MMPT as a reactive oxygen species generator induces apoptosis via the depletion of intracellular GSH contents in A549 cells

European Journal of Pharmacology

Volumn 688, Issue 1-3, 2012, Pages 6-13

  Zhao, Yun Feng ^a,b   Zhang, Cui ^c   Suo, You Rui ^b  

^a QUFU NORMAL UNIVERSITY   (China)

^b NORTHWEST INSTITUTE OF PLATEAU BIOLOGY   (China)

^c TAISHAN UNIVERSITY   (China)

Author keywords

A549 cells apoptosis; Caspase; GSH; MMPT; Reactive oxygen species

Indexed keywords

5 [(4 METHYLPHENYL)METHYLENE] 2 (PHENYLAMINO) 4(5H)THIAZOLONE; BUTHIONINE SULFOXIMINE; CASPASE 3; GLUTATHIONE; GLUTATHIONE DISULFIDE; REACTIVE OXYGEN METABOLITE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; PRIORITY JOURNAL;

ACETYLCYSTEINE; ANILINE COMPOUNDS; APOPTOSIS; BUTHIONINE SULFOXIMINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; G2 PHASE CELL CYCLE CHECKPOINTS; GLUTATHIONE; HUMANS; INTRACELLULAR SPACE; M PHASE CELL CYCLE CHECKPOINTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; THIAZOLES;

EID: 84863530720     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.05.003     Document Type: Article

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