Does triptolide induce lysosomal-mediated apoptosis in human breast cancer cells?

Medical Hypotheses

Volumn 77, Issue 1, 2011, Pages 91-93

  Messina, M E ^a   Halaby, R ^a  

^a MONTCLAIR STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRIPTOLIDE;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; DRUG STRUCTURE; HUMAN; LYSOSOME; RHEUMATOID ARTHRITIS;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BREAST NEOPLASMS; DITERPENES; EPOXY COMPOUNDS; FEMALE; HUMANS; LYSOSOMES; PHENANTHRENES;

TRIPTERYGIUM WILFORDII;

EID: 79958064970     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.03.034     Document Type: Article

References (15)

1. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics. CA Cancer J Clin 2002, 55:74-108.
2. American Cancer Society. Copyright: 2010. Accessed May 1, 2010. http://www.cancer.org.
3. Hussain M., Scher H.I., Halabi S., Tannock I., Morris M., Sternberg C.N., et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the prostate cancer clinical trials working group. J Clin Oncol 2008, 26:1148-1159.
4. Stewart THM, Sage RD, Stewart AFR, Cameron DW. Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus. Br J Cancer 1999;82:446-51.
5. Brinker A.M., Ma J., Lipsky P.E., Raskin I. Medicinal chemistry and pharmacology of genus Tripteryguim. Phytochemistry 2007, 68:732-766.
6. Chan M.A., Kohlmeier J.E., Branden M., Jung M., Benedict S.H. Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. Phytother Res 1999, 13:464-467.
7. Lee K.Y., Chang W.-T., Qiu D., Kao P.N., Rosen G.D. PG490 (triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells. J Biol Chem 1999, 274:13451-13455.
8. Suganuma M, Okabe S, Kurusu M, lida N, Ohshima S, Saeki Y, Kishimoto T, Fujiki H. Discrete roles of cytokines, TNF-α, IL-1, IL-6 in tumor promotion and cell transformation. Int J Oncol 2002;20:131-6.
9. Halaby R., Moreno-Boyle A., Pych J. Lysosomal enzymes induce regression of MCF-7 (a human breast carcinoma cell line) tumors growing in athymic mice. Breast Dis 2004, 19:225-229.
10. Linder S., Shoshan M.C. Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy. Drug Resist Updat 2005, 8:199-204.
11. Johansson A., Appelqvist H., Nilsson C., Kagedal K., Roberg K., Ollinger K. Regulation of apoptosis-associated lysosomal membrane permeabiliztion. Apoptosis 2010, 15:527-540.
12. Ono K., Kim S.O., Han J. Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death. Mol Cell Biol 2003, 23:665-676.
13. Roberg K., Ollinger K. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am J Pathol 1998, 152:1151-1156.
14. Wan C.H., Wang C., Cheung H.Y., Yang M., Fong W.F. Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells. Cancer Lett 2006, 241:31-41.
15. Hishita T., Tada-Oikawa S., Tohyama K., Miura Y., Nishihara T., Tohyama Y., et al. Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. Cancer Res 2001, 61:2878-2881.