Invasive fibroblast-like synoviocytes in rheumatoid arthritis: Passive responders or transformed aggressors?

Arthritis and Rheumatism

Volumn 39, Issue 11, 1996, Pages 1781-1790

  Firestein, Gary S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; CYTOKINE; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; GAMMA INTERFERON; HERMES ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 4; INTERLEUKIN 6; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

APOPTOSIS; CELL DEATH; EXTRACELLULAR MATRIX; FIBROBLAST; HYPERPLASIA; ONCOGENE; PANNUS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVITIS; SYNOVIUM; T LYMPHOCYTE; TISSUE NECROSIS;

ARTHRITIS, RHEUMATOID; FIBROBLASTS; HUMANS; SYNOVIAL MEMBRANE;

EID: 0029914194     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780391103     Document Type: Review

References (85)

1. Firestein GS: Rheumatoid synovitis and pannus. In, Rheumatology. First edition. Edited by J Klippel, P Dieppe. St. Louis, Mosby, 1994
2. Edwards JCW, Willoughby DA: Demonstration of bone marrow derived cells in synovial lining by means of giant intracellular granules as genetic markers. Ann Rheum Dis 41:177-182, 1982
3. Szekanccz Z, Haines GK, Lin TR, Harlow LA, Goerdt S, Rayan G, Koch AE: Differential distribution of intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) and the MS-1 antigen in normal and diseased human synovia: their possible pathogenetic and clinical significance in rheumatoid arthritis. Arthritis Rheum 37:221-231, 1994
4. Johnson BA, Haines GK, Harlow LA, Koch AE: Adhesion molecule expression in human synovial tissue. Arthritis Rheum, 36:137-146, 1993
5. Nikkari L, Haapasalmi K, Aho H, Torvinen A, Sheppard D, Larjava H, Heino J: Localization of the α V subfamily of integrins and their putative ligands in synovial lining cell layer. J Rheumatol 22:16-23, 1995
6. Pitsillides AA, Wilkinson LS, Mehdizadeh S, Bayliss MT, Edwards JC: Uridine diphosphoglucose dehydrogenase activity in normal and rheumatoid synovium: the description of a specialized synovial lining cell. Int J Exp Pathol 74:27-34, 1993
7. Morales-Ducret J, Wayner E, Elices MJ, Alvaro-Gracia JM, Zvaifler NJ, Firestein GS: α4/β1 integrin (VLA-4) ligands in arthritis: vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes. J Immunol 149:1424-1431, 1992
8. Wilkinson LS, Edwards JC, Poston RN, Haskard DO: Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium. Lab Invest 68:82-88, 1993
9. Kriegsmann J, Keyszer GM, Geiler T, Brauer R, Gay RE, Gay S: Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry. Lab Invest 72:209-214, 1995
10. Marlor CW, Webb DL, Bombara MP, Greve JM, Blue ML: Expression of vascular cell adhesion molecule-1 in fibroblast-like synoviocytes after stimulation with tumor necrosis factor. Am J Pathol 140:1055-1060, 1992
11. 3H-thymidine incorporating cells in rheumatoid arthritis synovial membrane. Rheumatol Int 6:269-271, 1986
12. Lalor PA, Mapp PI, Hall PA, Revell PA: Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67. Rheumatol Int 7:183-186, 1987
13. Qu Z, Garcia CH, O'Rourke LM, Planck SR, Kohli M, Rosenbaum JT: Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia: results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. Arthritis Rheum 37:212-220, 1994
14. Aicher WK, Heer AH, Trabandt A, Bridges SL Jr, Schroeder HW Jr, Gay RE, Eibel H, Peter HH, Siebenlist U, Koopman WJ, Gay S: Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients. J Immunol 152:5940-5948, 1994
15. Trabandt A, Gay RE, Gay S: Oncogene activation in rheumatoid synovium. APMIS 100:861-875, 1992
16. Ritchlin C, Dwyer E, Bucala R, Winchester R: Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis. Scand J Immunol 40:292-298, 1994
17. Roivainen A, Isomaki P, Nikkari S, Saario R, Vuori K, Toivanen P: Oncogene expression in synovial fluid cells in reactive and early rheumatoid arthritis: a brief report. Br J Rheumatol 34:805-808, 1995
18. Pelletier J-P, Faure MP, DiBattista JA, Wilhelm S, Visco D, Martel-Pelletier J: Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis: an immunohistochemical study. Am J Pathol 142:95-105, 1993
19. Keyszer GM, Heer AH, Kriegsmann J, Geiler T, Trabandt A, Keysser M, Gay RE, Gay S: Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization. Arthritis Rheum 38:976-984, 1995
20. Woessner JF Jr: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145-2154, 1991
21. Firestein GS, Paine MM, Littman BH: Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium: quantitative analysis and effect of intraarticular corticosteroids. Arthritis Rheum 34:1094-1105, 1991
22. McCachren SS, Haynes BF, Niedel JE: Localization of collagenase mRNA in rheumatoid arthritis synovium by in situ hybridization histochemistry. J Clin Immunol 10:19-27, 1990
23. Firestein GS, Paine MM, Boyle DL: Mechanisms of methotrexate action in rheumatoid arthritis: selective decrease in synovial collagenase gene expression. Arthritis Rheum 37:193-200, 1994
24. Crofford LJ, Wilder RL, Ristimaki AP, Sano H, Remmers EF, Epps HR, Hla T: Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues: effects of interleukin-1β, phorbol ester, and corticosteroids. J Clin Invest 93:1095-1101, 1994
25. Burmester GR, Dimitriu-Bona A, Waters SJ, Winchester R: Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts. Scand J Immunol 17:69-82, 1983
26. Alvaro-Gracia JM, Zvaifler NJ, Firestein GS: Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-γ and tumor necrosis factor-α on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. J Clin Invest 86:1790-1798, 1990
27. 2 production by human synovial cells. J Clin Invest 77:645-648, 1986
28. Guerne P-A, Zuraw BL, Vaughan JH, Carson DA, Lotz M: Synovium as a source of interleukin 6 in vitro: contribution to local and systemic manifestations of arthritis. J Clin Invest 183:585-592, 1989
29. Müller-Ladner, U, Elices M, Kriegsmann JB, Strahl D, Gay RE, Firestein GS, Gay S: Expression of the alternatively spliced CS-1 fibronectin isoform and its counter-receptor VLA-4 in rheumatoid arthritis synovium. Submitted for publication
30. Elices MJ, Tsai V, Strahl D, Goel AS, Tollefson V, Arrhenius T, Wayner EA, Gaeta FCA, Fikes JD, Firestein GS: Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature. J Clin Invest 93:405-416, 1994
31. Tsai C, Diaz LA Jr, Singer NG, Li LL, Kirsch AH, Mitra R, Nickoloff BJ, Crofford LJ, Fox DA: Responsiveness of human T lymphocytes to bacterial superantigens presented by cultured rheumatoid arthritis synoviocytes. Arthritis Rheum 39:125-136, 1996
32. MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI: Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts: synergistic effects of interleukin-1 and tumor necrosis factor-a on stromelysin expression. J Biol Chem 265:17238-17245, 1990
33. Boyle DL, Sajjadi FG, Firestein GS: Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum 39:923-930, 1996
34. Trabandt A, Aicher WK, Gay RE, Sukhatme VP, Fassbender HG, Gay S: Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts. Rheumatol Int 12:53-59, 1992
35. Lafyatis R, Kim SJ, Angel P, Roberts AB, Sporn MB, Karin M, Wilder RL: Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5′ activator protein-1-binding site. Mol Endocrinol 4:973-980, 1990
36. Conca W, Kaplan PB, Krane SM: Increases in levels of procollagenase messenger RNA in cultured fibroblasts induced by human recombinant interleukin 1β or serum follow c-jun expression and are dependent on new protein synthesis. J Clin Invest 83:1753-1757, 1989
37. Kumkumian GK, Lafyatis R, Remmers EF, Case JP, Kim SJ, Wilder RL: Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis: regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. J Immunol 143:833-837, 1989
38. 2 production by human synovial cells and dermal fibroblasts. J Exp Med 162:2163-2168, 1985
39. Ehrlich W, Huser H, Kroger H: Induction and activation of procollagenase in rabbit synovial fibroblasts after treatment with active oxygen released by xanthine/xanthine oxidase. Rheumatol Int 15:131-136, 1996
40. Overall CM, Wrana JL, Sodek J: Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-β. J Biol Chem 264:1860-1869, 1989
41. Unemori EN, Bair MJ, Bauer EA, Amento EP: Stromelysin expression regulates collagenase activation in human fibroblasts: dissociable control of two metalloproteinases by interferon-γ. J Biol Chem 266:23477-23482, 1991
42. 1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts. Endocrinology 131:21-28, 1992
43. Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH: Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol 109:877-889, 1989
44. Unemori EN, Hibbs MS, Amento EP: Constitutive expression of a 92-kD gelatinase (type V collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Clin Invest 88:1656-1662, 1991
45. Huet G, Flipo R-M, Colin C, Janin A, Hemon B, Collyn-d'Hooghe M, Lafyatis R, Duquesnoy B, Degand P: Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor α and interleukin-1. Arthritis Rheum 36:772-780, 1993
46. Firestein GS, Paine MM: Stromelysin and tissue inhibitor of metalloproteinases (TIMP) gene expression in rheumatoid arthritis synovium. Am J Pathol 140:1309-1314, 1992
47. Lotz M, Guerne PA: Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 266:2017-2020, 1991
48. Wright JK, Cawston TE, Hazleman BL: Transforming growth factor β stimulates the production of the tissue inhibitor of metalloproteinases (TIMP) by human synovial and skin fibroblasts. Biochim Biophys Acta 1094:207-210, 1991
49. Okada Y. Gonoji Y, Nakanishi I, Nagase H, Hayakawa T: Immunohistochemical demonstration of collagenase and tissue inhibitor of metalloproteinases (TIMP) in synovial lining cells of rheumatoid synovium. Virchows Arch 59:305-12, 1990
50. Firestein GS, Zvaifler NJ: How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum 33:768-773, 1990
51. Firestein, GS, Alvaro-Gracia JM, Maki R: Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 144:3347-3353, 1990
52. Arend WP, Dayer J-M: Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum 33:305-315, 1990
53. Ben-Av P, Crofford LJ, Wilder RL, Hla T: Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett 372:83-87, 1995
54. Sano H, Forough R, Maier JA, Case JP, Jackson A, Engleka K, Maciag T, Wilder RL: Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints. J Cell Biol 110:1417-1426, 1990
55. Alvaro-Gracia, JM, NJ Zvaifler, CB Brown, K Kaushansky, GS Firestein: Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and TNF-α. J Immunol 146:3365-3371, 1991
56. Koch AE, Kunkel SL, Burrows JC, Evanoff HL, Haines GK, Pope RM, Stricter RM: Synovial tissue macrophage as a source of the chemotactic cytokine IL-8. J Immunol 147:2187-2195, 1991
57. Alvaro-Gracia JM, Yu C, Zvaifler NJ, Firestein GS: Mutual antagonism between interferon-γ and tumor necrosis factor-α on fibroblast-like synoviocytes: paradoxical induction of IFN-γ and TNF-α receptor expression. J Clin Immunol 13:212-218, 1993
58. Taylor DJ: Cytokine combinations increase p75 tumor necrosis factor receptor binding and stimulate receptor shedding in rheumatoid synovial fibroblasts. Arthritis Rheum 37:232-235, 1994
59. Firestein GS, Boyle DL, Yu C, Paine MM, Whisenand TD, Zvaifler NJ, Arend WP: Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum 37:644-652, 1994
60. Alvaro-Gracia, JM, NJ Zvaifler, GS Firestein: Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis. J Exp Med 170:865-875, 1989
61. Goddard DH, Grossman SL, Williams WV, Weiner DB, Gross JL, Eidsvoog K, Dasch JR: Regulation of synovial cell growth: coexpression of transforming growth factor β and basic fibroblast growth factor by cultured synovial cells. Arthritis Rheum 35:1296-1303, 1992
62. Lafyatis R, Remmers EF, Roberts AB, Yocum DE, Sporn MB, Wilder RL: Anchorage-independent growth of synoviocytes from arthritic and normal joints: stimulation by exogenous plateletderived growth factor and inhibition by transforming growth factor-β and retinoids. J Clin Invest 83:1267-1276, 1989
63. Gay S, Gay RE: Cellular basis and oncogene expression of rheumatoid joint destruction. Rheumatol Int 9:105-113, 1989
64. Bucala R, Ritchlin C, Winchester R, Cerami A: Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. J Exp Med 173:569-574, 1991
65. Remmers EF, Lafyatis R, Kumkumian GK, Case JP, Roberts AB, Sporn MB, Wilder RL: Cytokines and growth regulation of synoviocytes from patients with rheumatoid arthritis and rats with streptococcal cell wall arthritis. Growth Factors 2:179-188, 1990
66. Geiler T, Kriegsmann J, Keyszer GM, Gay RE, Gay S: A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 37:1664-1671, 1994
67. Müller-Ladner L, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, Gay S: Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol (in press)
68. Zvaifler NJ, Firestein GS: Pannus and pannocytes: alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 37:783-789, 1994
69. Zvaifler NJ, Tsai V, von Kempis J, Alsalameh S, Firestein GS, Lotz M: Pannocytes: distinctive cells found in articular cartilage erosions from the joints of patients with rheumatoid arthritis. Am J Pathol (in press)
70. Schwarz H, Tuckwell J, Lotz M: A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. Gene 134:295-298, 1993
71. Palmer RM, Hickery MS, Charles IG, Moncada S, Bayliss MT: Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Commun 193:398-405, 1993
72. Xue C, Takahashi M, Aono H, Hasunuma T, Nishioka K: Characterization of alternative fibroblast-like cells sharing the properties of fibroblasts and chondrocytes in RA pannus lesions (abstract). Arthritis Rheum 38 (suppl 9):S344, 1995
73. Martin SJ, Green DR: Protease activation during apoptosis: death by a thousand cuts? Cell 82:349-352, 1995
74. Orrenius S: Apoptosis: molecular mechanisms and implications for human disease. J Intern Med 237:529-536, 1995
75. Firestein GS, Yeo M, Zvaifler NJ: Apoptosis in rheumatoid arthritis synovium. J Clin Invest 96:1631-1638, 1995
76. Mountz JD, Wu J, Cheng J, Zhou T: Autoimmune disease: a problem of defective apoptosis. Arthritis Rheum 37:1415-1420, 1994
77. Ueda N, Shah SV: Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells. J Clin Invest 90:2593-2597, 1992
78. Nakajima T, Aono H, asunuma T, Yamamoto K, Shirai T, Hirohata K, Nishioka K: Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 38:485-491, 1995
79. Lane DP: Cancer: p53, guardian of the genome. Nature 358:15-16, 1992
80. Conway JG, Wakefield JA, Brown RH, Marron BE, Sekut L, Stimpson SA, McElroy A, Menius JA, Jeffreys JJ, Clark RL, McGeehan GM, Connolly KM: Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor. J Exp Med 182:449-457, 1995
81. Firestein GS, Nguyenk, Aupperle K, Yeo M, Boyle DL, Zvaifler NJ: Apoptosis in rheumatoid arthritis. II. p53 overexpression in rheumatoid arthritis synovium. Am J Pathol (in press)
82. Gearing AJ, Beckett P, Christodoulou M, Churchill M, Clements J, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL, Leber TM, Mangan M, Miller K, Nayee P, Owen K, Patel S, Thomas W, Wells G, Wood LM, Wolley K: Processing of tumour necrosis factor-α precursor by metalloproteinases. Nature 370(6490):555-557, 1994
83. Seibert K, Masferrer J, Zhang Y, Gregory S, Olson G, Hauser S, Leahy K, Perkins W, Isakson P: Mediation of inflammation by cyclooxygenase-2. Agents Actions 46 (suppl):41-50, 1995
84. Harris RR, Carter GW, Bell RL, Moore JL, Brooks DW: Clinical activity of leukotriene inhibitors. Int J Immunopharmacol 17:147-56 1995
85. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243, 1991