Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways

Gastroenterology

Volumn 139, Issue 2, 2010, Pages 598-608

  Mujumdar, Nameeta ^a   MacKenzie, Tiffany N ^b   Dudeja, Vikas ^a   Chugh, Rohit ^a   Antonoff, Mara B ^a   Borja Cacho, Daniel ^a   Sangwan, Veena ^a   Dawra, Rajinder ^a   Vickers, Selwyn M ^a,c   Saluja, Ashok K ^a,b,c  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; Autophagy; Cell Death; Pancreatic Cancer

Indexed keywords

ACRIDINE ORANGE; AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE 3; CYTOCHROME C; LIPOCORTIN 5; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROPIDIUM IODIDE; PROTEIN KINASE B; SMALL INTERFERING RNA; TRIPTOLIDE; ALKYLATING AGENT; APOPTOSIS REGULATORY PROTEIN; ATG5 PROTEIN, HUMAN; BECN1 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; DITERPENE; EPOXIDE; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PHENANTHRENE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; S6 KINASE; SIGNAL PEPTIDE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL PROTECTION; CELL STRAIN BX PC3; CELL STRAIN CAPAN 1; CELL STRAIN HS766T; CELL STRAIN MIAPACA 2; CELL STRAIN S2 013; CELL STRAIN S2 VP10; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LIGHT CHAIN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STAINING; UPREGULATION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PANCREATIC NEOPLASMS; PHENANTHRENES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 77955496813     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.04.046     Document Type: Article

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