Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II)

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Wang, Ying ^a   Lu, Jin jian ^a,b   He, Li ^a   Yu, Qiang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; PROTEIN KINASE; RNA POLYMERASE II; TRIPTOLIDE; DITERPENE; EPOXIDE; HERBACEOUS AGENT; PHENANTHRENE DERIVATIVE; POLR2J PROTEIN, HUMAN; POSITIVE TRANSCRIPTION ELONGATION FACTOR B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DRUG POTENCY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; ONCOGENE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RPB1 GENE; TRANSCRIPTION REGULATION; CELL DEATH; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; HELA CELL; METABOLISM; PHOSPHORYLATION; TIME;

TRIPTERYGIUM WILFORDII;

CELL DEATH; DITERPENES; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; EPOXY COMPOUNDS; HELA CELLS; HUMANS; PHENANTHRENES; PHOSPHORYLATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RNA POLYMERASE II; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 80052726052     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023993     Document Type: Article

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