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Volumn 20, Issue 12, 2012, Pages 3781-3792

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

(10) Cilibrizzi, Agostino a Schepetkin, Igor A b Bartolucci, Gianluca a Crocetti, Letizia a Dal Piaz, Vittorio a Giovannoni, Maria Paola a Graziano, Alessia a Kirpotina, Liliya N b Quinn, Mark T b Vergelli, Claudia a

a UNIVERSITY OF FLORENCE (Italy)

b MONTANA STATE UNIVERSITY (United States)

Author keywords

Chiral agonists; Enantiomers; Formyl peptide receptors; Inflammation; Neutrophils; Pyridazin 3(2H) ones

Indexed keywords

2 ACETAMIDO 2,3 DIMETHYLBUTANOIC ACID; 6 METHYL 2,4 DISUBSTITUTED PYRIDAZIN 3(2H) ONE DERIVATIVE; ANTIINFLAMMATORY AGENT; BETA ARRESTIN; BROMO N (4 BROMOPHENYL)PROPANAMIDE; FORMYLPEPTIDE RECEPTOR; N (4 BROMOPHENYL) 2 [ (3 METHOXYBENZYL) 3 METHYL 6 OXOPYRIDAZIN 1 (6H) YL]BUTANAMIDE; N (4 BROMOPHENYL) 2 [5 (3 METHOXYBENZYL) 3 METHYL 6 OXOPYRIDAZIN 1 (6H) YL]PENTANAMIDE; N (4 BROMOPHENYL) 2 [5 (3 METHOXYBENZYL) 3 METHYL 6 OXOPYRIDAZIN 1 (6H) YL]PROPANAMIDE; N FORMYLPEPTIDE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

CALCIUM TRANSPORT; CHIRALITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; NEUTROPHIL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; HL-60 CELLS; HUMANS; MODELS, MOLECULAR; NEUTROPHILS; PYRIDAZINES; RECEPTORS, FORMYL PEPTIDE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861571323 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.04.043 Document Type: Conference Paper

Times cited : (23)

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