3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2

Biochemical Pharmacology

Volumn 85, Issue 3, 2013, Pages 404-416

  Schepetkin, Igor A ^a   Kirpotina, Liliya N ^a   Khlebnikov, Andrei I ^b   Leopoldo, Marcello ^c   Lucente, Ermelinda ^c   Lacivita, Enza ^c   De Giorgio, Paola ^c   Quinn, Mark T ^a  

^a MONTANA STATE UNIVERSITY   (United States)

^b ALTAI STATE TECHNICAL UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Agonist; Chiral recognition; Enantiomer; G protein coupled receptor; N formyl peptide receptor

Indexed keywords

3 (1H INDOL E 3Y) 2 [3 (4 NIROPHENYL)UREIDO]PROPANAMIDE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BOMBESIN RECEPTOR; CALCIUM ION; EMY 124; EMY 87; EMY 89; EMY 96; FORMYLPEPTIDE RECEPTOR; FORMYLPEPTIDE RECEPTOR 1; FORMYLPEPTIDE RECEPTOR 2; ML 16; ML 18; MOLECULAR SCAFFOLD; PD 168368; PD 175252; PD 176252; PD 360; PD 361; PD 362; PROPIONAMIDE DERIVATIVE; ST 11; ST 12; ST 13; ST 14; ST 15; ST 16; ST 6; ST 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; ENANTIOMER; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; MOUSE; NEUTROPHIL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM SIGNALING; CATALYTIC DOMAIN; CELLS, CULTURED; HL-60 CELLS; HUMANS; INDOLES; MODELS, MOLECULAR; NEUTROPHILS; PYRIDINES; RECEPTORS, BOMBESIN; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, LIPOXIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872677928     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.11.015     Document Type: Article

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