Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway

Toxicology

Volumn 304, Issue , 2013, Pages 120-131

  Liu, Yanwu ^a   Wang, Lingjuan ^a   Wu, Yaoping ^a   Lv, Changwei ^a   Li, Xinkui ^a   Cao, Xiaorui ^a   Yang, Min ^a   Feng, Dapeng ^a   Luo, Zhuojing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antitumor activity; JAK2 STAT3 signaling; Osteosarcoma; Pterostilbene

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOCHROME C; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; P21 ACTIVATED KINASE; PROTEIN BCL 10; PTEROSTILBENE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; STILBENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL ADHESION; CELL GROWTH; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME INHIBITION; GENE TARGETING; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JANUS KINASE 2; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OSTEOSARCOMA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STILBENES; TIME FACTORS; TYRPHOSTINS; UP-REGULATION;

EID: 84872689881     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.12.018     Document Type: Article

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