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Volumn 5, Issue 12, 2010, Pages

The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common crohn's disease susceptibility gene variants

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; GENOMIC DNA; NOD2 PROTEIN, HUMAN;

EID: 78651239059     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014466     Document Type: Article
Times cited : (30)

References (46)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448: 427-434.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 2
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK (2002) Inflammatory bowel disease. N Engl J Med 347: 417-429.
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 3
    • 30344445931 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities
    • Hanauer SB (2006) Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis 12 Suppl 1: S3-9.
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.SUPPL 1
    • Hanauer, S.B.1
  • 4
    • 67650224449 scopus 로고    scopus 로고
    • Crohn's disease: Th1, Th17 or both? The change of a paradigm: New immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    • Brand S (2009) Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 58: 1152-1167.
    • (2009) Gut , vol.58 , pp. 1152-1167
    • Brand, S.1
  • 5
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3    Lesage, S.4    Cezard, J.P.5
  • 6
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5
  • 7
    • 33748999808 scopus 로고    scopus 로고
    • CARD15/NOD2 mutations in Crohn's disease
    • Hugot JP (2006) CARD15/NOD2 mutations in Crohn's disease. Ann N Y Acad Sci 1072: 9-18.
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 9-18
    • Hugot, J.P.1
  • 8
    • 26844557333 scopus 로고    scopus 로고
    • Nod2 in normal and abnormal intestinal immune function
    • Abreu MT (2005) Nod2 in normal and abnormal intestinal immune function. Gastroenterology 129: 1302-1304.
    • (2005) Gastroenterology , vol.129 , pp. 1302-1304
    • Abreu, M.T.1
  • 9
    • 33750532088 scopus 로고    scopus 로고
    • Recent understanding of IBD pathogenesis: Implications for future therapies
    • Kucharzik T, Maaser C, Lugering A, Kagnoff M, Mayer L, et al. (2006) Recent understanding of IBD pathogenesis: implications for future therapies. Inflamm Bowel Dis 12: 1068-1083.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1068-1083
    • Kucharzik, T.1    Maaser, C.2    Lugering, A.3    Kagnoff, M.4    Mayer, L.5
  • 10
    • 34447617459 scopus 로고    scopus 로고
    • Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease
    • Leon F, Smythies LE, Smith PD, Kelsall BL (2006) Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease. Adv Exp Med Biol 579: 117-132.
    • (2006) Adv Exp Med Biol , vol.579 , pp. 117-132
    • Leon, F.1    Smythies, L.E.2    Smith, P.D.3    Kelsall, B.L.4
  • 11
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314: 1461-1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5
  • 12
    • 39649106413 scopus 로고    scopus 로고
    • rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: Combined analysis of IL23R, CARD15, and OCTN1/2 variants
    • Glas J, Seiderer J, Wetzke M, Konrad A, Torok HP, et al. (2007) rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. PLoS ONE 2: e819.
    • (2007) PLoS ONE , vol.2
    • Glas, J.1    Seiderer, J.2    Wetzke, M.3    Konrad, A.4    Torok, H.P.5
  • 13
    • 21344449654 scopus 로고    scopus 로고
    • Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease
    • Torok HP, Glas J, Tonenchi L, Lohse P, Muller-Myhsok B, et al. (2005) Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease. Gut 54: 1421-1427.
    • (2005) Gut , vol.54 , pp. 1421-1427
    • Torok, H.P.1    Glas, J.2    Tonenchi, L.3    Lohse, P.4    Muller-Myhsok, B.5
  • 14
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, et al. (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39: 207-211.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3    Till, A.4    Teuber, M.5
  • 15
    • 0242298205 scopus 로고    scopus 로고
    • NOD2/CARD15 and the Paneth cell: Another piece in the genetic jigsaw of inflammatory bowel disease
    • Aldhous MC, Nimmo ER, Satsangi J (2003) NOD2/CARD15 and the Paneth cell: another piece in the genetic jigsaw of inflammatory bowel disease. Gut 52: 1533-1535.
    • (2003) Gut , vol.52 , pp. 1533-1535
    • Aldhous, M.C.1    Nimmo, E.R.2    Satsangi, J.3
  • 16
    • 0037221395 scopus 로고    scopus 로고
    • Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan
    • Bonen DK, Ogura Y, Nicolae DL, Inohara N, Saab L, et al. (2003) Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 124: 140-146.
    • (2003) Gastroenterology , vol.124 , pp. 140-146
    • Bonen, D.K.1    Ogura, Y.2    Nicolae, D.L.3    Inohara, N.4    Saab, L.5
  • 17
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278: 8869-8872.
    • (2003) J Biol Chem , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3    Chamaillard, M.4    Labigne, A.5
  • 18
    • 33645972882 scopus 로고    scopus 로고
    • Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"?
    • Lakatos PL, Fischer S, Lakatos L, Gal I, Papp J (2006) Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll"? World J Gastroenterol 12: 1829-1841.
    • (2006) World J Gastroenterol , vol.12 , pp. 1829-1841
    • Lakatos, P.L.1    Fischer, S.2    Lakatos, L.3    Gal, I.4    Papp, J.5
  • 19
    • 13244277880 scopus 로고    scopus 로고
    • Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    • Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, et al. (2005) Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307: 734-738.
    • (2005) Science , vol.307 , pp. 734-738
    • Maeda, S.1    Hsu, L.C.2    Liu, H.3    Bankston, L.A.4    Iimura, M.5
  • 20
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • Watanabe T, Kitani A, Murray PJ, Strober W (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-808.
    • (2004) Nat Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3    Strober, W.4
  • 21
    • 33751561942 scopus 로고    scopus 로고
    • Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: Results of a prospective study
    • Seiderer J, Brand S, Herrmann KA, Schnitzler F, Hatz R, et al. (2006) Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study. Inflamm Bowel Dis 12: 1114-1121.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 1114-1121
    • Seiderer, J.1    Brand, S.2    Herrmann, K.A.3    Schnitzler, F.4    Hatz, R.5
  • 22
    • 33748654515 scopus 로고    scopus 로고
    • Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis
    • Seiderer J, Schnitzler F, Brand S, Staudinger T, Pfennig S, et al. (2006) Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis. Scand J Gastroenterol 41: 1421-1432.
    • (2006) Scand J Gastroenterol , vol.41 , pp. 1421-1432
    • Seiderer, J.1    Schnitzler, F.2    Brand, S.3    Staudinger, T.4    Pfennig, S.5
  • 23
    • 11144279151 scopus 로고    scopus 로고
    • Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: A metaanalysis
    • Economou M, Trikalinos TA, Loizou KT, Tsianos EV, Ioannidis JP (2004) Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol 99: 2393-2404.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2393-2404
    • Economou, M.1    Trikalinos, T.A.2    Loizou, K.T.3    Tsianos, E.V.4    Ioannidis, J.P.5
  • 24
    • 0036202885 scopus 로고    scopus 로고
    • The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    • Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, et al. (2002) The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 122: 867-874.
    • (2002) Gastroenterology , vol.122 , pp. 867-874
    • Cuthbert, A.P.1    Fisher, S.A.2    Mirza, M.M.3    King, K.4    Hampe, J.5
  • 25
    • 0036201577 scopus 로고    scopus 로고
    • CARD15/ NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
    • Lesage S, Zouali H, Cezard JP, Colombel JF, Belaiche J, et al. (2002) CARD15/ NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet 70: 845-857.
    • (2002) Am J Hum Genet , vol.70 , pp. 845-857
    • Lesage, S.1    Zouali, H.2    Cezard, J.P.3    Colombel, J.F.4    Belaiche, J.5
  • 26
    • 33645457756 scopus 로고    scopus 로고
    • Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease
    • Schnitzler F, Brand S, Staudinger T, Pfennig S, Hofbauer K, et al. (2006) Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease. Immunogenetics 58: 99-106.
    • (2006) Immunogenetics , vol.58 , pp. 99-106
    • Schnitzler, F.1    Brand, S.2    Staudinger, T.3    Pfennig, S.4    Hofbauer, K.5
  • 27
    • 0024810567 scopus 로고
    • Classification of inflammatory bowel disease
    • discussion 16-19
    • Lennard-Jones JE (1989) Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 170: 2-6; discussion 16-19.
    • (1989) Scand J Gastroenterol , vol.170 , Issue.SUPPL , pp. 2-6
    • Lennard-Jones, J.E.1
  • 28
    • 84894353884 scopus 로고    scopus 로고
    • Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    • Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, et al. (2005) Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 19 Suppl A: 5-36.
    • (2005) Can J Gastroenterol , vol.19 , Issue.SUPPL A , pp. 5-36
    • Silverberg, M.S.1    Satsangi, J.2    Ahmad, T.3    Arnott, I.D.4    Bernstein, C.N.5
  • 29
    • 40949112379 scopus 로고    scopus 로고
    • The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
    • Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, et al. (2008) The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am J Gastroenterol 103: 682-691.
    • (2008) Am J Gastroenterol , vol.103 , pp. 682-691
    • Glas, J.1    Konrad, A.2    Schmechel, S.3    Dambacher, J.4    Seiderer, J.5
  • 30
    • 27644562698 scopus 로고    scopus 로고
    • Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence
    • Alvarez-Lobos M, Arostegui JI, Sans M, Tassies D, Plaza S, et al. (2005) Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence. Ann Surg 242: 693-700.
    • (2005) Ann Surg , vol.242 , pp. 693-700
    • Alvarez-Lobos, M.1    Arostegui, J.I.2    Sans, M.3    Tassies, D.4    Plaza, S.5
  • 31
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, et al. (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11: 55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3    Hussey, S.4    Kim, Y.G.5
  • 32
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, Baker J, Brain O, Danis B, Pichulik T, et al. (2010) NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16: 90-97.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3    Danis, B.4    Pichulik, T.5
  • 33
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, et al. (2004) NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53: 1658-1664.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3    Schwab, M.4    Schaffeler, E.5
  • 34
    • 46349102893 scopus 로고    scopus 로고
    • Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    • Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, et al. (2008) Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 57: 903-910.
    • (2008) Gut , vol.57 , pp. 903-910
    • Simms, L.A.1    Doecke, J.D.2    Walsh, M.D.3    Huang, N.4    Fowler, E.V.5
  • 35
    • 33745556685 scopus 로고    scopus 로고
    • Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation
    • Kramer M, Netea MG, de Jong DJ, Kullberg BJ, Adema GJ (2006) Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation. J Leukoc Biol 79: 860-866.
    • (2006) J Leukoc Biol , vol.79 , pp. 860-866
    • Kramer, M.1    Netea, M.G.2    de Jong, D.J.3    Kullberg, B.J.4    Adema, G.J.5
  • 36
    • 27444444603 scopus 로고    scopus 로고
    • Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease
    • van Heel DA, Ghosh S, Hunt KA, Mathew CG, Forbes A, et al. (2005) Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. Gut 54: 1553-1557.
    • (2005) Gut , vol.54 , pp. 1553-1557
    • van Heel, D.A.1    Ghosh, S.2    Hunt, K.A.3    Mathew, C.G.4    Forbes, A.5
  • 37
    • 56149111709 scopus 로고    scopus 로고
    • Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages
    • Kim YG, Park JH, Daignault S, Fukase K, Nunez G (2008) Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages. J Immunol 181: 4340-4346.
    • (2008) J Immunol , vol.181 , pp. 4340-4346
    • Kim, Y.G.1    Park, J.H.2    Daignault, S.3    Fukase, K.4    Nunez, G.5
  • 38
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-734.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3    Henegariu, O.4    Inohara, N.5
  • 40
  • 41
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR (2007) Inflammatory bowel disease: cause and immunobiology. Lancet 369: 1627-1640.
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 42
    • 22044432709 scopus 로고    scopus 로고
    • The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease
    • Brand S, Staudinger T, Schnitzler F, Pfennig S, Hofbauer K, et al. (2005) The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease. Inflamm Bowel Dis 11: 645-652.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 645-652
    • Brand, S.1    Staudinger, T.2    Schnitzler, F.3    Pfennig, S.4    Hofbauer, K.5
  • 43
    • 33744962883 scopus 로고    scopus 로고
    • Genetic advances in inflammatory bowel disease
    • Cho J (2006) Genetic advances in inflammatory bowel disease. Curr Treat Options Gastroenterol 9: 191-200.
    • (2006) Curr Treat Options Gastroenterol , vol.9 , pp. 191-200
    • Cho, J.1
  • 44
    • 33846171221 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease
    • Dambacher J, Staudinger T, Seiderer J, Sisic Z, Schnitzler F, et al. (2007) Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease. Inflamm Bowel Dis 13: 71-82.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 71-82
    • Dambacher, J.1    Staudinger, T.2    Seiderer, J.3    Sisic, Z.4    Schnitzler, F.5
  • 45
    • 12744274602 scopus 로고    scopus 로고
    • Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease
    • Yamazaki K, Takazoe M, Tanaka T, Ichimori T, Saito S, et al. (2004) Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease. J Hum Genet 49: 664-668.
    • (2004) J Hum Genet , vol.49 , pp. 664-668
    • Yamazaki, K.1    Takazoe, M.2    Tanaka, T.3    Ichimori, T.4    Saito, S.5
  • 46
    • 84876035012 scopus 로고    scopus 로고
    • Clinical manifestations of inflammatory bowel disease: East and West differences
    • Wang YF, Zhang H, Ouyang Q (2007) Clinical manifestations of inflammatory bowel disease: East and West differences. J Dig Dis 8: 121-127.
    • (2007) J Dig Dis , vol.8 , pp. 121-127
    • Wang, Y.F.1    Zhang, H.2    Ouyang, Q.3


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