Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 8, 2012, Pages 1878-1888

  Du, Wan ^a   Hong, Jie ^a   Wang, Ying Chao ^a   Zhang, Yan Jie ^a   Wang, Ping ^a   Su, Wen Yu ^a   Lin, Yan Wei ^a   Lu, Rong ^a   Zou, Wei Ping ^b   Xiong, Hua ^a   Fang, Jing Yuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Colorectal cancer; JAK2 STAT3; Mitochondrial apoptotic pathway

Indexed keywords

ALPHA CYANO (3,4 DIHYDROXY) N BENZYLCINNAMIDE; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; CASPASE; CYTOCHROME C; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TYRPHOSTIN;

ANIMAL; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; COLORECTAL TUMOR; CYTOSOL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NUDE MOUSE; PATHOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYTOCHROMES C; CYTOSOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JANUS KINASE 2; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MITOCHONDRIA; MODELS, BIOLOGICAL; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TYRPHOSTINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864394567     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01483.x     Document Type: Article

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