Insulin-sparing effects of troglitazone in rat pancreatic islets

Journal of Molecular Endocrinology

Volumn 31, Issue 1, 2003, Pages 61-69

  Bollheimer, L C ^a   Troll, S ^a   Landauer, H ^a   Wrede, C E ^a   Scholmerich J ^a   Buettner, Roland ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; MESSENGER RNA; OLEIC ACID; PREPROINSULIN; THIAZOLIDINE DERIVATIVE; TROGLITAZONE;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GLUCAGON RELEASE; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SYNTHESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; RAT;

ANIMALS; C-PEPTIDE; CHROMANS; GENE EXPRESSION REGULATION; GLUCAGON; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; MALE; PROGLUCAGON; PROINSULIN; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RNA, MESSENGER; THIAZOLIDINEDIONES;

EID: 0042854917     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0310061     Document Type: Article

References (35)

1. Adams M, Montague CT, Prins JB, Holder JC, Smith SA, Sanders L, Digby JE, Sewter CP, Lazar MA, Chatterjee VK et al. 1997 Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. Journal of Clinical Investigation 100 3149-3153.
2. Bahr M, Spelleken M, Bock M, von Holtey M, Kiehn R & Eckel J 1996 Acute and chronic effects of troglitazone (CS-045) on isolated rat ventricular cardiomyocytes. Diabetologia 39 766-774.
3. Bollheimier LC, Skelly RH, Chester MW, McGarry JD & Rhodes CJ 1998 Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. Journal Clinical Investigation 101 1094-1101.
4. Bollheimer LC, Kestler TM, Michel J, Buettner R, Scholmerich J & Palitzsch K-D 2001 Intracellular depletion of insulin by oleate is due to an inhibited synthesis and not to an increased secretion. Biochemical and Biophysical Research Communications 287 397-401.
5. Bollheimer LC, Kagerbauer SM, Buettner R, Kemptner DM, Palitzsch K-D, Schölmerich J & Hügl S 2002 Synergistic effects of troglitazone and oleate on the translatability of preproiusulin mRNA from INS-1-cells. Biochemical Pharmacolgy 64 1629-1636.
6. Briaud I, Harmon JS, Kelpe CL, Segu VB & Poitout V 2001 Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50 315-321.
7. Brunmair B, Gras F, Neschen S, Roden M, Wagner L, Waldhausl W & Furnsinn C 2001 Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression. Diabetes 50 2309-2315.
8. Buchanan TA, Xiang AH, Peters RK, Kjos SL, Berkowitz K, Marroquin A, Goico J, Ochoa C & Azen SP 2000 Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes. Diabetes 49 782-788.
9. Burris TP, Pelton PD, Zhou L, Osborne MC, Cryan E & Demarest KT 1999 A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator-activated receptor gamma agonist actions on aP2 gene expression detected using branched DNA messenger RNA quantitation. Molecular Endocrinology 13 410-417.
10. Camp HS, Li O, Wise SC, Hong YH, Frankowski CL, Shen X, Vanbogelen R & Leff T 2000 Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone. Diabetes 49 539-547.
11. Cnop NJ, Hannaert JC & Pipeleers DG 2002 Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity. Biochemical Pharmacology 63 1281-1285.
12. Davies GF, Khandelwal RL, Wu L, Juurlink BH & Roesler WJ 2001 Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by troglitazone: a peroxisome proliferator-activated receptor-gamma (PPARgamma)-independent, antioxidant-related mechanism. Biochemical Pharmacolgy 62 1071-1079.
13. Dubois M, Pattou F, Kerr-Conte J, Gmyr V, Vandewalle B, Desreumaux P, Auwerx J, Schoonjans K & Lefebvre J 2000 Expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) in normal human pancreatic islet cells. Diabetologia 43 1165-1169.
14. Gough NM 1988 Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells. Analytical Biochemistry 173 93-95.
15. Halban PA & Wollheim CB 1980 Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content. Journal of Biological Chemistry 255 6003-6006.
16. Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, & Unger RH 1999 Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. PNAS 96 11513-11518.
17. Itoh N & Okamoto H 1980 Translational control of proinsulin synthesis by glucose. Nature 283 100-102.
18. Kimai T, Hirose H, Seto Y, Fujita H, Fujita H, Ukeda K & Saruta T 2002 Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma. Diabetes Research and Clinical Practice 56 83-92.
19. Kim HI, Kim JW, Kim SH, Cha JY, Kim KS & Ahn YH 2000 Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter. Diabetes 49 1517-1524.
20. Kim HI, Cha JY, Kim SY, Kim JW, Roh KJ, Seong JK, Lee NT, Choi KY, Kim KS & Ahn YH 2002 Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells. Diabetes 51 676-685.
21. Lekanne Deprez RH, Fijnvandraat AC, Ruijter JM & Moorman AFM 2002 Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions. Analytical Biochemistry 307 63-69.
22. Masuda K, Okamoto Y, Tsuura Y, Kato S, Miura T, Tsuda K, Horikoshi H, Ishida H & Seino Y 1995 Effects of troglitazone (CS-045 on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide. Diabetologia 38 24-30.
23. Newgard CB & McGarry JD 1995 Metabolic coupling factors in pancreatic beta-cell signal transduction. Annual Review of Biochemistry 64 689-719.
24. Ohtani KI, Shimizu H, Sato N & Mori M 1998 Troglitazone (CS-045) inhibits beta-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells. Endocrinology 139 172-178.
25. Olefsky JM & Saltiel AR 2000 PPARgamma and the treatment of insulin resistance. Trends in Endocrinology and Metabolism 11 362-368.
26. Parker JC 2002 Troglitazone: the discovery and development of a novel therapy for the treatment of type 2 diabetes mellitus. Advanced Drug Delivery Reviews 54 1173-1197.
27. Patane G, Anello M, Piro S, Vigneri R, Purrello F & Rabuazzo AM 2002 Role of ATP production and uncoupling protien-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition. Diabetes 51 2749-2756.
28. Prigeon RL, Kahn SE & Porte D Jr 1998 Effect of troglitazone on B cell function, insulin sensitivity, and glycemic control in subjects is with type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 83 819-823.
29. Reginato MJ & Lazar MA 1999 Mechanisms by which thiazolidinediones enhance insulin action. Trends in Endocrinology and Metabolism 10 9-13.
30. Ririe KM, Rasmussen RP & Wittwer CT 1997 Product differentiation by analysis of DNA melting curves during the polymerase chain reaction. Analytical Biochemistry 245 154-160.
31. Schinner S, Dellas C, Schroder M, Heinlein CA, Chang C, Fischer J & Knepel W 2002 Repression of glucagon gene transcription by peroxisome proliferator-activated receptor gamma through inhibition of Pax6 transcriptional activity. Journal of Biological Chemistry 277 1941-1948.
32. Shimabukuro M, Zhou YT, Lee Y & Unger RH 1998 Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. Journal of Biological Chemistry 273 3547-3550.
33. Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE & Rhodes CJ 1998 A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moietics. Biochemical Journal 331 553-561.
34. Wang M, Wise SC, Leff T & Su TZ 1999 Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma. Diabetes 48 254-260.
35. Wrede CE, Dickson LM, Lingohr MK, Briaud I & Rhodes CJ 2002 Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). Journal of Biologiocal Chemistry 277 49676-49684.