Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

Nature

Volumn 459, Issue 7246, 2009, Pages 574-577

  Rivière, Stéphane ^a   Challet, Ludivine ^a   Fluegge, Daniela ^b,c   Spehr, Marc ^b,c   Rodriguez, Ivan ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; FORMYLPEPTIDE RECEPTOR; FORMYLPEPTIDE RECEPTOR LIKE 1; FORMYLPEPTIDE RECEPTOR LIKE 3; FORMYLPEPTIDE RECEPTOR LIKE 4; FORMYLPEPTIDE RECEPTOR LIKE 6; FORMYLPEPTIDE RECEPTOR LIKE 7; LIGAND; UNCLASSIFIED DRUG;

BIOCHEMISTRY; CHEMORECEPTION; DISEASE INCIDENCE; LIGAND; ODOR; OLFACTION; PATHOGEN; PEPTIDE; PHEROMONE; PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; IN VITRO STUDY; INFLAMMATION; MAMMAL; MOLECULAR SENSOR; MOLECULE; MOUSE; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; VOMERONASAL ORGAN;

ANIMALS; CALCIUM SIGNALING; CELL LINE; DENDRITES; DISEASE; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; LIGANDS; MICE; OLFACTORY PERCEPTION; OLFACTORY RECEPTOR NEURONS; ORGAN SPECIFICITY; RECEPTORS, FORMYL PEPTIDE; SMELL; VOMERONASAL ORGAN;

MAMMALIA;

EID: 66449113577     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08029     Document Type: Article

References (20)

1. Kelliher, K. R. The combined role of the main olfactory and vomeronasal systems in social communication in mammals. Horm. Behav. 52, 561-570 (2007).
2. Buck, L. & Axel, R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175-187 (1991).
3. Liberles, S. D. & Buck, L. B. A second class of chemosensory receptors in the olfactory epithelium. Nature 442, 645-650 (2006).
4. Dulac, C. & Axel, R. A novel family of genes encoding putative pheromone receptors in mammals. Cell 83, 195-206 (1995).
5. Matsunami, H. & Buck, L. B. A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 90, 775-784 (1997).
6. Herrada, G. & Dulac, C. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Cell 90, 763-773 (1997).
7. Ryba, N. J. & Tirindelli, R. A new multigene family of putative pheromone receptors. Neuron 19, 371-379 (1997).
8. Migeotte, I., Communi, D. & Parmentier, M. Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev. 17, 501-519 (2006).
9. Roppolo, D. et al. Gene cluster lock after pheromone receptor gene choice. EMBO J. 26, 3423-3430 (2007).
10. Le, Y. et al. Biologically active peptides interacting with the G protein-coupled formylpeptide receptor. Protein Pept. Lett. 14, 846-853 (2007).
11. Le, Y., Murphy, P. M. & Wang, J. M. Formyl-peptide receptors revisited. Trends Immunol. 23, 541-548 (2002).
12. Leinders-Zufall, T. et al. Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature 405, 792-796 (2000).
13. Takata, M. et al. Detection of amyloid beta protein in the urine of Alzheimer's disease patients and healthy individuals. Neurosci. Lett. 435, 126-130 (2008).
14. Chromek, M. et al. The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nature Med. 12, 636-641 (2006).
15. Casella, R., Shariat, S. F., Monoski, M. A. & Lerner, S. P. Urinary levels of urokinase-type plasminogen activator and its receptor in the detection of bladder carcinoma. Cancer 95, 2494-2499 (2002).
16. Nodari, F. et al. Sulfated steroids as natural ligands of mouse pheromone-sensing neurons. J. Neurosci. 28, 6407-6418 (2008).
17. Kavaliers, M., Choleris, E., Agmo, A. & Pfaff, D. W. Olfactory-mediated parasite recognition and avoidance: linking genes to behavior. Horm. Behav. 46, 272-283 (2004).
18. Kavaliers, M. et al. Inadvertent social information and the avoidance of parasitized male mice: a role for oxytocin. Proc. Natl Acad. Sci. USA 103, 4293-4298 (2006).
19. Kavaliers, M., Choleris, E. & Pfaff, D. W. Genes, odours and the recognition of parasitized individuals by rodents. Trends Parasitol. 21, 423-429 (2005).
20. Spehr, M., Hatt, H. & Wetzel, C. H. Arachidonic acid plays a role in rat vomeronasal signal transduction. J. Neurosci. 22, 8429-8437 (2002).