메뉴 건너뛰기




Volumn 37, Issue 8, 2010, Pages 833-840

Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells

Author keywords

A549 cells; cardiotoxin III; epidermal growth factor receptor; Janus tyrosine kinase 2 signal transducer and activator of transcription 3; phosphatidylinositol 3 kinase Akt

Indexed keywords

CARDIOTOXIN; CASPASE 3; CASPASE 9; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLSERINE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN MCL 1; STAT3 PROTEIN; WORTMANNIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 77955120989     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (21)

References (40)
  • 2
    • 25444480013 scopus 로고    scopus 로고
    • Chemotherapy for advanced non-small-cell lung cancer
    • Raez LE, Lilenbaum R. Chemotherapy for advanced non-small-cell lung cancer. Clin. Adv. Hematol. Oncol. 2004 2:173 178.
    • (2004) Clin. Adv. Hematol. Oncol. , vol.2 , pp. 173-178
    • Raez, L.E.1    Lilenbaum, R.2
  • 3
    • 24944465616 scopus 로고    scopus 로고
    • The role of targeted agents in adjuvant therapy for non-small cell lung cancer
    • Kelly K. The role of targeted agents in adjuvant therapy for non-small cell lung cancer. Clin. Cancer Res. 2005 11 (Suppl. S5027 9.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.SUPPL. , pp. 5027-5029
    • Kelly, K.1
  • 5
    • 0035901570 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling
    • Bogdan S, Klambt C. Epidermal growth factor receptor signaling. Curr. Biol. 2001 11 (Suppl. R292 5.
    • (2001) Curr. Biol. , vol.11 , Issue.SUPPL. , pp. 292-295
    • Bogdan, S.1    Klambt, C.2
  • 6
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J. Clin. Oncol. 2002 20 (Suppl. S1 13.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.SUPPL. , pp. 1-13
    • Mendelsohn, J.1
  • 7
    • 0037010076 scopus 로고    scopus 로고
    • Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia
    • Arteaga CL. Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin. Oncol. 2002 29 (Suppl. S3 9.
    • (2002) Semin. Oncol. , vol.29 , Issue.SUPPL. , pp. 3-9
    • Arteaga, C.L.1
  • 8
    • 0028292482 scopus 로고
    • Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis
    • Shin DM, Ro JY, Hong WK, Hittelman WN. Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis. Cancer Res. 1994 54:3153 3159.
    • (1994) Cancer Res. , vol.54 , pp. 3153-3159
    • Shin, D.M.1    Ro, J.Y.2    Hong, W.K.3    Hittelman, W.N.4
  • 11
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002 296:1655 1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 12
    • 0036625960 scopus 로고    scopus 로고
    • The role of STATs in apoptosis
    • Battle TE, Frank DA. The role of STATs in apoptosis. Curr. Mol. Med. 2002 2:381 392.
    • (2002) Curr. Mol. Med. , vol.2 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 13
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer: New molecular targets come of age
    • Yu H, Jove R. The STATs of cancer: New molecular targets come of age. Nat. Rev. Cancer 2004 4:97 105.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 14
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: Intracellular signaling by proteolysis
    • Salvesen GS, Dixit VM. Caspases: Intracellular signaling by proteolysis. Cell 1997 91:443 446.
    • (1997) Cell , vol.91 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 15
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams JM, Cory S. The Bcl-2 protein family: Arbiters of cell survival. Science 1998 281:1322 1326.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 17
    • 0002233448 scopus 로고    scopus 로고
    • The structure and pharmacology of Elapid cytotoxins
    • In. Harvey, A.L. ed). Pergamon Press
    • Dufton MJ, Hider RC. The structure and pharmacology of Elapid cytotoxins. In:Harvey AL (ed). Snake Toxins. Pergamon Press
    • Snake Toxins.
    • Dufton, M.J.1    Hider, R.C.2
  • 18
    • 0025801848 scopus 로고
    • Fusion of sphingomyelin vesicles induced by proteins from Taiwan cobra (Naja naja atra) venom Interaction of zwitterionic phospholipids with cardiotoxin analogues
    • Chien KY, Huang WN, Jean JH, Wu WG. Fusion of sphingomyelin vesicles induced by proteins from Taiwan cobra (Naja naja atra) venom Interaction of zwitterionic phospholipids with cardiotoxin analogues. J. Biol. Chem. 1991 266:3235 3259.
    • (1991) J. Biol. Chem. , vol.266 , pp. 3235-3259
    • Chien, K.Y.1    Huang, W.N.2    Jean, J.H.3    Wu, W.G.4
  • 19
    • 0027532044 scopus 로고
    • Pharmacokinetics of cytotoxin from Chinese cobra (Naja naja atra) venom
    • Guo MP, Wang QC, Liu GF. Pharmacokinetics of cytotoxin from Chinese cobra (Naja naja atra) venom. Toxicon 1993 31:339 343.
    • (1993) Toxicon , vol.31 , pp. 339-343
    • Guo, M.P.1    Wang, Q.C.2    Liu, G.F.3
  • 20
    • 0027528497 scopus 로고
    • Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: Comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and model of enzyme inhibition
    • Chiou SH, Raynor RL, Zheng B, Chambars TC, Kuo JF. Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: Comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and model of enzyme inhibition. Biochemistry 1993 32:2062 2067.
    • (1993) Biochemistry , vol.32 , pp. 2062-2067
    • Chiou, S.H.1    Raynor, R.L.2    Zheng, B.3    Chambars, T.C.4    Kuo, J.F.5
  • 22
    • 14844285387 scopus 로고    scopus 로고
    • Induction of apoptosis in human leukemia K562 cells by cardiotoxin III
    • Yang SH, Lu MC, Chien CM et al. Induction of apoptosis in human leukemia K562 cells by cardiotoxin III. Life Sci. 2005 76:2513 2522.
    • (2005) Life Sci. , vol.76 , pp. 2513-2522
    • Yang, S.H.1    Lu, M.C.2    Chien, C.M.3
  • 23
    • 16344384077 scopus 로고    scopus 로고
    • Cardiotoxin III induces apoptosis in T24 cells via reactive oxygen species-independent mitochondrial death pathway
    • Chien CM, Yang SH, Lu MC, Chang LS, Lin SR. Cardiotoxin III induces apoptosis in T24 cells via reactive oxygen species-independent mitochondrial death pathway. Drug Dev. Res. 2004 63:219 224.
    • (2004) Drug Dev. Res. , vol.63 , pp. 219-224
    • Chien, C.M.1    Yang, S.H.2    Lu, M.C.3    Chang, L.S.4    Lin, S.R.5
  • 24
    • 33645067914 scopus 로고    scopus 로고
    • Mechanism of cardiotoxin III-induced apoptosis in human colorectal cancer Colo 205 cells
    • Tsai CH, Yang SH, Chien CM et al. Mechanism of cardiotoxin III-induced apoptosis in human colorectal cancer Colo 205 cells. Clin. Exp. Pharmacol. Physiol. 2006 33:177 182.
    • (2006) Clin. Exp. Pharmacol. Physiol. , vol.33 , pp. 177-182
    • Tsai, C.H.1    Yang, S.H.2    Chien, C.M.3
  • 25
    • 38549093268 scopus 로고    scopus 로고
    • Cardiotoxin III induces c-Jun N-terminal kinase-dependent apoptosis in HL-60 human leukemia cells
    • Chien CM, Yang SH, Yang CC, Chang LS, Lin SR. Cardiotoxin III induces c-Jun N-terminal kinase-dependent apoptosis in HL-60 human leukemia cells. Cell Biochem. Funct. 2008 26:111 118.
    • (2008) Cell Biochem. Funct. , vol.26 , pp. 111-118
    • Chien, C.M.1    Yang, S.H.2    Yang, C.C.3    Chang, L.S.4    Lin, S.R.5
  • 26
    • 65649150091 scopus 로고    scopus 로고
    • Effects of cardiotoxin III on NFκB function, proliferation and apoptosis in human breast MCF-7 cancer cells
    • Chiu CC, Lin KL, Chien CM, Chang LS, Lin SR. Effects of cardiotoxin III on NFκB function, proliferation and apoptosis in human breast MCF-7 cancer cells. Oncol. Res. 2009 17:311 321.
    • (2009) Oncol. Res. , vol.17 , pp. 311-321
    • Chiu, C.C.1    Lin, K.L.2    Chien, C.M.3    Chang, L.S.4    Lin, S.R.5
  • 27
    • 70350497588 scopus 로고    scopus 로고
    • Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra
    • Chien CM, Lin KL, Su JC, Chang LS, Lin SR. Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra. J. Nat. Prod. 2009 72:1735 1740.
    • (2009) J. Nat. Prod. , vol.72 , pp. 1735-1740
    • Chien, C.M.1    Lin, K.L.2    Su, J.C.3    Chang, L.S.4    Lin, S.R.5
  • 28
    • 52649133897 scopus 로고    scopus 로고
    • Separation and structure-function studies of Taiwan cobra cardiotoxins
    • Lin SR, Chang LS, Chang KL. Separation and structure-function studies of Taiwan cobra cardiotoxins. J. Protein Chem. 2005 21:81 6.
    • (2005) J. Protein Chem. , vol.21 , pp. 81-86
    • Lin, S.R.1    Chang, L.S.2    Chang, K.L.3
  • 29
    • 2442460088 scopus 로고    scopus 로고
    • Role of mitochondrial membrane permeabilization in apoptosis and cancer
    • Henry-Mowatt J, Dive C, Martinou JC, James D. Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 2004 23:2850 2860.
    • (2004) Oncogene , vol.23 , pp. 2850-2860
    • Henry-Mowatt, J.1    Dive, C.2    Martinou, J.C.3    James, D.4
  • 30
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A. Tyrosine kinase inhibition: An approach to drug development. Science 1995 267:1782 1788.
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 31
    • 0032780007 scopus 로고    scopus 로고
    • 4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition
    • Liu W, Akhand AA, Kato M et al. 4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition. J. Cell Sci. 1999 112:2409 2417.
    • (1999) J. Cell Sci. , vol.112 , pp. 2409-2417
    • Liu, W.1    Akhand, A.A.2    Kato, M.3
  • 32
    • 0034613302 scopus 로고    scopus 로고
    • Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1
    • Jiang X, Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J. Biol. Chem. 2000 275:31.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31
    • Jiang, X.1    Wang, X.2
  • 33
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: A play in three Akts. Genes Dev. 1999 13:2905 2927.
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 34
    • 34447277695 scopus 로고    scopus 로고
    • Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells
    • Huang SH, Chen Y, Tung PY et al. Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells. J. Cell. Biochem. 2007 101:1011 1022.
    • (2007) J. Cell. Biochem. , vol.101 , pp. 1011-1022
    • Huang, S.H.1    Chen, Y.2    Tung, P.Y.3
  • 35
    • 66849113659 scopus 로고    scopus 로고
    • Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells
    • Kuo PL, Ni WC, Tsai EM, Hsu YL. Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells. Mol. Cancer Ther. 2009 8:1328 1339.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1328-1339
    • Kuo, P.L.1    Ni, W.C.2    Tsai, E.M.3    Hsu, Y.L.4
  • 36
    • 33745726223 scopus 로고    scopus 로고
    • Additive antitumor effects of gefitinib and imatinib on anaplastic thyroid cancer cells
    • Kurebayashi J, Okubo S, Yamamoto Y et al. Additive antitumor effects of gefitinib and imatinib on anaplastic thyroid cancer cells. Cancer Chemother. Pharmacol. 2006 58:460 470.
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , pp. 460-470
    • Kurebayashi, J.1    Okubo, S.2    Yamamoto, Y.3
  • 37
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    • Willis SN, Chen L, Dewson G et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 2005 19:1294 1305.
    • (2005) Genes Dev. , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3
  • 38
    • 60549089718 scopus 로고    scopus 로고
    • Indomethacin causes renal epithelial cell injury involving Mcl-1 down-regulation
    • Ou YC, Yang CR, Cheng CL et al. Indomethacin causes renal epithelial cell injury involving Mcl-1 down-regulation. Biochem. Biophys. Res. Commun. 2009 380:531 536.
    • (2009) Biochem. Biophys. Res. Commun. , vol.380 , pp. 531-536
    • Ou, Y.C.1    Yang, C.R.2    Cheng, C.L.3
  • 39
    • 0034646644 scopus 로고    scopus 로고
    • Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-responsive element-binding protein
    • Pugazhenthi S, Nesterova A, Sable C et al. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-responsive element-binding protein. J. Biol. Chem. 2000 275:10.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10
    • Pugazhenthi, S.1    Nesterova, A.2    Sable, C.3
  • 40
    • 26644449670 scopus 로고    scopus 로고
    • The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt knase pathwaysin PTEN-deficient tumor cells
    • She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt knase pathwaysin PTEN-deficient tumor cells. Cancer Cell 2005 8:287 297.
    • (2005) Cancer Cell , vol.8 , pp. 287-297
    • She, Q.B.1    Solit, D.B.2    Ye, Q.3    O'Reilly, K.E.4    Lobo, J.5    Rosen, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.