A potent lead induces apoptosis in pancreatic cancer cells

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Liu, Zuojia ^a   Li, Dan ^a   Zhao, Wenjing ^a   Zheng, Xiliang ^a   Wang, Jin ^a,b   Wang, Erkang ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (BENZO[D]OXAZOL 3(2H) YLMETHYL) 5 [(CYCLOHEXYLAMINO)METHYL]BENZENE 1,4 DIOL; ANTINEOPLASTIC AGENT; CASPASE; CYTOCHROME C; NSC 48693; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RESISTANCE; DRUG SPECIFICITY; EMBRYO; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; PANCREAS CANCER; PROTEIN SECRETION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES;

EID: 84862653283     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037841     Document Type: Article

References (37)

1. Jemal A, Siegel R, Ward E, Hao YP, Xu JQ, et al. (2009) Thun, Cancer statistics 2009. CA Cancer J Clin 59: 225-249.
2. Jemal A, Siegel R, Xu J, Ward E, (2010) Cancer statistics, 2010. CA Cancer J Clin 60: 277-300.
3. Andersson R, Aho U, Nilsson BI, Peters GJ, Pastor-Anglada M, et al. (2009) Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions. Scand J Gastroentero 44: 782-786.
4. Paul EO, Muhammad WS, (2011) First-line treatment for advanced pancreatic cancer. JOP J Pancreas 12: 96-100.
5. Stathis A, Moore J, (2010) Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 7: 163-172.
6. Ker JFK, Wyllie AH, Currie AR, (1972) Apoptosis, a basic biological phenomena with wider implications in tissue kinetics. Brit J Cancer 26: 239-245.
7. Kohl NE, Mosser SD, de Solms SJ, Giuliani EA, Pompliano DL, et al. (1993) Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 260: 1934-1937.
8. Nicholson DW, (2000) From bench to clinic with apoptosis-based therapeutic agents. Nature 407: 810-816.
9. Mimeault M, Hauke R, Batra SK, (2007) Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther 83: 673-691.
10. Murtaza I, Saleem M, Adhami VM, Hafeez BB, Mukhtar H, (2009) Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells. Cancer Res 69: 1156-1165.
11. Bradley F, Karlheinz S, Sean B, Dafna BS, Nicolas N, (2005) Structure of the G60A mutant of Ras: implications for the dominant negative effect. J Bio Chem 280: 25697-25705.
12. Schüttelkopf AW, van Aalten DMF, (2004) Prodrg: a tool for high-throughput crystallography of protein-ligand complexes. Acta Cryst D60: 1355-1363.
13. Wang J, Zheng XL, Yang Y, Drueckhammer D, Yang W, et al. (2007) Quantifying intrinsic specificity: a potential complement to affinity in drug screening. Phys Rev Lett 99: 1981011-1981014.
14. Pratima NM, Larry T, Malathy PVS, Eduardo P, Victor H, (2007) Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum, Int. J. Cancer 121: 884-894.
15. Min JK, Kim JH, Cho YL, Maeng YS, Lee SJ, (2006) 20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway. Biochem Biophy Res Commun 349: 987-994.
16. Ren DD, Peng GH, Huang HG, (2006) Effect of rhodoxanthin from potamogeton crispus L on cell apoptosis in Hela cells. Toxicol In Vitro 20: 1411-1418.
17. Zou GM, Maitra A, (2008) Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration. Mol Cancer Ther 7: 2012-2021.
18. Beauparlant P, Shore GC, (2003) Therapeutic activation of caspases in cancer: a question of selectivity. Curr Opin Drug Discov Dev 6: 179-187.
19. Kerr JF, Wyllie AH, Currie AR, (1972) Apoptosis: a basic biological phenomenon with wild-ranging implications in tissue kinetics. Br J Cancer 26: 239-257.
20. Karaguni IM, Glüsenkamp KH, Langerak A, Geisen C, Ullrich V, (2002) New indene-derivatives with anti-proliferative properties. Bioorg Med Chem Lett 12: 709-713.
21. Engeland MV, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP, (1998) Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31: 1-9.
22. Yip-Schneider MT, Sweeney CJ, Jung SH, Crowell PL, Marshall MS, (2001) Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther 298: 976-985.
23. Stahnke K, Mohr A, Liu J, Meyer LH, Karawajew L, (2004) Identification of deficient mitochondrial signaling in apoptosis resistant leukemia cells by flow cytometric analysis of intracellular cytochrome c, caspase-3 and apoptosis. Apoptosis 9: 457-465.
24. Heerdt BG, Houston MA, Anthony GM, Augenlicht LH, (1998) Mitochondrial membrane potential (ΔΨmt) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. Cancer Res 58: 2869-2875.
25. Lisa BH, Cristina MP, Samuel C, Douglas RG, (2008) Measuring apoptosis at the single cell level. Methods 44: 222-228.
26. Taraphdar AK, Roy M, Bhattacharya RK, (2001) Natural products as inducers of apoptosis: implication for cancer therapy and prevention. Curr Sci India 80: 1387-1396.
27. Ma D, Tremblay P, Mahngar K, Akbari-Asl P, Collins J, et al. (2011) Induction of apoptosis and autophagy in human pancreatic cancer cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin. Am J Biomed Sci 3: 278-291.
28. You BR, Park WH, (2010) Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase. Toxicol in Vitro 24: 1356-1362.
29. Fisher DE, (1994) Apoptosis in cancer therapy: crossing the threshold. Cell 78: 539-542.
30. Evans DB, Abbruzzese JL, Rich TZ, (1997) Cancer of the pancreas. In DeVita VT, Hellman S, Rosenberg SA, eds. Cancer, Principles and Practice of Oncology, Fifth Edition. Philadelphia: JB Lippincott Co, 1054-1058.
31. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132.
32. Hegardt C, Andersson G, Stina MO, (2001) Different roles of spermine in glucocorticoid and Fas-induced apoptosis. Exp Cell Res 266: 333-341.
33. Liu X, Kim CN, Yang J, Jemmerson R, Wang X, (1996) Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell: 86 147-157.
34. Xiao D, Lew KL, Zeng Y, Xiao H, Marynowski SW, (2006) Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of mitochondrial membran potential. Carcinogenesis 27: 2223-2234.
35. McCollum AK, Teneyck CJ, Sauer BM, Toft DO, Erlichman C, (2006) Up-regulation of heat shock protein 27 induces resistance to 17-allylamino- demethoxygel-danamycin through a glutathione-mediated mechanism. Cancer Res 66: 10967-10975.
36. Blanc C, Deveraux QL, Krajewski S, Janicke RU, Porter AG, (2000) Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res 60: 4386-4390.
37. Heerdt BG, Houston MA, Anthony GM, Augenlicht LH, (1998) Mitochondrial membrane potential (ΔΨmt) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. Cancer Res 58: 2869-2875.