Globular adiponectin improves high glucose-suppressed endothelial progenitor cell function through endothelial nitric oxide synthase dependent mechanisms

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 1, 2011, Pages 109-119

  Huang, Po Hsun ^a,b   Chen, Jia Shiong ^b   Tsai, Hsiao Ya ^b   Chen, Yung Hsiang ^c   Lin, Feng Yen ^d   Leu, Hsin Bang ^a,b   Wu, Tao Cheng ^a,b   Lin, Shing Jong ^a,b   Chen, Jaw Wen ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adiponectin; Endothelial progenitor cell; Hyperglycemia; Mitogen activated protein kinase; Nitric oxide

Indexed keywords

ADIPONECTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROTEIN KINASE B;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CELL AGING; CELL FUNCTION; CELL MIGRATION; CELL SHAPE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN FUNCTION; STEM CELL; UPREGULATION;

ADIPONECTIN; ANIMALS; CELL AGING; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GLUCOSE; HUMANS; HYPERGLYCEMIA; IMIDAZOLES; MICE; MICE, NUDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RANDOM ALLOCATION; STEM CELLS;

MUS MUSCULUS;

EID: 79956327626     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.03.008     Document Type: Article

References (42)

1. The DCCT/EDIC Study Research Group Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005, 353:2643-2653.
2. Bonetti P.O., Lerman L.O., Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003, 23:168-175.
3. Fujiyama S., Amano K., Uehira K., Yoshida M., Nishiwaki Y., Nozawa Y., et al. Bone marrow monocyte lineage cells adhere on injured endothelium in a monocyte chemoattractant protein-1-dependent manner and accelerate reendothelialization as endothelial progenitor cells. Circ Res 2003, 93:980-989.
4. Werner N., Priller J., Laufs U., Endres M., Böhm M., Dirnagl U., et al. Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arterioscler Thromb Vasc Biol 2002, 22:1567-1572.
5. Hill J.M., Zalos G., Halcox J.P., Schenke W.H., Waclawiw M.A., Quyyumi A.A., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003, 348:593-600.
6. Loomans C.J., de Koning E.J., Staal F.J., Rookmaaker M.B., Verseyden C., de Boer H.C., et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004, 53:195-199.
7. Fadini G.P., Miorin M., Facco M., Bonamico S., Baesso I., Grego F., et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 2005, 45:1449-1457.
8. Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005, 353:999-1007.
9. Dimmeler S., Zeiher A.M. Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?. J Mol Med 2004, 82:671-677.
10. Chen Y.H., Lin S.J., Lin F.Y., Wu T.C., Tsao C.R., Huang P.H., et al. High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 2007, 56:1559-1568.
11. Trayhurn P., Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001, 60:329-339.
12. Hopkins T., Ouchi N., Shibata R., Walsh K. Adiponectin actions in the cardiovascular system. Cardiovasc Res 2007, 74:11-18.
13. Snijder M.B., Heine R.J., Seidell J.C., Bouter L.M., Stehouwer C.D., Nijpels G., et al. Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the hoorn study. Diabetes Care 2006, 29:2498-2503.
14. Huang S.S., Huang P.H., Chen Y.H., Chiang K.H., Chen J.W., Lin S.J. Association of adiponectin with future cardiovascular events in patients after acute myocardial infarction. J Atheroscler Thromb 2010, 17:295-303.
15. Hattori Y., Suzuki M., Hattori S., Kasai K. Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 2003, 46:1543-1549.
16. Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M.J. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003, 278:45021-45026.
17. Ouedraogo R., Wu X., Xu S.Q., Fuchsel L., Motoshima H., Mahadev K., et al. Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 2006, 55:1840-1846.
18. Yoon C.H., Hur J., Oh I.Y., Park K.W., Kim T.Y., Shin J.H., et al. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 2004, 24:288-293.
19. Huang P.H., Chen Y.H., Wang C.H., Chen J.S., Tsai H.Y., Lin F.Y., et al. Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2009, 29:1179-1184.
20. Huang P.H., Chen Y.H., Chen Y.L., Wu T.C., Chen J.W., Lin S.J. Vascular endothelial function and circulating endothelial progenitor cells in patients with cardiac syndrome X. Heart 2007, 93:1064-1070.
21. Chen J.W., Chen Y.H., Lin F.Y., Chen Y.L., Lin S.J. Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. Arterioscler Thromb Vasc Biol 2003, 23:1559-1566.
22. Huang P.H., Sata M., Nishimatsu H., Sumi M., Hirata Y., Nagai R. Pioglitazone ameliorates endothelial dysfunction and restores ischemia-induced angiogenesis in diabetic mice. Biomed Pharmacother 2008, 62:46-52.
23. Kalka C., Masuda H., Takahashi T., Kalka-Moll W.M., Silver M., Kearney M., et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 2000, 97:3422-3427.
24. Aicher A., Heeschen C., Mildner-Rihm C., Urbich C., Ihling C., Technau-Ihling K., et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003, 9:1370-1376.
25. Chang J., Li Y., Huang Y., Lam K.S., Hoo R.L., Wong W.T., et al. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes 2010, 59:2949-2959.
26. Rauscher F.M., Goldschmidt-Clermont P.J., Davis B.H., Wang T., Gregg D., Ramaswami P., et al. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 2003, 108:457-463.
27. Tepper O.M., Galiano R.D., Capla J.M., Kalka C., Gagne P.J., Jacobowitz G.R., et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002, 106:2781-2786.
28. Berg A.H., Scherer P.E. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005, 96:939-949.
29. Han S.H., Quon M.J., Kim J.A., Koh K.K. Adiponectin and cardiovascular disease: response to therapeutic interventions. J Am Coll Cardiol 2007, 49:531-538.
30. Ouchi N., Kihara S., Funahashi T., Matsuzawa Y., Walsh K. Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 2003, 14:561-566.
31. Wu X., Motoshima H., Mahadev K., Stalker T.J., Scalia R., Goldstein B.J. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 2003, 52:1355-1363.
32. Okamoto Y., Arita Y., Nishida M., Muraguchi M., Ouchi N., Takahashi M., et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res 2000, 32:47-50.
33. κB signaling through cAMP-dependent pathway. Circulation 2000, 102:1296-1301.
34. Kumada M., Kihara S., Sumitsuji S., Kawamoto T., Matsumoto S., Ouchi N., et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003, 23:85-89.
35. Kojima S., Funahashi T., Sakamoto T., Miyamoto S., Soejima H., Hokamaki J., et al. The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction. Heart 2003, 89:667.
36. Otsuka F., Sugiyama S., Kojima S., Maruyoshi H., Funahashi T., Matsui K., et al. Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease. J Am Coll Cardiol 2006, 48:1155-1162.
37. Shibata R., Skurk C., Ouchi N., Galasso G., Kondo K., Ohashi T., et al. Adiponectin promotes endothelial progenitor cell number and function. FEBS Lett 2008, 582:1607-1612.
38. Montagnani M., Chen H., Barr V.A., Quon M.J. Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem 2001, 276:30392-30398.
39. Seeger F.H., Haendeler J., Walter D.H., Rochwalsky U., Reinhold J., Urbich C., et al. p38 mitogen-activated protein kinase downregulates endothelial progenitor cells. Circulation 2005, 111:1184-1191.
40. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
41. Piñeiro R., Iglesias M.J., Gallego R., Raghay K., Eiras S., Rubio J., et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 2005, 579:5163-5169.
42. Tan K.C., Xu A., Chow W.S., Lam M.C., Ai V.H., Tam S.C., et al. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 2004, 89:765-769.