메뉴 건너뛰기




Volumn 8, Issue 1, 2013, Pages

IRGM Variants and Susceptibility to Inflammatory Bowel Disease in the German Population

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; GENOMIC DNA; INTERLEUKIN 23 RECEPTOR;

EID: 84872862285     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054338     Document Type: Article
Times cited : (59)

References (47)
  • 1
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor B, Gardet A, Xavier RJ, (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474: 307-317.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 2
    • 67650224449 scopus 로고    scopus 로고
    • Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    • Brand S, (2009) Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 58: 1152-1167.
    • (2009) Gut , vol.58 , pp. 1152-1167
    • Brand, S.1
  • 3
    • 80455140368 scopus 로고    scopus 로고
    • Ulcerative colitis
    • Danese S, Fiocchi C, (2011) Ulcerative colitis. N Engl J Med 365: 1713-1725.
    • (2011) N Engl J Med , vol.365 , pp. 1713-1725
    • Danese, S.1    Fiocchi, C.2
  • 4
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Abraham C, Cho JH, (2009) Inflammatory bowel disease. N Engl J Med 361: 2066-2078.
    • (2009) N Engl J Med , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 5
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42: 1118-1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5
  • 6
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, et al. (2011) Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43: 246-252.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3    Franke, A.4    D'Amato, M.5
  • 7
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, et al. (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40: 955-962.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3    Cho, J.H.4    Duerr, R.H.5
  • 8
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314: 1461-1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5
  • 9
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, et al. (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39: 207-211.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3    Till, A.4    Teuber, M.5
  • 10
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, et al. (2007) Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39: 596-604.
    • (2007) Nat Genet , vol.39 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3    Silverberg, M.S.4    Goyette, P.5
  • 11
    • 40949112379 scopus 로고    scopus 로고
    • The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
    • Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, et al. (2008) The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am J Gastroenterol 103: 682-691.
    • (2008) Am J Gastroenterol , vol.103 , pp. 682-691
    • Glas, J.1    Konrad, A.2    Schmechel, S.3    Dambacher, J.4    Seiderer, J.5
  • 12
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, et al. (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39: 830-832.
    • (2007) Nat Genet , vol.39 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3    Tremelling, M.4    Anderson, C.A.5
  • 13
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • WTCC Consortium
    • WTCC Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 14
    • 66749106217 scopus 로고    scopus 로고
    • Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach
    • Palomino-Morales RJ, Oliver J, Gomez-Garcia M, Lopez-Nevot MA, Rodrigo L, et al. (2009) Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach. Genes Immun 10: 356-364.
    • (2009) Genes Immun , vol.10 , pp. 356-364
    • Palomino-Morales, R.J.1    Oliver, J.2    Gomez-Garcia, M.3    Lopez-Nevot, M.A.4    Rodrigo, L.5
  • 15
    • 62049085384 scopus 로고    scopus 로고
    • Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
    • Weersma RK, Stokkers PC, Cleynen I, Wolfkamp SC, Henckaerts L, et al. (2009) Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol 104: 630-638.
    • (2009) Am J Gastroenterol , vol.104 , pp. 630-638
    • Weersma, R.K.1    Stokkers, P.C.2    Cleynen, I.3    Wolfkamp, S.C.4    Henckaerts, L.5
  • 17
    • 67349233285 scopus 로고    scopus 로고
    • Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children
    • Amre DK, Mack DR, Morgan K, Krupoves A, Costea I, et al. (2009) Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm Bowel Dis 15: 501-507.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 501-507
    • Amre, D.K.1    Mack, D.R.2    Morgan, K.3    Krupoves, A.4    Costea, I.5
  • 18
    • 51249103405 scopus 로고    scopus 로고
    • Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort
    • Roberts RL, Hollis-Moffatt JE, Gearry RB, Kennedy MA, Barclay ML, et al. (2008) Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes Immun 9: 561-565.
    • (2008) Genes Immun , vol.9 , pp. 561-565
    • Roberts, R.L.1    Hollis-Moffatt, J.E.2    Gearry, R.B.3    Kennedy, M.A.4    Barclay, M.L.5
  • 19
    • 44349136821 scopus 로고    scopus 로고
    • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    • Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, et al. (2008) Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet 40: 710-712.
    • (2008) Nat Genet , vol.40 , pp. 710-712
    • Fisher, S.A.1    Tremelling, M.2    Anderson, C.A.3    Gwilliam, R.4    Bumpstead, S.5
  • 20
    • 77952515610 scopus 로고    scopus 로고
    • Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
    • Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, et al. (2010) Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Hum Mol Genet 19: 1828-1839.
    • (2010) Hum Mol Genet , vol.19 , pp. 1828-1839
    • Prescott, N.J.1    Dominy, K.M.2    Kubo, M.3    Lewis, C.M.4    Fisher, S.A.5
  • 21
    • 79952134938 scopus 로고    scopus 로고
    • A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
    • Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, et al. (2011) A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet 43: 242-245.
    • (2011) Nat Genet , vol.43 , pp. 242-245
    • Brest, P.1    Lapaquette, P.2    Souidi, M.3    Lebrigand, K.4    Cesaro, A.5
  • 22
    • 50449091647 scopus 로고    scopus 로고
    • Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    • McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, et al. (2008) Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 40: 1107-1112.
    • (2008) Nat Genet , vol.40 , pp. 1107-1112
    • McCarroll, S.A.1    Huett, A.2    Kuballa, P.3    Chilewski, S.D.4    Landry, A.5
  • 23
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh SB, Davis AS, Taylor GA, Deretic V, (2006) Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313: 1438-1441.
    • (2006) Science , vol.313 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 24
    • 77649194674 scopus 로고    scopus 로고
    • Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly
    • Lapaquette P, Glasser AL, Huett A, Xavier RJ, Darfeuille-Michaud A, (2010) Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 12: 99-113.
    • (2010) Cell Microbiol , vol.12 , pp. 99-113
    • Lapaquette, P.1    Glasser, A.L.2    Huett, A.3    Xavier, R.J.4    Darfeuille-Michaud, A.5
  • 25
    • 0024810567 scopus 로고
    • Classification of inflammatory bowel disease
    • Lennard-Jones JE, (1989) Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 170: 2-6 discussion 16-19.
    • (1989) Scand J Gastroenterol , Issue.SUPPL. 170 , pp. 2-6
    • Lennard-Jones, J.E.1
  • 26
    • 84894353884 scopus 로고    scopus 로고
    • Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    • Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, et al. (2005) Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 19 Suppl A: 5-36.
    • (2005) Can J Gastroenterol , vol.19 , Issue.SUPPL. , pp. 5-36
    • Silverberg, M.S.1    Satsangi, J.2    Ahmad, T.3    Arnott, I.D.4    Bernstein, C.N.5
  • 28
    • 77956407594 scopus 로고    scopus 로고
    • Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset
    • Glas J, Seiderer J, Nagy M, Fries C, Beigel F, et al. (2010) Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. PLoS One 5: e10373.
    • (2010) PLoS One , vol.5
    • Glas, J.1    Seiderer, J.2    Nagy, M.3    Fries, C.4    Beigel, F.5
  • 29
    • 61949327205 scopus 로고    scopus 로고
    • rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
    • Glas J, Seiderer J, Pasciuto G, Tillack C, Diegelmann J, et al. (2009) rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. Am J Gastroenterol 104: 665-672.
    • (2009) Am J Gastroenterol , vol.104 , pp. 665-672
    • Glas, J.1    Seiderer, J.2    Pasciuto, G.3    Tillack, C.4    Diegelmann, J.5
  • 30
    • 80051516622 scopus 로고    scopus 로고
    • Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease
    • Glas J, Seiderer J, Fischer D, Tengler B, Pfennig S, et al. (2011) Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease. Inflamm Bowel Dis 17: 1917-1924.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1917-1924
    • Glas, J.1    Seiderer, J.2    Fischer, D.3    Tengler, B.4    Pfennig, S.5
  • 31
    • 67650421536 scopus 로고    scopus 로고
    • Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease
    • Glas J, Stallhofer J, Ripke S, Wetzke M, Pfennig S, et al. (2009) Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease. Am J Gastroenterol 104: 1737-1744.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1737-1744
    • Glas, J.1    Stallhofer, J.2    Ripke, S.3    Wetzke, M.4    Pfennig, S.5
  • 32
    • 33751561942 scopus 로고    scopus 로고
    • Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study
    • Seiderer J, Brand S, Herrmann KA, Schnitzler F, Hatz R, et al. (2006) Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study. Inflamm Bowel Dis 12: 1114-1121.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1114-1121
    • Seiderer, J.1    Brand, S.2    Herrmann, K.A.3    Schnitzler, F.4    Hatz, R.5
  • 33
    • 33748654515 scopus 로고    scopus 로고
    • Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis
    • Seiderer J, Schnitzler F, Brand S, Staudinger T, Pfennig S, et al. (2006) Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis. Scand J Gastroenterol 41: 1421-1432.
    • (2006) Scand J Gastroenterol , vol.41 , pp. 1421-1432
    • Seiderer, J.1    Schnitzler, F.2    Brand, S.3    Staudinger, T.4    Pfennig, S.5
  • 34
    • 78651239059 scopus 로고    scopus 로고
    • The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
    • Glas J, Seiderer J, Tillack C, Pfennig S, Beigel F, et al. (2010) The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants. PLoS One 5: e14466.
    • (2010) PLoS One , vol.5
    • Glas, J.1    Seiderer, J.2    Tillack, C.3    Pfennig, S.4    Beigel, F.5
  • 35
    • 39649106413 scopus 로고    scopus 로고
    • rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants
    • Glas J, Seiderer J, Wetzke M, Konrad A, Torok HP, et al. (2007) rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. PLoS One 2: e819.
    • (2007) PLoS One , vol.2
    • Glas, J.1    Seiderer, J.2    Wetzke, M.3    Konrad, A.4    Torok, H.P.5
  • 36
    • 77955426386 scopus 로고    scopus 로고
    • Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis
    • Jurgens M, Laubender RP, Hartl F, Weidinger M, Seiderer J, et al. (2010) Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis. Am J Gastroenterol 105: 1811-1819.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1811-1819
    • Jurgens, M.1    Laubender, R.P.2    Hartl, F.3    Weidinger, M.4    Seiderer, J.5
  • 37
    • 58149464668 scopus 로고    scopus 로고
    • On the level: IRGM gene function is all about expression
    • Huett A, McCarroll SA, Daly MJ, Xavier RJ, (2009) On the level: IRGM gene function is all about expression. Autophagy 5: 96-99.
    • (2009) Autophagy , vol.5 , pp. 96-99
    • Huett, A.1    McCarroll, S.A.2    Daly, M.J.3    Xavier, R.J.4
  • 38
    • 79251634077 scopus 로고    scopus 로고
    • Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans
    • King KY, Lew JD, Ha NP, Lin JS, Ma X, et al. (2011) Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS One 6: e16317.
    • (2011) PLoS One , vol.6
    • King, K.Y.1    Lew, J.D.2    Ha, N.P.3    Lin, J.S.4    Ma, X.5
  • 39
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, et al. (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491: 119-124.
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3    Duerr, R.H.4    McGovern, D.P.5
  • 40
    • 60749133895 scopus 로고    scopus 로고
    • Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease
    • Latiano A, Palmieri O, Cucchiara S, Castro M, D'Inca R, et al. (2009) Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease. Am J Gastroenterol 104: 110-116.
    • (2009) Am J Gastroenterol , vol.104 , pp. 110-116
    • Latiano, A.1    Palmieri, O.2    Cucchiara, S.3    Castro, M.4    D'Inca, R.5
  • 41
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, Baker J, Brain O, Danis B, Pichulik T, et al. (2010) NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16: 90-97.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3    Danis, B.4    Pichulik, T.5
  • 42
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, et al. (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11: 55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3    Hussey, S.4    Kim, Y.G.5
  • 43
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, et al. (2008) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134: 743-756.
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1    Lee, A.H.2    Franke, A.3    Glickman, J.N.4    Zeissig, S.5
  • 44
    • 77950298959 scopus 로고    scopus 로고
    • Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    • McGovern DP, Gardet A, Torkvist L, Goyette P, Essers J, et al. (2010) Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 42: 332-337.
    • (2010) Nat Genet , vol.42 , pp. 332-337
    • McGovern, D.P.1    Gardet, A.2    Torkvist, L.3    Goyette, P.4    Essers, J.5
  • 45
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, et al. (2008) A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456: 259-263.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3    Miyoshi, H.4    Loh, J.5
  • 46
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, et al. (2004) NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53: 1658-1664.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3    Schwab, M.4    Schaffeler, E.5
  • 47
    • 82255179222 scopus 로고    scopus 로고
    • Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
    • Zhang F, Liu H, Chen S, Low H, Sun L, et al. (2011) Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet 43: 1247-1251.
    • (2011) Nat Genet , vol.43 , pp. 1247-1251
    • Zhang, F.1    Liu, H.2    Chen, S.3    Low, H.4    Sun, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.