189
71. Lin W.J., Huang L.I. Influence of pluronics on protein-loaded poly(epsilon-caprolactone) microparticles. J. Microencapsul. 18:2001a;191-197
72. Lin W.J., Huang L.I. Fabrication of porous poly(epsilon-caprolactone) microparticles for protein release. J. Microencapsul. 18:2001b;577-584
73. Lin W.J., Yu C.C. Comparison of protein loaded poly(epsilon-caprolactone) microparticles prepared by the hot-melt technique. J. Microencapsul. 18:2001;585-592
74. Losa C., Alonso M.J., Vila J.L., Orallo F., Martinez J., Saavedra J.A., Pastor J.C. Reduction of cardiovascular side effects associated with ocular administration of metipranolol by inclusion in polymeric nanocapsules. J. Ocul. Pharmacol. 8:1992;191-198
75. Losa C., Marchal-Heussler L., Orallo F., Vila Jato J.L., Alonso M.J. Design of new formulations for topical ocular administration: polymeric nanocapsules containing metipranolol. Pharm. Res. 10:1993;80-87
76. Lu Z., Bei J., Wang S. A method for the preparation of polymeric nanocapsules without stabilizer. J. Control Rel. 61:1999;107-112
77. Luo Q., Chen J., Dai K. Study on the cytocompatibility of biodegradable poly(epsilon-caprolactone) microspheres in vitro. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 20:2003;14-16
78. Marchal-Heussler L., Sirbat D., Hoffman M., Maincent P. Poly(epsilon-capralactone) nanocapsule in cartelol ophthalmic delivery. Pharm Res. 10:1993;386-390
79. Martini L.G., Collett J.H., Attwood D. The release of 5-FU from microspheres of poly (ε-caprolactone-co-ethyleneoxide). Drug. Dev. Ind. Pharm. 26:2000;7-12
80. Marty J.J., Oppenheim R.G., Speiser P.P. Nanoparticles - a new colloidal drug delivery systems. Pharm. Acta. Helv. 53:1978;17
81. Mathiowitz E., Langer R. Poly anhydride microspheres as drug carrier, hot melt encapsulation. J. Control. Rel. 5:1987;13
82. Menci P., Crouc A., Daniel V., Pouplard B.A., Benoit J.P. Fate and biocompatibility of three types of microspheres implanted into brain. J. Biomed. Mater. Res. 28:1994;1079-1085
83. Molpeceres J., Chacon M., Guzman M., Berges L., del Rosario Aberturas M. A polycaprolactone nanoparticle formulation of cyclosporin A improves the prediction of area under the curve using a limited sampling strategy. Int. J. Pharm. 187:1999;101-113
84. Molpeceres J., Aberturas M.R., Guzman M. Biodegradable nanoparticles as a delivery system for cyclosporine: preparation and characterization. J. Microencapsul. 17:2000;599-614
85. Muller C.R., Schaffazick S.R., Pohlmann A.R., DeLucca F.L., Pesce Da Silveira N., Dalla Costa T., Guterres S.S. Spray-dried diclofenac-loaded poly(ε-caprolactone) nanocapsules and nanospheres. Preparation and physicochemical characterization. Pharmazie. 56:2001;864-867
86. Murillo M., Gamazo C., Goni M., Irache J., Blanco-Prieto M. Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis. Int. J. Pharm. 242:2002;341-344
87. Murthy, R.S.R., 1997. Biodegradable polymers. In: Jain, N.K. (Eds.), Controlled and Novel Drug Delivery. CBS Publisher, New Delhi, pp. 27-51.
88. Nakamura T., Shimizu Y., Matsui T., Okumura N., Hyon S.H., Nishiya K. A novel bioabsorbable monofilament surgical suture made from PCL, L-lactide copolymer. Degrad. Phenom. Polym. Biomater. 45:1992;153-162
89. Perez M.H., Zinutti C., Lamprecht A., Ubrich N., Astier A., Hoffman M., Bodmeier R., Maincent P. The preparation and evaluation of poly(ε- caprolactone) microsparticles containing both lipophillic and hydrophilic drug. J. Control. Rel. 65:2000;429-438
90. Phillips E.M., Stella V.J. Rapid expansion from supercritical solutions: application to pharmaceutical processes. Int. J. Pharm. 94:1993;1-10
91. Pitt C.G., Gratzl M.M., Kimmel G.L., Surles J., Schindler A. Aliphatic polyesters II. The degradation of poly (D, L-lactide), poly(ε- caplrolactone) and their copolymers in vivo. Biomaterials. 2:1981;215
92. Pitt, C.G., 1990. Poly (ε-caprolactone) and its co-polymers. In: Chasin, M., Langer, R. (Eds.), Biodegradable Polymers as Drug Delivery Systems. Marcel Decker, New York, pp. 71-120.
93. Rollot J.M., Couvreur P., Robolt- Treupel L., Puisieux F. Physicochemical and morphological characterization of polyisobutylcyanoacrylate nanocapsules. J. Pharm. Sci. 75:1986;361-364
94. Ryu J., Jeong Y.I., Kim I.S., Lee J.H., Nah J.W., Kim S.H. Clonazepam release from core-shell type nanoparticles of poly(epsilon-caprolactone)/ poly(ethylene glycol)/poly(epsilon-caprolactone) triblock copolymers. Int. J. Pharm. 200:2000;231-242
95. Saez A., Guzman M., Molpeceres J., Aberturas M.R. Freeze drying of polycaprolactone and poly(D, L-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs. Eur. J. Pharm. Biopharm. 50:2000;379-387
96. Sah H.K., Toddywala R., Chien Y.W. Biodegradable microcapsules prepared by a w/o/w technique: effects of shear force to make a primary w/o emulsion on their morphology and protein release. J. Microencapsul. 12:1995;59-69
97. Shenoy D.B., D'Souza R.J., Tiwari S.B., Udupa N. Potential applications of polymeric microsphere suspension as subcutaneous depot for insulin. Drug Dev. Ind. Pharm. 29:2003;555-563
98. Sondhof A.F., Mallapragada S., Booth L.C., Heath C., Rosenbusch R., Apley M., Hsu W. Polylactic acid (biodegradable) microspheres for sustained antimicrobial drug release in the equine joint: preliminary in vivo results. Int. J. Symp. Control. Rel. Bioact. Mater. 25:1998;651-652
99. Speiser, P., 1979. In: Neubreger, A., Tatum, E.L. (Eds.), Frontiers of Biology. Elsevier/North Holland Biomedical Press, New York, vol. 6, p. 653.
100. Tang L., Lucas A.H., Eaton J.W. Inflammatory responses to implanted polymeric biomaterials: role of surface-adsorbed-immunoglobulin G. J. Lab. Clin. Med. 122:1993;292-300
101. Thombre, A.G., Cardinal, J.R., 1990. Biopolymers for controlled drug delivery. In: Swarbick, J., Boylan, J.C. (Eds.), Encyclopedia of Pharmaceutical Technology, vol. 2. Marcel Dekker, New York, pp. 61-88.
102. Tarvainen T., Karjalainen T., Malin M., Perakorpi K., Tuominen J., Seppala J., Jarvinen K. Drug release profiles from and degradation of a novel biodegradable polymer, 2, 2-bis(2-oxazoline) linked poly(epsilon-caprolactone). Eur. J. Pharm. Sci. 16:2002;323-331
103. Tarvainen T., Malin M., Suutari T., Pollanen M., Tuominen J., Seppala J., Jarvinen K. Pancreatin enhanced erosion of and macromolecule release from 2, 2-bis (2-oxazoline)-linked poly(epsilon-caprolactone). J. Control. Rel. 86:2003;213-222
104. Van Natta F.J., Hill J.W., Carruthers W.H. Polymerization and ring formation, ε-caprolactone and its polymers. J. Am. Chem. Soc. 56:1934;455-459
105. Varela M.C., Guzman M., Molpeceres J., del Rosario Aberturas M., Rodriguez-Puyol D., Rodriguez-Puyol M. Cyclosporine loaded polycaprolactone nanoparticles: immunosuppression and nephrotoxicity in rats. Eur. J. Pharm. Sci. 12:2001;471-478
106. Yang Y.Y., Chung T.S., Ping Ng N. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials. 22:2001;231-241
107. Youan B.B.C., Benoit M.A., Baras B., Gillbard J. Protein-loaded poly(ε-caprolactone) microparticles, optimization of the preparation by (water-in-oil) in-water emulsion solvent evaporation. J. Microencapsul. 16:1999a;587-599
108. Youan B.B.C., Benoit M.A., Rollmann B., Riveau G., Gillard J. Protein-loaded poly (ε-caprolactone) microparticles. II. Muramyl dipeptide for oral controlled release of adjuvant. J. Microencapsul. 16:1999b;601-612