Impact of mutations on the allosteric conformational equilibrium

Journal of Molecular Biology

Volumn 425, Issue 3, 2013, Pages 647-661

  Weinkam, Patrick ^a   Chen, Yao Chi ^b   Pons, Jaume ^c   Sali, Andrej ^a  

^a University of California   (United States)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c PFIZER INC   (United States)

Author keywords

allostery; energy landscape; Keywords; machine learning; protein dynamics

Indexed keywords

BETA LACTAMASE; CALMODULIN; CASPASE 7; GLUCOKINASE; HEMOGLOBIN; MALTOSE BINDING PROTEIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN TYROSINE PHOSPHATASE; THROMBIN;

ACCURACY; ALGORITHM; ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; ENERGY; EQUILIBRIUM CONSTANT; MACHINE LEARNING; MOLECULAR MECHANICS; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; STEREOCHEMISTRY; THERMODYNAMICS;

EID: 84872835595     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.11.041     Document Type: Article

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