PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53

Arthritis Research and Therapy

Volumn 8, Issue 6, 2006, Pages

  You, Xin ^a   Boyle, David L ^a   Hammaker, Deepa ^a   Firestein, Gary S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN P53; SMALL INTERFERING RNA;

ANIMAL; ARTHRITIS, RHEUMATOID; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; PATHOLOGY; PROCEDURES; SYNOVIUM; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; ARTHRITIS, RHEUMATOID; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENETIC THERAPY; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; SYNOVIAL MEMBRANE; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34547878987     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2052     Document Type: Article

References (26)

1. Firestein GS: Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum 1996, 39:1781-1790.
2. Okamoto K, Asahara H, Kobayashi T, Matsuno H, Hasunuma T, Kobata T, Sumida T, Nishioka K: Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Ther 1998, 5 331-338.
3. Yao Q, Seol DW, Mi Z, Robbins PD: Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis. Arthritis Res Ther 2005, 8 R16.
4. Yao Q, Wang S, Glorioso JC, Evans CH, Robbins PD, Ghivizzani SC, Oligino TJ: Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation. Mol Ther 2001, 3 901-910.
5. Cha HS, Rosengren S, Boyle DL, Firestein GS: PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis Rheum 2006, 54:587-592.
6. Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR: PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 2005, 309:1732-1735.
7. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, et al.: Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003, 4:321-328.
8. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A: p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003, 302:1036-1038.
9. Nakano K, Vousden KH: PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001, 7:683-694.
10. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B: PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001, 7 673-682.
11. Yamanishi Y, Boyle DL, Rosengren S, Green DR, Zvaifler NJ, Firestein GS: Regional analysis of p53 mutations in rheumatoid arthritis synovium Proc Natl Acad Sci USA 2002, 99:10025-10030.
12. Firestein GS, Echeverri F, Yeo M, Zvaifler NJ, Green DR: Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci USA 1997, 94:10895-10900.
13. Inazuka M, Tahira T, Horiuchi T, Harashima S, Sawabe T, Kondo M, Miyahara H, Hayashi K: Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium. Rheumatology (Oxford 2000, 39:262-266.
14. Han Z, Boyle DL, Shi Y, Green DR, Firestein GS: Dominant-negative p53 mutations in rheumatoid arthritis. Arthritis Rheum 1999, 42 1088-1092.
15. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al.: The American Rheumatism Association 1987 revised criteria for the lassification of rheumatoid arthritis. Arthritis Rheum 1988, 31:315-324.
16. Alvaro-Gracia JM, Yu C, Zvaifler NJ, Firestein GS: Mutual antagonism between interferon-γ and tumor necrosis factor-α on fibroblast-like synoviocytes: Paradoxical induction of IFN-γ and TNF-α receptor expression. J Clin Immunol 1993, 13:212-218.
17. Yamanishi Y, Boyle DL, Pinkoski MJ, Mahboubi A, Lin T, Han Z, Zvaifler NJ, Green DR, Firestein GS: Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol 2002, 160:123-130.
18. Pap T, Aupperle KR, Gay S, Firestein GS, Gay RE: Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion. Arthritis Rheum 2001, 44:676-681.
19. Franz JK, Pap T, Hummel KM, Nawrath M, Aicher WK, Shigeyama Y, Muller-Ladner U, Gay RE, Gay S: Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis. Arthritis Rheum 2000, 43:599-607.
20. Pap T, Franz JK, Hummel KM, Jeisy E, Gay R, Gay S: Activation of synovial fibroblasts in rheumatoid arthritis: Lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction. Arthritis Res 2000, 2:59-64.
21. Reme T, Travaglio A, Gueydon E, Adla L, Jorgensen C, Sany J: Mutations of the p53 tumour suppressor gene in erosive rheumatoid synovial tissue. Clin Exp Immunol 1998, 111:353-358.
22. Kullmann F, Judex M, Neudecker I, Lechner S, Justen HP, Green DR, Wessinghage D, Firestein GS, Gay S, Scholmerich J, et al.: Analysis of the p53 tumor suppressor gene in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 1999, 42:1594-1600.
23. Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L: PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003, 100:1931-1936.
24. Karst AM, Dai DL, Martinka M, Li G: PUMA expression is significantly reduced in human cutaneous melanomas. Oncogene 2005, 24 1111-1116.
25. Ito H, Kanzawa T, Miyoshi T, Hirohata S, Kyo S, Iwamaru A, Aoki H, Kondo Y, Kondo S: Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status. Hum Gene Ther 2005, 16:685-698.
26. Liu FT, Newland AC, Jia L: Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. Biochem Biophys Res Commun 2003, 310:956-962.