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Volumn 229, Issue 1, 2013, Pages 121-131

Nod2 deficiency impairs inflammatory and epithelial aspects of the cutaneous wound-healing response

Author keywords

inflammation; Pattern recognition receptor; skin; wound healing

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CHEMOKINE RECEPTOR CXCR2; TOLL LIKE RECEPTOR 2;

EID: 84872839188     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4095     Document Type: Article
Times cited : (22)

References (53)
  • 1
    • 84989030540 scopus 로고
    • Definitions and guidelines for assessment of wounds and evaluation of healing
    • Lazarus GS, Cooper DM, Knighton DR, et al,. Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair Regen 1994; 2: 165-170.
    • (1994) Wound Repair Regen , vol.2 , pp. 165-170
    • Lazarus, G.S.1    Cooper, D.M.2    Knighton, D.R.3
  • 2
    • 23044470282 scopus 로고    scopus 로고
    • Pathophysiology of chronic nonhealing wounds
    • Medina A, Scott PG, Ghahary A, et al,. Pathophysiology of chronic nonhealing wounds. J Burn Care Rehabil 2005; 26: 306-319.
    • (2005) J Burn Care Rehabil , vol.26 , pp. 306-319
    • Medina, A.1    Scott, P.G.2    Ghahary, A.3
  • 3
    • 0031253473 scopus 로고    scopus 로고
    • Evidence-based management of patients with leg ulcers
    • Ruckley CV,. Evidence-based management of patients with leg ulcers. J Wound Care 1997; 6: 442-444.
    • (1997) J Wound Care , vol.6 , pp. 442-444
    • Ruckley, C.V.1
  • 4
    • 53749097505 scopus 로고    scopus 로고
    • Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)
    • Dowd SE, Wolcott RD, Sun Y, et al,. Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP). PLoS One 2008; 3: e3326.
    • (2008) PLoS One , vol.3
    • Dowd, S.E.1    Wolcott, R.D.2    Sun, Y.3
  • 5
    • 33847356485 scopus 로고    scopus 로고
    • Infection following soft tissue injury: Its role in wound healing
    • Ryan TJ,. Infection following soft tissue injury: its role in wound healing. Curr Opin Infect Dis 2007; 20: 124-128.
    • (2007) Curr Opin Infect Dis , vol.20 , pp. 124-128
    • Ryan, T.J.1
  • 6
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara N, Ogura Y, Fontalba A, et al,. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 2003; 278: 5509-5512.
    • (2003) J Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 7
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J, et al,. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003; 278: 8869-8872.
    • (2003) J Biol Chem , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 8
    • 33846330896 scopus 로고    scopus 로고
    • Nod-like proteins in immunity, inflammation and disease
    • Fritz JH, Ferrero RL, Philpott DJ, et al,. Nod-like proteins in immunity, inflammation and disease. Nat Immunol 2006; 7: 1250-1257.
    • (2006) Nat Immunol , vol.7 , pp. 1250-1257
    • Fritz, J.H.1    Ferrero, R.L.2    Philpott, D.J.3
  • 9
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • Kanneganti TD, Lamkanfi M, Nunez G,. Intracellular NOD-like receptors in host defense and disease. Immunity 2007; 27: 549-559.
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Nunez, G.3
  • 10
    • 58349118715 scopus 로고    scopus 로고
    • Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes
    • Kobayashi M, Yoshiki R, Sakabe J, et al,. Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes. Br J Dermatol 2009; 160: 297-304.
    • (2009) Br J Dermatol , vol.160 , pp. 297-304
    • Kobayashi, M.1    Yoshiki, R.2    Sakabe, J.3
  • 11
    • 0037075549 scopus 로고    scopus 로고
    • Involvement of receptor-interacting protein 2 in innate and adaptive immune responses
    • Chin AI, Dempsey PW, Bruhn K, et al,. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 2002; 416: 190-194.
    • (2002) Nature , vol.416 , pp. 190-194
    • Chin, A.I.1    Dempsey, P.W.2    Bruhn, K.3
  • 12
    • 0037075551 scopus 로고    scopus 로고
    • RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    • Kobayashi K, Inohara N, Hernandez LD, et al,. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 2002; 416: 194-199.
    • (2002) Nature , vol.416 , pp. 194-199
    • Kobayashi, K.1    Inohara, N.2    Hernandez, L.D.3
  • 13
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • Strober W, Murray PJ, Kitani A, et al,. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 2006; 6: 9-20.
    • (2006) Nat Rev Immunol , vol.6 , pp. 9-20
    • Strober, W.1    Murray, P.J.2    Kitani, A.3
  • 14
    • 84860389274 scopus 로고    scopus 로고
    • NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease
    • Strober W, Watanabe T,. NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease. Mucosal Immunol 2011; 4: 484-495.
    • (2011) Mucosal Immunol , vol.4 , pp. 484-495
    • Strober, W.1    Watanabe, T.2
  • 15
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al,. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 16
    • 20444459502 scopus 로고    scopus 로고
    • NOD2 and Crohn's disease: Loss or gain of function?
    • Eckmann L, Karin M,. NOD2 and Crohn's disease: loss or gain of function? Immunity 2005; 22: 661-667.
    • (2005) Immunity , vol.22 , pp. 661-667
    • Eckmann, L.1    Karin, M.2
  • 17
    • 0036201577 scopus 로고    scopus 로고
    • CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
    • Lesage S, Zouali H, Cezard JP, et al,. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet 2002; 70: 845-857.
    • (2002) Am J Hum Genet , vol.70 , pp. 845-857
    • Lesage, S.1    Zouali, H.2    Cezard, J.P.3
  • 19
    • 58149474704 scopus 로고    scopus 로고
    • Clinical and genetic aspects of Blau syndrome: A 25-year follow-up of one family and a literature review
    • Punzi L, Furlan A, Podswiadek M, et al,. Clinical and genetic aspects of Blau syndrome: a 25-year follow-up of one family and a literature review. Autoimmun Rev 2009; 8: 228-232.
    • (2009) Autoimmun Rev , vol.8 , pp. 228-232
    • Punzi, L.1    Furlan, A.2    Podswiadek, M.3
  • 20
    • 57749170732 scopus 로고    scopus 로고
    • Leg ulcers: A new symptom of Blau syndrome?
    • Dhondt V, Hofman S, Dahan K, et al,. Leg ulcers: a new symptom of Blau syndrome? Eur J Dermatol 2008; 18: 635-637.
    • (2008) Eur J Dermatol , vol.18 , pp. 635-637
    • Dhondt, V.1    Hofman, S.2    Dahan, K.3
  • 21
    • 79953167155 scopus 로고    scopus 로고
    • Impaired wound healing with defective expression of chemokines and recruitment of myeloid cells in TLR3-deficient mice
    • Lin Q, Fang D, Fang J, et al,. Impaired wound healing with defective expression of chemokines and recruitment of myeloid cells in TLR3-deficient mice. J Immunol 2011; 186: 3710-3717.
    • (2011) J Immunol , vol.186 , pp. 3710-3717
    • Lin, Q.1    Fang, D.2    Fang, J.3
  • 22
    • 78049337495 scopus 로고    scopus 로고
    • TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice
    • Dasu MR, Thangappan RK, Bourgette A, et al,. TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice. Lab Invest 2011; 90: 1628-1636.
    • (2011) Lab Invest , vol.90 , pp. 1628-1636
    • Dasu, M.R.1    Thangappan, R.K.2    Bourgette, A.3
  • 23
    • 0142123222 scopus 로고    scopus 로고
    • Role of nod2 in the response of macrophages to toll-like receptor agonists
    • Pauleau AL, Murray PJ,. Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 2003; 23: 7531-7539.
    • (2003) Mol Cell Biol , vol.23 , pp. 7531-7539
    • Pauleau, A.L.1    Murray, P.J.2
  • 24
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
    • Takeuchi O, Hoshino K, Kawai T, et al,. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 1999; 11: 443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3
  • 25
    • 0038665391 scopus 로고    scopus 로고
    • Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor
    • Ashcroft GS, Mills SJ, Lei K, et al,. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest 2003; 111: 1309-1318.
    • (2003) J Clin Invest , vol.111 , pp. 1309-1318
    • Ashcroft, G.S.1    Mills, S.J.2    Lei, K.3
  • 26
    • 0036731981 scopus 로고    scopus 로고
    • Androgen receptor-mediated inhibition of cutaneous wound healing
    • Ashcroft GS, Mills SJ,. Androgen receptor-mediated inhibition of cutaneous wound healing. J Clin Invest 2002; 110: 615-624.
    • (2002) J Clin Invest , vol.110 , pp. 615-624
    • Ashcroft, G.S.1    Mills, S.J.2
  • 27
    • 0036192016 scopus 로고    scopus 로고
    • Tissue dispersion and flow cytometry for the cellular analysis of wound healing
    • Wilson L, Fathke C, Isik F,. Tissue dispersion and flow cytometry for the cellular analysis of wound healing. Biotechniques 2002; 32: 548-551.
    • (2002) Biotechniques , vol.32 , pp. 548-551
    • Wilson, L.1    Fathke, C.2    Isik, F.3
  • 28
    • 66649121430 scopus 로고    scopus 로고
    • Unique and synergistic roles for 17β-estradiol and macrophage migration inhibitory factor during cutaneous wound closure are cell type specific
    • Emmerson E, Campbell L, Ashcroft GS, et al,. Unique and synergistic roles for 17β-estradiol and macrophage migration inhibitory factor during cutaneous wound closure are cell type specific. Endocrinology 2009; 150: 2749-2757.
    • (2009) Endocrinology , vol.150 , pp. 2749-2757
    • Emmerson, E.1    Campbell, L.2    Ashcroft, G.S.3
  • 29
    • 33644646320 scopus 로고    scopus 로고
    • Numerous keratinocyte subtypes involved in wound re-epithelialization
    • Patel GK, Wilson CH, Harding KG, et al,. Numerous keratinocyte subtypes involved in wound re-epithelialization. J Invest Dermatol 2006; 126: 497-502.
    • (2006) J Invest Dermatol , vol.126 , pp. 497-502
    • Patel, G.K.1    Wilson, C.H.2    Harding, K.G.3
  • 30
    • 33744780764 scopus 로고    scopus 로고
    • The molecular biology of chronic wounds and delayed healing in diabetes
    • Blakytny R, Jude E,. The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med 2006; 23: 594-608.
    • (2006) Diabet Med , vol.23 , pp. 594-608
    • Blakytny, R.1    Jude, E.2
  • 31
    • 77956159711 scopus 로고    scopus 로고
    • Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium
    • 904-917, 917
    • Richardson WM, Sodhi CP, Russo A, et al. Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium. Gastroenterology 2010; 139: 904-917, 917, e901-906.
    • (2010) Gastroenterology , vol.139
    • Richardson, W.M.1    Sodhi, C.P.2    Russo, A.3
  • 32
    • 66349097787 scopus 로고    scopus 로고
    • The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    • Shimada K, Chen S, Dempsey PW, et al,. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog 2009; 5: e1000379.
    • (2009) PLoS Pathog , vol.5
    • Shimada, K.1    Chen, S.2    Dempsey, P.W.3
  • 33
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • Watanabe T, Kitani A, Murray PJ, et al,. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 2004; 5: 800-808.
    • (2004) Nat Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3
  • 34
    • 80052580369 scopus 로고    scopus 로고
    • Nod2 is essential for temporal development of intestinal microbial communities
    • Rehman A, Sina C, Gavrilova O, et al,. Nod2 is essential for temporal development of intestinal microbial communities. Gut 2011; 60: 1354-1362.
    • (2011) Gut , vol.60 , pp. 1354-1362
    • Rehman, A.1    Sina, C.2    Gavrilova, O.3
  • 35
    • 69149087051 scopus 로고    scopus 로고
    • NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation
    • Hruz P, Zinkernagel AS, Jenikova G, et al,. NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation. Proc Natl Acad Sci USA 2009; 106: 12873-12878.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12873-12878
    • Hruz, P.1    Zinkernagel, A.S.2    Jenikova, G.3
  • 36
    • 76849099915 scopus 로고    scopus 로고
    • Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine
    • Hagiwara S, Iwasaka H, Hasegawa A, et al,. Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine. Surg Today 2010; 40: 137-145.
    • (2010) Surg Today , vol.40 , pp. 137-145
    • Hagiwara, S.1    Iwasaka, H.2    Hasegawa, A.3
  • 37
    • 84857090736 scopus 로고    scopus 로고
    • Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host
    • Rosenthal LA, Szakaly RJ, Amineva SP, et al,. Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host. PLoS One 2012; 7: e32061.
    • (2012) PLoS One , vol.7
    • Rosenthal, L.A.1    Szakaly, R.J.2    Amineva, S.P.3
  • 38
    • 78649731644 scopus 로고    scopus 로고
    • Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells
    • Conforti-Andreoni C, Beretta O, Licandro G, et al,. Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells. J Leukoc Biol 2010; 88: 1207-1216.
    • (2010) J Leukoc Biol , vol.88 , pp. 1207-1216
    • Conforti-Andreoni, C.1    Beretta, O.2    Licandro, G.3
  • 39
    • 80052361740 scopus 로고    scopus 로고
    • Organic dust augments nucleotide-binding oligomerization domain expression via an NF-κB pathway to negatively regulate inflammatory responses
    • Poole JA, Kielian T, Wyatt TA, et al,. Organic dust augments nucleotide-binding oligomerization domain expression via an NF-κB pathway to negatively regulate inflammatory responses. Am J Physiol Lung Cell Mol Physiol 2011; 301: L296-306.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301
    • Poole, J.A.1    Kielian, T.2    Wyatt, T.A.3
  • 40
    • 80051665832 scopus 로고    scopus 로고
    • NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice
    • Rosenzweig HL, Galster K, Vance EE, et al,. NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice. Invest Ophthalmol Vis Sci 2011; 52: 4106-4112.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 4106-4112
    • Rosenzweig, H.L.1    Galster, K.2    Vance, E.E.3
  • 41
    • 84861148380 scopus 로고    scopus 로고
    • Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis
    • Vieira SM, Cunha TM, Franca RF, et al. Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis. J Immunol 2012; 188: 5116-5122.
    • (2012) J Immunol , vol.188 , pp. 5116-5122
    • Vieira, S.M.1    Cunha, T.M.2    Franca, R.F.3
  • 42
    • 66149113283 scopus 로고    scopus 로고
    • Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria
    • Finney CA, Lu Z, LeBourhis L, et al,. Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria. Am J Trop Med Hyg 2009; 80: 718-722.
    • (2009) Am J Trop Med Hyg , vol.80 , pp. 718-722
    • Finney, C.A.1    Lu, Z.2    Lebourhis, L.3
  • 43
    • 0033883014 scopus 로고    scopus 로고
    • Delayed wound healing in CXCR2 knockout mice
    • Devalaraja RM, Nanney LB, Du J, et al,. Delayed wound healing in CXCR2 knockout mice. J Invest Dermatol 2000; 115: 234-244.
    • (2000) J Invest Dermatol , vol.115 , pp. 234-244
    • Devalaraja, R.M.1    Nanney, L.B.2    Du, J.3
  • 44
    • 0035075706 scopus 로고    scopus 로고
    • Chemokines in cutaneous wound healing
    • Gillitzer R, Goebeler M,. Chemokines in cutaneous wound healing. J Leukoc Biol 2001; 69: 513-521.
    • (2001) J Leukoc Biol , vol.69 , pp. 513-521
    • Gillitzer, R.1    Goebeler, M.2
  • 45
    • 0033517356 scopus 로고    scopus 로고
    • Cutaneous wound healing
    • Singer AJ, Clark RA,. Cutaneous wound healing. N Engl J Med 1999; 341: 738-746.
    • (1999) N Engl J Med , vol.341 , pp. 738-746
    • Singer, A.J.1    Clark, R.A.2
  • 47
    • 38049153165 scopus 로고    scopus 로고
    • TAK1 is a central mediator of NOD2 signaling in epidermal cells
    • Kim JY, Omori E, Matsumoto K, et al,. TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem 2008; 283: 137-144.
    • (2008) J Biol Chem , vol.283 , pp. 137-144
    • Kim, J.Y.1    Omori, E.2    Matsumoto, K.3
  • 48
    • 76749083806 scopus 로고    scopus 로고
    • RIP2: A novel player in the regulation of keratinocyte proliferation and cutaneous wound repair?
    • Adams S, Valchanova RS, Munz B,. RIP2: a novel player in the regulation of keratinocyte proliferation and cutaneous wound repair? Exp Cell Res 2010; 316: 728-736.
    • (2010) Exp Cell Res , vol.316 , pp. 728-736
    • Adams, S.1    Valchanova, R.S.2    Munz, B.3
  • 49
    • 81255138157 scopus 로고    scopus 로고
    • Nod2 downregulates TLR2/1 mediated IL-1β gene expression in mouse peritoneal macrophages
    • Dahiya Y, Pandey RK, Sodhi A,. Nod2 downregulates TLR2/1 mediated IL-1β gene expression in mouse peritoneal macrophages. PLoS One 2011; 6: e27828.
    • (2011) PLoS One , vol.6
    • Dahiya, Y.1    Pandey, R.K.2    Sodhi, A.3
  • 50
    • 38849163741 scopus 로고    scopus 로고
    • Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    • Watanabe T, Asano N, Murray PJ, et al,. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest 2008; 118: 545-559.
    • (2008) J Clin Invest , vol.118 , pp. 545-559
    • Watanabe, T.1    Asano, N.2    Murray, P.J.3
  • 51
    • 38349014249 scopus 로고    scopus 로고
    • Wound healing is impaired in MyD88-deficient mice: A role for MyD88 in the regulation of wound healing by adenosine A2A receptors
    • Macedo L, Pinhal-Enfield G, Alshits V, et al,. Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors. Am J Pathol 2007; 171: 1774-1788.
    • (2007) Am J Pathol , vol.171 , pp. 1774-1788
    • MacEdo, L.1    Pinhal-Enfield, G.2    Alshits, V.3
  • 52
    • 71549150339 scopus 로고    scopus 로고
    • Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury
    • Lai Y, Di Nardo A, Nakatsuji T, et al,. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med 2009; 15: 1377-1382.
    • (2009) Nat Med , vol.15 , pp. 1377-1382
    • Lai, Y.1    Di Nardo, A.2    Nakatsuji, T.3
  • 53
    • 78349239324 scopus 로고    scopus 로고
    • Accelerated wound healing mediated by activation of Toll-like receptor 9
    • Sato T, Yamamoto M, Shimosato T, et al,. Accelerated wound healing mediated by activation of Toll-like receptor 9. Wound Repair Regen 2010; 18: 586-593.
    • (2010) Wound Repair Regen , vol.18 , pp. 586-593
    • Sato, T.1    Yamamoto, M.2    Shimosato, T.3


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