-
1
-
-
79952106497
-
Triptolide and its expanding multiple pharmacological functions
-
Liu Q: Triptolide and its expanding multiple pharmacological functions. Int Immunopharmacol 11: 377-383, 2011.
-
(2011)
Int Immunopharmacol
, vol.11
, pp. 377-383
-
-
Liu, Q.1
-
2
-
-
33745944185
-
Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells
-
DOI 10.1182/blood-2005-09-3898
-
Carter BZ, Mak DH, Schober WD, et al: Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 108: 630-637, 2006. (Pubitemid 44061364)
-
(2006)
Blood
, vol.108
, Issue.2
, pp. 630-637
-
-
Carter, B.Z.1
Mak, D.H.2
Schober, W.D.3
McQueen, T.4
Harris, D.5
Estrov, Z.6
Evans, R.L.7
Andreeff, M.8
-
3
-
-
0032433899
-
Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters
-
DOI 10.1016/S0304-3835(98)00222-5, PII S0304383598002225
-
Tengchaisri T, Chawengkirttikul R, Rachaphaew N, et al: Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters. Cancer Lett 133: 169-175, 1998. (Pubitemid 29069041)
-
(1998)
Cancer Letters
, vol.133
, Issue.2
, pp. 169-175
-
-
Tengchaisri, T.1
Chawengkirttikul, R.2
Rachaphaew, N.3
Reutrakul, V.4
Sangsuwan, R.5
Sirisinha, S.6
-
4
-
-
0642287879
-
PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy
-
Fidler JM, Li K, Chung C, et al: PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. Mol Cancer Ther 2: 855-862, 2003.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 855-862
-
-
Fidler, J.M.1
Li, K.2
Chung, C.3
-
5
-
-
0000597684
-
PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells
-
Lee KY, Chang W, Qiu D, et al: PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. J Biol Chem 274: 13451-13455, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 13451-13455
-
-
Lee, K.Y.1
Chang, W.2
Qiu, D.3
-
6
-
-
34250869896
-
Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells
-
Wan CK, Wang C, Cheung HY, et al: Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells. Cancer Lett 241: 31-41, 2006.
-
(2006)
Cancer Lett
, vol.241
, pp. 31-41
-
-
Wan, C.K.1
Wang, C.2
Cheung, H.Y.3
-
7
-
-
0038771255
-
Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells
-
DOI 10.1016/S0006-2952(03)00282-X
-
Choi YJ, Kim TG, Kim YH, et al: Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. Biochem Pharmacol 66: 273-280, 2003. (Pubitemid 36776400)
-
(2003)
Biochemical Pharmacology
, vol.66
, Issue.2
, pp. 273-280
-
-
Choi, Y.-J.1
Kim, T.G.2
Kim, Y.-H.3
Lee, S.-H.4
Kwon, Y.K.5
Suh, S.-I.6
Park, J.-W.7
Kwon, T.K.8
-
8
-
-
48549086880
-
Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure
-
Leuenroth S and Crews CM: Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure. Cancer Res 68: 5257-5266, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 5257-5266
-
-
Leuenroth, S.1
Crews, C.M.2
-
9
-
-
73549100626
-
Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells
-
Soundararajan R, Sayat R, Robertson GS, et al: Triptolide: an inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells. Cancer Biol Ther 8: 2054-2062, 2009.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 2054-2062
-
-
Soundararajan, R.1
Sayat, R.2
Robertson, G.S.3
-
10
-
-
0016255753
-
Selective alkylation: A biomimetic reaction of the antileukemic triptolides?
-
Kupchan SM and Schubert RM: Selective alkylation: a biomimetic reaction of the antileukemic triptolides? Science 185: 791-793, 1974.
-
(1974)
Science
, vol.185
, pp. 791-793
-
-
Kupchan, S.M.1
Schubert, R.M.2
-
11
-
-
28844476583
-
Studies on calcium dependence reveal multiple modes of action for triptolide
-
DOI 10.1016/j.chembiol.2005.09.009, PII S1074552105002991
-
Leuenroth SJ and Crews CM: Studies on calcium dependence reveal multiple modes of action for triptolide. Chem Biol 12: 1259-1268, 2005. (Pubitemid 41779466)
-
(2005)
Chemistry and Biology
, vol.12
, Issue.12
, pp. 1259-1268
-
-
Leuenroth, S.J.1
Crews, C.M.2
-
12
-
-
0033959520
-
Cancer statistics, 2000
-
Greenlee RT, Murray T, Bolden S, et al: Cancer statistics, 2000. CA Cancer J Clin 50: 7-33, 2000. (Pubitemid 30072093)
-
(2000)
Ca-A Cancer Journal for Clinicians
, vol.50
, Issue.1
, pp. 7-33
-
-
Greenlee, R.T.1
Murray, T.2
Bolden, S.3
Wingo, P.A.4
-
13
-
-
7644240644
-
Oligonucleosome DNA fragmentation of caspase 3 deficient MCF-7 cells in palmitate-induced apoptosis
-
DOI 10.1081/NCN-200026024
-
Semenov DV, Aronov PA, Kuligina EV, et al: Oligonucleosome DNA fragmentation of caspase 3 deficient MCF-7 cells in palmitate-induced apoptosis. Nucleosides Nucleotides Nucleic Acids 23: 831-836, 2004. (Pubitemid 39456481)
-
(2004)
Nucleosides, Nucleotides and Nucleic Acids
, vol.23
, Issue.6-7
, pp. 831-836
-
-
Semenov, D.V.1
Aronov, P.A.2
Kuligina, E.V.3
Potapenko, M.O.4
Richter, V.A.5
-
15
-
-
70349768102
-
Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines
-
Liu J, Jiang Z, Xiao J, et al: Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomedicine 16: 1006-1013, 2009.
-
(2009)
Phytomedicine
, vol.16
, pp. 1006-1013
-
-
Liu, J.1
Jiang, Z.2
Xiao, J.3
-
16
-
-
21744435478
-
The role of focal-adhesion kinase in cancer - A new therapeutic opportunity
-
DOI 10.1038/nrc1647
-
McLean GW, Carragher NO, Avizienyte E, et al: The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer 5: 505-515, 2005. (Pubitemid 40942827)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.7
, pp. 505-515
-
-
McLean, G.W.1
Carragher, N.O.2
Avizienyte, E.3
Evans, J.4
Brunton, V.G.5
Frame, M.C.6
-
17
-
-
0034044795
-
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes
-
Cance WG, Harris JE, Iacocca MV, et al: Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6: 2417-2423, 2000. (Pubitemid 30399210)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.6
, pp. 2417-2423
-
-
Cance, W.G.1
Harris, J.E.2
Iacocca, M.V.3
Roche, E.4
Yang, X.H.5
Chang, J.6
Simkins, S.7
Xu, L.H.8
-
18
-
-
9644275426
-
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis
-
DOI 10.1007/s10549-004-1022-8
-
Lightfoot HM Jr, Lark A, Livasy CA, et al: Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat 88: 109-116, 2004. (Pubitemid 39575569)
-
(2004)
Breast Cancer Research and Treatment
, vol.88
, Issue.2
, pp. 109-116
-
-
Lightfoot, H.M.1
Lark, A.2
Livasy, C.A.3
Moore, D.T.4
Cowan, D.5
Dressler, L.6
Craven, R.J.7
Cance, W.G.8
-
19
-
-
0029039421
-
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors
-
Owens LV, Xu L, Craven RJ, et al: Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55: 2752-2755, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 2752-2755
-
-
Owens, L.V.1
Xu, L.2
Craven, R.J.3
-
20
-
-
0025797665
-
Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines
-
Wei YS and Adachi I: Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines. Zhongguo Yao Li Xue Bao 12: 406-410, 1991.
-
(1991)
Zhongguo Yao Li Xue Bao
, vol.12
, pp. 406-410
-
-
Wei, Y.S.1
Adachi, I.2
-
21
-
-
0344395628
-
1
-
Kim B, Van Golen CM and Feldman EL: Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells. Neoplasia 5: 405-416, 2003. (Pubitemid 37475649)
-
(2003)
Neoplasia
, vol.5
, Issue.5
, pp. 405-416
-
-
Kim, B.1
Van Golen, C.M.2
Feldman, E.L.3
-
22
-
-
0030867842
-
Cleavage of focal adhesion kinase by caspases during apoptosis
-
DOI 10.1074/jbc.272.41.26056
-
Wen LP, Fahrni JA, Troie S, et al: Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem 272: 26056-26061, 1997. (Pubitemid 27438936)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.41
, pp. 26056-26061
-
-
Wen, L.-P.1
Fahrni, J.A.2
Troie, S.3
Guan, J.-L.4
Orth, K.5
Rosen, G.D.6
-
23
-
-
65949097277
-
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis
-
Barbero S, Mielgo A, Torres V, et al: Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res 69: 3755-3763, 2009.
-
(2009)
Cancer Res
, vol.69
, pp. 3755-3763
-
-
Barbero, S.1
Mielgo, A.2
Torres, V.3
-
24
-
-
0029257377
-
Signal transduction through integrins: A central role for focal adhesion kinase?
-
Richardson A and Parsons JT: Signal transduction through integrins: a central role for focal adhesion kinase? Bioessays 17: 229-236, 1995.
-
(1995)
Bioessays
, vol.17
, pp. 229-236
-
-
Richardson, A.1
Parsons, J.T.2
-
25
-
-
0029666080
-
Pp125FAK in the focal adhesion
-
Otey CA: pp125FAK in the focal adhesion. Int Rev Cytol 167: 161-183, 1996.
-
(1996)
Int Rev Cytol
, vol.167
, pp. 161-183
-
-
Otey, C.A.1
-
26
-
-
1642586962
-
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
-
DOI 10.1038/ncb1094
-
Webb DJ, Donais K, Whitmore LA, et al: FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 6: 154-161, 2004. (Pubitemid 38425715)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.2
, pp. 154-161
-
-
Webb, D.J.1
Donais, K.2
Whitmore, L.A.3
Thomas, S.M.4
Turner, C.E.5
Parsons, J.T.6
Horwitz, A.F.7
-
27
-
-
0037178855
-
Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt
-
DOI 10.1074/jbc.M201963200
-
Kim B and Feldman EL: Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem 277: 27393-27400, 2002. (Pubitemid 34951760)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.30
, pp. 27393-27400
-
-
Kim, B.1
Feldman, E.L.2
-
28
-
-
77952469195
-
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
-
Schultze A and Fiedler W: Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer. Expert Opin Investig Drugs 19: 777-788, 2010.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 777-788
-
-
Schultze, A.1
Fiedler, W.2
-
29
-
-
42949160485
-
p53 regulates FAK expression in human tumor cells
-
DOI 10.1002/mc.20395
-
Golubovskaya VM, Finch R, Kweh F, et al: p53 regulates FAK expression in human tumor cells. Mol Carcinog 47: 373-382, 2008. (Pubitemid 351614577)
-
(2008)
Molecular Carcinogenesis
, vol.47
, Issue.5
, pp. 373-382
-
-
Golubovskaya, V.M.1
Finch, R.2
Kweh, F.3
Massoll, N.A.4
Campbell-Thompson, M.5
Wallace, M.R.6
Cance, W.G.7
|